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Acute Kidney Injure

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7 papers 0 to 25 followers
By P O Pediatrics, Nephrology
Kent Doi, Hamid Rabb
Acute kidney injury (AKI) is a common complication in critically ill patients and subsequently worsens outcomes. Although many drugs to prevent and treat AKI have shown benefits in preclinical models, no specific agent has been shown to benefit AKI in humans. Moreover, despite remarkable advances in dialysis techniques that enable management of AKI in hemodynamically unstable patients with shock, dialysis-requiring severe AKI is still associated with an unacceptably high mortality rate. Thus, focusing only on kidney damage and loss of renal function has not been sufficient to improve outcomes of patients with AKI...
March 2016: Kidney International
Ae Jin Kim, Han Ro, Hyunsook Kim, Jae Hyun Chang, Hyun Hee Lee, Wookyung Chung, Ji Yong Jung
Early detection and accurate differentiation of the cause of AKI may improve the prognosis of the patient. However, to date, there are few reliable biomarkers that can discriminate between pre-renal and intrinsic AKI. In this study, we determined whether AKI is associated with altered serum and urinary levels of Klotho, S100A8/A9 (an endogenous ligand of toll-like receptor 4), and neutrophil gelatinase-associated lipocalin (NGAL), which may allow differentiation between pre-renal and intrinsic AKI. A volume-depleted pre-renal AKI model was induced in male Sprague Dawley rats fed a low-salt diet (0...
2016: PloS One
J W Deuel, C A Schaer, F S Boretti, L Opitz, I Garcia-Rubio, J H Baek, D R Spahn, P W Buehler, D J Schaer
Intravascular hemolysis can result in hemoglobinuria with acute kidney injury. In this study we systematically explored two in vivo animal models and a related cell culture system to identify hemoglobinuria-triggered damage pathways. In models of stored blood transfusion and hemoglobin (Hb) exposure in guinea pigs and beagle dogs we found that hemoglobinuria led to intrarenal conversion of ferrous Hb(Fe(2+)) to ferric Hb(Fe(3+)), accumulation of free heme and Hb-cross-linking products, enhanced 4-hydroxynonenal reactivity in renal tissue, and acute tubule injury...
2016: Cell Death & Disease
Taku Mitome, Kazuhiro Furuya, Masashi Imano, Kimito Osaka, Yumiko Yokomizo, Narihiko Hayashi, Noboru Nakaigawa, Shoji Yamanaka, Masahiro Yao
Renal lymphoma as an initial lesion is relatively rare. Bilateral renal lymphoma frequently presents as acute kidney injury. With systematic chemotherapy for the lymphoma, patients usually recover their kidney function. However, in the case we describe here, the patient's kidney function recovered greatly after an open renal biopsy. Here, we review and discuss this unique case.
January 2016: Clinical Case Reports
Diana Jansen, Esther Peters, Suzanne Heemskerk, Linda Koster-Kamphuis, Martijn P W J M Bouw, Hennie M J Roelofs, Wim van Oeveren, Arno F J van Heijst, Peter Pickkers
OBJECTIVE: We evaluated whether urinary excretion of tubular injury markers could be useful for early detection of gentamicin (GM)-induced renal damage in neonates. STUDY DESIGN: We conducted a prospective, observational trial in neonates admitted to the neonatal intensive care unit (26 GM treated, 20 control). Kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-β-D-glucosaminidase (NAG), and π- and α-glutathione-S-transferase (GSTP1-1 and GSTA1-1) were measured every 2 hours during admission and compared with serum creatinine (sCr) and urine output...
January 2016: American Journal of Perinatology
Biljana Pejović, Jelena Erić-Marinković, Marija Pejović, Jelena Kotur-Stevuljević, Amira Peco-Antić
INTRODUCTION: Acute kidney injury (AKI) is common in neonatal intensive care units (NICU). In recent years, every effort is made for early detection of AKI. Our hypothesis was that serum neutrophil gelatinase-associated lipocalin (sNGAL) may be a reliable screening test for early diagnosis of AKI in premature neonates after perinatal asphyxia. Therefore, our aim was to assess the diagnostic accuracy of sNGAL for AKI in premature asphyxiated neonates. MATERIALS AND METHODS: AKI was defined in the third day of life (DOL 3) as a serum creatinine (sCr) increase ≥26...
2015: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
Gunnar Schley, Carmen Köberle, Ekaterina Manuilova, Sandra Rutz, Christian Forster, Michael Weyand, Ivan Formentini, Rosemarie Kientsch-Engel, Kai-Uwe Eckardt, Carsten Willam
BACKGROUND: New renal biomarkers measured in urine promise to increase specificity for risk stratification and early diagnosis of acute kidney injury (AKI) but concomitantly may be altered by urine concentration effects and chronic renal insufficiency. This study therefore directly compared the performance of AKI biomarkers in urine and plasma. METHODS: This single-center, prospective cohort study included 110 unselected adults undergoing cardiac surgery with cardiopulmonary bypass between 2009 and 2010...
2015: PloS One
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