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By Fatih Kelesoglu ...
Amita Aggarwal, Puja Srivastava
About 20% of systemic lupus erythematosus (SLE) starts in childhood and children have less gender bias in favor of females as compared to adults. Systemic manifestations, nephritis, neuro-psychiatric disease and cytopenias are more common in children at presentation than adults. Since most children develop lupus in their early adolescence, dealing with the diagnosis of an unpredictable lifelong disease during this phase of life is challenging. Physicians must recognise specific medical and social needs of this age group, for optimal long-term outcome...
February 2015: International Journal of Rheumatic Diseases
Anne E Richardson, Kishore Warrier, H Vyas
Pleuropulmonary manifestations of rheumatological diseases are rare in children but pose a significant risk to overall morbidity and mortality. We have reviewed the literature to provide an overview of the respiratory complications of the commonest rheumatological diseases to occur in children (juvenile systemic lupus erythematosus, scleroderma, juvenile dermatomyositis, mixed connective tissue disease, granulomatosis with polyangitis and juvenile idiopathic arthritis). Pulmonary function testing in these patients can be used to refine the differential diagnosis and establish disease severity, but also has a role in ongoing monitoring for respiratory complications...
August 2016: Archives of Disease in Childhood
Qiong Wu, Hema Chaplin, Nicola Ambrose, Debajit Sen, Maria J Leandro, Charlotte Wing, Nicola Daly, Kate Webb, Corinne Fisher, Linda Suffield, Francesca Josephs, Clarissa Pilkington, Despina Eleftheriou, Muthana Al-Obaidi, Sandrine Compeyrot-Lacassagne, Lucy R Wedderburn, Yiannis Ioannou
No abstract text is available yet for this article.
March 2016: Annals of the Rheumatic Diseases
Lianne Kearsley-Fleet, Rebecca Davies, Mark Lunt, Taunton R Southwood, Kimme L Hyrich
OBJECTIVES: The objectives of this study were to investigate change in disease activity, and explore factors associated with response, in children with JIA over the initial year of etanercept treatment. METHODS: This analysis included children with JIA starting etanercept in the British Society for Paediatric and Adolescent Rheumatology Etanercept Cohort Study. Response was assessed using change in juvenile arthritis disease activity score-71 (JADAS-71), an excellent response (ACR Pedi 90), and achieving minimal disease activity (MDA) at 1 year...
May 2016: Rheumatology
(no author information available yet)
No abstract text is available yet for this article.
December 9, 2015: Nursing Standard
V Boom, J Anton, P Lahdenne, P Quartier, A Ravelli, N M Wulffraat, S J Vastert
BACKGROUND: Macrophage activation syndrome (MAS) is a severe and potentially lethal complication of several inflammatory diseases but seems particularly linked to systemic juvenile idiopathic arthritis (sJIA). Standardized diagnostic and treatment guidelines for MAS in sJIA are currently lacking. The aim of this systematic literature review was to evaluate currently available literature on diagnostic criteria for MAS in sJIA and provide an overview of possible biomarkers for diagnosis, disease activity and treatment response and recent advances in treatment...
December 3, 2015: Pediatric Rheumatology Online Journal
A Şahin, A Yetişgin, M Şahin, Y Durmaz, A K Cengiz
Background: In humans, it has been suggested that low-level mean platelet volume (MPV) may be related to secondary thrombosis due to inflammation. For this reason, MPV can be used as a marker showing inflammation in the body. Objectives: To evaluate the association of MPV with erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Disease Activity Score-28 (DAS-28), and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) in patients with rheumatic diseases...
May 6, 2015: West Indian Medical Journal
Camila Pugliese, Roberta T A van der Vinne, Lucia M A Campos, Priscila R Guardieiro, Cynthia Saviolli, Eloisa Bonfá, Rosa M R Pereira, Vilma S Viana, Eduardo F Borba, Clovis A Silva
The impact of juvenile idiopathic arthritis (JIA) in periodontal diseases is controversial probably due to gender and age heterogeneity. We therefore evaluated a homogeneous female post-pubertal JIA population for these conditions. Thirty-five JIA patients and 35 gender/age comparable healthy controls were evaluated according to demographic data, complete periodontal evaluation, fasting lipoproteins, and anti-lipoprotein lipase antibodies. JIA scores, laboratorial tests, X-rays, and treatment were also assessed...
January 2016: Clinical Rheumatology
Sanaz Javadi, J Herman Kan, Robert C Orth, Marietta DeGuzman
OBJECTIVE: The purpose of this study was to characterize the extent of joint and tendon involvement in patients with juvenile idiopathic arthritis referred for MRI of the wrist or ankle. MATERIALS AND METHODS: Forty-five patients (32 female and 13 male patients; mean age, 10 years; age range, 1-19 years) with an established diagnosis of juvenile idiopathic arthritis were referred for MRI of the wrist or ankle between January 2000 and August 2012 (39 wrists and 33 ankles)...
February 2014: AJR. American Journal of Roentgenology
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