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https://www.readbyqxmd.com/read/25207767/pancreatic-adenocarcinoma
#1
REVIEW
David P Ryan, Theodore S Hong, Nabeel Bardeesy
New England Journal of Medicine, Volume 371, Issue 11, Page 1039-1049, September 2014.
September 11, 2014: New England Journal of Medicine
https://www.readbyqxmd.com/read/24430321/sigmoid-diverticulitis-a-systematic-review
#2
REVIEW
Arden M Morris, Scott E Regenbogen, Karin M Hardiman, Samantha Hendren
IMPORTANCE: Diverticulitis is a common disease. Recent changes in understanding its natural history have substantially modified treatment paradigms. OBJECTIVE: To review the etiology and natural history of diverticulitis and recent changes in treatment guidelines. EVIDENCE REVIEW: We searched the MEDLINE and Cochrane databases for English-language articles pertaining to diagnosis and management of diverticulitis published between January 1, 2000, and March 31, 2013...
January 15, 2014: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/24894746/hepatocellular-carcinoma-a-comprehensive-overview-of-surgical-therapy
#3
REVIEW
Annabelle L Fonseca, Charles H Cha
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, with a rising incidence in the United States. The increase in medical and locally ablative therapies have improved prognosis, however surgery, either liver resection or transplantation, remains the mainstay of therapy. An increased understanding of liver anatomy, improved imaging modalities and refinements of surgical technique have all led to improved outcomes after surgery. Both resection and transplantation may be used in a complementary manner...
November 2014: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28160528/meta-analysis-of-individual-patient-data-from-evar-1-dream-over-and-ace-trials-comparing-outcomes-of-endovascular-or-open-repair-for-abdominal-aortic-aneurysm-over-5-years
#4
REVIEW
J T Powell, M J Sweeting, P Ulug, J D Blankensteijn, F A Lederle, J-P Becquemin, R M Greenhalgh
BACKGROUND: The erosion of the early mortality advantage of elective endovascular aneurysm repair (EVAR) compared with open repair of abdominal aortic aneurysm remains without a satisfactory explanation. METHODS: An individual-patient data meta-analysis of four multicentre randomized trials of EVAR versus open repair was conducted to a prespecified analysis plan, reporting on mortality, aneurysm-related mortality and reintervention. RESULTS: The analysis included 2783 patients, with 14 245 person-years of follow-up (median 5·5 years)...
February 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28181265/differences-in-the-multimodal-treatment-of-gastric-cancer-east-versus-west
#5
Ashley Russo, Ping Li, Vivian E Strong
There has been a great deal of interest about varying treatment paradigms of gastric cancer in Eastern and Western countries. Differences in tumor biology, screening initiatives, surgical approach, extent of lymphadenectomy, and neoadjuvant versus adjuvant chemotherapy regimens have been studied and documented in the literature. The purpose of this review is to give an updated report on the current status and management differences in the treatment of gastric cancer between Eastern and Western countries.
February 9, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28187868/no-clinical-benefit-from-routine-histologic-examination-of-stapler-doughnuts-at-low-anterior-resection-for-rectal-cancer
#6
Jeremy Sugrue, Francois Dagbert, John Park, Slawomir Marecik, Leela M Prasad, Vivek Chaudhry, Jennifer Blumetti, Rajyasree Emmadi, Anders Mellgren, Johan Nordenstam
BACKGROUND: The aim of this study was to evaluate the clinical utility and cost-effectiveness of routine histologic examination of the doughnuts from stapled anastomoses in patients undergoing a low anterior resection for rectal cancer. METHODS: We performed a retrospective review of 486 patients who underwent a low anterior resection with stapled anastomosis for rectal cancer between 2002 and 2015 at 3 institutions. Pathologic findings in the doughnuts and their impact on patient management were recorded...
February 7, 2017: Surgery
https://www.readbyqxmd.com/read/28218406/randomized-clinical-trial-of-mesh-fixation-with-glue-or-sutures-for-lichtenstein-hernia-repair
#7
C Hoyuela, M Juvany, F Carvajal, A Veres, D Troyano, M Trias, A Martrat, J Ardid, J Obiols, M López-Cano
BACKGROUND: Pain is the most likely reason for delay in resuming normal activities after groin hernia repair. The primary aim of this study was to determine whether the use of glue to fix the mesh instead of sutures reduced acute postoperative pain after inguinal hernia repair. Secondary objectives were to compare postoperative complications, chronic pain and early recurrence rates during 1-year follow-up. METHODS: Some 370 patients who underwent Lichtenstein hernia repair were randomized to receive either glue (Histoacryl®) or non-absorbable polypropylene sutures for fixation of lightweight polypropylene mesh...
May 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28259285/serum-and-tissue-markers-in-colorectal-cancer-state-of-art
#8
REVIEW
Massimiliano Berretta, Lara Alessandrini, Chiara De Divitiis, Guglielmo Nasti, Arben Lleshi, Raffaele Di Francia, Gaetano Facchini, Carla Cavaliere, Carlo Buonerba, Vincenzo Canzonieri
Colorectal cancer (CRC) represents one of the most commonly diagnosed cancers worldwide. It is the second leading cause of cancer death in Western Countries. In the last decade, the survival of patients with metastatic CRC has improved dramatically. Due to the advent of new drugs (irinotecan and oxaliplatin) and target therapies (i.e. bevacizumab, cetuximab, panitumab, aflibercept and regorafenib), the median overall survival has risen from about 12 mo in the mid nineties to 30 mo recently. Molecular studies have recently widened the opportunity for testing new possible markers, but actually, only few markers can be recommended for practical use in clinic...
March 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28267992/clostridium-difficile-disease-diagnosis-pathogenesis-and-treatment-update
#9
REVIEW
Lena M Napolitano, Charles E Edmiston
Clostridium difficile infections are the leading cause of health care-associated infectious diarrhea, posing a significant risk for both medical and surgical patients. Because of the significant morbidity and mortality associated with C difficile infections, knowledge of the epidemiology of C difficile in combination with a high index of suspicion and susceptible patient populations (including surgical, postcolectomy, and inflammatory bowel disease patients) is warranted. C difficile infections present with a wide spectrum of disease, ranging from mild diarrhea to fulminant colitis or small bowel enteritis and recurrent C difficile infections...
March 3, 2017: Surgery
https://www.readbyqxmd.com/read/28213607/efficacy-and-safety-of-nonoperative-treatment-for-acute-appendicitis-a-meta-analysis
#10
REVIEW
Roxani Georgiou, Simon Eaton, Michael P Stanton, Agostino Pierro, Nigel J Hall
CONTEXT: Nonoperative treatment (NOT) with antibiotics alone of acute uncomplicated appendicitis (AUA) in children has been proposed as an alternative to appendectomy. OBJECTIVE: To determine safety and efficacy of NOT based on current literature. DATA SOURCES: Three electronic databases. STUDY SELECTION: All articles reporting NOT for AUA in children. DATA EXTRACTION: Two reviewers independently verified study inclusion and extracted data...
March 2017: Pediatrics
https://www.readbyqxmd.com/read/28328681/predictors-of-mortality-following-emergency-general-surgery-an-american-college-of-surgeons-national-surgical-quality-improvement-program-risk-calculator
#11
Ivy N Haskins, Patrick J Maluso, Mary E Schroeder, Richard L Amdur, Khashayar Vaziri, Samir Agarwal, Babak Sarani
BACKGROUND: The complex nature of current morbidity and mortality predictor models do not lend themselves to clinical application at the bedside of patients undergoing emergency general surgery (EGS). Our aim was to develop a simplified risk calculator for prediction of early postoperative mortality following EGS. STUDY DESIGN: EGS cases other than appendectomy and cholecystectomy were identified within the American College of Surgeons National Surgery Quality Improvement Program (ACS-NSQIP) database from 2005-2014...
March 21, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28320242/early-goal-directed-therapy-for-septic-shock-a-patient-level-meta-analysis
#12
(no author information available yet)
Background After a single-center trial and observational studies suggesting that early, goal-directed therapy (EGDT) reduced mortality from septic shock, three multicenter trials (ProCESS, ARISE, and ProMISe) showed no benefit. This meta-analysis of individual patient data from the three recent trials was designed prospectively to improve statistical power and explore heterogeneity of treatment effect of EGDT. Methods We harmonized entry criteria, intervention protocols, outcomes, resource-use measures, and data collection across the trials and specified all analyses before unblinding...
March 21, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/26583669/prospective-study-of-malabsorption-and-malnutrition-after-esophageal-and-gastric-cancer-surgery
#13
Helen M Heneghan, Alexandra Zaborowski, Michelle Fanning, Aisling McHugh, Suzanne Doyle, Jenny Moore, Nayarasamy Ravi, John V Reynolds
OBJECTIVE: To study malabsorption and malnutrition after curative resection of esophageal and gastric cancer. DESIGN: Prospective cohort study. BACKGROUND: Improved cure rates for esophageal and gastric cancer have increased focus on health-related quality of life (HR-QL) in survivorship. Although malnutrition is well described in long-term follow-up, and gastrointestinal symptoms are common, data on gut and pancreatic-related malabsorption are scant...
November 2015: Annals of Surgery
https://www.readbyqxmd.com/read/27664260/gastric-cancer-esmo-clinical-practice-guidelines-for-diagnosis-treatment-and-follow-up
#14
E C Smyth, M Verheij, W Allum, D Cunningham, A Cervantes, D Arnold
No abstract text is available yet for this article.
September 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27686365/randomized-clinical-trial-of-observational-versus-antibiotic-treatment-for-a-first-episode-of-ct-proven-uncomplicated-acute-diverticulitis
#15
RANDOMIZED CONTROLLED TRIAL
L Daniels, Ç Ünlü, N de Korte, S van Dieren, H B Stockmann, B C Vrouenraets, E C Consten, J A van der Hoeven, Q A Eijsbouts, I F Faneyte, W A Bemelman, M G Dijkgraaf, M A Boermeester
BACKGROUND: Antibiotics are advised in most guidelines on acute diverticulitis, despite a lack of evidence to support their routine use. This trial compared the effectiveness of a strategy with or without antibiotics for a first episode of uncomplicated acute diverticulitis. METHODS: Patients with CT-proven, primary, left-sided, uncomplicated, acute diverticulitis were included at 22 clinical sites in the Netherlands, and assigned randomly to an observational or antibiotic treatment strategy...
January 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/27788918/comparison-of-outcomes-of-patients-with-acute-appendicitis-between-an-acute-care-surgery-model-and-traditional-call-coverage-model-in-the-same-community
#16
COMPARATIVE STUDY
Shaina Schaetzel, Rachel Dirks, James Davis
BACKGROUND: This study compared outcomes, patient flow, and cost between an acute care surgery (ACS) and traditional call model (TRAD) for acute appendicitis in the same community and time period. METHODS: Patients who underwent appendectomy from 7/1/2012 to 6/30/2014 were retrospectively reviewed. An ACS and TRAD were compared. Demographic data, outcomes, cost, and time intervals were compared. RESULTS: Of the 945 patients reviewed, the ACS group had more perforated appendicitis on preoperative computed tomography scan (9% vs 3%, P < ...
December 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27793458/nonoperative-management-of-appendicitis-in-adults-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#17
REVIEW
John M Findlay, Jihène El Kafsi, Clare Hammer, Jeffrey Gilmour, Richard S Gillies, Nicholas D Maynard
No abstract text is available yet for this article.
December 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27521713/gallbladder-disease-in-children
#18
REVIEW
David H Rothstein, Carroll M Harmon
Biliary disease in children has changed over the past few decades, with a marked rise in incidence-perhaps most related to the parallel rise in pediatric obesity-as well as a rise in cholecystectomy rates. In addition to stone disease (cholelithiasis), acalculous causes of gallbladder pain such as biliary dyskinesia, also appear to be on the rise and present diagnostic and treatment conundrums to surgeons.
August 2016: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/27759621/antibiotics-versus-surgical-therapy-for-uncomplicated-appendicitis-systematic-review-and-meta-analysis-of-controlled-trials-prospero-2015-crd42015016882
#19
Julian C Harnoss, Isabelle Zelienka, Pascal Probst, Kathrin Grummich, Catharina Müller-Lantzsch, Jonathan M Harnoss, Alexis Ulrich, Markus W Büchler, Markus K Diener
OBJECTIVE: The aim was to investigate available evidence regarding effectiveness and safety of surgical versus conservative treatment of acute appendicitis. SUMMARY OF BACKGROUND DATA: There is ongoing debate on the merits of surgical and conservative treatment for acute appendicitis. METHODS: A systematic literature search (Cochrane Library, Medline, Embase) and hand search of retrieved reference lists up to January 2016 was conducted to identify randomized and nonrandomized studies...
May 2017: Annals of Surgery
https://www.readbyqxmd.com/read/27567926/laparoscopic-lavage-is-superior-to-colon-resection-for-perforated-purulent-diverticulitis-a-meta-analysis
#20
REVIEW
Eva Angenete, David Bock, Jacob Rosenberg, Eva Haglind
PURPOSE: Perforated diverticulitis often requires surgery with a colon resection such as Hartmann's procedure, with inherent morbidity. Recent studies suggest that laparoscopic lavage may be an alternative surgical treatment. The aim of this study was to compare re-operations, morbidity, and mortality as well as health economic outcomes between laparoscopic lavage and colon resection for perforated purulent diverticulitis. METHODS: PubMed, Cochrane, Centre for Reviews and Dissemination, and Embase were searched...
February 2017: International Journal of Colorectal Disease
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