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General pediatrics

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39 papers 500 to 1000 followers
By Neil Fernandes Pediatric resident currently pediatric critical care fellow next!
https://www.readbyqxmd.com/read/29727363/benzodiazepines-and-development-of-delirium-in-critically-ill-children-estimating-the-causal-effect
#1
Kalgi Mody, Savneet Kaur, Elizabeth A Mauer, Linda M Gerber, Bruce M Greenwald, Gabrielle Silver, Chani Traube
OBJECTIVES: Benzodiazepine use may be associated with delirium in critically ill children. However, benzodiazepines remain the first-line sedative choice in PICUs. Objectives were to determine the temporal relationship between administration of benzodiazepines and delirium development, control for time-varying covariates such as mechanical ventilation and opiates, and evaluate the association between dosage of benzodiazepines and subsequent delirium. DESIGN: Retrospective observational study...
May 4, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29530658/systemic-antibiotics-for-the-treatment-of-skin-and-soft-tissue-abscesses-a-systematic-review-and-meta-analysis
#2
REVIEW
Michael Gottlieb, Joshua M DeMott, Marilyn Hallock, Gary D Peksa
STUDY OBJECTIVE: The addition of antibiotics to standard incision and drainage is controversial, with earlier studies demonstrating no significant benefit. However, 2 large, multicenter trials have recently been published that have challenged the previous literature. The goal of this review was to determine whether systemic antibiotics for abscesses after incision and drainage improve cure rates. METHODS: PubMed, the Cumulative Index of Nursing and Allied Health Literature, Scopus, the Cochrane Database of Systematic Reviews, the Cochrane Central Register of Controlled Trials, and bibliographies of selected articles were assessed for all randomized controlled trials comparing adjuvant antibiotics with placebo in the treatment of drained abscesses, with an outcome of treatment failure assessed within 21 days...
March 9, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29187579/urinary-tract-infection-antibiotic-trial-study-design-a-systematic-review
#3
REVIEW
Romain Basmaci, Konstantinos Vazouras, Julia Bielicki, Laura Folgori, Yingfen Hsia, Theoklis Zaoutis, Mike Sharland
CONTEXT: Urinary tract infections (UTIs) represent common bacterial infections in children. No guidance on the conduct of pediatric febrile UTI clinical trials (CTs) exist. OBJECTIVE: To assess the criteria used for patient selection and the efficacy end points in febrile pediatric UTI CTs. DATA SOURCES: Medline, Embase, Cochrane central databases, and clinicaltrials.gov were searched between January 1, 1990, and November 24, 2016. STUDY SELECTION: We combined Medical Subject Headings terms and free-text terms for "urinary tract infections" and "therapeutics" and "clinical trials" in children (0-18 years), identifying 3086 articles...
December 2017: Pediatrics
https://www.readbyqxmd.com/read/29470322/pediatric-gastroesophageal-reflux-clinical-practice-guidelines-joint-recommendations-of-the-north-american-society-for-pediatric-gastroenterology-hepatology-and-nutrition-and-the-european-society-for-pediatric-gastroenterology-hepatology-and-nutrition
#4
Rachel Rosen, Yvan Vandenplas, Maartje Singendonk, Michael Cabana, Carlo DiLorenzo, Frederic Gottrand, Sandeep Gupta, Miranda Langendam, Annamaria Staiano, Nikhil Thapar, Neelesh Tipnis, Merit Tabbers
This document serves as an update of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) 2009 clinical guidelines for the diagnosis and management of gastroesophageal reflux disease (GERD) in infants and children and is intended to be applied in daily practice and as a basis for clinical trials. Eight clinical questions addressing diagnostic, therapeutic and prognostic topics were formulated...
March 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29700201/antibiotic-allergy-in-pediatrics
#5
REVIEW
Allison Eaddy Norton, Katherine Konvinse, Elizabeth J Phillips, Ana Dioun Broyles
The overlabeling of pediatric antibiotic allergy represents a huge burden in society. Given that up to 10% of the US population is labeled as penicillin allergic, it can be estimated that at least 5 million children in this country are labeled with penicillin allergy. We now understand that most of the cutaneous symptoms that are interpreted as drug allergy are likely viral induced or due to a drug-virus interaction, and they usually do not represent a long-lasting, drug-specific, adaptive immune response to the antibiotic that a child received...
April 26, 2018: Pediatrics
https://www.readbyqxmd.com/read/29493089/intravenous-iron-safe-and-underutilized-in-children
#6
Elpis Mantadakis
No abstract text is available yet for this article.
June 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29384890/nutrition-in-paediatric-inflammatory-bowel-disease-a-position-paper-on-behalf-of-the-porto-ibd-group-of-espghan
#7
Erasmo Miele, Raanan Shamir, Marina Aloi, Amit Assa, Christian Braegger, Jiri Bronsky, Lissy de Ridder, Johanna C Escher, Iva Hojsak, Sanja Kolaček, Sibylle Koletzko, Arie Levine, Paolo Lionetti, Massimo Martinelli, Frank Ruemmele, Richard K Russell, Rotem Sigall Boneh, Johan van Limbergen, Gigi Veereman, Annamaria Staiano
BACKGROUND AND AIMS: A growing body of evidence supports the need for detailed attention to nutrition and diet in children with IBD. We aimed to define the steps in instituting dietary or nutritional management in light of the current evidence and to offer a useful and practical guide to physicians and dieticians involved in the care of paediatric IBD patients. METHODS: A group of 20 experts in paediatric IBD participated in an iterative consensus process including 2 face-to-face meetings, following an open call to ESPGHAN Porto, IBD Interest and Nutrition Committee...
January 29, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29339563/the-diagnosis-of-uti-colony-count-criteria-revisited
#8
Kenneth B Roberts, Ellen R Wald
No abstract text is available yet for this article.
February 2018: Pediatrics
https://www.readbyqxmd.com/read/27349388/pfapa-syndrome-a-review-on-treatment-and-outcome
#9
REVIEW
Federica Vanoni, Katerina Theodoropoulou, Michaël Hofer
The syndrome of periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA syndrome) is the most common cause of periodic fever in childhood. The current pharmacological treatment includes corticosteroids, which usually are efficacious in the management of fever episodes, colchicine, for the prophylaxis of febrile episodes, and other medication for which efficacy has not been proven so far. Tonsillectomy is an option for selected patients. Usually PFAPA syndrome resolves during adolescence, but there is increasing evidence that this condition may persist into adulthood...
June 27, 2016: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/25407568/trismus-in-the-paediatric-population
#10
REVIEW
Peter M Shires, Gabriel Chow
Trismus is a rare presentation affecting neonates, children, and adults. In newborns there are serious implications, with potential to affect feeding, cause airway problems, and make intubation difficult. Causes of trismus seen in the paediatric patient are discussed in this review article; they are divided into intra- and extra-articular types. The extra-articular group consists of congenital and acquired disorders. The acquired group includes infective causes such as tetanus, iatrogenic causes related to drugs, cancer or dental treatment, and trauma causing articulation difficulty or triggering a rare type of bone growth in myositis ossificans...
April 2015: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28196933/can-i-stop-phototherapy-for-this-baby
#11
COMMENT
Ian M Paul, M Jeffrey Maisels
No abstract text is available yet for this article.
March 2017: Pediatrics
https://www.readbyqxmd.com/read/27803030/management-of-endocrine-disease-growth-and-growth-hormone-therapy-in-short-children-born-preterm
#12
REVIEW
Margaret Cristina da Silva Boguszewski, Adriane de Andre Cardoso-Demartini
Approximately 15 million babies are born preterm across the world every year, with less than 37 completed weeks of gestation. Survival rates increased during the last decades with the improvement of neonatal care. With premature birth, babies are deprived of the intense intrauterine growth phase, and postnatal growth failure might occur. Some children born prematurely will remain short at later ages and adult life. The risk of short stature increases if the child is also born small for gestational age. In this review, the effects of being born preterm on childhood growth and adult height and the hormonal abnormalities possibly associated with growth restriction are discussed, followed by a review of current information on growth hormone treatment for those who remain with short stature during infancy and childhood...
March 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28193791/epinephrine-for-first-aid-management-of-anaphylaxis
#13
REVIEW
Scott H Sicherer, F Estelle R Simons
Anaphylaxis is a severe, generalized allergic or hypersensitivity reaction that is rapid in onset and may cause death. Epinephrine (adrenaline) can be life-saving when administered as rapidly as possible once anaphylaxis is recognized. This clinical report from the American Academy of Pediatrics is an update of the 2007 clinical report on this topic. It provides information to help clinicians identify patients at risk of anaphylaxis and new information about epinephrine and epinephrine autoinjectors (EAs). The report also highlights the importance of patient and family education about the recognition and management of anaphylaxis in the community...
March 2017: Pediatrics
https://www.readbyqxmd.com/read/25569020/the-role-of-tonsillectomy-in-the-treatment-of-pediatric-autoimmune-neuropsychiatric-disorders-associated-with-streptococcal-infections-pandas
#14
Daniel Demesh, Jordan M Virbalas, John P Bent
IMPORTANCE: Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) in children describes neuropsychiatric symptom exacerbations that relate temporally to streptococcal infections. Recent case reports suggest tonsillectomy may effectively reduce these symptoms; however, no consensus treatment guidelines exist. This study examines whether tonsillectomy improves neuropsychiatric symptoms in children with PANDAS who have incomplete response to antibiotic therapy...
March 2015: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/26801356/interventions-for-hidradenitis-suppurativa-a-cochrane-systematic-review-incorporating-grade-assessment-of-evidence-quality
#15
REVIEW
J R Ingram, P N Woo, S L Chua, A D Ormerod, N Desai, A C Kai, K Hood, T Burton, F Kerdel, S E Garner, V Piguet
More than 50 interventions have been used to treat hidradenitis suppurativa (HS), and so therapy decisions can be challenging. Our objective was to summarize and appraise randomized controlled trial (RCT) evidence for HS interventions in adults. Searches were conducted in Medline, Embase, CENTRAL, LILACS, five trials registers and abstracts from eight dermatology conferences until 13 August 2015. Two review authors independently assessed study eligibility, extracted data and assessed methodological quality...
May 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27940788/urine-concentration-and-pyuria-for-identifying-uti-in-infants
#16
Pradip P Chaudhari, Michael C Monuteaux, Richard G Bachur
BACKGROUND: Varying urine white blood cell (WBC) thresholds have been recommended for the presumptive diagnosis of urinary tract infection (UTI) among young infants. These thresholds have not been studied with newer automated urinalysis systems that analyze uncentrifuged urine that might be influenced by urine concentration. Our objective was to determine the optimal urine WBC threshold for UTI in young infants by using an automated urinalysis system, stratified by urine concentration...
November 2016: Pediatrics
https://www.readbyqxmd.com/read/28044040/charge-syndrome
#17
EDITORIAL
Alexandra Hudson, Carrie-Lee Trider, Kim Blake
No abstract text is available yet for this article.
January 2017: Pediatrics in Review
https://www.readbyqxmd.com/read/27647842/clinical-presentation-of-childhood-leukaemia-a-systematic-review-and-meta-analysis
#18
REVIEW
Rachel T Clarke, Ann Van den Bruel, Clare Bankhead, Christopher D Mitchell, Bob Phillips, Matthew J Thompson
OBJECTIVE: Leukaemia is the most common cancer of childhood, accounting for a third of cases. In order to assist clinicians in its early detection, we systematically reviewed all existing data on its clinical presentation and estimated the frequency of signs and symptoms presenting at or prior to diagnosis. DESIGN: We searched MEDLINE and EMBASE for all studies describing presenting features of leukaemia in children (0-18 years) without date or language restriction, and, when appropriate, meta-analysed data from the included studies...
October 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27542848/evaluation-of-a-new-strategy-for-clean-catch-urine-in-infants
#19
Mélanie Labrosse, Arielle Levy, Julie Autmizguine, Jocelyn Gravel
BACKGROUND AND OBJECTIVES: A new noninvasive bladder stimulation technique has been described to obtain clean-catch urine (CCU) in infants aged <30 days. Objectives were (1) to determine proportion and predictive factors for successful CCU collections using a stimulation maneuver technique among infants <6 months and (2) to determine the proportion of bacterial contamination with this method. METHODS: A prospective cohort study was conducted in a tertiary pediatric emergency department among infants <6 months needing a urine sample...
September 2016: Pediatrics
https://www.readbyqxmd.com/read/22978406/how-not-to-miss-autoinflammatory-diseases-masquerading-as-urticaria
#20
REVIEW
K Krause, C E Grattan, C Bindslev-Jensen, M Gattorno, T Kallinich, H D de Koning, H J Lachmann, D Lipsker, A A Navarini, A Simon, C Traidl-Hoffmann, M Maurer
Urticarial skin reactions are one of the most frequent problems seen by allergists and clinical immunologists in daily practice. The most common reason for recurrent wheals is spontaneous urticaria. There are, however, several less common diseases that present with urticarial rash, such as urticarial vasculitis and autoinflammatory disorders. The latter include cryopyrin-associated periodic syndrome and Schnitzler's syndrome, both rare and disabling conditions mediated by increased interleukin-1 secretion. Apart from the urticarial rash, patients are suffering from a variety of systemic symptoms including recurrent fever attacks, arthralgia or arthritis and fatigue...
December 2012: Allergy
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