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Michael R King, Karim S Ladha, Amanda M Gelineau, T Anthony Anderson
BACKGROUND: N-methyl-D-aspartate receptor antagonists have been shown to reduce perioperative pain and opioid use. The authors performed a meta-analysis to determine whether the use of perioperative dextromethorphan lowers opioid consumption or pain scores. METHODS: PubMed, Web of Science, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Pubget, and EMBASE were searched. Studies were included if they were randomized, double-blinded, placebo-controlled trials written in English, and performed on patients 12 yr or older...
March 2016: Anesthesiology
Faraj W Abdallah, Tim Dwyer, Vincent W S Chan, Ahtsham U Niazi, Darrell J Ogilvie-Harris, Stephanie Oldfield, Rajesh Patel, Justin Oh, Richard Brull
BACKGROUND: Perineural and IV dexmedetomidine have each been suggested to prolong the duration of analgesia when administered in conjunction with peripheral nerve blocks. In the first randomized, triple-masked, placebo-controlled trial to date, the authors aimed to define and compare the efficacy of perineural and IV dexmedetomidine in prolonging the analgesic duration of single-injection interscalene brachial plexus block (ISB) for outpatient shoulder surgery. METHODS: Ninety-nine patients were randomized to receive ISB using 15 ml ropivacaine, 0...
March 2016: Anesthesiology
Eckhard Mauermann, Joerg Filitz, Patrick Dolder, Katharina M Rentsch, Oliver Bandschapp, Wilhelm Ruppen
BACKGROUND: Although opioids in general and remifentanil in particular have been shown to induce hyperalgesia, data regarding fentanyl are scarce. Thus, the authors investigated the effect of fentanyl dosing on pain perception and central sensitization in healthy volunteers using established pain models. METHODS: Twenty-one healthy, male volunteers were included in this randomized, double-blind, crossover study and received either intravenous low-dose (1 μg/kg) or high-dose (10 μg/kg) fentanyl...
February 2016: Anesthesiology
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