John T Kanegaye, Jefferson M Jones, Jane C Burns, Sonia Jain, Xiaoying Sun, Susan Jimenez-Fernandez, Erika Berry, Joan M Pancheri, Preeti Jaggi, Octavio Ramilo, Adriana H Tremoulet
BACKGROUND: Important therapeutic decisions are made based on the presence or absence of fever in patients with Kawasaki disease (KD), yet no standard method or threshold exists for temperature measurement during the diagnosis and treatment of these patients. We sought to compare surface and internal (rectal or oral) routes of temperature measurement for the detection of fever as a marker of treatment resistance. METHODS: From a randomized, placebo-controlled trial of infliximab as an adjunct to primary intravenous immunoglobulin treatment for acute KD, we collected concurrent (within 5 minutes) axillary and internal temperature measurements and performed receiver-operating characteristic and Bland-Altman analyses...
January 2016: Pediatric Infectious Disease Journal