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Cancer: ParuchMD

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26 papers 25 to 100 followers
By John Paruch Combined training in Internal Medicine-Psychiatry with holistic, evidence-based, preventive approach to implementation and promotion of wellness.
https://www.readbyqxmd.com/read/27170029/fruit-and-vegetable-consumption-in-adolescence-and-early-adulthood-and-risk-of-breast-cancer-population-based-cohort-study
#1
Maryam S Farvid, Wendy Y Chen, Karin B Michels, Eunyoung Cho, Walter C Willett, A Heather Eliassen
OBJECTIVE:  To evaluate the association between fruit and vegetable intake during adolescence and early adulthood and risk of breast cancer. DESIGN:  Prospective cohort study. SETTING:  Health professionals in the United States. PARTICIPANTS:  90 476 premenopausal women aged 27-44 from the Nurses' Health Study II who completed a questionnaire on diet in 1991 as well as 44 223 of those women who completed a questionnaire about their diet during adolescence in 1998...
May 11, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/21158707/cancer-chemoprevention-by-targeting-the-epigenome
#2
REVIEW
Joseph Huang, Christoph Plass, Clarissa Gerhauser
The term "epigenetics" refers to modifications in gene expression caused by heritable, but potentially reversible, changes in DNA methylation and chromatin structure. Given the fact that epigenetic modifications occur early in carcinogenesis and represent potentially initiating events in cancer development, they have been identified as promising new targets for prevention strategies. The present review will give a comprehensive overview of the current literature on chemopreventive agents and their influence on major epigenetic mechanisms, that is DNA methylation, histone acetylation and methylation, and microRNAs, both in vitro and in rodent and human studies, taking into consideration specific mechanisms of action, target sites, concentrations, methods used for analysis, and outcome...
December 2011: Current Drug Targets
https://www.readbyqxmd.com/read/23856911/recent-progress-in-pancreatic-cancer
#3
REVIEW
Christopher L Wolfgang, Joseph M Herman, Daniel A Laheru, Alison P Klein, Michael A Erdek, Elliot K Fishman, Ralph H Hruban
Pancreatic cancer is currently one of the deadliest of the solid malignancies. However, surgery to resect neoplasms of the pancreas is safer and less invasive than ever, novel drug combinations have been shown to improve survival, advances in radiation therapy have resulted in less toxicity, and enormous strides have been made in the understanding of the fundamental genetics of pancreatic cancer. These advances provide hope but they also increase the complexity of caring for patients. It is clear that multidisciplinary care that provides comprehensive and coordinated evaluation and treatment is the most effective way to manage patients with pancreatic cancer...
September 2013: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/27727446/the-primary-care-provider-pcp-cancer-specialist-relationship-a-systematic-review-and-mixed-methods-meta-synthesis
#4
Lesly A Dossett, Janella N Hudson, Arden M Morris, M Catherine Lee, Richard G Roetzheim, Michael D Fetters, Gwendolyn P Quinn
Although they are critical to models of coordinated care, the relationship and communication between primary care providers (PCPs) and cancer specialists throughout the cancer continuum are poorly understood. By using predefined search terms, the authors conducted a systematic review of the literature in 3 databases to examine the relationship and communication between PCPs and cancer specialists. Among 301 articles identified, 35 met all inclusion criteria and were reviewed in-depth. Findings from qualitative, quantitative, and disaggregated mixed-methods studies were integrated using meta-synthesis...
October 11, 2016: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/26747086/cardiac-outcomes-in-adult-survivors-of-childhood-cancer-exposed-to-cardiotoxic-therapy-a-cross-sectional-study
#5
Daniel A Mulrooney, Gregory T Armstrong, Sujuan Huang, Kirsten K Ness, Matthew J Ehrhardt, Vijaya M Joshi, Juan Carlos Plana, Elsayed Z Soliman, Daniel M Green, Deokumar Srivastava, Aimee Santucci, Matthew J Krasin, Leslie L Robison, Melissa M Hudson
BACKGROUND: Studies of cardiac disease among adult survivors of childhood cancer have generally relied on self-reported or registry-based data. OBJECTIVE: To systematically assess cardiac outcomes among survivors of childhood cancer. DESIGN: Cross-sectional study. SETTING: St. Jude Children's Research Hospital. PATIENTS: 1853 adult survivors of childhood cancer, aged 18 years or older, who received cancer-related cardiotoxic therapy at least 10 years earlier...
January 19, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/24343361/cancer-as-a-metabolic-disease-implications-for-novel-therapeutics
#6
REVIEW
Thomas N Seyfried, Roberto E Flores, Angela M Poff, Dominic P D'Agostino
Emerging evidence indicates that cancer is primarily a metabolic disease involving disturbances in energy production through respiration and fermentation. The genomic instability observed in tumor cells and all other recognized hallmarks of cancer are considered downstream epiphenomena of the initial disturbance of cellular energy metabolism. The disturbances in tumor cell energy metabolism can be linked to abnormalities in the structure and function of the mitochondria. When viewed as a mitochondrial metabolic disease, the evolutionary theory of Lamarck can better explain cancer progression than can the evolutionary theory of Darwin...
March 2014: Carcinogenesis
https://www.readbyqxmd.com/read/27130532/screening-for-lung-cancer-a-systematic-review-and-meta-analysis
#7
REVIEW
Muhammad Usman Ali, John Miller, Leslea Peirson, Donna Fitzpatrick-Lewis, Meghan Kenny, Diana Sherifali, Parminder Raina
OBJECTIVES: To examine evidence on benefits and harms of screening average to high-risk adults for lung cancer using chest radiology (CXR), sputum cytology (SC) and low-dose computed tomography (LDCT). METHODS: This systematic review was conducted to provide up to date evidence for Canadian Task Force on Preventive Health Care (CTFPHC) lung cancer screening guidelines. Four databases were searched to March 31, 2015 along with utilizing a previous Cochrane review search...
August 2016: Preventive Medicine
https://www.readbyqxmd.com/read/27287662/recent-relocation-and-decreased-survival-following-a-cancer-diagnosis
#8
Vinayak Muralidhar, Paul L Nguyen, Reginald D Tucker-Seeley
OBJECTIVE: To determine the impact of recent relocation prior to a cancer diagnosis on cancer-specific outcomes. METHODS: We identified 272,718 patients with two different entries in the Surveillance, Epidemiology, and End Results database within 3years of each other. Those who had relocated to a different county between entries were identified and we determined the risk of stage IV disease or cancer-specific mortality among relocators and non-relocators after adjusting for other patient-specific demographic and clinical factors...
August 2016: Preventive Medicine
https://www.readbyqxmd.com/read/27287664/lung-cancer-screening-makes-the-grade
#9
EDITORIAL
Christine D Berg
No abstract text is available yet for this article.
August 2016: Preventive Medicine
https://www.readbyqxmd.com/read/27384232/predictive-validity-of-the-acc-aha-pooled-cohort-equations-in-predicting-cancer-specific-mortality-in-a-national-prospective-cohort-study-of-adults-in-the-united-states
#10
P D Loprinzi
BACKGROUND: The American College of Cardiology/American Heart Association Task Force on Practice Guidelines recently developed the Pooled Cohort Risk (PCR) equations to predict 10-years risk for a first atherosclerotic cardiovascular disease (ASCVD) event. The predictive validity of these PCR equations on cancer-specific mortality among a national sample of US adults has yet to be evaluated, which was this study's purpose. METHODS: Data from the 1999-2010 National Health and Nutrition Examination Survey were used, with participants followed through December 31, 2011 to ascertain cancer mortality status via the National Death Index probabilistic algorithm...
August 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/27183032/association-of-leisure-time-physical-activity-with-risk-of-26-types-of-cancer-in-1-44-million-adults
#11
Steven C Moore, I-Min Lee, Elisabete Weiderpass, Peter T Campbell, Joshua N Sampson, Cari M Kitahara, Sarah K Keadle, Hannah Arem, Amy Berrington de Gonzalez, Patricia Hartge, Hans-Olov Adami, Cindy K Blair, Kristin B Borch, Eric Boyd, David P Check, Agnès Fournier, Neal D Freedman, Marc Gunter, Mattias Johannson, Kay-Tee Khaw, Martha S Linet, Nicola Orsini, Yikyung Park, Elio Riboli, Kim Robien, Catherine Schairer, Howard Sesso, Michael Spriggs, Roy Van Dusen, Alicja Wolk, Charles E Matthews, Alpa V Patel
IMPORTANCE: Leisure-time physical activity has been associated with lower risk of heart-disease and all-cause mortality, but its association with risk of cancer is not well understood. OBJECTIVE: To determine the association of leisure-time physical activity with incidence of common types of cancer and whether associations vary by body size and/or smoking. DESIGN, SETTING, AND PARTICIPANTS: We pooled data from 12 prospective US and European cohorts with self-reported physical activity (baseline, 1987-2004)...
June 1, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27196525/preventable-incidence-and-mortality-of-carcinoma-associated-with-lifestyle-factors-among-white-adults-in-the-united-states
#12
Mingyang Song, Edward Giovannucci
IMPORTANCE: Lifestyle factors are important for cancer development. However, a recent study has been interpreted to suggest that random mutations during stem cell divisions are the major contributor to human cancer. OBJECTIVE: To estimate the proportion of cases and deaths of carcinoma (all cancers except skin, brain, lymphatic, hematologic, and nonfatal prostate malignancies) among whites in the United States that can be potentially prevented by lifestyle modification...
September 1, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/21371954/melanoma-and-vitamin-d
#13
REVIEW
Sinead Field, Julia A Newton-Bishop
Vitamin D is a fat-soluble steroid hormone, which is essential to health and for which epidemiological studies suggest a role in autoimmune disease, infections, cardiovascular disease and cancer. It is ingested in foods such as oily fish and supplements, so that average levels vary between countries, but most individuals worldwide make most of their vitamin D as a result of the effects of sun exposure on the skin. Many studies in different populations around the world have in recent years shown that sub-optimal levels of vitamin D (<70 nmol/L) are common...
April 2011: Molecular Oncology
https://www.readbyqxmd.com/read/20835749/links-between-private-habits-psychological-stress-and-brain-cancer-a-case-control-pilot-study-in-france
#14
Cécilia Cabaniols, Roch Giorgi, Olivier Chinot, Nabila Ferahta, Valérie Spinelli, Philippe Alla, Maryline Barrie, Marie-Pascale Lehucher-Michel
Numerous studies have increasingly suggested that medical history and lifestyle factors could be involved in the increase of cancer risk in adults. The issue whether psychological factors can influence the development of cancer has been discussed for many years. In the field of brain cancer, psychological stress has not so far been investigated. We conducted a French case-control pilot study with 122 adult incident cases and 122 controls free of any cancer diagnosis, matched for age and gender, to investigate links between malignant primitive brain tumours (MPBT) and medical history, private habits and psychological stress...
June 2011: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27037811/a-multicenter-study-on-the-relative-effectiveness-of-a-12-week-physical-training-program-for-adults-with-an-oncologic-diagnosis
#15
Hoang Tran, Cheng Lin, Fang Yu, Angie Frederick, Molly Mieras, Lorena Baccaglini
PURPOSE: The purpose of this study was to examine the association between cancer survivors' socio-demographic and clinical characteristics and aerobic fitness changes following a physical training program. METHODS: We assessed the association between participant's characteristics and aerobic fitness in the six-min walk test (6MWT) after a 12-week LIVESTRONG® at Young Men's Christian Association (YMCA) exercise program for adults with an oncologic diagnosis using linear mixed effects models...
September 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/26645470/correlation-of-disturbed-sleep-and-cancer-stress
#16
Gregory S Vander Wal, Kenneth L Lichstein, Cynthia K Perkins
To illuminate the course of insomnia in the presence of an acute comorbidity, we examined the association between insomnia severity and breast cancer symptom severity over time and determined if this association varies with insomnia history and presleep arousal. Twenty-nine newly diagnosed breast cancer patients, who also exhibited insomnia, completed sleep diary and cancer symptom severity questionnaires every other week (total of 28 days) over 7 weeks, as well as baseline and postobservation measures. Participants were defined as having insomnia prior to cancer (IPC) or insomnia secondary to cancer (ISC) based on precancer sleep status...
December 8, 2015: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/26789828/cancer-prevention-state-of-the-art-and-future-prospects
#17
REVIEW
I Valle, D Tramalloni, N L Bragazzi
Cancer imposes a heavy societal burden worldwide, in terms of both epidemiology and costs. The introduction of more sophisticated imaging and diagnostic techniques and advanced drugs that specifically target tumor cells is leading to increasingly expensive treatments, which may be affordable only for few patients. Prevention, and particularly primary prevention, is an effective way of addressing the challenging issue of cancer, since between a third and a half of cancers could be prevented on the basis of our current knowledge of risk factors...
2015: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/22142401/systems-cancer-medicine-towards-realization-of-predictive-preventive-personalized-and-participatory-p4-medicine
#18
REVIEW
Q Tian, N D Price, L Hood
A grand challenge impeding optimal treatment outcomes for patients with cancer arises from the complex nature of the disease: the cellular heterogeneity, the myriad of dysfunctional molecular and genetic networks as results of genetic (somatic) and environmental perturbations. Systems biology, with its holistic approach to understanding fundamental principles in biology, and the empowering technologies in genomics, proteomics, single-cell analysis, microfluidics and computational strategies, enables a comprehensive approach to medicine, which strives to unveil the pathogenic mechanisms of diseases, identify disease biomarkers and begin thinking about new strategies for drug target discovery...
February 2012: Journal of Internal Medicine
https://www.readbyqxmd.com/read/21364692/predictive-personalized-preventive-participatory-p4-cancer-medicine
#19
Leroy Hood, Stephen H Friend
Medicine will move from a reactive to a proactive discipline over the next decade--a discipline that is predictive, personalized, preventive and participatory (P4). P4 medicine will be fueled by systems approaches to disease, emerging technologies and analytical tools. There will be two major challenges to achieving P4 medicine--technical and societal barriers--and the societal barriers will prove the most challenging. How do we bring patients, physicians and members of the health-care community into alignment with the enormous opportunities of P4 medicine? In part, this will be done by the creation of new types of strategic partnerships--between patients, large clinical centers, consortia of clinical centers and patient-advocate groups...
March 2011: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/26543649/psychosocial-predictors-for-cancer-prevention-behaviors-in-workplace-using-protection-motivation-theory
#20
Mohammad Javad Zare Sakhvidi, Maryam Zare, Mehrdad Mostaghaci, Amir Houshang Mehrparvar, Mohammad Ali Morowatisharifabad, Elham Naghshineh
Backgrounds. The aim of this study was to describe the preventive behaviors of industrial workers and factors influencing occupational cancer prevention behaviors using protection motivation theory. Methods. A self-administered questionnaire was completed by 161 petrochemical workers in Iran in 2014 which consisted of three sections: background information, protection motivation theory measures, and occupational cancers preventive behaviors. Results. A statistically significant positive correlation was found between PM and self-efficacy, response efficacy, and the cancer preventive behaviors...
2015: Advances in Preventive Medicine
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