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Delayed cord clamping

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20 papers 0 to 25 followers
Aminata Mansaray, Robert Yetman, Pamela Berens
OBJECTIVE: The purpose of this study was to determine if there is a difference in neonatal hematocrit at 24 hours of life in full-term newborns for which delayed cord clamping is performed above versus below the perineum. MATERIALS AND METHODS: One hundred one patients with singleton pregnancies >37 weeks of gestation presenting for delivery were randomized to delayed cord clamping above or below the perineum. At 24 hours of life, neonatal hematocrit was determined, and the difference was compared using statistical analysis...
December 2015: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
Judith S Mercer, Debra A Erickson-Owens, Betty R Vohr, Richard J Tucker, Ashley B Parker, William Oh, James F Padbury
OBJECTIVE: To assess the effect of delayed cord clamping (DCC) vs immediate cord clamping (ICC) on intraventricular hemorrhage (IVH), late onset sepsis (LOS), and 18-month motor outcomes in preterm infants. STUDY DESIGN: Women (n = 208) in labor with singleton fetuses (<32 weeks gestation) were randomized to either DCC (30-45 seconds) or ICC (<10 seconds). The primary outcomes were IVH, LOS, and motor outcomes at 18-22 months corrected age. Intention-to-treat was used for primary analyses...
January 2016: Journal of Pediatrics
Arif Aktug Ertekin, Nilufer Nihan Ozdemir, Zeki Sahinoglu, Tugba Gursoy, Nazan Erbil, Erdal Kaya
OBJECTIVE: We investigated the effects of delayed and early clamping of the cord on the hematologic status of the baby at birth and at the end of second month. METHODS: Umbilical cord of 74 babies were clamped in the first 30 s (Group 1) and 76 were clamped at 90-120 s (Group 2). Levels of hemoglobin, hematocrit, iron and ferritin were analyzed from the umbilical cord blood at birth and from the venous samples at the end of second month. RESULTS: Hemoglobin, hematocrit, iron and ferritin levels of cord blood were similar in both groups...
September 2016: Journal of Maternal-fetal & Neonatal Medicine
Angie C Jelin, Marya G Zlatnik, Miriam Kuppermann, Steven E Gregorich, Sanae Nakagawa, Ronald Clyman
OBJECTIVE: Randomized controlled trials have demonstrated that delayed umbilical cord clamping (DCC) in preterm infants results in improved neonatal outcomes, including increased hematocrit, and decreased rates of intraventricular hemorrhage (IVH) and packed red blood cell transfusions. We hypothesized that implementation of a DCC policy in preterm infants would result in similarly improved outcomes, despite initial clinician resistance. STUDY DESIGN: A DCC policy (30-60 s) for singleton infants <35 weeks gestation was implemented in September 2011...
2016: Journal of Maternal-fetal & Neonatal Medicine
Anup C Katheria, Giang Truong, Larry Cousins, Bryan Oshiro, Neil N Finer
BACKGROUND AND OBJECTIVE: Delayed cord clamping (DCC) is recommended for premature infants to improve blood volume. Most preterm infants are born by cesarean delivery (CD), and placental transfusion may be less effective than in vaginal delivery (VD). We sought to determine whether infants <32 weeks born by CD who undergo umbilical cord milking (UCM) have higher measures of systemic blood flow than infants who undergo DCC. METHODS: This was a 2-center trial. Infants delivered by CD were randomly assigned to undergo UCM or DCC...
July 2015: Pediatrics
Ola Andersson, Barbro Lindquist, Magnus Lindgren, Karin Stjernqvist, Magnus Domellöf, Lena Hellström-Westas
IMPORTANCE: Prevention of iron deficiency in infancy may promote neurodevelopment. Delayed umbilical cord clamping (CC) prevents iron deficiency at 4 to 6 months of age, but long-term effects after 12 months of age have not been reported. OBJECTIVE: To investigate the effects of delayed CC compared with early CC on neurodevelopment at 4 years of age. DESIGN, SETTING, AND PARTICIPANTS: Follow-up of a randomized clinical trial conducted from April 16, 2008, through May 21, 2010, at a Swedish county hospital...
July 2015: JAMA Pediatrics
Prateek Jaiswal, Amit Upadhyay, Sunil Gothwal, Hema Chaudhary, Ashutosh Tandon
OBJECTIVE: To compare the effect of umbilical cord milking (UCM) and delayed cord clamping (DCC) on cerebral blood flow in term neonates. METHODS: This randomized controlled trial was conducted at a teaching hospital in India during 2012 to 2013. Two hundred newborns (>36wk) were randomized to UCM and DCC groups. UCM was done on 25cm of cord length. In DCC group, clamping was delayed by 60 to 90s. Resistive Index (RI), Pulsatility Index (PI) and cerebral blood flow velocities of middle cerebral artery (MCA) were measured at 24 to 48h of life...
October 2015: Indian Journal of Pediatrics
Hasan Kilicdag, Hande Gulcan, Deniz Hanta, Birgin Torer, Zeynel Gokmen, Sonay Incesoy Ozdemir, Bulent Ali Antmen
OBJECTIVE: The role of cord milking as an alternative to delayed cord clamping is an area that requires more research. Purpose of this clinical trial was to investigate the impact of umbilical cord milking on the absolute neutrophil counts (ANCs) and the neutropenia frequency of preterm infants. METHODS: Fifty-eight pregnant women were randomly assigned to one of the umbilical cord milking and control groups. A total of 54 preterm infants (gestational age ≤ 32 weeks) were enrolled into the study...
2016: Journal of Maternal-fetal & Neonatal Medicine
Margaret S Krueger, Fabien G Eyal, Keith J Peevy, Charles R Hamm, Richard M Whitehurst, David F Lewis
OBJECTIVE: Autologous blood transfusion from the placenta to the neonate at birth has been proven beneficial. Transfusion can be accomplished by either delayed cord clamping or cord stripping. Both are equally effective in previous randomized trials. We hypothesized that combining these 2 techniques would further improve outcomes in preterm neonates. STUDY DESIGN: This was a prospective randomized trial for singleton deliveries with estimated gestational ages between 22 and 31 6/7 weeks...
March 2015: American Journal of Obstetrics and Gynecology
Andrew Elimian, Jean Goodman, Marilyn Escobedo, Lydia Nightingale, Eric Knudtson, Marvin Williams
OBJECTIVE: The comparative risks and benefits of early compared with delayed cord clamping in the preterm neonate remain unclear. Our objective was to evaluate the short-term effects of delayed clamping of the umbilical cord in preterm neonates. METHODS: We conducted a randomized controlled trial comparing immediate with delayed cord clamping among preterm neonates born between 24 and 34 weeks of gestation. The primary study outcome was the need for blood transfusion...
December 2014: Obstetrics and Gynecology
Sybrich Tiemersma, Julia Heistein, Roos Ruijne, Gustavo Lopez, Jeroen van Lobenstein, Patrick van Rheenen
OBJECTIVE: To evaluate safety and haematological effects of delayed cord clamping (DCC) in infants with expected low birthweight born in a resource-poor setting. METHODS: Randomised controlled trial involving pregnant women in early labour ≥18 years with intrapartum symphysal-fundal height ≤32 cm. Mothers were randomised for either early cord clamping (ECC, <30 s) or DCC (2-3 min after birth). RESULTS: We included 104 vigorous infants born by vaginal delivery, of whom 39% had a birthweight <2500 g...
February 2015: Tropical Medicine & International Health: TM & IH
William O Tarnow-Mordi, Lelia Duley, David Field, Neil Marlow, Jonathan Morris, John Newnham, Nigel Paneth, Roger F Soll, David Sweet
In December 2012, the American College of Obstetricians and Gynecologists published a Committee Opinion entitled "Timing of umbilical cord clamping after birth." It stated that "evidence exists to support delayed cord clamping in preterm infants, when feasible. The single most important benefit for preterm infants is the possibility for a nearly 50% reduction in IVH." However, the Committee Opinion added that the ideal timing of umbilical cord clamping has yet to be determined and recommended that large clinical trials be conducted in the most preterm infants...
August 2014: American Journal of Obstetrics and Gynecology
Ryan M McAdams
Immediate umbilical cord clamping after delivery is routine in the United States despite little evidence to support this practice. Numerous trials in both term and preterm neonates have demonstrated the safety and benefit of delayed cord clamping. In premature neonates, delayed cord clamping has been shown to stabilize transitional circulation, lessening needs for inotropic medications and reducing blood transfusions, necrotizing enterocolitis, and intraventricular hemorrhage. In term neonates, delayed cord clamping has been associated with decreased iron-deficient anemia and increased iron stores with potential valuable effects that extend beyond the newborn period, including improvements in long-term neurodevelopment...
March 2014: Obstetrics and Gynecology
Ola Andersson, Magnus Domellöf, Dan Andersson, Lena Hellström-Westas
AIM: To investigate the effect that delayed and early umbilical cord clamping have on neurodevelopment, immunoglobulin G (IgG) and symptoms of infection during the first 4 months of life. METHODS: Full-term infants (n = 382) were randomised to delayed (≥180 sec) or early cord clamping (≤10 sec). The Ages and Stages Questionnaire (ASQ) was used to assess neurodevelopment at 4 months. Immunoglobulin G was measured at birth, 2-3 days and 4 months. Parents recorded any symptoms indicating infection during the first 4 months of life...
May 2013: Acta Paediatrica
Milena Garofalo, Haim A Abenhaim
The optimal timing for cord clamping, early versus delayed, in the third stage of labour is a controversial subject. Issues surrounding the timing of cord clamping include gestational age and maternal and neonatal considerations. Delayed cord clamping (DCC) has been shown to increase placental transfusion, leading to an increase in neonatal blood volume at birth of approximately 30%. In the term infant, although this may result in an increase in iron stores, thereby decreasing the risk of anemia, it may adversely increase the risk of jaundice and the need for phototherapy...
June 2012: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Ross Sommers, Barbara S Stonestreet, William Oh, Abbot Laptook, Toby Debra Yanowitz, Christina Raker, Judith Mercer
BACKGROUND AND OBJECTIVE: Delayed cord clamping (DCC) has been advocated during preterm delivery to improve hemodynamic stability during the early neonatal period. The hemodynamic effects of DCC in premature infants after birth have not been previously examined. Our objective was to compare the hemodynamic differences between premature infants randomized to either DCC or immediate cord clamping (ICC). METHODS: This prospective study was conducted on a subset of infants who were enrolled in a randomized controlled trial to evaluate the effects of DCC versus ICC...
March 2012: Pediatrics
W Oh, A A Fanaroff, W A Carlo, E F Donovan, S A McDonald, W K Poole
OBJECTIVE: Delayed cord clamping (DCC) may be beneficial in very-preterm and very-low-birth-weight infants. STUDY DESIGN: This study was a randomized unmasked controlled trial. It was performed at three centers of the NICHD (National Institute of Child Health and Human Development) Neonatal Research Network. DCC in very-preterm and very-low-birth-weight infants will result in an increase in hematocrit levels at 4 h of age. Infants with a gestational age of 24 to 28 weeks were randomized to either early cord clamping (<10 s) or DCC (30 to 45 s)...
April 2011: Journal of Perinatology: Official Journal of the California Perinatal Association
Heike Rabe, Amanda Jewison, Ramon Fernandez Alvarez, David Crook, Denise Stilton, Robert Bradley, Desmond Holden
OBJECTIVE: To compare two strategies to enhance placento-fetal blood transfusion in preterm neonates before 33 weeks of gestation. METHODS: We recruited women at risk for singleton preterm deliveries. All delivered before 33 completed weeks of gestation. In this single-center trial, women were randomized to either standard treatment (clamping the cord for 30 seconds after delivery) or repeated (four times) milking of the cord toward the neonate. Exclusion criteria included inadequate time to obtain consent before delivery, known congenital abnormalities of the fetus, Rhesus sensitization, or fetal hydrops...
February 2011: Obstetrics and Gynecology
C A Ultee, J van der Deure, J Swart, C Lasham, A L van Baar
BACKGROUND: Even mild iron deficiency and anaemia in infancy may be associated with cognitive deficits. A delay in clamping the cord improves haematocrit levels and results in greater vascular stability and less need for packed cell transfusions for anaemia in the first period after birth. Follow-up data on haemoglobin levels after the neonatal period were not available. OBJECTIVE: To provide neonatal and follow-up data for the effects of early or delayed clamping of the cord...
January 2008: Archives of Disease in Childhood. Fetal and Neonatal Edition
Judith S Mercer, Betty R Vohr, Margaret M McGrath, James F Padbury, Michael Wallach, William Oh
OBJECTIVE: This study compared the effects of immediate (ICC) and delayed (DCC) cord clamping on very low birth weight (VLBW) infants on 2 primary variables: bronchopulmonary dysplasia (BPD) and suspected necrotizing enterocolitis (SNEC). Other outcome variables were late-onset sepsis (LOS) and intraventricular hemorrhage (IVH). STUDY DESIGN: This was a randomized, controlled unmasked trial in which women in labor with singleton fetuses <32 weeks' gestation were randomly assigned to ICC (cord clamped at 5-10 seconds) or DCC (30-45 seconds) groups...
April 2006: Pediatrics
2016-01-14 04:34:54
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