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26 papers 100 to 500 followers
https://www.readbyqxmd.com/read/27456511/oxygen-targeting-in-extremely-low-birth-weight-infants
#1
James J Cummings, Richard A Polin
The use of supplemental oxygen plays a vital role in the care of the critically ill preterm infant, but the unrestricted use of oxygen can lead to unintended harms, such as chronic lung disease and retinopathy of prematurity. An overly restricted use of supplemental oxygen may have adverse effects as well. Ideally, continuous monitoring of tissue and cellular oxygen delivery would allow clinicians to better titrate the use of supplemental oxygen, but such monitoring is not currently feasible in the clinical setting...
August 2016: Pediatrics
https://www.readbyqxmd.com/read/27542848/evaluation-of-a-new-strategy-for-clean-catch-urine-in-infants
#2
Mélanie Labrosse, Arielle Levy, Julie Autmizguine, Jocelyn Gravel
BACKGROUND AND OBJECTIVES: A new noninvasive bladder stimulation technique has been described to obtain clean-catch urine (CCU) in infants aged <30 days. Objectives were (1) to determine proportion and predictive factors for successful CCU collections using a stimulation maneuver technique among infants <6 months and (2) to determine the proportion of bacterial contamination with this method. METHODS: A prospective cohort study was conducted in a tertiary pediatric emergency department among infants <6 months needing a urine sample...
September 2016: Pediatrics
https://www.readbyqxmd.com/read/27429428/guideline-for-the-evaluation-of-cholestatic-jaundice-in-infants-joint-recommendations-of-the-north-american-society-for-pediatric-gastroenterology-hepatology-and-nutrition-naspghan-and-the-european-society-for-pediatric-gastroenterology-hepatology-and-nutrition
#3
Rima Fawaz, Ulrich Baumann, Udeme Ekong, Björn Fischler, Nedim Hadzic, Cara L Mack, Valérie A McLin, Jean P Molleston, Ezequiel Neimark, Vicky Lee Ng, Saul J Karpen
Cholestatic jaundice in infancy affects approximately 1 in every 2500 term infants and is infrequently recognized by primary providers in the setting of physiologic jaundice. Cholestatic jaundice is always pathologic and indicates hepatobiliary dysfunction. Early detection by the primary care physician and timely referrals to the pediatric gastroenterologist/hepatologist are important contributors to optimal treatment and prognosis. The most common causes of cholestatic jaundice in the first months of life are biliary atresia (BA, 25-40%) followed by an expanding list of monogenic disorders (25%), plus many unknown or multifactorial (e...
July 16, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27238078/repeated-courses-of-oral-ibuprofen-in-premature-infants-with-patent-ductus-arteriosus-efficacy-and-safety
#4
Haşim Olgun, Naci Ceviz, İbrahim Kartal, İbrahim Caner, Mehmet Karacan, Ayhan Taştekin, Necip Becit
BACKGROUND: There are limited data about the results of repeated oral ibuprofen (OIBU) treatment. This study aimed to describe patent ductus arteriosus (PDA) closure rates and adverse events after repeated courses of OIBU in premature infants with PDA. METHODS: Preterm infants with hemodynamically significant (hs)PDA were enrolled in the study. If the first course of OIBU treatment failed, a second and, if required, third course was administered. RESULTS: A total of 100 patients received OIBU...
April 29, 2016: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/27379585/donor-breast-milk
#5
Megan A Moreno
No abstract text is available yet for this article.
July 1, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27355828/chorioamnionitis-and-five-year-neurodevelopmental-outcome-in-preterm-infants
#6
Milla Ylijoki, Liisa Lehtonen, Annika Lind, Eeva Ekholm, Helena Lapinleimu, Harry Kujari, Leena Haataja
BACKGROUND: Chorioamnionitis, a risk factor for preterm delivery, has been suggested to be associated with suboptimal neurological development in premature infants. OBJECTIVE: To evaluate the association between chorioamnionitis and neurodevelopment in preterm infants at 5 years of age. Methods Very low birth weight and very low gestational age infants (n = 197) were recruited. Placental samples (n = 117) were evaluated for histological chorioamnionitis. Fetal histological chorioamnionitis was analyzed as a subgroup...
2016: Neonatology
https://www.readbyqxmd.com/read/27322346/evaluation-and-management-of-febrile-children-a-review
#7
Leigh-Anne Cioffredi, Ravi Jhaveri
IMPORTANCE: Management of febrile children is an intrinsic aspect of pediatric practice. Febrile children account for 15% of emergency department visits and outcomes range from the presence of serious bacterial infection to benign self-limited illness. OBSERVATIONS: Studies from 1979 to 2015 examining febrile infants and children were included in this review. Management of febrile infants younger than 90 days has evolved considerably in the last 30 years. Increased rates of Escherichia coli urinary tract infections, increasing resistance to ampicillin, and advances in viral diagnostics have had an effect on the approach to caring for these patients...
August 1, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27236858/prevalence-of-maternal-colonisation-with-group-b-streptococcus-a-systematic-review-and-meta-analysis
#8
Gaurav Kwatra, Marianne C Cunnington, Elizabeth Merrall, Peter V Adrian, Margaret Ip, Keith P Klugman, Wing Hung Tam, Shabir A Madhi
BACKGROUND: The most important risk factor for early-onset (babies younger than 7 days) invasive group B streptococcal disease is rectovaginal colonisation of the mother at delivery. We aimed to assess whether differences in colonisation drive regional differences in the incidence of early-onset invasive disease. METHODS: We did a systematic review of maternal group B streptococcus colonisation studies by searching MEDLINE, Embase, Pascal Biomed, WHOLIS, and African Index Medicus databases for studies published between January, 1997, and March 31, 2015, that reported the prevalence of group B streptococcus colonisation in pregnant women...
September 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27273573/newborn-screening
#9
Megan A Moreno
No abstract text is available yet for this article.
June 1, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/26732078/anemia-and-transfusion-in-the-neonate
#10
REVIEW
Raffaella Colombatti, Laura Sainati, Daniele Trevisanuto
Neonatal anemia is a frequent occurrence in neonatal intensive care units. Red blood cell transfusion criteria in case of blood loss are clearly defined but optimal hemoglobin or hematocrit thresholds of transfusion for anemia due to decreased production or increased destruction are less evident. This review focuses on the causes of anemia in the newborn period and the most recent evidence-based treatment options, including transfusion and erythropoiesis-stimulating agents.
February 2016: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27129489/serial-c-reactive-protein-values-predict-sensitivity-of-organisms-to-empirical-antibiotics-in-neonates-a-nested-case-control-study
#11
Sandeep Patil, Sourabh Dutta, Savita Verma Attri, Pallab Ray, Praveen Kumar
BACKGROUND: It is common clinical practice to repeat serum C reactive protein (CRP) estimation in the first 48 h after starting empirical antibiotics for neonatal sepsis. The change in CRP is believed to indicate whether the empirical antibiotics are appropriate or not, but there is little evidence to support this practice. METHODS: This was a nested case-control study on neonates with suspected sepsis (clinical signs+baseline CRP >10 mg/L). We drew samples for serum CRP at baseline and at 24, 36 and 48 h after starting empirical antibiotics and stored them at -20°C...
April 29, 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/26589959/etiologies-of-conjugated-hyperbilirubinemia-in-infancy-a-systematic-review-of-1692-subjects
#12
REVIEW
Lena E Gottesman, Michael T Del Vecchio, Stephen C Aronoff
BACKGROUND: The etiologies of conjugated hyperbilirubinemia in infancy are diverse. OBJECTIVE: Determine the prevalence rates of the specific etiologies of conjugated hyperbilirubinemia in infancy. DATA SOURCES: EMBASE and Pubmed were searched electronically and the bibliographies of selected studies were search manually. The search was conducted independently by two authors. STUDY SELECTION: (1) prospective or retrospective case series or cohort study with 10 or more subjects; (2) consecutive infants who presented with conjugated hyperbilirubinemia; (3) subjects underwent appropriate diagnostic work-up for conjugated hyperbilirubinemia; (4) no specific diagnoses were excluded in the studied cohort...
2015: BMC Pediatrics
https://www.readbyqxmd.com/read/27064480/association-between-laboratory-calibration-of-a-serum-bilirubin-assay-neonatal-bilirubin-levels-and-phototherapy-use
#13
Michael W Kuzniewicz, Dina N Greene, Eileen M Walsh, Charles E McCulloch, Thomas B Newman
IMPORTANCE: The American Academy of Pediatrics treatment recommendations for neonatal jaundice are based on age-specific total serum bilirubin (TSB) levels. In May 2012, Ortho Clinical Diagnostics adjusted the calibrator values for Vitros Chemistry Products BuBc Slides (Ortho Clinical Diagnostics), a widely used method to quantify TSB, after concerns of positively biased results. OBJECTIVE: To investigate the association between recalibration of a reflectance spectrophotometry serum bilirubin assay and TSB levels and phototherapy use among newborns...
June 1, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/26862504/short-and-long-term-prognosis-in-perinatal-asphyxia-an-update
#14
REVIEW
Caroline E Ahearne, Geraldine B Boylan, Deirdre M Murray
Interruption of blood flow and gas exchange to the fetus in the perinatal period, known as perinatal asphyxia, can, if significant, trigger a cascade of neuronal injury, leading on to neonatal encephalopathy (NE) and resultant long-term damage. While the majority of infants who are exposed to perinatal hypoxia-ischaemia will recover quickly and go on to have a completely normal survival, a proportion will suffer from an evolving clinical encephalopathy termed hypoxic-ischaemic encephalopathy (HIE) or NE if the diagnosis is unclear...
February 8, 2016: World Journal of Clinical Pediatrics
https://www.readbyqxmd.com/read/26707690/neonatal-hypoglycemia-is-60-the-new-40-the-questions-remain-the-same
#15
REVIEW
D H Adamkin, R Polin
No abstract text is available yet for this article.
January 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/21949150/phototherapy-to-prevent-severe-neonatal-hyperbilirubinemia-in-the-newborn-infant-35-or-more-weeks-of-gestation
#16
Vinod K Bhutani
OBJECTIVE: To standardize the use of phototherapy consistent with the American Academy of Pediatrics clinical practice guideline for the management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. METHODS: Relevant literature was reviewed. Phototherapy devices currently marketed in the United States that incorporate fluorescent, halogen, fiber-optic, or blue light-emitting diode light sources were assessed in the laboratory. RESULTS: The efficacy of phototherapy units varies widely because of differences in light source and configuration...
October 2011: Pediatrics
https://www.readbyqxmd.com/read/24762414/causes-of-hemolysis-in-neonates-with-extreme-hyperbilirubinemia
#17
R D Christensen, R H Nussenzveig, H M Yaish, E Henry, L D Eggert, A M Agarwal
OBJECTIVE: We instituted a quality improvement process to enhance our capacity to diagnose genetic hemolytic conditions in neonates with extreme hyperbilirubinemia. STUDY DESIGN: During a 1-year period, whenever the total serum bilirubin (TSB) was >25 mg dl(-1) a special evaluation was performed. If we deemed an erythrocyte membrane defect likely, based on red blood cell morphology, EMA-flow cytometry was performed. Otherwise 'next-generation' sequencing was performed using a panel of genes involved in neonatal hyperbilirubinemia...
August 2014: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/25284470/hyperbilirubinemia-hemolysis-and-increased-bilirubin-neurotoxicity
#18
REVIEW
Michael Kaplan, Ruben Bromiker, Cathy Hammerman
Increased hemolysis in the presence of severe neonatal hyperbilirubinemia appears to augment the risk of bilirubin neurotoxicity. The mechanism of this intensifying effect is uncertain. In direct antiglobulin titer (DAT) positive, isoimmune hemolytic disease, the bilirubin threshold at which neurotoxicity occurs appears to be lower than in DAT-negative hyperbilirubinemia. In other hemolytic conditions, the hemolysis may simply facilitate the development of extremely high serum bilirubin levels. Whether the hemolytic process per se exerts an independent effect or whether a very rapid rise in serum bilirubin might lead to greater penetration of the blood-brain barrier is unclear...
November 2014: Seminars in Perinatology
https://www.readbyqxmd.com/read/26471383/part-13-neonatal-resuscitation-2015-american-heart-association-guidelines-update-for-cardiopulmonary-resuscitation-and-emergency-cardiovascular-care-reprint
#19
Myra H Wyckoff, Khalid Aziz, Marilyn B Escobedo, Vishal S Kapadia, John Kattwinkel, Jeffrey M Perlman, Wendy M Simon, Gary M Weiner, Jeanette G Zaichkin
No abstract text is available yet for this article.
November 2015: Pediatrics
https://www.readbyqxmd.com/read/26148104/the-use-of-automated-external-defibrillators-in-infants-a-report-from-the-american-red-cross-scientific-advisory-council
#20
REVIEW
Joseph W Rossano, Wendell E Jones, Stamatios Lerakis, Michael G Millin, Ira Nemeth, Pascal Cassan, Joan Shook, Siobán Kennedy, David Markenson, Richard N Bradley
OBJECTIVE: Automated external defibrillators (AEDs) have been used successfully in many populations to improve survival for out-of-hospital cardiac arrest. While ventricular fibrillation and pulseless ventricular tachycardia are more prevalent in adults, these arrhythmias do occur in infants. The Scientific Advisory Council of the American Red Cross reviewed the literature on the use of AEDs in infants in order to make recommendations on use in the population. METHODS: The Cochrane library and PubMed were searched for studies that included AEDs in infants, any external defibrillation in infants, and simulation studies of algorithms used by AEDs on pediatric arrhythmias...
July 2015: Pediatric Emergency Care
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