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52 papers 25 to 100 followers
https://www.readbyqxmd.com/read/27785689/complications-of-feeding-jejunostomy-tubes-in-patients-with-gastroesophageal-cancer
#1
Audrey H Choi, Michael P O'Leary, Shaila J Merchant, Virginia Sun, Joseph Chao, Dan J Raz, Jae Y Kim, Joseph Kim
BACKGROUND: Feeding jejunostomy tubes (FJT) in patients undergoing resection of gastroesophageal cancers facilitate perioperative nutrition. Data regarding FJT use and complications are limited. STUDY DESIGN: A single institution review was performed for patients who underwent perioperative FJT placement for gastrectomy or esophagogastrectomy from 2007 to 2015. FJT-related and unrelated complications were evaluated. RESULTS: FJTs were inserted for total/completion gastrectomy (n = 49/117, 41...
October 26, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27697984/multimodality-therapy-of-localized-gastric-adenocarcinoma
#2
Brian Badgwell
Surgical resection is the primary method of obtaining a potential cure for patients with gastric adenocarcinoma. However, chemotherapy or chemoradiotherapy offer significant improvement in survival over surgery alone. Much of the difficulty in deciding the optimal treatment strategy is choosing between perioperative chemotherapy or adjuvant chemoradiotherapy. Adding to the complexity is the potential for incorporating treatment strategies based on clinical trials performed in Asia. There is likely a difference in tumor biology between Eastern and Western patients with gastric adenocarcinoma, in addition to the clear differences in screening, pathologic assessment, and surgical technique...
October 2016: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/27689845/outcome-of-neoadjuvant-therapies-for-cancer-of-the-oesophagus-or-gastro-oesophageal-junction-based-on-a-national-data-registry
#3
F Klevebro, M Lindblad, J Johansson, L Lundell, M Nilsson
BACKGROUND: Randomized trials have shown that neoadjuvant treatment improves survival in the curative treatment of oesophageal and gastro-oesophageal junction cancer. Results from population-based observational studies are, however, sparse and ambiguous. METHODS: This prospective population-based cohort study included all patients who had oesophagectomy for cancer in Sweden, excluding clinical T1 N0, recorded in the National Register for Oesophageal and Gastric Cancer, 2006-2014...
December 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/27664260/gastric-cancer-esmo-clinical-practice-guidelines-for-diagnosis-treatment-and-follow-up
#4
E C Smyth, M Verheij, W Allum, D Cunningham, A Cervantes, D Arnold
No abstract text is available yet for this article.
September 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27617855/prognostic-significant-or-not-the-positive-circumferential-resection-margin-in-esophageal-cancer-impact-on-local-recurrence-and-overall-survival-in-patients-without-neoadjuvant-treatment
#5
Tarik Ghadban, Matthias Reeh, Alexandra M Koenig, Michael F Nentwich, Eugen Bellon, Jakob R Izbicki, Yogesh K Vashist, Asad Kutup
OBJECTIVE: The aim of this study is to investigate the impact of the circumferential resection margin (CRM) in esophageal cancer on survival and recurrence in patients without pretreatment. BACKGROUND: Whereas the infiltration of the proximal or distal resection margin is associated with poor survival and higher recurrence, studies looking at the role of the circumferential resection margin on survival and local recurrence after esophagectomy are conflicting. METHODS: Influence of CRM infiltration according to the College of American Pathologists (CAP) and Royal College of Pathologists (RCP) on long-term survival of 180 patients with resected pT3 tumors and without neoadjuvant therapy was analyzed...
September 9, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27492355/non-elective-paraesophageal-hernia-repair-portends-worse-outcomes-in-comparable-patients-a-propensity-adjusted-analysis
#6
Vernissia Tam, James D Luketich, Daniel G Winger, Inderpal S Sarkaria, Ryan M Levy, Neil A Christie, Omar Awais, Manisha R Shende, Katie S Nason
INTRODUCTION: Patients undergoing non-elective paraesophageal hernia repair (PEHR) have worse perioperative outcomes. Because they are usually older and sicker, however, these patients may be more prone to adverse events, independent of surgical urgency. Our study aimed to determine whether non-elective PEHR is associated with differential postoperative outcome compared to elective repair, using propensity-score weighting. METHODS: We abstracted data for patients undergoing PEHR (n = 924; non-elective n = 171 (19 %); 1997-2010)...
August 4, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27418164/serum-fibrinogen-levels-are-positively-correlated-with-advanced-tumor-stage-and-poor-survival-in-patients-with-gastric-cancer-undergoing-gastrectomy-a-large-cohort-retrospective-study
#7
Xuefeng Yu, Fulan Hu, Qiang Yao, Chunfeng Li, Hongfeng Zhang, Yingwei Xue
BACKGROUND: Platelet and blood coagulation abnormalities frequently occur in cancer patients. Fibrinogen is an important hemostatic factor that regulates the hemostatic pathway. Hyperfibrinogenemia is increasing recognized as an important risk factor influencing cancer development and outcome. However, few reports have investigated the prognostic potential of fibrinogen for predicting the survival of gastric cancer (GC) patients. The primary aim of this study was to evaluate the usefulness of preoperative serum fibrinogen as a biomarker for predicating tumor progression and survival of patients with GC...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27459982/timing-of-adjuvant-chemotherapy-and-impact-on-survival-for-resected-gastric-cancer
#8
Erin K Greenleaf, Afif N Kulaylat, Christopher S Hollenbeak, Khaldoun Almhanna, Joyce Wong
BACKGROUND: Because postoperative convalescence often prolongs the interval between surgery and chemotherapy in patients undergoing treatment for advanced gastric cancer, this study assesses the survival impact of timing of adjuvant chemotherapy (AC) in patients undergoing curative resection for gastric cancer. METHODS: The 2003-2012 ACS NCDB was analyzed for patients treated with gastrectomy for stages 1-3 gastric cancer. Treatment groups were stratified by time to initiation of AC: initiation of chemotherapy within 8 weeks postoperatively, between 8 and 12 weeks postoperatively, after 12 weeks postoperatively, and no chemotherapy...
July 26, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/26541743/total-laparoscopic-resection-for-advanced-gastric-cancer-is-safe-and-feasible-in-the-western-population
#9
Rebecca Tuttle, Steven N Hochwald, Moshim Kukar, Kfir Ben-David
BACKGROUND: There is debate surrounding the use of laparoscopic resection for advanced gastric cancer in the Western population. Here we aim to assess the feasibility and short-term outcomes of laparoscopic gastrectomy in consecutive patients in a Western population. METHODS: From 2012 to 2014, retrospective review of 28 patients with clinically staged advanced gastric cancer (≥T3 or ≥N1) treated with laparoscopic resection. RESULTS: Sixty-one percentage of patients were male...
August 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/26895951/the-oncological-value-of-omentectomy-in-gastrectomy-for-cancer
#10
Leonie Haverkamp, Hylke J F Brenkman, Jelle P Ruurda, Fiebo J W Ten Kate, Richard van Hillegersberg
AIM: The aim of this study was to determine the oncologic value of omentectomy in patients undergoing gastrectomy for gastric cancer. METHODS: All consecutive patients with gastric cancer that underwent gastrectomy with curative intent between April 2012 and August 2015 were prospectively analyzed. The greater omentum was separately marked during operation and pathologically evaluated for the presence of omental lymph nodes and tumor deposits. RESULTS: In total, 50 patients were included...
May 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/26805552/clinical-and-experimental-role-of-ring-finger-protein-180-on-lymph-node-metastasis-and-survival-in-gastric-cancer
#11
J Deng, H Liang, R Zhang, Y Hou, Y Liu, G Ying, Y Pan, X Hao
BACKGROUND: The hypermethylation of ring finger protein (RNF) 180 DNA promoter is significantly associated with lymph node metastasis of gastric cancer. The present study explored the potential mechanism of RNF180-regulated lymph node metastasis of gastric cancer. METHODS: Associations between clinicopathological and survival data and RNF180 expression in gastric cancer tissues were analysed. The effects of RNF180 re-expression on gastric cancer cells were determined by means of proliferation, invasion, growth and lymphangiogenesis assays...
March 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/26772734/correlation-of-kit-and-pdgfra-mutational-status-with-clinical-benefit-in-patients-with-gastrointestinal-stromal-tumor-treated-with-sunitinib-in-a-worldwide-treatment-use-trial
#12
Peter Reichardt, George D Demetri, Hans Gelderblom, Piotr Rutkowski, Seock-Ah Im, Sudeep Gupta, Yoon-Koo Kang, Patrick Schöffski, Jochen Schuette, Denis Soulières, Jean-Yves Blay, David Goldstein, Kolette Fly, Xin Huang, Massimo Corsaro, Maria Jose Lechuga, Jean-Francois Martini, Michael C Heinrich
BACKGROUND: Several small studies indicated that the genotype of KIT or platelet-derived growth factor receptor-α (PDGFRA) contributes in part to the level of clinical effectiveness of sunitinib in gastrointestinal stromal tumor (GIST) patients. This study aimed to correlate KIT and PDGFRA mutational status with clinical outcome metrics (progression-free survival [PFS], overall survival [OS], objective response rate [ORR]) in a larger international patient population. METHODS: This is a non-interventional, retrospective analysis in patients with imatinib-resistant or intolerant GIST who were treated in a worldwide, open-label treatment-use study (Study 1036; NCT00094029) in which sunitinib was administered at a starting dose of 50 mg/day on a 4-week-on, 2-week-off schedule...
January 15, 2016: BMC Cancer
https://www.readbyqxmd.com/read/26753752/adjuvant-therapy-improves-survival-for-t2n0-gastric-cancer-patients-with-sub-optimal-lymphadenectomy
#13
Haejin In, Olga Kantor, Susan M Sharpe, Marshall S Baker, Mark S Talamonti, Mitchell C Posner
BACKGROUND: The benefit of adjuvant therapy following resection of early stage, node-negative gastric adenocarcinoma following a margin negative (R0) resection is unclear. METHODS: The National Cancer Data Base was used to identify patients with a T2N0 gastric adenocarcinoma (tumor invasion into the muscularis propria) who underwent R0 resection. Patients treated with neoadjuvant therapy and those for whom lymph node count was unavailable were excluded from the analysis...
June 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/26727917/perioperative-treatment-not-surgical-approach-influences-overall-survival-in-patients-with-gastroesophageal-junction-tumors-a-nationwide-population-based-study-in-the-netherlands
#14
Marijn Koëter, Kevin Parry, Rob H A Verhoeven, Misha D P Luyer, Jelle P Ruurda, Richard van Hillegersberg, Valery E P P Lemmens, Grard A P Nieuwenhuijzen
BACKGROUND: Resectable gastroesophageal junction (GEJ) tumors are treated either with an esophageal-cardia resection or with gastrectomy. The difference in outcome between these two treatment modalities is unknown; Therefore, the aim of this study was to evaluate population-based treatment strategies for patients with resectable adenocarcinomas of the GEJ and to compare the oncological outcomes. METHODS: Patients with potentially resectable GEJ tumors diagnosed between 2005 and 2012 were selected from the nationwide, population-based Netherlands Cancer Registry...
May 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/26747230/recurrence-of-gastric-cancer-in-patients-who-are-disease-free-for-more-than-5-years-after-primary-resection
#15
Ju-Hee Lee, Hyun-Il Kim, Min Gyu Kim, Tae Kyung Ha, Min-Sung Jung, Sung Joon Kwon
BACKGROUND: Late recurrence of gastric cancer is rare and there are few data on recurrence in patients who are disease free for >5 years after gastrectomy. The aim of this study was to evaluate the predictors and status of tumor recurrence among these patients. METHODS: Clinicopathologic characteristics, patterns of recurrence, and postrecurrence survival were analyzed in patients who were diagnosed as disease free at 5 years postoperatively and thereafter experienced recurrence...
April 2016: Surgery
https://www.readbyqxmd.com/read/26732274/patterns-and-predictors-of-weight-loss-after-gastrectomy-for-cancer
#16
Jeremy L Davis, Luke V Selby, Joanne F Chou, Mark Schattner, David H Ilson, Marinela Capanu, Murray F Brennan, Daniel G Coit, Vivian E Strong
BACKGROUND: Weight loss following gastrectomy for patients with gastric cancer has not been well characterized. We assessed the impact of patient and procedure-specific variables on postoperative weight loss following gastrectomy for cancer. METHODS: A prospectively maintained gastric cancer database identified patients undergoing gastrectomy for cancer. Clinical and pathologic characteristics, baseline body mass index (BMI), and postoperative weights were extracted...
May 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/26733419/the-clinicopathological-features-and-long-term-survival-outcomes-of-mucinous-gastric-carcinoma-a-consecutive-series-of-244-cases-from-a-single-institute
#17
Xiaolong Tang, Jianwei Zhang, Xu Che, Zhongmin Lan, Yingtai Chen, Chengfeng Wang
BACKGROUND AND OBJECTIVES: Mucinous gastric carcinoma (MGC) is a rare kind of malignancy with unclear prognosis. This study aims to assess the clinicopathological features and prognosis of MGC. METHODS: We retrospectively analyzed a consecutive series of 244 MGC patients who underwent radical gastrectomy with D2 lymphadenectomy, and compared the data with 260 gastric signet ring cell carcinoma (SRC) patients. RESULTS: The univariate survival analysis showed that the surgical types, diameter of the primary tumor, the Borrmann type, pathological depth of tumor invasion (pT), pathological number of metastatic lymph node (pN), pathological tumor lymph metastasis (pTNM), and vascular invasion were all significant predictors of survival (all P < 0...
April 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/26662226/the-importance-of-surgical-margins-in-gastric-cancer
#18
REVIEW
Lauren M Postlewait, Shishir K Maithel
Interpretation and management of the surgical margin is paramount to the treatment of gastric adenocarcinoma. Although in early-stage disease, a microscopically positive margin may be associated with poor outcomes, in later stages, it does not persist as an independent poor prognostic factor but rather is likely a marker of other adverse pathologic characteristics that ultimately determine outcomes. Thus, the decision to extend a resection to achieve a negative margin should be deliberate and individualized...
March 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26629969/an-evidence-based-approach-to-the-treatment-of-gastroesophageal-reflux-disease
#19
REVIEW
Marco G Patti
IMPORTANCE: Gastroesophageal reflux disease (GERD) is prevalent worldwide, particularly in developed countries. It is estimated that the prevalence of GERD in the United States is approximately 20% and that it is increasing because of the epidemic of obesity. OBJECTIVE: To review the pathophysiology, clinical presentation, diagnostic evaluation, and treatment of GERD. EVIDENCE REVIEW: A search of PubMed was conducted for the years spanning 1985 to 2015 and included the following terms: heartburn, regurgitation, dysphagia, gastroesophageal reflux disease, cough, aspiration, laryngitis, GERD, GORD, endoscopy, manometry, pH monitoring, proton pump inhibitors, open fundoplication, and laparoscopic fundoplication...
January 2016: JAMA Surgery
https://www.readbyqxmd.com/read/26620645/prognostic-significance-of-carcinoembryonic-antigen-staining-in-cancer-tissues-of-gastric-cancer-patients
#20
Wei Wang, Sharvesh Raj Seeruttun, Cheng Fang, Jiewei Chen, Yong Li, Zhimin Liu, Youqing Zhan, Wei Li, Yingbo Chen, Xiaowei Sun, Yuanfang Li, Dazhi Xu, Yuanxiang Guan, Zhiwei Zhou
PURPOSE: The aim of this study was to assess the significance of the correlation among tissue carcinoembryonic antigen (CEA) expression with serum CEA (sCEA) levels and long-term survival to highlight the clinical prognostic significance of tissue CEA expression in gastric cancer patients. METHODS: Immunohistological method and radioimmunoassay were used to assess tissue and sCEA expression, respectively. Univariate and multivariate analyses were performed to determine correlations, and the Kaplan-Meier method was used to investigate the prognostic significance...
April 2016: Annals of Surgical Oncology
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