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Michael Jaronczyk, William Boyan, Michael Goldfarb
No abstract text is available yet for this article.
February 2016: American Surgeon
Aaron P Thrift
Since the early 1970s, the incidence of oesophageal adenocarcinoma has increased dramatically in most Western populations. In contrast, the incidence of oesophageal squamous-cell carcinoma has decreased in these same populations. Epidemiological studies conducted over the past decade have provided great insights into the etiology of oesophageal cancer. These studies have identified gastro-oesophageal reflux disease, obesity and cigarette smoking as risk factors for oesophageal adenocarcinoma, while use of nonsteroidal anti-inflammatory drugs and infection with Helicobacter pylori are associated with reduced risk of oesophageal adenocarcinoma...
April 2016: Cancer Epidemiology
Adam Kaczorowski, Katharina Hammer, Li Liu, Sabine Villhauer, Clifford Nwaeburu, Pei Fan, Zhefu Zhao, Jury Gladkich, Wolfgang GroƟ, Dirk M Nettelbeck, Ingrid Herr
Pancreatic ductal adenocarcinoma (PDA) is one of the most aggressive malignancies and has poor therapeutic options. We evaluated improved oncolytic adenoviruses (OAds), in which the adenoviral gene E1B19K was deleted or a TRAIL transgene was inserted. Bone marrow mesenchymal stromal cells (MSCs) served as carriers for protected and tumor-specific virus transfers. The infection competence, tumor migration, and oncolysis were measured in cancer stem cell (CSC) models of primary and established tumor cells and in tumor xenografts...
February 23, 2016: Oncotarget
V M Leow, M S Faizah, S Mohd Sharifudin, L Vasu Pillai, K F Yang, K S Manisekar
OBJECTIVE: Various techniques and instruments have been developed to provide safe and secure closure of laparoscopic wounds. Herein we describe a simple method to close laparoscopic supraumbilical wounds with the aid of a laparoscopic port. METHOD: This was a retrospective review of prospective data, which were from 151 patients who underwent laparoscopic cholecystectomy for symptomatic gallstone disease from December 2009 to December 2010 in Sultanah Bahiyah Hospital...
October 2015: Medical Journal of Malaysia
Oscar K Serrano, Kevin Huang, Nicole Ng, Julie Yang, Patricia Friedmann, Steven K Libutti, Timothy J Kennedy
BACKGROUND: Recent evidence validates the effectiveness of neoadjuvant chemotherapy in the treatment of gastric adenocarcinoma. Endoscopic ultrasonographic (EUS) staging has been proposed as a useful adjunct in this setting. METHODS: We performed a retrospective review of patients treated at our institution for gastric adenocarcinoma between July 2005 and January 2014. We identified patients referred for EUS before surgery as part of a prospective treatment plan...
January 2016: Journal of Surgical Oncology
Mohammadtaghi Rajabi Mashhadi, Reza Bagheri, Abbas Abdollahi, Mohammad Javad Ghamari, Soudabeh Shahidsales, Maryam Salehi, Reza Shahkaram, Mohamad Reza Majidi, Shima Sheibani
INTRODUCTION: Early diagnosis and appropriate treatment is required in esophageal cancer due to its invasive nature. The aim of this study was to evaluate early post-esophagectomy complications in patients with esophageal cancer who received neoadjuvant chemoradiotherapy (NACR). MATERIALS AND METHODS: This randomized clinical trial was carried out between 2009 and 2011. Patients with lower-third esophageal cancer were randomly assigned to one of two groups. The first group consisted of 50 patients receiving standard chemoradiotherapy (Group A) and then undergoing surgery, and the second group consisted of 50 patients undergoing surgery only (Group B)...
July 2015: Iranian Journal of Otorhinolaryngology
Yasumichi Yagi, Shozo Sasaki, Akemi Yoshikawa, Yuji Tsukioka, Wataru Fukushima, Takashi Fujimura, Hisashi Hirosawa, Ryohei Izumi, Katsuhiko Saito
Metastases to the gastrointestinal tract rarely occur in breast cancer except in invasive lobular carcinoma. The present study reports a rare case of metastatic gastric cancer from invasive ductal carcinoma (IDC) of the breast mimicking primary gastric linitis plastica. A 51-year-old premenopausal female, who had a history of partial mastectomy for right breast cancer at the age of 40, was referred to Toyama City Hospital (Toyoma, Japan) for an endoscopic diagnosis of gastric linitis plastica. Abdominal computed tomography (CT) revealed left hydronephrosis, while peritoneal metastasis and malignant ascites were not detected...
December 2015: Oncology Letters
Norihito Ogawa, Mikito Inokuchi, Yoko Takagi, Hirofumi Sugita, Keiji Kato, Kazuyuki Kojima, Kenichi Sugihara
Platelet-derived growth factor (PDGF)-C and PDGF-D are frequently upregulated in human cancers and play important roles in tumor progression, angiogenesis and metastasis. However, the distribution, frequency and prognostic value of PDGF-C and PDGF-D expression in gastric cancer have not been clarified. The present study evaluated the association between expression of PDGF-C and PDGF-D, clinicopathological factors and outcomes, in patients with gastric cancer. Gastric adenocarcinoma tumor samples were obtained from 204 patients who underwent curative gastrectomy between 2003 and 2007...
December 2015: Oncology Letters
Jong-Shiaw Jin, Lien-Fu Lin, Jui-Chang Chen, Chia-Chi Huang, Jeng-Horng Sheu, Wenlung Chen, Tang-Yi Tsao, Chih-Wei Hsu
The expression of cyclin A, B1, D1 and E in gastric adenocarcinoma is known to be associated with clinical outcome. However, few studies have investigated the role of cyclin T1 and cyclin-dependent kinase 9 (CDK9) in gastric adenocarcinoma. Therefore, this study assessed the clinical significance of cyclin T1 and CDK9 expression in gastric adenocarcinoma. A total of 39 gastric adenocarcinoma patients received either radical total or distal gastrectomy in this study. Surgical tissue slides were stained with CDK9 and cyclin T1 antibodies, and immunohistochemistry scores and disease-free survival (DFS) rates were analyzed...
December 2015: Oncology Letters
Akira Matsui, Yasutaka Kuribayashi, Kosuke Nomura, Takumi Tanaka, Takahito Toba, Akhiro Yamada, Tsukasa Furuhata, Satoshi Yamashita, Daisuke Kikuchi, Toshifumi Mitani, Osamu Ogawa, Toshiro Iizuka, Shu Hoteya, Mitsuru Kaise
BACKGROUND: Superficial Barrett's esophageal adenocarcinoma (BEA) arising from short-segment Barrett's esophagus (SSBE) is visualized as a reddish lesion located on the right or anterior side wall of the esophagogastric mucosal junction (EGJ) and showing an elevated macroscopic appearance under conventional white light endoscopy (WLE). However, because the form and color are variable, misdiagnosis as reflux esophagitis or SSBE is frequent under WLE. The aim of this study is to clarify conventional WLE features of small superficial BEA...
2016: Digestion
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