Katrin J Svensson, Jonathan Z Long, Mark P Jedrychowski, Paul Cohen, James C Lo, Sara Serag, Serkan Kir, Kosaku Shinoda, Julia A Tartaglia, Rajesh R Rao, Alain Chédotal, Shingo Kajimura, Steven P Gygi, Bruce M Spiegelman
Activation of brown and beige fat can reduce obesity and improve glucose homeostasis through nonshivering thermogenesis. Whether brown or beige fat also secretes paracrine or endocrine factors to promote and amplify adaptive thermogenesis is not fully explored. Here we identify Slit2, a 180 kDa member of the Slit extracellular protein family, as a PRDM16-regulated secreted factor from beige fat cells. In isolated cells and in mice, full-length Slit2 is cleaved to generate several smaller fragments, and we identify an active thermogenic moiety as the C-terminal fragment...
March 8, 2016: Cell Metabolism