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Andrew J Sinnamon, Madalyn G Neuwirth, Charles C Vining, Catherine E Sharoky, Yu-Xiao Yang, Rachel R Kelz, Douglas L Fraker, Robert E Roses, Giorgos C Karakousis
BACKGROUND: Prophylactic cholecystectomy at time of surgery for small bowel neuroendocrine tumor (SBNET) has been advocated, as these patients often go on to require somatostatin analogue therapy, which is known to increase risk of cholestasis and associated complications. Little is known regarding patterns of adoption of this practice or its associated morbidity. METHODS: The American College of Surgeons National Surgical Quality Improvement Program database (2008-2014) was queried to identify patients who underwent SBNET resection...
January 2018: Annals of Surgical Oncology
Long-Long Cao, Jun Lu, Jian-Xian Lin, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Qi-Yue Chen, Mi Lin, Ru-Hong Tu, Chang-Ming Huang
PURPOSE: Evaluate the predictive value of the preoperative blood neutrophil-to-lymphocyte ratio (NLR) on the clinical outcomes of patients with gastric neuroendocrine neoplasms (g-NENs) after radical surgery. RESULTS: The NLR was significantly higher in patients with g-NENs than in matched normal volunteers (P < 0.05). A higher blood NLR was not significantly associated with clinical characteristics (all P > 0.05). According to the multivariate analysis, the NLR was an independent prognostic factor of RFS and OS...
July 5, 2016: Oncotarget
Ville Sallinen, Caj Haglund, Hanna Seppänen
BACKGROUND: Nonfunctional pancreatic neuroendocrine tumors (NF-PNETs) are rare tumors with highly variable outcome. Current guidelines recommend surveillance for small tumors (≤ 2 cm), but a scientific basis for such recommendation is scarce. METHODS: Patients who underwent surgery for NF-PNET during 2001-2013 were identified from a prospectively maintained database and reviewed retrospectively. RESULTS: Fifty-eight patients that had undergone an operative procedure for NF-PNET were identified...
December 2015: Surgery
Arnaud Pasquer, Thomas Walter, Valérie Hervieu, Julien Forestier, Jean-Yves Scoazec, Catherine Lombard-Bohas, Gilles Poncet
BACKGROUND: Small bowel neuroendocrine tumors (SB-NETs) are characterized by two main features: they usually are metastatic at diagnosis and multiple in 30 % of cases. As such, SB-NETs require specific surgical management. This retrospective study examined local recurrence, survival, and prognosis of SB-NETs after adapted surgery. METHODS: All consecutive patients with SB-NETs who underwent resection of at least one primary tumor between 1 January 2000 and 1 January 2013 were analyzed...
December 2015: Annals of Surgical Oncology
Malcolm H Squires, N Volkan Adsay, David M Schuster, Maria C Russell, Kenneth Cardona, Keith A Delman, Joshua H Winer, Deniz Altinel, Juan M Sarmiento, Bassel El-Rayes, Natalyn Hawk, Charles A Staley, Shishir K Maithel, David A Kooby
BACKGROUND: Clinicians may order Octreoscan or positron emission tomography (PET) scan for staging patients with neuroendocrine tumors (NETs). (111)In-Octreoscan (Octreoscan) identifies tumors by radiolabeled targeting of somatostatin receptors, while 18F-fluorodeoxyglucose-positron emission tomography ((18)FDG-PET) measures differential tissue glucose transport. We assessed the sensitivity of both nuclear imaging modalities with pathologic correlation to define the best initial choice for NET staging after standard cross-sectional imaging...
July 2015: Annals of Surgical Oncology
David Jérémie Birnbaum, Olivier Turrini, Luca Vigano, Nadia Russolillo, Aurélie Autret, Vincent Moutardier, Lorenzo Capussotti, Yves-Patrice Le Treut, Jean-Robert Delpero, Jean Hardwigsen
BACKGROUND: The role of extended resections in the management of advanced pancreatic neuroendocrine tumors (PNETs) is not well defined. METHODS: Between 1995 and 2012, 134 patients with PNET underwent isolated (isoPNET group: 91 patients) or extended pancreatic resection (synchronous liver metastases and/or adjacent organs) (advPNET group: 43 patients). RESULTS: The associated resections included 27 hepatectomies, 9 vascular resections, 12 colectomies, 10 gastrectomies, 4 nephrectomies, 4 adrenalectomies, and 3 duodenojejunal resections...
March 2015: Annals of Surgical Oncology
Morikatsu Yoshida, Shinya Shiraishi, Fumi Sakamoto, Toru Beppu, Daisuke Utsunomiya, Hirohisa Okabe, Seiji Tomiguchi, Hideo Baba, Yasuyuki Yamashita
BACKGROUND: The liver itself regenerates after hepatectomy but little is known about how much hepatic function recovers during the regeneration. The liver uptake value (LUV), calculated from Tc-99m-labeled galactosyl-human-serum-albumin ((99m)Tc-GSA) SPECT/CT fused images, is reliable and useful for evaluating hepatic function. In this study, we evaluated the clinical usefulness of LUV for estimating hepatic functional regeneration after hepatectomy. METHODS: We enrolled 95 patients who had undergone (99m)Tc-GSA SPECT/CT tests before/on days 30 and 90 after hepatectomy...
October 2014: Annals of Nuclear Medicine
Annabelle L Fonseca, Charles H Cha
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, with a rising incidence in the United States. The increase in medical and locally ablative therapies have improved prognosis, however surgery, either liver resection or transplantation, remains the mainstay of therapy. An increased understanding of liver anatomy, improved imaging modalities and refinements of surgical technique have all led to improved outcomes after surgery. Both resection and transplantation may be used in a complementary manner...
November 2014: Journal of Surgical Oncology
Cesare Bordi
The current knowledge on gastric neuroendocrine pathology essentially developed in the last four decades. The historical evolution of the concepts and of the relevant clinical implications is described from the perspective of a group actively participating in this research domain. The histamine-producing enterochromaffin-like (ECL) cells have been recognized as the leading cell type involved in the most significant alterations of gastric neuroendocrine cells. The trophic stimulus exerted by circulating gastrin has been demonstrated to have a crucial role on proliferative changes of ECL cells through a sequence of hyperplasia-dysplasia-neoplasia described by Solcia et al...
June 2014: Endocrine Pathology
Timothy X Yang, Terence C Chua, David L Morris
This review examines the clinical efficacy and safety of the use of hepatic arterial chemoembolization, bland embolization and radioembolization in the treatment of unresectable neuroendocrine tumor liver metastases (NETLM). Response to treatment, survival outcome and toxicity were examined in this review of 37 studies comprising 1575 patients. These therapies are safe and effective in the treatment of NETLM. Prospective clinical trials to compare the relative efficacy and toxicity are warranted.
December 2012: Surgical Oncology
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