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BPT Study 2017

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8 papers 0 to 25 followers Western Health BPT
https://www.readbyqxmd.com/read/26559572/effect-of-pci-on-long-term-survival-in-patients-with-stable-ischemic-heart-disease
#1
RANDOMIZED CONTROLLED TRIAL
Steven P Sedlis, Pamela M Hartigan, Koon K Teo, David J Maron, John A Spertus, G B John Mancini, William Kostuk, Bernard R Chaitman, Daniel Berman, Jeffrey D Lorin, Marcin Dada, William S Weintraub, William E Boden
BACKGROUND: Percutaneous coronary intervention (PCI) relieves angina in patients with stable ischemic heart disease, but clinical trials have not shown that it improves survival. Between June 1999 and January 2004, we randomly assigned 2287 patients with stable ischemic heart disease to an initial management strategy of optimal medical therapy alone (medical-therapy group) or optimal medical therapy plus PCI (PCI group) and did not find a significant difference in the rate of survival during a median follow-up of 4...
November 12, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/26572669/contrast-induced-nephropathy
#2
REVIEW
Julian L Wichmann, Richard W Katzberg, Sheldon E Litwin, Peter L Zwerner, Carlo N De Cecco, Thomas J Vogl, Philip Costello, U Joseph Schoepf
No abstract text is available yet for this article.
November 17, 2015: Circulation
https://www.readbyqxmd.com/read/25286173/%C3%AE-lactam-monotherapy-vs-%C3%AE-lactam-macrolide-combination-treatment-in-moderately-severe-community-acquired-pneumonia-a-randomized-noninferiority-trial
#3
RANDOMIZED CONTROLLED TRIAL
Nicolas Garin, Daniel Genné, Sebastian Carballo, Christian Chuard, Gerhardt Eich, Olivier Hugli, Olivier Lamy, Mathieu Nendaz, Pierre-Auguste Petignat, Thomas Perneger, Olivier Rutschmann, Laurent Seravalli, Stephan Harbarth, Arnaud Perrier
IMPORTANCE: The clinical benefit of adding a macrolide to a β-lactam for empirical treatment of moderately severe community-acquired pneumonia remains controversial. OBJECTIVE: To test noninferiority of a β-lactam alone compared with a β-lactam and macrolide combination in moderately severe community-acquired pneumonia. DESIGN, SETTING, AND PARTICIPANTS: Open-label, multicenter, noninferiority, randomized trial conducted from January 13, 2009, through January 31, 2013, in 580 immunocompetent adult patients hospitalized in 6 acute care hospitals in Switzerland for moderately severe community-acquired pneumonia...
December 2014: JAMA Internal Medicine
https://www.readbyqxmd.com/read/25199059/mepolizumab-treatment-in-patients-with-severe-eosinophilic-asthma
#4
RANDOMIZED CONTROLLED TRIAL
Hector G Ortega, Mark C Liu, Ian D Pavord, Guy G Brusselle, J Mark FitzGerald, Alfredo Chetta, Marc Humbert, Lynn E Katz, Oliver N Keene, Steven W Yancey, Pascal Chanez
BACKGROUND: Some patients with severe asthma have frequent exacerbations associated with persistent eosinophilic inflammation despite continuous treatment with high-dose inhaled glucocorticoids with or without oral glucocorticoids. METHODS: In this randomized, double-blind, double-dummy study, we assigned 576 patients with recurrent asthma exacerbations and evidence of eosinophilic inflammation despite high doses of inhaled glucocorticoids to one of three study groups...
September 25, 2014: New England Journal of Medicine
https://www.readbyqxmd.com/read/25196117/withdrawal-of-inhaled-glucocorticoids-and-exacerbations-of-copd
#5
RANDOMIZED CONTROLLED TRIAL
Helgo Magnussen, Bernd Disse, Roberto Rodriguez-Roisin, Anne Kirsten, Henrik Watz, Kay Tetzlaff, Lesley Towse, Helen Finnigan, Ronald Dahl, Marc Decramer, Pascal Chanez, Emiel F M Wouters, Peter M A Calverley
BACKGROUND: Treatment with inhaled glucocorticoids in combination with long-acting bronchodilators is recommended in patients with frequent exacerbations of severe chronic obstructive pulmonary disease (COPD). However, the benefit of inhaled glucocorticoids in addition to two long-acting bronchodilators has not been fully explored. METHODS: In this 12-month, double-blind, parallel-group study, 2485 patients with a history of exacerbation of COPD received triple therapy consisting of tiotropium (at a dose of 18 μg once daily), salmeterol (50 μg twice daily), and the inhaled glucocorticoid fluticasone propionate (500 μg twice daily) during a 6-week run-in period...
October 2, 2014: New England Journal of Medicine
https://www.readbyqxmd.com/read/25608756/adjunct-prednisone-therapy-for-patients-with-community-acquired-pneumonia-a-multicentre-double-blind-randomised-placebo-controlled-trial
#6
RANDOMIZED CONTROLLED TRIAL
Claudine Angela Blum, Nicole Nigro, Matthias Briel, Philipp Schuetz, Elke Ullmer, Isabelle Suter-Widmer, Bettina Winzeler, Roland Bingisser, Hanno Elsaesser, Daniel Drozdov, Birsen Arici, Sandrine Andrea Urwyler, Julie Refardt, Philip Tarr, Sebastian Wirz, Robert Thomann, Christine Baumgartner, Hervé Duplain, Dieter Burki, Werner Zimmerli, Nicolas Rodondi, Beat Mueller, Mirjam Christ-Crain
BACKGROUND: Clinical trials yielded conflicting data about the benefit of adding systemic corticosteroids for treatment of community-acquired pneumonia. We assessed whether short-term corticosteroid treatment reduces time to clinical stability in patients admitted to hospital for community-acquired pneumonia. METHODS: In this double-blind, multicentre, randomised, placebo-controlled trial, we recruited patients aged 18 years or older with community-acquired pneumonia from seven tertiary care hospitals in Switzerland within 24 h of presentation...
April 18, 2015: Lancet
https://www.readbyqxmd.com/read/26095867/perioperative-bridging-anticoagulation-in-patients-with-atrial-fibrillation
#7
RANDOMIZED CONTROLLED TRIAL
James D Douketis, Alex C Spyropoulos, Scott Kaatz, Richard C Becker, Joseph A Caprini, Andrew S Dunn, David A Garcia, Alan Jacobson, Amir K Jaffer, David F Kong, Sam Schulman, Alexander G G Turpie, Vic Hasselblad, Thomas L Ortel
BACKGROUND: It is uncertain whether bridging anticoagulation is necessary for patients with atrial fibrillation who need an interruption in warfarin treatment for an elective operation or other elective invasive procedure. We hypothesized that forgoing bridging anticoagulation would be noninferior to bridging with low-molecular-weight heparin for the prevention of perioperative arterial thromboembolism and would be superior to bridging with respect to major bleeding. METHODS: We performed a randomized, double-blind, placebo-controlled trial in which, after perioperative interruption of warfarin therapy, patients were randomly assigned to receive bridging anticoagulation therapy with low-molecular-weight heparin (100 IU of dalteparin per kilogram of body weight) or matching placebo administered subcutaneously twice daily, from 3 days before the procedure until 24 hours before the procedure and then for 5 to 10 days after the procedure...
August 27, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/26002889/air-versus-oxygen-in-st-segment-elevation-myocardial-infarction
#8
RANDOMIZED CONTROLLED TRIAL
Dion Stub, Karen Smith, Stephen Bernard, Ziad Nehme, Michael Stephenson, Janet E Bray, Peter Cameron, Bill Barger, Andris H Ellims, Andrew J Taylor, Ian T Meredith, David M Kaye
BACKGROUND: Oxygen is commonly administered to patients with ST-elevation-myocardial infarction despite previous studies suggesting a possible increase in myocardial injury as a result of coronary vasoconstriction and heightened oxidative stress. METHODS AND RESULTS: We conducted a multicenter, prospective, randomized, controlled trial comparing oxygen (8 L/min) with no supplemental oxygen in patients with ST-elevation-myocardial infarction diagnosed on paramedic 12-lead ECG...
June 16, 2015: Circulation
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