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Proteinuria

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17 papers 0 to 25 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/27901544/quantitative-urinalysis-using-aggregation-induced-emission-bioprobes-for-monitoring-chronic-kidney-disease
#1
Tong Chen, Ni Xie, Lucia Viglianti, Yabin Zhou, Hui Tan, Ben Zhong Tang, Youhong Tang
Early detection and appropriate management of chronic kidney disease can reduce the progression of kidney failure and cardiovascular disease. The urine albumin to creatinine ratio (UACR) test is a standard urine test for identifying individuals at high risk of developing progressive kidney disease. In this study, IDATPE, a novel fluorescent probe with aggregation-induced emission (AIE) features, is successfully developed for creatinine detection and quantitation. An excellent correlation between fluorescent light intensity and creatinine concentration is achieved...
November 30, 2016: Faraday Discussions
https://www.readbyqxmd.com/read/27873229/subclinical-kidney-damage-in-hypertensive-patients-a-renal-window-opened-on-the-cardiovascular-system-focus-on-microalbuminuria
#2
Giuseppe Mulè, Antonella Castiglia, Claudia Cusumano, Emilia Scaduto, Giulio Geraci, Dario Altieri, Epifanio Di Natale, Onofrio Cacciatore, Giovanni Cerasola, Santina Cottone
The kidney is one of the major target organs of hypertension.Kidney damage represents a frequent event in the course of hypertension and arterial hypertension is one of the leading causes of end-stage renal disease (ESRD).ESRD has long been recognized as a strong predictor of cardiovascular (CV) morbidity and mortality. However, over the past 20 years a large and consistent body of evidence has been produced suggesting that CV risk progressively increases as the estimated glomerular filtration rate (eGFR) declines and is already significantly elevated even in the earliest stages of renal damage...
November 22, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27515965/association-between-high-and-very-high-albuminuria-and-nighttime-blood-pressure-influence-of-diabetes-and-chronic-kidney-disease
#3
Gema Ruiz-Hurtado, Luis M Ruilope, Alex de la Sierra, Pantelis Sarafidis, Juan J de la Cruz, Manuel Gorostidi, Julián Segura, Ernest Vinyoles, José R Banegas
OBJECTIVE: Nighttime blood pressure (BP) and albuminuria are two important and independent predictors of cardiovascular morbidity and mortality. Here, we examined the quantitative differences in nighttime systolic BP (SBP) across albuminuria levels in patients with and without diabetes and chronic kidney disease. RESEARCH DESIGN AND METHODS: A total of 16,546 patients from the Spanish Ambulatory Blood Pressure Monitoring Registry cohort (mean age 59.6 years, 54...
October 2016: Diabetes Care
https://www.readbyqxmd.com/read/26933188/association-of-plasminuria-with-overhydration-in-patients-with-ckd
#4
Anja Schork, Matthias Woern, Hubert Kalbacher, Wolfgang Voelter, Regina Nacken, Marko Bertog, Silke Haerteis, Christoph Korbmacher, Nils Heyne, Andreas Peter, Hans-Ulrich Häring, Ferruh Artunc
BACKGROUND AND OBJECTIVES: Hypervolemia is a common feature of patients with CKD and associated with hypertension. Recent work has shown stimulation of sodium retention by urinary plasmin during nephrotic syndrome. However, it is unclear whether plasminuria plays a role in patients with stable CKD and non-nephrotic proteinuria. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In this cross-sectional study, we analyzed the fluid status of 171 patients with CKD consecutively presenting to our outpatient clinic from 2012 to 2013 using bioimpedance spectroscopy (Body Composition Monitor [BCM]; Fresenius Medical Care, Germany) and its associations to the urinary excretion of plasminogen and plasmin from a spot urine sample...
May 6, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/26790449/individual-long-term-albuminuria-exposure-during-angiotensin-receptor-blocker-therapy-is-the-optimal-predictor-for-renal-outcome
#5
Tobias Felix Kröpelin, Dick de Zeeuw, Frank Arjan Holtkamp, David Kenneth Packham, Hiddo J L Heerspink
BACKGROUND: Albuminuria reduction due to angiotensin receptor blockers (ARBs) predicts subsequent renoprotection. Relating the initial albuminuria reduction to subsequent renoprotection assumes that the initial ARB-induced albuminuria reduction remains stable during follow-up. The aim of this study was to assess individual albuminuria fluctuations after the initial ARB response and to determine whether taking individual albuminuria fluctuations into account improves renal outcome prediction...
September 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/26776964/the-effect-of-statins-on-microalbuminuria-proteinuria-progression-of-kidney-function-and-all-cause-mortality-in-patients-with-non-end-stage-chronic-kidney-disease-a-meta-analysis
#6
REVIEW
Zhenhong Zhang, Pingsheng Wu, Jiping Zhang, Shunyin Wang, Gengxin Zhang
Conclusive evidence regarding the effect of statins on non-end stage chronic kidney disease (CKD) has not been reported previously. This meta-analysis evaluated the association between statins and microalbuminuria, proteinuria, progression, and all-cause mortality in patients with non-end stage CKD. Databases (e.g., PubMed, Embase and the Cochrane Library) were searched for randomized controlled trials (RCTs) with data on statins, microalbuminuria, proteinuria, renal health endpoints, and all-cause mortality patients with non-end stage CKD to perform this meta-analysis...
March 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/26835152/consecutive-first-morning-urine-samples-to-measure-change-in-the-albumin-to-creatinine-ratio-a-pilot-study-of-a-home-urine-collection-protocol
#7
Jessica M Sontrop, Amit X Garg, Lihua Li, Kerri Gallo, Virginia Schumann, Jennifer Winick-Ng, William F Clark, Matthew A Weir
BACKGROUND: Multiple first-morning urine samples are recommended for measuring the urine albumin-to-creatinine ratio (ACR); however, this can be challenging in community-based research. METHODS: The objectives of the study are to pilot-test a home urine collection protocol and examine how the average and variance of ACR varied with the number of urine collections and time to laboratory analysis. This is a prospective observational pilot study. This study was conducted in London, Ontario, Canada at the London Health Sciences Centre (2012-2013)...
2016: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/26759048/megalin-and-cubilin-in-proximal-tubule-protein-reabsorption-from-experimental-models-to-human-disease
#8
REVIEW
Rikke Nielsen, Erik Ilsø Christensen, Henrik Birn
Proximal tubule protein uptake is mediated by 2 receptors, megalin and cubilin. These receptors rescue a variety of filtered ligands, including biomarkers, essential vitamins, and hormones. Receptor gene knockout animal models have identified important functions of the receptors and have established their essential role in modulating urinary protein excretion. Rare genetic syndromes associated with dysfunction of these receptors have been identified and characterized, providing additional information on the importance of these receptors in humans...
January 2016: Kidney International
https://www.readbyqxmd.com/read/26649562/estimation-of-the-24-h-urinary-protein-excretion-based-on-the-estimated-urinary-creatinine-output
#9
Masamitsu Ubukata, Takashi Takei, Kosaku Nitta
BACKGROUND: The urinary protein/creatinine ratio [Up/Ucr (g/gCr)] has been used in the clinical management of patients with chronic kidney disease (CKD). However, a discrepancy is often noted between the Up/Ucr and 24-h urinary protein excretion [24hUp (g/day)] in patients with extremes of muscle mass. We examined devised a method for precise estimation of the 24-h urinary protein excretion (E-24hUp) based on estimation of 24-h urinary creatinine output (E-24hCr). METHODS: Three parameters, spot Up/Ucr, 24hUP and E-24hUp (=Up/Ucr × E-24hCr), were determined in 116 adult patients with CKD...
June 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/26402986/efficacy-of-long-term-low-dose-sulodexide-in-diabetic-and-non-diabetic-nephropathies
#10
Diana-Silvia Zilişteanu, Teodora Atasie, M Voiculescu
BACKGROUND AND AIMS: Sulodexide has been reported to have antiproteinuric and nephroprotective properties. We investigated the effects of long-term low-dose Sulodexide on proteinuria and renal function in patients with chronic kidney disease (CKD) caused by diabetic nephropathy (DN), hypertensive nephropathy (HN) and primary glomerulonephritis (GN). MATERIAL AND METHODS: 100 patients with CKD received low-dose Sulodexide 50 mg/day for 12 months. Treatment efficacy was evaluated as proteinuria reduction compared to baseline; response was defined as a decline in proteinuria below 0...
April 2015: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/26353117/diagnostic-accuracy-of-urine-protein-creatinine-ratio-is-influenced-by-urine-concentration
#11
Chih-Yu Yang, Fu-An Chen, Chun-Fan Chen, Wen-Sheng Liu, Chia-Jen Shih, Shuo-Ming Ou, Wu-Chang Yang, Chih-Ching Lin, An-Hang Yang
BACKGROUND: The usage of urine protein/creatinine ratio to estimate daily urine protein excretion is prevalent, but relatively little attention has been paid to the influence of urine concentration and its impact on test accuracy. We took advantage of 24-hour urine collection to examine both urine protein/creatinine ratio (UPCR) and daily urine protein excretion, with the latter as the reference standard. Specific gravity from a concomitant urinalysis of the same urine sample was used to indicate the urine concentration...
2015: PloS One
https://www.readbyqxmd.com/read/26335919/evaluation-and-management-of-proteinuria-after-kidney-transplantation
#12
REVIEW
Anne Tsampalieros, Greg A Knoll
Proteinuria occurs commonly after kidney transplantation. Because there are no specific guidelines for defining and detecting proteinuria in transplant recipients, its prevalence can vary depending on the methods used. Most often, the same cutoffs for defining proteinuria in the nontransplant population are applied. There are several risk factors for proteinuria, including some transplant-specific diagnoses and immunosuppressive medications. Posttransplantation proteinuria is associated with reduced graft survival as well as an increased risk of cardiovascular events and death...
October 2015: Transplantation
https://www.readbyqxmd.com/read/26325557/effect-of-finerenone-on-albuminuria-in-patients-with-diabetic-nephropathy-a-randomized-clinical-trial
#13
RANDOMIZED CONTROLLED TRIAL
George L Bakris, Rajiv Agarwal, Juliana C Chan, Mark E Cooper, Ron T Gansevoort, Hermann Haller, Giuseppe Remuzzi, Peter Rossing, Roland E Schmieder, Christina Nowack, Peter Kolkhof, Amer Joseph, Alexander Pieper, Nina Kimmeskamp-Kirschbaum, Luis M Ruilope
IMPORTANCE: Steroidal mineralocorticoid receptor antagonists, when added to a renin-angiotensin system blocker, further reduce proteinuria in patients with chronic kidney disease but may be underused because of a high risk of adverse events. OBJECTIVE: To evaluate the safety and efficacy of different oral doses of the nonsteroidal mineralocorticoid receptor antagonist finerenone, given for 90 days to patients with diabetes and high or very high albuminuria who are receiving an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker...
September 1, 2015: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/26311058/sodium-restriction-potentiates-the-renoprotective-effects-of-combined-vitamin-d-receptor-activation-and-angiotensin-converting-enzyme-inhibition-in-established-proteinuric-nephropathy
#14
Katarina Mirkovic, Anne-Roos S Frenay, Jacob van den Born, Harry van Goor, Gerjan Navis, Martin H de Borst
BACKGROUND: Renin-angiotensin-aldosterone system (RAAS) blockade provides renoprotective effects in chronic kidney disease (CKD); yet progressive renal function loss remains common. Dietary sodium restriction potentiates the renoprotective effects of RAAS blockade. Vitamin D receptor activator (VDRA) treatment reduces proteinuria, inflammation and fibrosis, but whether these effects depend on sodium intake has not been studied. We hypothesized that the renoprotective effects of VDRA treatment, with or without RAAS blockade, are modulated by sodium intake...
August 25, 2015: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/26308670/diverse-diuretics-regimens-differentially-enhance-the-antialbuminuric-effect-of-renin-angiotensin-blockers-in-patients-with-chronic-kidney-disease
#15
Enrique Morales, Jara Caro, Eduardo Gutierrez, Angel Sevillano, Pilar Auñón, Cristina Fernandez, Manuel Praga
The addition of spironolactone or hydrochlorothiazide enhances the antialbuminuric effect of renin-angiotensin blockers. However, comparative studies on the effect of different diuretics are lacking. We conducted a prospective randomized crossover study to compare the effects of spironolactone (25 mg/day), hydrochlorothiazide (50 mg/day) without/with amiloride (5 mg/day) on top of enalapril treatment in 21 patients with CKD stages 1-3 and a urinary albumin-to-creatinine ratio (UACR) over 300 mg/g. Treatment periods lasted 4 weeks...
December 2015: Kidney International
https://www.readbyqxmd.com/read/26251711/a-review-of-the-re-emergence-of-adrenocorticotrophic-hormone-therapy-in-glomerular-disease-more-than-a-drug-of-last-resort
#16
Christopher J Goldsmith, Salim Hammad
There has been a re-emergence of interest in adrenocorticotropic hormone (ACTH) in patients with resistant nephrotic syndrome. We describe a patient with severe nephrosis and advanced chronic kidney disease with idiopathic membranous nephropathy resistant to conventional immunosuppressive therapies that achieved lasting remission with ACTH therapy. We explore the literature showing the extra renoprotective effects which might explain the response of proteinuric renal diseases to this treatment.
August 2015: Clinical Kidney Journal
https://www.readbyqxmd.com/read/24798807/diagnostic-performance-of-random-urine-samples-using-albumin-concentration-vs-ratio-of-albumin-to-creatinine-for-microalbuminuria-screening-in-patients-with-diabetes-mellitus-a-systematic-review-and-meta-analysis
#17
REVIEW
Hon-Yen Wu, Yu-Sen Peng, Chih-Kang Chiang, Jenq-Wen Huang, Kuan-Yu Hung, Kwan-Dun Wu, Yu-Kang Tu, Kuo-Liong Chien
IMPORTANCE: A random urine sample measuring the albumin concentration (UAC) without simultaneously measuring the urinary creatinine is less expensive than measuring the ratio of albumin to creatinine (ACR), but comparisons of their diagnostic performance for microalbuminuria screening among patients with diabetes mellitus (DM) have not been undertaken in previous meta-analyses. OBJECTIVE: To compare the diagnostic performance of the UAC vs the ACR in random urine samples for microalbuminuria screening among patients with DM...
July 2014: JAMA Internal Medicine
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