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pneumonia steroids

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6 papers 0 to 25 followers
By Jason Mann No BS pulmonary critical care fellow
https://www.readbyqxmd.com/read/27694410/corticosteroids-for-community-acquired-pneumonia-a-critical-view-of-the-evidence
#1
EDITORIAL
James D Chalmers
No abstract text is available yet for this article.
October 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27076965/corticosteroids-in-the-adjunctive-therapy-of-community-acquired-pneumonia-an-appraisal-of-recent-meta-analyses-of-clinical-trials
#2
REVIEW
Charles Feldman, Ronald Anderson
Improving the outcome of patients with community-acquired pneumonia (CAP) is an ongoing challenge, even in the setting of significant advances in antimicrobial chemotherapy and critical care. Recognition of the underlying involvement of inflammation-mediated organ dysfunction as a determinant of adverse outcomes in CAP has aroused intense interest in the protective potential of adjunctive anti-inflammatory therapies in CAP, particularly the role of corticosteroids (CS). This is the primary topic of the current review which is focused on an evaluation of the latest meta-analyses encompassing both recent and earlier clinical trials, with particular emphasis on the stringent meta-analysis undertaken by Siemieniuk and colleagues (Ann Intern Med 2015;163:519-528)...
March 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/25688779/effect-of-corticosteroids-on-treatment-failure-among-hospitalized-patients-with-severe-community-acquired-pneumonia-and-high-inflammatory-response-a-randomized-clinical-trial
#3
RANDOMIZED CONTROLLED TRIAL
Antoni Torres, Oriol Sibila, Miquel Ferrer, Eva Polverino, Rosario Menendez, Josep Mensa, Albert Gabarrús, Jacobo Sellarés, Marcos I Restrepo, Antonio Anzueto, Michael S Niederman, Carles Agustí
IMPORTANCE: In patients with severe community-acquired pneumonia, treatment failure is associated with excessive inflammatory response and worse outcomes. Corticosteroids may modulate cytokine release in these patients, but the benefit of this adjunctive therapy remains controversial. OBJECTIVE: To assess the effect of corticosteroids in patients with severe community-acquired pneumonia and high associated inflammatory response. DESIGN, SETTING, AND PARTICIPANTS: Multicenter, randomized, double-blind, placebo-controlled trial conducted in 3 Spanish teaching hospitals involving patients with both severe community-acquired pneumonia and a high inflammatory response, which was defined as a level of C-reactive protein greater than 150 mg/L at admission...
February 17, 2015: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/25608756/adjunct-prednisone-therapy-for-patients-with-community-acquired-pneumonia-a-multicentre-double-blind-randomised-placebo-controlled-trial
#4
RANDOMIZED CONTROLLED TRIAL
Claudine Angela Blum, Nicole Nigro, Matthias Briel, Philipp Schuetz, Elke Ullmer, Isabelle Suter-Widmer, Bettina Winzeler, Roland Bingisser, Hanno Elsaesser, Daniel Drozdov, Birsen Arici, Sandrine Andrea Urwyler, Julie Refardt, Philip Tarr, Sebastian Wirz, Robert Thomann, Christine Baumgartner, Hervé Duplain, Dieter Burki, Werner Zimmerli, Nicolas Rodondi, Beat Mueller, Mirjam Christ-Crain
BACKGROUND: Clinical trials yielded conflicting data about the benefit of adding systemic corticosteroids for treatment of community-acquired pneumonia. We assessed whether short-term corticosteroid treatment reduces time to clinical stability in patients admitted to hospital for community-acquired pneumonia. METHODS: In this double-blind, multicentre, randomised, placebo-controlled trial, we recruited patients aged 18 years or older with community-acquired pneumonia from seven tertiary care hospitals in Switzerland within 24 h of presentation...
April 18, 2015: Lancet
https://www.readbyqxmd.com/read/26258555/corticosteroid-therapy-for-patients-hospitalized-with-community-acquired-pneumonia-a-systematic-review-and-meta-analysis
#5
REVIEW
Reed A C Siemieniuk, Maureen O Meade, Pablo Alonso-Coello, Matthias Briel, Nathan Evaniew, Manya Prasad, Paul E Alexander, Yutong Fei, Per O Vandvik, Mark Loeb, Gordon H Guyatt
BACKGROUND: Community-acquired pneumonia (CAP) is common and often severe. PURPOSE: To examine the effect of adjunctive corticosteroid therapy on mortality, morbidity, and duration of hospitalization in patients with CAP. DATA SOURCES: MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials through 24 May 2015. STUDY SELECTION: Randomized trials of systemic corticosteroids in hospitalized adults with CAP...
October 6, 2015: Annals of Internal Medicine
https://www.readbyqxmd.com/read/26370691/what-s-new-in-severe-community-acquired-pneumonia-corticosteroids-as-adjunctive-treatment-to-antibiotics
#6
Antoni Torres, Miquel Ferrer
No abstract text is available yet for this article.
August 2016: Intensive Care Medicine
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