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99 papers 25 to 100 followers
W Hartwig, A Gluth, U Hinz, D Koliogiannis, O Strobel, T Hackert, J Werner, M W Büchler
BACKGROUND: In the recent International Study Group of Pancreatic Surgery (ISGPS) consensus on extended pancreatectomy, several issues on perioperative outcome and long-term survival remained unclear. Robust data on outcomes are sparse. The present study aimed to assess the outcome of extended pancreatectomy for borderline resectable and locally advanced pancreatic cancer. METHODS: A consecutive series of patients with primary pancreatic adenocarcinoma undergoing extended pancreatectomies, as defined by the new ISGPS consensus, were compared with patients who had a standard pancreatectomy...
September 30, 2016: British Journal of Surgery
Jin-Young Jang, Taesung Park, Selyeong Lee, Yongkang Kim, Seung Yeoun Lee, Sun-Whe Kim, Song-Cheol Kim, Ki-Byung Song, Masakazu Yamamoto, Takashi Hatori, Seiko Hirono, Sohei Satoi, Tsutomu Fujii, Satoshi Hirano, Yasushi Hashimoto, Yashuhiro Shimizu, Dong Wook Choi, Seong Ho Choi, Jin Seok Heo, Fuyuhiko Motoi, Ippei Matsumoto, Woo Jung Lee, Chang Moo Kang, Ho-Seong Han, Yoo-Seok Yoon, Masayuki Sho, Hiroaki Nagano, Goro Honda, Sang Geol Kim, Hee Chul Yu, Jun Chul Chung, Yuichi Nagakawa, Hyung Il Seo, Hiroki Yamaue
OBJECTIVES: This study evaluated individual risks of malignancy and proposed a nomogram for predicting malignancy of branch duct type intraductal papillary mucinous neoplasms (BD-IPMNs) using the large database for IPMN. BACKGROUND: Although consensus guidelines list several malignancy predicting factors in patients with BD-IPMN, those variables have different predictability and individual quantitative prediction of malignancy risk is limited. METHODS: Clinicopathological factors predictive of malignancy were retrospectively analyzed in 2525 patients with biopsy proven BD-IPMN at 22 tertiary hospitals in Korea and Japan...
September 6, 2016: Annals of Surgery
Barbara Grünwald, Veronika Harant, Susanne Schaten, Monika Frühschütz, Ria Spallek, Bastian Höchst, Katharina Stutzer, Sonja Berchtold, Mert Erkan, Olga Prokopchuk, Marc Martignoni, Irene Esposito, Mathias Heikenwalder, Aayush Gupta, Jens Siveke, Paul Saftig, Percy Knolle, Dirk Wohlleber, Achim Krüger
BACKGROUND & AIMS: Pancreatic ductal adenocarcinoma (PDAC) metastasizes to liver at early stages, making this disease highly lethal. Tissue inhibitor of metalloproteinases-1 (TIMP1) creates a metastasis-susceptible environment in the liver. We investigated the role of TIMP1 and its receptor CD63 in metastasis of early-stage pancreatic tumors using mice and human cell lines and tissue samples. METHODS: We obtained liver and plasma samples from patients in Germany with chronic pancreatitis, pancreatic intra-epithelial neoplasia, or PDAC, as well as hepatic stellate cells (HSCs)...
August 6, 2016: Gastroenterology
Hai V Nguyen, Jesse Gore, Xin Zhong, Sudha S Savant, Samantha Deitz-McElyea, C Max Schmidt, Michael G House, Murray Korc
Lymph node involvement in pancreatic adenocarcinoma (PAC) predicts postresection survival, but early lymph node metastasis detection is not easily accomplished. We assessed a panel of microRNAs (miRNAs) in a common hepatic artery lymph node (station 8) that is readily accessible during pancreatoduodenectomy (PD) to determine if increased miRNA levels correlate with postresection recurrence. Station 8 lymph nodes overlying the common hepatic artery collected during PD were assayed for miRNA-10b, miRNA-30c, miRNA-21, and miRNA-155 and cytokeratin-19 (CK19), an epithelial cell marker, using quantitative PCR...
October 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Julie Perinel, Christophe Mariette, Bertrand Dousset, Igor Sielezneff, Alain Gainant, Jean-Yves Mabrut, Sylvie Bin-Dorel, Michel El Bechwaty, Dominique Delaunay, Lorraine Bernard, Alain Sauvanet, Marc Pocard, Emmanuel Buc, Mustapha Adham
OBJECTIVES: The aim of this study was to compare nasojejunal early enteral nutrition (NJEEN) with total parenteral nutrition (TPN), after pancreaticoduodenectomy (PD), in terms of postoperative complications. BACKGROUND: Current nutritional guidelines recommend the use of enteral over parenteral nutrition in patients undergoing gastrointestinal surgery. However, the NJEEN remains controversial in patients undergoing PD. METHODS: Multicenter, randomized, controlled trial was conducted between 2011 and 2014...
July 15, 2016: Annals of Surgery
Thilo Hackert, Milena Sachsenmaier, Ulf Hinz, Lutz Schneider, Christoph W Michalski, Christoph Springfeld, Oliver Strobel, Dirk Jäger, Alexis Ulrich, Markus W Büchler
OBJECTIVE: For patients with locally advanced and unresectable pancreatic cancer (PDAC), neodadjuvant treatment and consecutive surgical exploration have been studied during the last decade with various neoadjuvant therapies including chemotherapy and combinations with radiation. Aim of the study was the evaluation of neoadjuvant therapy with a focus on Folfirinox. METHODS: All consecutive patients undergoing surgery for PDAC after neoadjuvant treatment were analyzed (clinico-pathological characteristics, secondary resection rates, outcome)...
September 2016: Annals of Surgery
M D Chandrasegaram, D Goldstein, J Simes, V Gebski, J G Kench, A J Gill, J S Samra, N D Merrett, A J Richardson, A P Barbour
BACKGROUND: R0 resection rates (complete tumour removal with negative resection margins) in pancreatic cancer are 70-80 per cent when a 0-mm margin is used, declining to 15-24 per cent with a 1-mm margin. This review evaluated the R0 resection rates according to different margin definitions and techniques. METHODS: Three databases (MEDLINE from 1946, PubMed from 1946 and Embase from 1949) were searched to mid-October 2014. The search terms included 'pancreatectomy OR pancreaticoduodenectomy' and 'margin'...
November 2015: British Journal of Surgery
Luis Sabater, Fabio Ausania, Olaf J Bakker, Jaume Boadas, J Enrique Domínguez-Muñoz, Massimo Falconi, Laureano Fernández-Cruz, Luca Frulloni, Víctor González-Sánchez, José Lariño-Noia, Björn Lindkvist, Félix Lluís, Francisco Morera-Ocón, Elena Martín-Pérez, Carlos Marra-López, Ángel Moya-Herraiz, John P Neoptolemos, Isabel Pascual, Ángeles Pérez-Aisa, Raffaele Pezzilli, José M Ramia, Belinda Sánchez, Xavier Molero, Inmaculada Ruiz-Montesinos, Eva C Vaquero, Enrique de-Madaria
OBJECTIVE: To provide evidence-based recommendations for the management of exocrine pancreatic insufficiency (EPI) after pancreatic surgery. BACKGROUND: EPI is a common complication after pancreatic surgery but there is certain confusion about its frequency, optimal methods of diagnosis, and when and how to treat these patients. METHODS: Eighteen multidisciplinary reviewers performed a systematic review on 10 predefined questions following the GRADE methodology...
April 1, 2016: Annals of Surgery
Víctor Fernando Andrade-Dávila, Mariana Chávez-Tostado, Carlos Dávalos-Cobián, Jesús García-Correa, Alejandro Montaño-Loza, Clotilde Fuentes-Orozco, Michel Dassaejv Macías-Amezcua, Jesús García-Rentería, Jorge Rendón-Félix, José Antonio Cortés-Lares, Gabriela Ambriz-González, Ana Olivia Cortés-Flores, Andrea del Socorro Alvarez-Villaseñor, Alejandro González-Ojeda
BACKGROUND: Acute pancreatitis is the most common major complication after endoscopic retrograde cholangiopancreatography (ERCP). Many drugs have been evaluated for prophylaxis, including nonsteroidal anti-inflammatory drugs (NSAIDs), which are potent inhibitors of phospholipase A2 and play a role in the pathogenesis of acute pancreatitis. Rectal NSAIDs have been shown in prospective studies to decrease the incidence of this complication, but the indication is not generalized in clinical practice...
2015: BMC Gastroenterology
John R Bergquist, Carlos A Puig, Christopher R Shubert, Ryan T Groeschl, Elizabeth B Habermann, Michael L Kendrick, David M Nagorney, Rory L Smoot, Michael B Farnell, Mark J Truty
BACKGROUND: Patient triage in anatomically resectable, early stage pancreatic ductal adenocarcinoma (PDAC) with elevated carbohydrate antigen 19-9 (CA 19-9) remains unclear. We hypothesized that any CA 19-9 elevation indicates biologically borderline resectability. STUDY DESIGN: The National Cancer Data Base (NCDB 2010 to 2012) was reviewed for PDAC patients with reported CA 19-9. Nonsecretors were analyzed separately. Early stage (I/II) patients were stratified by CA 19-9 above or below normal (37 U/mL)...
July 2016: Journal of the American College of Surgeons
L K Palani Velu, C J McKay, C R Carter, D C McMillan, N B Jamieson, E J Dickson
BACKGROUND: Pancreas-specific complications (PSCs), comprising postoperative pancreatic fistula, haemorrhage and intra-abdominal collections, are drivers of morbidity and mortality after pancreaticoduodenectomy (PD). A serum amylase concentration of 130 units/l or more on postoperative day (POD) 0 has been shown to be an objective surrogate of pancreatic texture, a determinant of PSCs. This study evaluated serial measurements of C-reactive protein (CRP) to refine PSC risk stratification...
April 2016: British Journal of Surgery
Tadafumi Asaoka, Atsushi Miyamoto, Sakae Maeda, Masanori Tsujie, Naoki Hama, Kazuyoshi Yamamoto, Masakazu Miyake, Naotsugu Haraguchi, Kazuhiro Nishikawa, Motohiro Hirao, Masataka Ikeda, Mitsugu Sekimoto, Shoji Nakamori
BACKGROUND: Recently, several preoperative proinflammatory markers and nutritional factors such as neutrophil-to-lymphocyte ratio (NLR) and prognostic nutrition index (PNI) have been reported as significant predictor for poor prognosis of various malignant tumors. In this study, we evaluated the prognostic values of these preoperative parameters in patients with resectable pancreatic head cancer. METHODS: We retrospectively reviewed consecutive patients who underwent PD for pancreatic head cancer between 2007 and 2012...
May 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Alexander P Stark, Greg D Sacks, Matthew M Rochefort, Timothy R Donahue, Howard A Reber, James S Tomlinson, David W Dawson, Guido Eibl, O Joe Hines
BACKGROUND: Long-term survival (LTS) is uncommon for patients with pancreatic ductal adenocarcinoma (PDAC). We sought to identify factors that predict 10-year, LTS after resection of PDAC. METHODS: We identified all patients with PDAC who underwent resection at UCLA after 1990 and included all patients eligible for observed LTS (1/1/1990-12/31/2004). An independent pathologist reconfirmed the diagnosis of PDAC in patients with LTS. Logistic regression was used to predict LTS on the basis of patient and tumor characteristics...
June 2016: Surgery
Omar Barakat, Martha N Cagigas, Shima Bozorgui, Claire F Ozaki, R Patrick Wood
BACKGROUND: Delayed gastric emptying (DGE) is a common complication of pancreaticoduodenectomy. We determined the efficiency of a new reconstruction technique, designed to preserve motilin-secreting cells and maximize the utility of their receptors, in reducing the incidence of DGE after pancreaticoduodenectomy. METHODS: From April 2005 to September 2014, 217 consecutive patients underwent pancreaticoduodenectomy at our institution. Nine patients who underwent total pancreatectomy were excluded...
May 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Woohyun Jung, Jin-Young Jang, Mee Joo Kang, Ye Rim Chang, Yong Chan Shin, Jihoon Chang, Sun-Whe Kim
BACKGROUND: Computed tomography and serum tumor markers have limited value in detecting recurrence after curative surgery of pancreatic cancer. This study evaluated the clinical utility of 18F-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) in diagnosing recurrence. METHODS: One hundred ten patients underwent curative resection of pancreatic cancer were enrolled. The diagnostic value of abdominal computed tomography (CT), PET-CT and serum carbohydrate antigen (CA) 19-9 concentration were compared...
January 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Burcu Saka, Serdar Balci, Olca Basturk, Pelin Bagci, Lauren M Postlewait, Shishir Maithel, Jessica Knight, Bassel El-Rayes, David Kooby, Juan Sarmiento, Takashi Muraki, Irma Oliva, Sudeshna Bandyopadhyay, Gizem Akkas, Michael Goodman, Michelle D Reid, Alyssa Krasinskas, Rhonda Everett, Volkan Adsay
BACKGROUND: Most studies have failed to identify any prognostic value of the current T-stage protocol for pancreatic ductal adenocarcinoma (PDAC) by the American Joint Committee on Cancer and the Union for International Cancer Control unless some grouping was performed. METHODS: To document the parameters included in this T-stage protocol, 223 consecutive pancreatoduodenectomy specimens with PDAC were processed by a uniform grossing protocol. RESULTS: Peripancreatic soft tissue (PST) involvement, the main pT3 parameter, was found to be inapplicable and irreproducible due to lack of a true capsule in the pancreas and variability in the amount and distribution of adipose tissue...
June 2016: Annals of Surgical Oncology
Amitasha Sinha, Yuval A Patel, Michael Cruise, Karen Matsukuma, Atif Zaheer, Elham Afghani, Dhiraj Yadav, Martin A Makary, Kenzo Hirose, Dana K Andersen, Vikesh K Singh
BACKGROUND: Post-operative pain relief in chronic pancreatitis (CP) is variable. Our objective was to determine clinical imaging or histopathologic predictor(s) of post-operative pain relief in CP patients undergoing the Whipple or Frey procedure. METHODS: All patients who underwent a Whipple (n = 30) or Frey procedure (n = 30) for painful CP between January 2003 and September 2013 were evaluated. A toxic etiology was defined as a history of alcohol use and/or smoking...
April 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
M C Giglio, D R C Spalding, A Giakoustidis, A Zarzavadjian Le Bian, L R Jiao, N A Habib, M Pai
BACKGROUND: Drain amylase content in the days immediately after major pancreatic resection has been investigated previously as a predictor of postoperative pancreatic fistula (POPF). Its accuracy, however, has not been determined conclusively. The purpose of this study was to evaluate the accuracy of drain amylase content on the first day after major pancreatic resection in predicting the occurrence of POPF. METHODS: A literature search of the MEDLINE, Embase and Scopus(®) databases to 13 May 2015 was performed to identify studies evaluating the accuracy of drain amylase values on day 1 after surgery in predicting the occurrence of POPF...
March 2016: British Journal of Surgery
Min Wang, Feng Zhu, Renyi Qin, Shuyou Peng
No abstract text is available yet for this article.
January 5, 2016: Annals of Surgery
Michael D Kluger, Irene Epelboym, Beth A Schrope, Krishnaraj Mahendraraj, Elizabeth M Hecht, Jonathan Susman, Joshua L Weintraub, John A Chabot
BACKGROUND: Irreversible electroporation (IRE) for treatment of locally advanced pancreatic tumors is garnering increasing attention. This study was conducted to determine perioperative morbidity and mortality for locally advanced pancreatic cancer. METHODS: Prospective data of 50 consecutive patients receiving IRE for T4 lesions at a single tertiary center were analyzed. The primary end point was Clavien-Dindo complications at 90 days, and the secondary outcomes were survival and recurrence...
May 2016: Annals of Surgical Oncology
2016-01-17 11:02:13
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