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https://www.readbyqxmd.com/read/28684104/acid-base-disorders-in-liver-disease
#1
REVIEW
Scheiner Bernhard, Lindner Gregor, Reiberger Thomas, Schneeweiss Bruno, Trauner Michael, Zauner Christian, Funk Georg-Christian
Next to the kidneys and lungs, the liver has been recognized as an important regulator of acid-base homeostasis. While respiratory alkalosis is the most common acid-base disorder in chronic liver disease, various complex metabolic acid-base disorders may occur with liver dysfunction. Although the standard variables of acid-base equilibrium, such as pH and overall base excess, often fail to unmask the underlying cause of acid-base disorders, the physical-chemical acid-base model allows a more in-depth pathophysiological understanding and clinical judgement of acid-base disorders in patients with liver diseases...
July 3, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/25371408/the-mersey-burns-app-evolving-a-model-of-validation
#2
COMPARATIVE STUDY
Jamie Barnes, Annie Duffy, Nathan Hamnett, Jane McPhail, Chris Seaton, Kayvan Shokrollahi, M Ian James, Paul McArthur, Rowan Pritchard Jones
INTRODUCTION: 'Mersey Burns App' is a smartphone/tablet application that aids in the assessment of total burn surface area (TBSA) and calculation of fluid resuscitation protocols in burns. This paper presents two studies assessing the speed and accuracy of calculations using Mersey Burns (App) in comparison with a Lund and Browder chart (paper) when a burn is assessed by medical students and clinicians. METHODS: The first study compared the speed and accuracy of TBSA and resuscitation calculation for a photograph of a burn with App and paper using burns and plastics and emergency medicine trainees and consultants...
August 2015: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28591533/management-of-septic-shock
#3
Rebecca E Berger, Emanuel Rivers, Mitchell M Levy
New England Journal of Medicine, Volume 376, Issue 23, Page 2282-2285, June 2017.
June 8, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/24962889/five-strategies-to-effectively-use-online-resources-in-emergency-medicine
#4
Brent Thoma, Nikita Joshi, N Seth Trueger, Teresa M Chan, Michelle Lin
No abstract text is available yet for this article.
October 2014: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/25027194/nebulized-fentanyl-vs-intravenous-morphine-for-ed-patients-with-acute-limb-pain-a-randomized-clinical-trial
#5
RANDOMIZED CONTROLLED TRIAL
Shervin Farahmand, Said Shiralizadeh, Mohammad-Taghi Talebian, Shahram Bagheri-Hariri, Mona Arbab, Hamed Basirghafouri, Morteza Saeedi, Mojtaba Sedaghat, Habibolla Mirzababai
OBJECTIVE: Intravenous morphine has been used as a common method of pain control in emergency care. Nebulized fentanyl is also an effective temporary substitute. This study was designed to compare the effectiveness of nebulized fentanyl with intravenous (IV) morphine on management of acute limb pain. METHODS: This was a placebo-controlled, double-blind randomized clinical trial. Ninety emergency department patients with moderate to severe pain aged 15 to 50 years were blocked randomized and enrolled in this study...
September 2014: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28590591/hot-off-the-press-point-of-care-ultrasound-for-non-angulated-distal-forearm-fractures-in-children
#6
Justin Morgenstern, Corey Heitz, William K Milne
This prospective, cross-sectional diagnostic study examined the performance of point of care ultrasound (POCUS) in the diagnosis of suspected non-angulated forearm fractures in pediatric patients aged 4-17 years, using x-rays as the gold standard. The test characteristics reported are a sensitivity of 94.7% (95% CI 89.7-99.8%), a specificity of 93.5% (95% CI 88.6-98.5%), a positive likelihood ratio of 14.6, and a negative likelihood ratio of 0.6. This article is protected by copyright. All rights reserved.
June 7, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28552658/epinephrine-dosing-interval-and-survival-outcomes-during-pediatric-in-hospital-cardiac-arrest
#7
Derek B Hoyme, Sonali S Patel, Ricardo A Samson, Tia T Raymond, Vinay M Nadkarni, Michael G Gaies, Dianne L Atkins
BACKGROUND: Current guidelines recommend epinephrine every 3-5min during cardiopulmonary resuscitation. For adults with in-hospital cardiac arrest (IHCA), longer dosing intervals are associated with improved survival to discharge. This study investigates whether longer epinephrine dosing intervals were associated with improved survival to discharge during pediatric IHCA. METHODS: Retrospective review of AHA Get With The Guidelines-Resuscitation registry identified 1630 pediatric IHCAs that met inclusion criteria...
August 2017: Resuscitation
https://www.readbyqxmd.com/read/28475282/risk-of-intracranial-hemorrhage-in-ground-level-fall-with-antiplatelet-or-anticoagulant-agents
#8
Michael Ganetsky, Gregory Lopez, Tara Coreanu, Victor Novack, Steven Horng, Nathan I Shapiro, Kenneth A Bauer
OBJECTIVES: Anticoagulant and antiplatelet medications are known to increase the risk and severity of traumatic intracranial hemorrhage (tICH), even with minor head trauma. Most studies on bleeding propensity with head trauma are retrospective, based on trauma registries, or include heterogeneous mechanisms of injury. The goal of this study was to determine the rate of tICH from only a common low-acuity mechanism of injury, that of a ground level fall, in patients taking one or more of the following antiplatelet or anticoagulant medications: aspirin, warfarin, prasugrel, ticagrelor, dabigatran, rivaroxaban, apixaban or enoxaparin...
May 5, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28549662/simplified-diagnostic-management-of-suspected-pulmonary-embolism-the-years-study-a-prospective-multicentre-cohort-study
#9
Tom van der Hulle, Whitney Y Cheung, Stephanie Kooij, Ludo F M Beenen, Thomas van Bemmel, Josien van Es, Laura M Faber, Germa M Hazelaar, Christian Heringhaus, Herman Hofstee, Marcel M C Hovens, Karin A H Kaasjager, Rick C J van Klink, Marieke J H A Kruip, Rinske F Loeffen, Albert T A Mairuhu, Saskia Middeldorp, Mathilde Nijkeuter, Liselotte M van der Pol, Suzanne Schol-Gelok, Marije Ten Wolde, Frederikus A Klok, Menno V Huisman
BACKGROUND: Validated diagnostic algorithms in patients with suspected pulmonary embolism are often not used correctly or only benefit subgroups of patients, leading to overuse of computed tomography pulmonary angiography (CTPA). The YEARS clinical decision rule that incorporates differential D-dimer cutoff values at presentation, has been developed to be fast, to be compatible with clinical practice, and to reduce the number of CTPA investigations in all age groups. We aimed to prospectively evaluate this novel and simplified diagnostic algorithm for suspected acute pulmonary embolism...
July 15, 2017: Lancet
https://www.readbyqxmd.com/read/28456509/effect-of-early-tranexamic-acid-administration-on-mortality-hysterectomy-and-other-morbidities-in-women-with-post-partum-haemorrhage-woman-an-international-randomised-double-blind-placebo-controlled-trial
#10
(no author information available yet)
BACKGROUND: Post-partum haemorrhage is the leading cause of maternal death worldwide. Early administration of tranexamic acid reduces deaths due to bleeding in trauma patients. We aimed to assess the effects of early administration of tranexamic acid on death, hysterectomy, and other relevant outcomes in women with post-partum haemorrhage. METHODS: In this randomised, double-blind, placebo-controlled trial, we recruited women aged 16 years and older with a clinical diagnosis of post-partum haemorrhage after a vaginal birth or caesarean section from 193 hospitals in 21 countries...
May 27, 2017: Lancet
https://www.readbyqxmd.com/read/28391629/effects-of-low-sodium-diet-versus-high-sodium-diet-on-blood-pressure-renin-aldosterone-catecholamines-cholesterol-and-triglyceride
#11
REVIEW
Niels Albert Graudal, Thorbjorn Hubeck-Graudal, Gesche Jurgens
BACKGROUND: In spite of more than 100 years of investigations the question of whether a reduced sodium intake improves health is still unsolved. OBJECTIVES: To estimate the effects of low sodium intake versus high sodium intake on systolic and diastolic blood pressure (SBP and DBP), plasma or serum levels of renin, aldosterone, catecholamines, cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and triglycerides. SEARCH METHODS: The Cochrane Hypertension Information Specialist searched the following databases for randomized controlled trials up to March 2016: the Cochrane Hypertension Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL) (2016, Issue 3), MEDLINE (from 1946), Embase (from 1974), the World Health Organization International Clinical Trials Registry Platform, and ClinicalTrials...
April 9, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28442101/ultrasound-guidelines-emergency-point-of-care-and-clinical-ultrasound-guidelines-in-medicine
#12
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
May 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28420641/should-we-intubate-patients-during-cardiopulmonary-resuscitation
#13
EDITORIAL
Carl L Gwinnutt
No abstract text is available yet for this article.
April 18, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28279428/nadroparin-or-fondaparinux-versus-no-thromboprophylaxis-in-patients-immobilised-in-a-below-knee-plaster-cast-protect-a-randomised-controlled-trial
#14
Marlieke M Bruntink, Yannick M E Groutars, Inger B Schipper, Roelf S Breederveld, Wim E Tuinebreijer, Robert J Derksen
BACKGROUND: The immobilisation of the lower leg is associated with deep vein thrombosis (DVT). However, thromboprophylaxis in patients with a below-knee plaster cast remains controversial. We examined the efficacy and safety of nadroparin and fondaparinux to ascertain the need for thromboprophylaxis in these patients. METHODS: PROTECT was a randomised, controlled, single-blind, multicentre study that enrolled adults with an ankle or foot fracture who required immobilisation for a minimum of four weeks...
April 2017: Injury
https://www.readbyqxmd.com/read/28283181/the-changing-epidemiology-of-fall-related-fractures-in-adults
#15
REVIEW
C M Court-Brown, N D Clement, A D Duckworth, L C Biant, M M McQueen
There has been very little analysis of the epidemiology of adult fall-related fractures outwith the osteoporotic population. We have analysed all in-patient and out-patient fall-related fractures in a one-year period in a defined population and documented their epidemiology. The overall prevalence of non-spinal fall-related fractures is 63.1% with 40.7% and 82.7% occurring in males and females respectively. In females aged 20-29 years >50% of fractures follow falls, the equivalent age range in males being 50-59 years...
March 2, 2017: Injury
https://www.readbyqxmd.com/read/28410544/does-respiratory-variation-in-inferior-vena-cava-diameter-predict-fluid-responsiveness-a-systematic-review-and-meta-analysis
#16
REVIEW
Elliot Long, Ed Oakley, Trevor Duke, Franz E Babl
BACKGROUND: The aim of fluid resuscitation is to increase stroke volume, yet this effect is observed in only 50% of patients. Prediction of fluid responsiveness may allow fluid resuscitation to be administered to those most likely to benefit. The aim of this study was to systematically review the test characteristics of respiratory variation in inferior vena cava (IVC) diameter as a predictor of fluid responsiveness in patients with acute circulatory failure. METHODS: Electronic searches combined with reference review of identified studies...
May 2017: Shock
https://www.readbyqxmd.com/read/28271513/proton-pump-inhibitors-for-functional-dyspepsia
#17
REVIEW
Maria Ines Pinto-Sanchez, Yuhong Yuan, Premysl Bercik, Paul Moayyedi
BACKGROUND: Functional dyspepsia (FD or non-ulcer dyspepsia) is defined as continuous or frequently recurring epigastric pain or discomfort for which no organic cause can be found. Acid suppressive therapy, including proton pump inhibitors (PPIs), has been proposed as a therapeutic option in FD, but its efficacy remains controversial. While PPIs are generally considered safe and well tolerated, they have been associated with adverse events, especially in the long term. For this reason, decisions on whether to initiate or continue PPI therapy should be made based on an appropriate clinical indication...
March 8, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28335927/should-kidney-stone-patients-with-diagnosis-by-ultrasonography-be-prescribed-tamsulosin
#18
LETTER
M Kennedy Hall, Mathew Sorenson, Jonathan Harper
No abstract text is available yet for this article.
April 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28395926/do-inhaled-anticholinergic-agents-in-addition-to-%C3%AE-agonists-improve-outcomes-in-acute-asthma-exacerbations
#19
EDITORIAL
Michael Gottlieb, Matthew J Kuhns
No abstract text is available yet for this article.
April 7, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28375565/emergency-department-vital-signs-and-outcomes-after-discharge
#20
Gelareh Z Gabayan, Michael K Gould, Robert E Weiss, Stephen F Derose, Vicki Y Chiu, Catherine A Sarkisian
OBJECTIVE: Vital signs are critical markers of illness severity in the Emergency Department (ED). Providers need to understand the abnormal vital signs in older adults that are problematic. We hypothesized that in patients age > 65 years discharged from the ED, there are abnormal vital signs that are associated with an admission to an inpatient bed within 7 days of discharge. METHODS: We conducted a retrospective cohort study using data from a regional integrated health system of members age > 65 years during the years 2009-2010...
April 4, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
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