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https://www.readbyqxmd.com/read/26730878/exercise-based-cardiac-rehabilitation-for-coronary-heart-disease
#1
REVIEW
Lindsey Anderson, David R Thompson, Neil Oldridge, Ann-Dorthe Zwisler, Karen Rees, Nicole Martin, Rod S Taylor
BACKGROUND: Coronary heart disease (CHD) is the single most common cause of death globally. However, with falling CHD mortality rates, an increasing number of people live with CHD and may need support to manage their symptoms and prognosis. Exercise-based cardiac rehabilitation (CR) aims to improve the health and outcomes of people with CHD. This is an update of a Cochrane systematic review previously published in 2011. OBJECTIVES: To assess the effectiveness and cost-effectiveness of exercise-based CR (exercise training alone or in combination with psychosocial or educational interventions) compared with usual care on mortality, morbidity and HRQL in patients with CHD...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27039945/blood-pressure-and-cholesterol-lowering-in-persons-without-cardiovascular-disease
#2
RANDOMIZED CONTROLLED TRIAL
Salim Yusuf, Eva Lonn, Prem Pais, Jackie Bosch, Patricio López-Jaramillo, Jun Zhu, Denis Xavier, Alvaro Avezum, Lawrence A Leiter, Leopoldo S Piegas, Alexander Parkhomenko, Matyas Keltai, Katalin Keltai, Karen Sliwa, Irina Chazova, Ron J G Peters, Claes Held, Khalid Yusoff, Basil S Lewis, Petr Jansky, Kamlesh Khunti, William D Toff, Christopher M Reid, John Varigos, Jose L Accini, Robert McKelvie, Janice Pogue, Hyejung Jung, Lisheng Liu, Rafael Diaz, Antonio Dans, Gilles Dagenais
BACKGROUND: Elevated blood pressure and elevated low-density lipoprotein (LDL) cholesterol increase the risk of cardiovascular disease. Lowering both should reduce the risk of cardiovascular events substantially. METHODS: In a trial with 2-by-2 factorial design, we randomly assigned 12,705 participants at intermediate risk who did not have cardiovascular disease to rosuvastatin (10 mg per day) or placebo and to candesartan (16 mg per day) plus hydrochlorothiazide (12...
May 26, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/26886419/randomized-trial-of-stent-versus-surgery-for-asymptomatic-carotid-stenosis
#3
RANDOMIZED CONTROLLED TRIAL
Kenneth Rosenfield, Jon S Matsumura, Seemant Chaturvedi, Tom Riles, Gary M Ansel, D Chris Metzger, Lawrence Wechsler, Michael R Jaff, William Gray
BACKGROUND: Previous clinical trials have suggested that carotid-artery stenting with a device to capture and remove emboli ("embolic protection") is an effective alternative to carotid endarterectomy in patients at average or high risk for surgical complications. METHODS: In this trial, we compared carotid-artery stenting with embolic protection and carotid endarterectomy in patients 79 years of age or younger who had severe carotid stenosis and were asymptomatic (i...
March 17, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/25908023/successful-treatment-of-a-massive-metoprolol-overdose-using-intravenous-lipid-emulsion-and-hyperinsulinemia-euglycemia-therapy
#4
Cassie A Barton, Nathan B Johnson, Nathan D Mah, Gillian Beauchamp, Robert Hendrickson
Adrenergic β-antagonists, commonly known as β-blockers, are prescribed for many indications including hypertension, heart failure, arrhythmias, and migraines. Metoprolol is a moderately lipophilic β-blocker that in overdose causes direct myocardial depression leading to bradycardia, hypotension, and the potential for cardiovascular collapse. We describe the case of a 59-year-old man who intentionally ingested ~7.5 g of metoprolol tartrate. Initial treatment of bradycardia and hypotension included glucagon, atropine, dopamine, and norepinephrine...
May 2015: Pharmacotherapy
https://www.readbyqxmd.com/read/26965534/platelet-inhibition-with-ticagrelor-60-mg-versus-90-mg-twice-daily-in-the-pegasus-timi-54-trial
#5
RANDOMIZED CONTROLLED TRIAL
Robert F Storey, Dominick J Angiolillo, Marc P Bonaca, Mark R Thomas, Heather M Judge, Fabiana Rollini, Francesco Franchi, Arif J Ahsan, Deepak L Bhatt, Julia F Kuder, Philippe Gabriel Steg, Marc Cohen, Rangasamy Muthusamy, Eugene Braunwald, Marc S Sabatine
BACKGROUND: The PEGASUS-TIMI 54 (Prevention of Cardiovascular Events in Patients with Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis In Myocardial Infarction 54) trial studied 2 doses of ticagrelor, 90 mg twice a day (bid) and 60 mg bid, for long-term prevention of ischemic events in patients with prior myocardial infarction. Both doses similarly reduced the rate of ischemic events versus placebo. The pharmacokinetics and pharmacodynamics of ticagrelor 60 mg bid have not been studied...
March 15, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/26890473/endarterectomy-stenting-or-neither-for-asymptomatic-carotid-artery-stenosis
#6
EDITORIAL
J David Spence, A Ross Naylor
No abstract text is available yet for this article.
March 17, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/26768210/the-management-of-acute-coronary-syndromes-towards-optimal-treatment-of-stemi-and-non-stemi
#7
EDITORIAL
Thomas F Lüscher
No abstract text is available yet for this article.
January 14, 2016: European Heart Journal
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