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Topimax for Methamphetamine abuse

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7 papers 0 to 25 followers
By Edwin Kim Resident Physician, Aspiring Addiction Psychiatrist
Johan Cohen, Alain Dervaux, Xavier Laqueille
BACKGROUND: Drug treatments used in substance use disorders are not effective in all patients. OBJECTIVE: To assess the effectiveness of topiramate use in the treatment of substance use disorders. INFORMATION SOURCES: Medline database from January 1966 to December 2013, Cochrane database and SELECTION OF STUDIES: We used keywords topiramate, addiction, substance abuse, alcohol, tobacco, nicotine, cocaine, methamphetamine, opiate, heroin, benzodiazepine, cannabis, bulimia nervosa, binge eating disorder, gambling...
September 2014: La Presse Médicale
Jennie Z Ma, Bankole A Johnson, Elmer Yu, David Weiss, Frances McSherry, Jim Saadvandi, Erin Iturriaga, Nassima Ait-Daoud, Richard A Rawson, Mark Hrymoc, Jan Campbell, Charles Gorodetzky, William Haning, Barry Carlton, Joseph Mawhinney, Dennis Weis, Michael McCann, Tony Pham, Christopher Stock, Ruth Dickinson, Ahmed Elkashef, Ming D Li
BACKGROUND: As reported previously, 140 methamphetamine-dependent participants at eight medical centers in the U.S. were assigned randomly to receive topiramate (N=69) or placebo (N=71) in a 13-week clinical trial. The study found that topiramate did not appear to reduce methamphetamine use significantly for the primary outcome (i.e., weekly abstinence from methamphetamine in weeks 6-12). Given that the treatment responses varied considerably among subjects, the objective of this study was to identify the heterogeneous treatment effect of topiramate and determine whether topiramate could reduce methamphetamine use effectively in a subgroup of subjects...
June 1, 2013: Drug and Alcohol Dependence
Ahmed Elkashef, Roberta Kahn, Elmer Yu, Erin Iturriaga, Shou-Hua Li, Ann Anderson, Nora Chiang, Nassima Ait-Daoud, David Weiss, Frances McSherry, Tracey Serpi, Richard Rawson, Mark Hrymoc, Dennis Weis, Michael McCann, Tony Pham, Christopher Stock, Ruth Dickinson, Jan Campbell, Charles Gorodetzky, William Haning, Barry Carlton, Joseph Mawhinney, Ming D Li, Bankole A Johnson
AIMS:   Topiramate has shown efficacy at facilitating abstinence from alcohol and cocaine abuse. This double-blind, placebo-controlled out-patient trial tested topiramate for treating methamphetamine addiction. DESIGN:   Participants (n = 140) were randomized to receive topiramate or placebo (13 weeks) in escalating doses from 25 mg/day [DOSAGE ERROR CORRECTED] to the target maintenance of 200 mg/day in weeks 6-12 (tapered in week 13). Medication was combined with weekly brief behavioral compliance enhancement treatment...
July 2012: Addiction
Ann K Shinn, Shelly F Greenfield
OBJECTIVE: To critically review the literature on topiramate in the treatment of substance-related disorders. DATA SOURCES: A PubMed search of human studies published in English through January 2009 was conducted using the following search terms: topiramate and substance abuse, topiramate and substance dependence, topiramate and withdrawal, topiramate and alcohol, topiramate and nicotine, topiramate and cocaine, topiramate and opiates, and topiramate and benzodiazepines...
May 2010: Journal of Clinical Psychiatry
Mark E Rose, Jon E Grant
BACKGROUND: Methamphetamine (METH) dependence is a significant public health, criminal justice, and social service concern, and although abuse of this drug spans the past 40 years in the U.S., effective treatments have only recently been developed and evaluated. Psychosocial therapies comprise the mainstay of treatment, yet many patients experience ongoing impairments in mood, cognition, emotional control, and motivation, suggesting a role for pharmacotherapy. METHODS: A search of the literature was performed to identify drug therapies utilized with METH dependent patients and the outcome of these trials...
July 2008: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
George A Kenna, Darci M Nielsen, Patricia Mello, Alison Schiesl, Robert M Swift
The US FDA has approved a limited number of treatments for alcohol, nicotine and opioid dependence; however, no treatments for other abused drugs such as marijuana, cocaine or methamphetamine are approved. This review focuses on research into drug pharmacotherapies, particularly single-drug therapies, for substance abuse and dependence contributing to the most important dual substance use disorders (SUDs). Given the implications of poly-substance abuse, it is essential that clinicians and researchers be aware of potential pharmacotherapies for the treatment of dual SUDs...
2007: CNS Drugs
Bankole A Johnson, John D Roache, Nassima Ait-Daoud, Lynda T Wells, Christopher L Wallace, Michael A Dawes, Lei Liu, Xin-Qun Wang
Clinical studies have shown that topiramate, a sulphamate-substituted fructopyranose derivative, might be an efficacious treatment for alcohol dependence, smoking cessation within an alcohol-dependent population, and cocaine dependence. Mechanistically, topiramate's therapeutic effects have been hypothesized to be due to inhibition of cortico-mesolimbic dopamine function, the primary substrate that governs the acquisition, maintenance, and reinstatement of goal-directed behaviour towards seeking abused drugs...
February 2007: International Journal of Neuropsychopharmacology
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