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AKI Hyponatremia

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26 papers 25 to 100 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/26239456/hyponatremia-associated-with-heart-failure-pathological-role-of-vasopressin-dependent-impaired-water-excretion
#1
REVIEW
San-E Ishikawa
An exaggerated increase in circulatory blood volume is linked to congestive heart failure. Despite this increase, reduction of the "effective circulatory blood volume" in congestive heart failure is associated with decreased cardiac output, and can weaken the sensitivity of baroreceptors. Thereafter, tonic inhibition of the baroreceptor-mediated afferent pathway of vagal nerves is removed, providing an increase in non-osmotic release of arginine vasopressin (AVP). In the renal collecting duct, the aquaporin-2 (AQP2) water channel is regulated by sustained elevation of AVP release, and this leads to augmented hydroosmotic action of AVP, that results in exaggerated water retention and dilutional hyponatremia...
2015: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/26205186/predialysis-hypernatremia-is-a-prognostic-marker-in-acute-kidney-injury-in-need-of-renal-replacement-therapy
#2
Renata S Mendes, Márcio Soares, Carla Valente, José Hermógenes Suassuna, Eduardo Rocha, Elizabeth R Maccariello
BACKGROUND AND OBJECTIVES: The present study aimed to evaluate the prognostic impact of predialysis dysnatremia in patients with acute kidney injury requiring renal replacement therapy (RRT). DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: A secondary analysis of a prospective multicenter cohort study was performed. Serum sodium (Na) concentrations were categorized immediately before the first RRT as normonatremia (135≤Na ≤145mEq/L), hyponatremia (mild [130≤Na ≤134mEq/L] or severe [Na ≤129mEq/L]), and hypernatremia (mild [146≤Na ≤155mEq/L] or severe [Na ≥156mEq/L])...
October 2015: Journal of Critical Care
https://www.readbyqxmd.com/read/24792353/treatment-of-severe-hyponatremia-in-patients-with-kidney-failure-role-of-continuous-venovenous-hemofiltration-with-low-sodium-replacement-fluid
#3
Lenar Yessayan, Jerry Yee, Stan Frinak, Balazs Szamosfalvi
Patients with hypervolemic hyponatremia and kidney failure pose a special therapeutic challenge. Hemodialysis to correct volume overload, azotemia, and abnormal electrolyte levels will result in rapid correction of serum sodium concentration and place the patient at risk for osmotic demyelination syndrome. We present a patient with acute kidney injury and severe hypervolemic hypotonic hyponatremia (serum sodium<100 mEq/L) who was treated successfully with continuous venovenous hemofiltration. This teaching case illustrates the limitations of hemodialysis and demonstrates how to regulate the sodium correction rate by single-pool sodium kinetic modeling during continuous venovenous hemofiltration...
August 2014: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29750929/hyponatremia-predicts-poor-outcomes-in-patients-with-chronic-kidney-disease-undergoing-heart-surgery
#4
Linda Shavit, Ofer Merin, Tal Grenader, Ehud Jacobson, Chani Waldenberg, Daniel Bitran, Daniel Fink, Shuli Silberman
BACKGROUND: Preoperative hyponatremia adversely impacts outcomes of cardiothoracic surgery. However, in patients with chronic kidney disease, the association of sodium levels on postoperative events has never been evaluated. We investigated the impact of preoperative hyponatremia on outcomes after cardiac surgery in patients with non-dialysis-dependent chronic kidney disease. Primary endpoints were operative mortality and acute kidney injury requiring dialysis. Secondary endpoints were major infection and long-term survival...
May 8, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29684381/serum-chloride-as-a-novel-marker-for-adding-prognostic-information-of-mortality-in-chronic-heart-failure
#5
Yang Zhang, Rui Peng, Xinqiang Li, Jinxing Yu, Xi Chen, Zhou Zhou
BACKGROUND: Serum chloride concentrations have clinical significance in the prognosis of heart failure (HF). Little is known regarding the prognostic value of serum chloride in patients with chronic heart failure (CHF). This study sought to investigate the prognostic ability of admission serum chloride for long-term mortality in CHF patients. METHODS: We identified 1021 consecutive patients diagnosed with CHF. Participants were followed up for all-cause mortality at 21 ± 9 months to establish the survival models and analyze the association between admission serum chloride concentrations and death risk...
August 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29566068/low-serum-sodium-levels-at-hospital-admission-outcomes-among-2-3-million-hospitalized-patients
#6
Saleem Al Mawed, V Shane Pankratz, Kelly Chong, Matthew Sandoval, Maria-Eleni Roumelioti, Mark Unruh
BACKGROUND: Hyponatremia is the most common electrolyte disorder among hospitalized patients. Controversies still exist over the relationship between hyponatremia and outcomes of hospitalized patients. METHODS: To analyze the association of low serum sodium levels at hospital admission with in-hospital mortality and patient disposition and to compare the distribution of the risk of death associated with hyponatremia across the lifespan of hospitalized patients, we conducted an observational study of 2...
2018: PloS One
https://www.readbyqxmd.com/read/29407090/long-term-prognostic-significance-of-urinary-sodium-concentration-in-patients-with-acute-heart-failure
#7
Satoshi Honda, Toshiyuki Nagai, Kunihiro Nishimura, Michikazu Nakai, Yasuyuki Honda, Hiroki Nakano, Naotsugu Iwakami, Yasuo Sugano, Yasuhide Asaumi, Takeshi Aiba, Teruo Noguchi, Kengo Kusano, Hiroyuki Yokoyama, Hisao Ogawa, Satoshi Yasuda, Toshihisa Anzai
BACKGROUND: Lower urinary sodium concentration (UNa) may reflect impaired renal perfusion, higher neurohormonal activity and diuretic resistance. However, the prognostic impact of UNa in patients with acute heart failure (AHF) has not been fully elucidated. METHODS: We investigate the association between UNa and clinical outcomes in 669 patients admitted with AHF in our prospective registry. Patients were stratified into tertiles based on UNa in a spot urine sample on admission...
March 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29369003/clinical-characteristics-and-prognosis-in-patients-with-a-first-acute-heart-failure-hospitalization-according-to-admission-hyponatremia
#8
Francesc Formiga, David Chivite, Ariadna Brasé, Irene Petit, Rafael Moreno-Gonzalez, Jose Carlos Arévalo-Lorido, Xavier Corbella
Objective Admission hyponatremia is related to poor outcomes in patients with heart failure (HF). Few studies have examined the influence of hyponatremia in the prognosis of HF patients without previous admissions. Our aim is to determine whether baseline hyponatremia predicts worse outcomes in a cohort of real-world HF patients admitted because of a first episode of acute HF. Methods We reviewed the medical records of 985 patients >50 years of age admitted within a two-year period for a first episode of decompensation of HF...
January 25, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29108375/association-between-postoperative-hyponatremia-and-renal-prognosis-in-major-urologic-surgery
#9
Sehoon Park, Jung Nam An, Jung Pyo Lee, Yun Kyu Oh, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Chun Soo Lim
Recent evidence for the clinical significance of postoperative hyponatremia after urologic surgeries remains scarce. We examined the incidence, risk factors, and outcomes of electrolyte imbalance in urologic surgery. Patients with newly developed hyponatremia, defined as a sodium level lower than 135 mEq/L within 7 days after surgery, were included in our study group. The primary outcome was progression to end-stage renal disease (ESRD). Secondary outcome was composition of progression to ESRD and creatinine doubling/eGFR halving from baseline...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28953555/acute-kidney-injury-and-electrolyte-disorders-in-the-critically-ill-patient-with-cancer
#10
Mitchell H Rosner, Giovambattista Capasso, Mark A Perazella
PURPOSE OF REVIEW: Patients with cancer increasingly make up a significant proportion of patients receiving care in the intensive care unit (ICU). Acute kidney injury and cancer-associated electrolyte disorders are encountered in many of these patients and can significantly impact both short-term and long-term outcomes. RECENT FINDINGS: Advances in chemotherapeutic regimens as well as in our understanding of cancer-associated kidney disease highlight the need for specialized knowledge of the unique causes and therapies required in this subset of critically ill patients...
December 2017: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/28770412/essential-elements-as-biomarkers-of-acute-kidney-injury-and-spontaneous-reversion
#11
Regiane Marinho da Silva, Gui Mi Ko, Rinaldo Florêncio Silva, Ludmila Cabreira Vieira, Rafael Vicente de Paula, Júlio Takehiro Marumo, Amanda Ikegami, Maria Helena Bellini
Acute kidney injury (AKI) is an important health problem and can be caused by number of factors. The use of aminoglycosides, such as gentamicin, is one of these factors. Recently, an effort has been made to find biomarkers to guide treatment protocols. Inductively coupled plasma optical emission spectroscopy (ICP-OES) was used to estimate the contents of Ca, Cu, Fe, K, Mg, Mn, Na, P, and Zn in serum and urine of the healthy, AKI, and spontaneous recovery (SR) groups of animals. The animal model of AKI and SR was validated by measuring serum and urinary urea and creatinine...
April 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/28697495/electrolyte-and-acid-base-abnormalities-in-infants-with-community-acquired-acute-pyelonephritis-prospective-cross-sectional-study
#12
Gregorio P Milani, Angela Grava, Mario G Bianchetti, Sebastiano A G Lava, Laura Dell''Era, Thomas Teatini, Emilio F Fossali
BACKGROUND: Retrospective case series suggest that abnormalities in fluid, electrolyte, and acid-base homeostasis may occur among infants with a febrile urinary tract infection. Potentially inaccurate laboratory methods of sodium testing have often been used. METHODS: Between January 2009 and June 2016, we managed 80 previously healthy infants (52 males and 28 females) ≥4 weeks to ≤24 months of age with their first episode of acute pyelonephritis. Ionized sodium, ionized potassium and ionized chloride were determined by direct potentiometry, as recommended by the International Federation of Clinical Chemistry...
2017: Nephron
https://www.readbyqxmd.com/read/28678861/ecstasy-induces-reactive-oxygen-species-kidney-water-absorption-and-rhabdomyolysis-in-normal-rats-effect-of-n-acetylcysteine-and-allopurinol-in-oxidative-stress-and-muscle-fiber-damage
#13
Ana C de Bragança, Regina L M Moreau, Thales de Brito, Maria H M Shimizu, Daniele Canale, Denise A de Jesus, Ana M G Silva, Pedro H Gois, Antonio C Seguro, Antonio J Magaldi
BACKGROUND: Ecstasy (Ec) use produces hyperthermia, excessive sweating, intense thirst, an inappropriate antidiuretic hormone secretion (SIADH) and a multisystemic toxicity due to oxidative stress (OS). Intense thirst induces high intake of pure water, which associated with SIADH, usually develops into acute hyponatremia (Hn). As Hn is induced rapidly, experiments to check if Ec acted directly on the Inner Medullary Collecting Ducts (IMCD) of rats were conducted. Rhabdomyolysis and OS were also studied because Ec is known to induce Reactive Oxygen Species (ROS) and tissue damage...
2017: PloS One
https://www.readbyqxmd.com/read/28673579/the-chloride-theory-a-unifying-hypothesis-for-renal-handling-and-body-fluid-distribution-in-heart-failure-pathophysiology
#14
Hajime Kataoka
Body fluid volume regulation is a complex process involving the interaction of various afferent (sensory) and neurohumoral efferent (effector) mechanisms. Historically, most studies focused on the body fluid dynamics in heart failure (HF) status through control of the balance of sodium, potassium, and water in the body, and maintaining arterial circulatory integrity is central to a unifying hypothesis of body fluid regulation in HF pathophysiology. The pathophysiologic background of the biochemical determinants of vascular volume in HF status, however, has not been known...
July 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28528344/dysnatremia-is-an-independent-indicator-of-mortality-in-hospitalized-patients
#15
Jiachang Hu, Yimei Wang, Xuemei Geng, Rongyi Chen, Pan Zhang, Jing Lin, Jie Teng, Xiaoyan Zhang, Xiaoqiang Ding
BACKGROUND Dysnatremia is a risk factor for poor outcomes. We aimed to describe the prevalence and outcomes of various dysnatremia in hospitalized patients. High-risk patients must be identified to improve the prognosis of dysnatremia. MATERIAL AND METHODS This prospective study included all adult patients admitted consecutively to a university hospital between October 1, 2014 and September 30, 2015. RESULTS All 90 889 patients were included in this study. According to the serum sodium levels during hospitalization, the incidence of hyponatremia and hypernatremia was 16...
May 21, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28497085/evaluation-of-water-and-electrolytes-disorders-in-severe-acute-diarrhea-patients-treated-by-who-protocol-in-eight-large-hospitals-in-tehran-a-nephrology-viewpoint
#16
Alireza Soleimani, Fatemeh Foroozanfard, Mohammad Reza Tamadon
Introduction: The most common cause of death from diarrhea is the shock caused by dehydration, electrolytes and acid-base disorders. Objectives: The aim of this study was to evaluate water and electrolytes disorders in diarrhea patients after treating severe acute diarrhea. Patients and Methods: In this study we used a historical cohort and studied patients who were hospitalized due to acute diarrhea and were similarly treated for dehydration and water and electrolyte disorders as recommended by the World Health Organization (WHO) guideline...
2017: Journal of Renal Injury Prevention
https://www.readbyqxmd.com/read/28352026/hyponatremia-secondary-to-acute-urinary-retention
#17
Jignesh Parikh, Shashank Dhareshwar, Shobhana Nayak-Rao, Indira Ramaiah
Acute urinary retention is a rare cause of hyponatremia. Symptomatic acute hyponatremia is of grave medical concern and needs to be managed aggressively. In our two cases with acute urinary retention, a simple bladder catheterization and drainage of urine followed by conservative management resulted in complete resolution of symptoms and normalization of sodium levels. Association of bladder distension and hyponatremia is considered to be due to release of vasopressin triggered by bladder distension itself or by pain due to bladder distension...
March 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28303369/clinical-aspects-of-changes-in-water-and-sodium-homeostasis-in-the-elderly
#18
REVIEW
Christian A Koch, Tibor Fulop
The population of elderly individuals is increasing worldwide. With aging, various hormonal and kidney changes occur, both affecting water homeostasis. Aging is a risk factor for chronic kidney disease (CKD) and many features of CKD are reproduced in the aging kidney. Dehydration and hyperosmolarity can be triggered by diminished thirst perception in this population. Elderly with dementia are especially susceptible to abnormalities of their electrolyte and body water homeostasis and should be (re-)assessed for polypharmacy...
March 2017: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/28215427/method-of-hypertonic-saline-administration-effects-on-osmolality-in-traumatic-brain-injury-patients
#19
Kelly L Maguigan, Bradley M Dennis, Susan E Hamblin, Oscar D Guillamondegui
Hypertonic saline (HTS) is an effective therapy for reducing intracranial pressure (ICP). The ideal method of administration is unknown. The purpose of this study was to evaluate the method of HTS infusion and time to goal osmolality. A retrospective cohort analysis was conducted in severe TBI patients with ICP monitoring in place who received 2 doses of HTS. Patients were divided into bolus versus continuous infusion HTS cohorts. The primary outcome was median time to goal osmolality. Secondary outcomes included percentage of patients reaching goal osmolality, percent time at goal osmolality, mean cerebral perfusion pressure (CPP) and ICP, ICU length of stay, and mortality...
May 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28248872/could-dysnatremias-play-a-role-as-independent-factors-to-predict-mortality-in-surgical-critically-ill-patients
#20
Edson A Nicolini, Roosevelt S Nunes, Gabriela V Santos, Silvana Lia da Silva, Mariana M Carreira, Fernanda G Pellison, Mayra G Menegueti, Maria Auxiliadora-Martins, Fernando Bellissimo-Rodrigues, Marcus A Feres, Anibal Basile-Filho
Several studies have demonstrated the impact of dysnatremias on mortality of intensive care unit (ICU) patients. The objective of this study was to assess whether dysnatremia is an independent factor to predict mortality in surgical critically ill patients admitted to ICU in postoperative phase.One thousand five hundred and ninety-nine surgical patients (58.8% males; mean age of 60.6 ± 14.4 years) admitted to the ICU in the postoperative period were retrospectively studied. The patients were classified according to their serum sodium levels (mmol/L) at admission as normonatremia (135-145), hyponatremia (<135), and hypernatremia (>145)...
March 2017: Medicine (Baltimore)
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