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Aurélien Archier, Arthur Varoquaux, Philippe Garrigue, Marion Montava, Carole Guerin, Sophie Gabriel, Eva Beschmout, Isabelle Morange, Nicolas Fakhry, Frédéric Castinetti, Frédéric Sebag, Anne Barlier, Anderson Loundou, Benjamin Guillet, Karel Pacak, David Taïeb
PURPOSE: Pheochromocytomas/paragangliomas (PHEOs/PGLs) overexpress somatostatin receptors and recent studies have already shown excellent results in the localization of these tumors using (68)Ga-labeled somatostatin analogs ((68)Ga-DOTA-SSA), especially in patients with germline succinate dehydrogenase subunit B gene (SDHB) mutations and head and neck PGLs (HNPGLs). The value of (68)Ga-DOTA-SSA has to be established in sporadic cases, including PHEOs. Thus, the aim of this study was to compare (68)Ga-DOTATATE PET/CT, (18)F-FDOPA PET/CT, and conventional imaging in patients with various PHEOs/PGLs with a special emphasis on sporadic cases, including those located in the adrenal gland...
July 2016: European Journal of Nuclear Medicine and Molecular Imaging
Darko Kastelan, Ivana Kraljevic, Tina Dusek, Nikola Knezevic, Mirsala Solak, Bojana Gardijan, Marko Kralik, Tamara Poljicanin, Tanja Skoric-Polovina, Zeljko Kastelan
OBJECTIVE: The current guidelines for the management of adrenal incidentaloma advise hormonal and radiological follow-up of patients for 2-5 years after the initial diagnosis. However, the vast majority of adrenal incidentaloma are non-functional benign cortical adenomas that require no treatment, so the routine application of the current strategies often results in a number of unnecessary biochemical and radiological investigations. The aim of this study was to analyse the clinical course of patients with adrenal incidentaloma and to provide a critical review of the current management strategy of the disease...
August 2015: European Journal of Endocrinology
Margaret Livingstone, Kaylene Duttchen, Jenny Thompson, Zahid Sunderani, Geoffrey Hawboldt, M Sarah Rose, Janice Pasieka
BACKGROUND: Ideal perioperative management of pheochromocytomas/paragangliomas (pheo) is a subject of debate and can be highly variable. The purpose of this study was to identify potential predictive factors of hemodynamic instability during pheo resection. METHODS: A retrospective review of pheo resections from 1992 to 2013 was undertaken. Intraoperative hemodynamics, patient demographics, tumor characteristics, and perioperative management were examined. Postoperative intensive-care admission, myocardial infarction, stroke, and 30-day mortality were reviewed...
December 2015: Annals of Surgical Oncology
Jacques W M Lenders, Quan-Yang Duh, Graeme Eisenhofer, Anne-Paule Gimenez-Roqueplo, Stefan K G Grebe, Mohammad Hassan Murad, Mitsuhide Naruse, Karel Pacak, William F Young
OBJECTIVE: The aim was to formulate clinical practice guidelines for pheochromocytoma and paraganglioma (PPGL). PARTICIPANTS: The Task Force included a chair selected by the Endocrine Society Clinical Guidelines Subcommittee (CGS), seven experts in the field, and a methodologist. The authors received no corporate funding or remuneration. EVIDENCE: This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe both the strength of recommendations and the quality of evidence...
June 2014: Journal of Clinical Endocrinology and Metabolism
Frederic Castinetti, Xiao-Ping Qi, Martin K Walz, Ana Luiza Maia, Gabriela Sansó, Mariola Peczkowska, Kornelia Hasse-Lazar, Thera P Links, Sarka Dvorakova, Rodrigo A Toledo, Caterina Mian, Maria Joao Bugalho, Nelson Wohllk, Oleg Kollyukh, Letizia Canu, Paola Loli, Simona R Bergmann, Josefina Biarnes Costa, Ozer Makay, Attila Patocs, Marija Pfeifer, Nalini S Shah, Thomas Cuny, Michael Brauckhoff, Birke Bausch, Ernst von Dobschuetz, Claudio Letizia, Marcin Barczynski, Maria K Alevizaki, Malgorzata Czetwertynska, M Umit Ugurlu, Gerlof Valk, John T M Plukker, Paola Sartorato, Debora R Siqueira, Marta Barontini, Malgorzata Szperl, Barbara Jarzab, Hans H G Verbeek, Tomas Zelinka, Petr Vlcek, Sergio P A Toledo, Flavia L Coutinho, Massimo Mannelli, Monica Recasens, Lea Demarquet, Luigi Petramala, Svetlana Yaremchuk, Dmitry Zabolotnyi, Francesca Schiavi, Giuseppe Opocher, Karoly Racz, Andrzej Januszewicz, Georges Weryha, Jean-Francois Henry, Thierry Brue, Bernard Conte-Devolx, Charis Eng, Hartmut P H Neumann
BACKGROUND: The prevention of medullary thyroid cancer in patients with multiple endocrine neoplasia type 2 syndrome has demonstrated the ability of molecular diagnosis and prophylactic surgery to improve patient outcomes. However, the other major neoplasia associated with multiple endocrine neoplasia type 2, phaeochromocytoma, is not as well characterised in terms of occurrence and treatment outcomes. In this study, we aimed to systematically characterise the outcomes of management of phaeochromocytoma associated with multiple endocrine neoplasia type 2...
May 2014: Lancet Oncology
Karel Pacak, Graeme Eisenhofer, Håkan Ahlman, Stefan R Bornstein, Anne-Paule Gimenez-Roqueplo, Ashley B Grossman, Noriko Kimura, Massimo Mannelli, Anne Marie McNicol, Arthur S Tischler
The First International Symposium on Pheochromocytoma, held in October 2005, included discussions about developments concerning these rare catecholamine-producing tumors. Recommendations were made during the symposium for biochemical diagnosis, localization, genetics, and treatment. Measurement of plasma or urinary fractionated metanephrines, the most accurate screening approach, was recommended as the first-line test for diagnosis; reference intervals should favor sensitivity over specificity. Localization studies should only follow reasonable clinical evidence of a tumor...
February 2007: Nature Clinical Practice. Endocrinology & Metabolism
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