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JOURNAL ARTICLE
Peter R Baker, Priyaanka Nanduri, Peter A Gottlieb, Liping Yu, Georgeanna J Klingensmith, George S Eisenbarth, Jennifer M Barker
CONTEXT: Autoantibodies to 21-hydroxylase (21OH-AA) precede onset of autoimmune Addison's disease (AD). Progression to AD can take months to years, and early detection of metabolic decompensation may prevent morbidity and mortality. OBJECTIVE: To define optimal methods of predicting progression to overt AD (defined by subnormal peak cortisol response to Cosyntropin) in 21OH-AA+ individuals. DESIGN, SETTING AND PARTICIPANTS: Individuals were screened for 21OH-AA at the Barbara Davis Center from 1993 to 2011...
May 2012: Clinical Endocrinology
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