Read by QxMD icon Read

Optic neuritis

shared collection
1 papers 0 to 25 followers
Rhian Raftopoulos, Simon J Hickman, Ahmed Toosy, Basil Sharrack, Shahrukh Mallik, David Paling, Daniel R Altmann, Marios C Yiannakas, Prasad Malladi, Rose Sheridan, Ptolemaios G Sarrigiannis, Nigel Hoggard, Martin Koltzenburg, Claudia A M Gandini Wheeler-Kingshott, Klaus Schmierer, Gavin Giovannoni, David H Miller, Raju Kapoor
BACKGROUND: Acute demyelinating optic neuritis, a common feature of multiple sclerosis, can damage vision through neurodegeneration in the optic nerve and in its fibres in the retina. Inhibition of voltage-gated sodium channels is neuroprotective in preclinical models. In this study we aimed to establish whether sodium-channel inhibition with phenytoin is neuroprotective in patient with acute optic neuritis. METHODS: We did a randomised, placebo-controlled, double-blind phase 2 trial at two UK academic hospitals in London and Sheffield...
March 2016: Lancet Neurology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"