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17 papers 0 to 25 followers
Rossel Morhij, Ashish Mahendra, Mike Jane, Donald C McMillan
BACKGROUND: The prognostic significance of markers of the systemic inflammatory response in patients with soft tissue and bone sarcomas remains unclear. Therefore, the present study aimed to compare the prognostic value of markers of the systemic inflammatory response in patients undergoing surgery for primary soft tissue and bone sarcoma. METHOD: Patients who underwent resection of primary soft tissue/bone sarcoma between 2008 and 2012 and had pre-operative measurements of the systemic inflammatory response [C-reactive protein, albumin, white cell, neutrophil, lymphocyte and platelet counts, and the combination of C-reactive protein and albumin (mGPS)] were included in the study (n = 111)...
May 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
Alessandro Gronchi, Dirk C Strauss, Rosalba Miceli, Sylvie Bonvalot, Carol J Swallow, Peter Hohenberger, Frits Van Coevorden, Piotr Rutkowski, Dario Callegaro, Andrew J Hayes, Charles Honoré, Mark Fairweather, Amanda Cannell, Jens Jakob, Rick L Haas, Milena Szacht, Marco Fiore, Paolo G Casali, Raphael E Pollock, Chandrajit P Raut
BACKGROUND: Retroperitoneal sarcomas (RPS) are rare tumors composed of several well defined histologic subtypes. The aim of this study was to analyze patterns of recurrence and treatment variations in a large population of patients, treated at reference centers. METHODS: All consecutive patients with primary RPS treated at 6 European and 2 North American institutions between January 2002 and December 2011 were included. Five, 8, and 10-year overall survival (OS) and crude cumulative incidence (CCI) of local recurrence (LR) and distant metastasis (DM) were calculated...
May 2016: Annals of Surgery
Benedetta Bedetti, Karsten Wiebe, Andreas Ranft, Hermann Aebert, Joachim Schmidt, Heribert Jürgens, Uta Dirksen
BACKGROUND: Primary Ewing sarcoma (ES) can sometimes present as a chest-wall tumor. Multidisciplinary management, including chemotherapy and local treatment consisting of surgery, radiotherapy (RT), or both, has improved the survival of patients with localized ES; however, the best approach to achieving local control remains controversial. METHODS: We retrospectively analyzed data from 198 patients with non-metastatic ES of the chest wall, who were registered in the database of the German Society of Pediatric Hematology and Oncology between July 1998 and April 2009...
September 2015: Annals of Surgical Oncology
Jens Jakob, Anna Simeonova, Bernd Kasper, Ulrich Ronellenfitsch, Frederik Wenz, Peter Hohenberger
BACKGROUND: Antiangiogenic substances and radiation therapy (RT) may have synergistic effects and improve irradiation efficacy. We present a cohort study evaluating the toxicity of combined sunitinib and RT as neoadjuvant treatment of extremity and retroperitoneal soft tissue sarcoma (STS). METHODS: Sixteen patients with locally advanced extremity (6/16) or retroperitoneal (10/16) STS were treated with continuous-dosing sunitinib (15/16: 37.5 mg daily; 1/16: 25 mg daily) and standard RT (45-50...
September 2015: Annals of Surgical Oncology
D Callegaro, R Miceli, C Brunelli, C Colombo, R Sanfilippo, S Radaelli, P G Casali, A Caraceni, A Gronchi, M Fiore
BACKGROUND: More than 60 per cent of patients treated surgically for primary retroperitoneal sarcoma survive for at least 5 years. Extended surgical resection has been proposed for primary disease, but long-term morbidity data are lacking. A cross-sectional study was conducted to assess the long-term morbidity of patients undergoing surgery for retroperitoneal sarcoma. METHODS: Patients operated on between January 2002 and December 2011 were eligible for the study...
August 2015: British Journal of Surgery
Chun-Han Hou, Alexander L Lazarides, Paul J Speicher, Daniel P Nussbaum, Daniel G Blazer, David G Kirsch, Brian E Brigman, William C Eward
BACKGROUND: It is a consensus that radiation therapy (RT) should be applied for all large, deep, high-grade soft tissue sarcomas (STS). Therefore, we investigated the National Cancer Database (NCDB) to study how these guidelines are being followed, to determine what factors may be associated with the decision not to use RT, and to see whether there was an association of RT use and survival. METHODS: We retrospectively analyzed localized high-grade STS patients in the NCDB from 1998 through 2006...
September 2015: Annals of Surgical Oncology
Marcus C B Tan, Murray F Brennan, Deborah Kuk, Narasimhan P Agaram, Cristina R Antonescu, Li-Xuan Qin, Nicole Moraco, Aimee M Crago, Samuel Singer
OBJECTIVE: To determine the prognostic significance of histologic type/subtype in a large series of patients with primary resected retroperitoneal sarcoma. BACKGROUND: The histologic diversity and rarity of retroperitoneal sarcoma has hampered the ability to predict patient outcome. METHODS: From a single-institution, prospective database, 675 patients treated surgically for primary, nonmetastatic retroperitoneal sarcoma during 1982 to 2010 were identified and histologic type/subtype was reviewed...
March 2016: Annals of Surgery
Sandro Pasquali, Ravinder Vohra, Ioanna Tsimopoulou, Deepak Vijayan, David Gourevitch, Anant Desai
BACKGROUND: Primary extended resection has been proposed as the initial treatment for patients with retroperitoneal sarcoma. This approach comprises an extended en-bloc resection of the directly infiltrated organs and adjacent uninvolved organs. The results of such radical surgery have yet to be validated. This retrospective study aims to investigate this practice in a contemporary series from a referral center in the UK. METHODS: We extracted data from consecutive patients who underwent extended resectional surgery between 2009 and 2013, and investigated the type of resection performed, the effectiveness of extended surgery in providing negative microscopic margins, and the occurrence of post-surgical adverse events...
October 2015: Annals of Surgical Oncology
Fatima Wilder, Sandra D'Angelo, Aimee M Crago
Soft tissue sarcomas of the trunk are rare lesions, generally managed using an algorithm similar to that employed for extremity sarcomas. This review summarizes the standard treatment of truncal sarcomas and considers how these recommendations differ for each of the various common histologic subtypes observed on the trunk: desmoid, dermatofibrosarcoma protuberans (DFSP), and angiosarcoma.
April 2015: Journal of Surgical Oncology
(no author information available yet)
BACKGROUND: Retroperitoneal soft tissue sarcomas (RPS) are rare tumors that include several well-defined histologic subtypes. Although surgery is the mainstay of curative therapy, no universally accepted recommendations concerning the best management have been developed to date. Optimization of the initial approach is critical for maximizing patient outcomes. METHODS: An RPS Trans-Atlantic Working Group was established in 2013. The primary aim was to evaluate the current evidence critically and to develop a consensus document on the approach to this difficult disease...
January 2015: Annals of Surgical Oncology
Alessandro Gronchi, Rosalba Miceli, Marc Antoine Allard, Dario Callegaro, Cecile Le Péchoux, Marco Fiore, Charles Honoré, Roberta Sanfilippo, Sara Coppola, Silvia Stacchiotti, Philippe Terrier, Paolo G Casali, Axel Le Cesne, Luigi Mariani, Chiara Colombo, Sylvie Bonvalot
PURPOSE: To explore patterns of failure and postrelapse outcome of patients with retroperitoneal sarcoma primarily treated by extended resection. METHODS: All consecutive patients with primary retroperitoneal sarcoma, treated between January 2002 and December 2011 at two European sarcoma centers were included. Five-year overall survival (OS) and crude cumulative incidence (CCI) of local recurrence (LR) and distant metastases (DM) were calculated. Multivariate analyses for OS and CCI of LR and DM were performed...
May 2015: Annals of Surgical Oncology
M J Wilkinson, J L Martin, A A Khan, A J Hayes, J M Thomas, D C Strauss
BACKGROUND: Tumours within the retroperitoneum can cause a diagnostic dilemma. A preoperative core needle biopsy often is required to establish a histological diagnosis. Preoperative core needle biopsy for extremity soft-tissue sarcoma is oncologically safe and biopsy site recurrence is extremely rare, attributed to placing the biopsy site within the planned resection field. This study investigates whether preoperative core needle biopsy affects oncological outcomes in retroperitoneal sarcomas...
March 2015: Annals of Surgical Oncology
Daniel P Nussbaum, Paul J Speicher, Brian C Gulack, Asvin M Ganapathi, Brian R Englum, David G Kirsch, Douglas S Tyler, Dan G Blazer
OBJECTIVE: To evaluate long-term survival among patients undergoing radiation therapy (RT), followed by surgical resection of retroperitoneal sarcomas (RPS). BACKGROUND: Despite a lack of level 1 evidence supporting neoadjuvant RT for RPS, its use has increased substantially over the past decade. METHODS: The 1998-2011 National Cancer Data Base was queried to identify patients who underwent resection of RPS. Subjects were grouped by use of neoadjuvant RT...
July 2015: Annals of Surgery
Jeffrey S Kneisl, Michelle M Coleman, Chandrajit P Raut
Adult soft tissue sarcomas (STSs) are heterogeneous neoplasms that account for 11,410 new diagnoses and 4,390 deaths per year. This article summarizes recent NCCN guidelines for diagnosis and management of STSs of the extremities and retroperitoneum, as well as gastrointestinal stromal tumors (GIST). AJCC staging and recently reported NCDB data regarding outcomes are reviewed. Currently accepted STS prognostic variables are presented, as are future directions regarding the utility of molecular prognosticators and nomograms...
October 2014: Journal of Surgical Oncology
M Toulmonde, S Bonvalot, P Méeus, E Stoeckle, O Riou, N Isambert, E Bompas, M Jafari, C Delcambre-Lair, E Saada, A Le Cesne, C Le Péchoux, J Y Blay, S Piperno-Neumann, C Chevreau, J O Bay, V Brouste, P Terrier, D Ranchère-Vince, A Neuville, A Italiano
BACKGROUND: Retroperitoneal sarcomas (RPS) are heterogeneous. No previous study has investigated the impact of specialized surgery, evaluated locoregional relapse (LRR), abdominal sarcomatosis and distant metastatic relapse as separate events, or considered histological subtypes separately. This study addresses these specific points in a homogeneous cohort of patients with completely resected primary RPS. PATIENTS AND METHODS: We conducted a retrospective analysis of adult patients diagnosed with a RPS between 1 January 1988 and 31 December 2008 and eventually referred to one of 12 centers of the French Sarcoma Group...
March 2014: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Syvie Bonvalot, Chandrajit P Raut, Raphael E Pollock, Piotr Rutkowski, Dirk C Strauss, Andrew J Hayes, Frits Van Coevorden, Marco Fiore, Eberhard Stoeckle, Peter Hohenberger, Alessandro Gronchi
BACKGROUND: Surgery is the principal treatment for retroperitoneal sarcoma. These tumors typically involve or abut multiple organs and therefore require multivisceral resections. Despite the complexity of such operations, a standardized approach has not been described. As a result, referral centers often see patients who have undergone suboptimal surgery, with gross disease left behind. This is one of the causes of the dismal prognosis of this disease. METHODS: These consensus statements came out from E-Surge, an educational symposium with live sarcoma surgery, performed by European and North American expert sarcoma surgeons illustrating an optimal technique to an international audience, held in 2010 and 2011...
September 2012: Annals of Surgical Oncology
A H Choi, J S Barnholtz-Sloan, J A Kim
BACKGROUND: Currently no prospective randomized trial has measured the efficacy of radiation therapy for resected retroperitoneal sarcomas (RPS). Our objective was to determine the effect of radiation therapy on disease-specific and overall survival between propensity score-matched surgically resected RPS patients using the Surveillance, Epidemiology, and End Results (SEER) database. PATIENTS AND METHODS: The study population consisted of patients with histologically confirmed RPS who underwent surgical resection between 1988 and 2006...
September 2012: Annals of Oncology: Official Journal of the European Society for Medical Oncology
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