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RIPC

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48 papers 0 to 25 followers Remote ischemic preconditioning
https://www.readbyqxmd.com/read/27908357/effect-of-remote-ischemic%C3%A2-preconditioning-on-coronary-procedure-related-impairment-of-vascular-dilator-function
#1
LETTER
Gaetano Antonio Lanza, Melania Cesarano, Antonio De Vita, Angelo Villano, Maria Milo, Giulio Russo, Filippo Crea
No abstract text is available yet for this article.
December 6, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27796666/effects-of-remote-ischemic-preconditioning-on-acute-myocardial-injury-in-patients-undergoing-valve-replacement
#2
Z Cao, R Shen, X Zhang, G Cheng, Z Yan
BACKGROUND: This study investigated the effects of remote ischemic preconditioning (RIPC) on acute myocardial injury and clinical outcome in adult patients undergoing valve replacement surgery. METHODS: Sixty-three adult patients scheduled for elective valve replacement undergoing cardiopulmonary bypass (CPB) were randomly assigned to control or remote ischemic preconditioning treatment. RIPC was applied beginning with the first surgical incision by three times of inflating the cuff to 200 mmHg for 5 min, followed by 5 min of deflation...
October 31, 2016: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/27814282/nephroprotective-effects-of-remote-ischemic-preconditioning-in-coronary-angiography
#3
Naufal Zagidullin, Alina Dunayeva, Alexander Gilmanov, Shamil Zagidullin, Valentin Pavlov
BACKGROUND: Contrast-induced nephropathy (CIN) is a formidable side effect of iodinated contrast medium use in subjects undergoing coronary angiogram (CAG). Remote ischemic preconditioning (RIPC) may reduce the risk of CIN. AIM: The aim of the study was to investigate the nephroprotective effects of RIPC in coronary heart disease (CHD) in patients, undergoing CAG, with mild to moderate lowered estimated glomerular filtration rate (eGFR). MATERIALS: In the randomized, blinded, sham RIPC (sRIPC) controlled study 51 patients with CHD and GFR less than 80 mL/min/m2, undergoing CAG, were investigated...
November 4, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27813282/renal-protection-using-remote-ischemic-peri-conditioning-during-inter-facility-helicopter-transport-of-patients-with-st-segment-elevation-myocardial-infarction-a-retrospective-study
#4
Oladipupo Olafiranye, Adetola Ladejobi, Max Wayne, Christian Martin-Gill, Andrew D Althouse, Michael S Sharbaugh, Francis X Guyette, Steven E Reis, John A Kellum, Catalin Toma
OBJECTIVE: To assess the impact of remote ischemic peri-conditioning (RIPC) during inter-facility air medical transport of ST-segment elevation myocardial infarction (STEMI) patients on the incidence of acute kidney injury (AKI) following primary percutaneous coronary intervention (pPCI). BACKGROUND: STEMI patients who receive pPCI have an increased risk of AKI for which there is no well-defined prophylactic therapy in the setting of emergent pPCI. METHODS: Using the ACTION Registry-GWTG, we evaluated the impact of RIPC applied during inter-facility helicopter transport of STEMI patients from non-PCI capable hospitals to 2 PCI-hospitals in the United States between March, 2013 and September, 2015 on the incidence of AKI following pPCI...
December 2016: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/24565591/remote-ischemic-preconditioning-and-endothelial-function-in-patients-with-acute-myocardial-infarction-and-primary-pci
#5
RANDOMIZED CONTROLLED TRIAL
Vladimir Manchurov, Nadezda Ryazankina, Tatyana Khmara, Dmitry Skrypnik, Roman Reztsov, Elena Vasilieva, Alexander Shpektor
BACKGROUND: Remote ischemic preconditioning by transient limb ischemia reduces myocardial ischemia-reperfusion injury in patients undergoing percutaneous coronary intervention. The aim of the study we report here was to assess the effect of remote ischemic preconditioning on endothelial function in patients with acute myocardial infarction who underwent primary percutaneous coronary intervention. METHODS: Forty-eight patients with acute myocardial infarction were enrolled...
July 2014: American Journal of Medicine
https://www.readbyqxmd.com/read/27823695/effect-of-remote-ischemic-conditioning-on-infarct-size-in-patients-with-anterior-st-elevation-myocardial-infarction
#6
Dinos Verouhis, Peder Sörensson, Andrey Gourine, Loghman Henareh, Jonas Persson, Nawzad Saleh, Magnus Settergren, Martin Sundqvist, Per Tornvall, Nils Witt, Felix Böhm, John Pernow
BACKGROUND: Previous studies indicate that remote ischemic conditioning performed before percutaneous coronary intervention (PCI) reduces infarct size in patients with ST-elevation myocardial infarction (STEMI). It remains unclear whether remote conditioning affords protection when performed in adjunct to primary PCI. We aimed to study whether remote ischemic per-postconditioning (RIperpostC) initiated after admission to the catheterization laboratory attenuates myocardial infarct size in patients with anterior STEMI...
November 2016: American Heart Journal
https://www.readbyqxmd.com/read/27539973/time-to-give-up-on-cardioprotection-a-critical-appraisal-of-clinical-studies-on-ischemic-pre-post-and-remote-conditioning
#7
REVIEW
Gerd Heusch, Tienush Rassaf
The mortality from acute myocardial infarction (AMI) remains significant, and the prevalence of post-myocardial infarction heart failure is increasing. Therefore, cardioprotection beyond timely reperfusion is needed. Conditioning procedures are the most powerful cardioprotective interventions in animal experiments. However, ischemic preconditioning cannot be used to reduce infarct size in patients with AMI because its occurrence is not predictable; several studies in patients undergoing surgical coronary revascularization report reduced release of creatine kinase and troponin...
August 19, 2016: Circulation Research
https://www.readbyqxmd.com/read/27559699/hypercholesterolemia-abrogates-remote-ischemic-preconditioning-induced-cardioprotection-role-of-reperfusion-injury-salvage-kinase-signals
#8
Lei-Lei Ma, Fei-Juan Kong, Jun-Jie Guo, Jian-Bing Zhu, Hong-Tao Shi, Yang Li, Ren-Hua Sun, Jun-Bo Ge
Remote ischemic preconditioning (RIPC) is one of the most powerful intrinsic cardioprotective strategies discovered so far and experimental data indicate that comorbidity may interfere with the protection by RIPC. Therefore, we investigate whether RIPC-induced cardioprotection was intact in hypercholesterolemic rat hearts exposed to ischemia reperfusion in vivo. Normal or hypercholesterolemic rat hearts were exposed to 30 min of ischemia and 2 h of reperfusion, with or without RIPC, PI3K inhibitor wortmannin, MEK-ERK1/2 inhibitor PD98059, GSK3β inhibitor SB216763...
August 24, 2016: Shock
https://www.readbyqxmd.com/read/27595164/review-of-remote-ischemic-preconditioning-from-laboratory-studies-to-clinical-trials
#9
Vesa Anttila, Henri Haapanen, Fredrik Yannopoulos, Johanna Herajärvi, Tuomas Anttila, Tatu Juvonen
In remote ischemic preconditioning (RIPC) short periods of non-lethal ischemia followed by reperfusion of tissue or organ prepare remote tissue or organ to resist a subsequent more severe ischemia-reperfusion injury. The signaling mechanism of RIPC can be humoral communication, neuronal stimulation, systemic modification of circulating immune cells, and activation of hypoxia inducible genes. Despite promising evidence from experimental studies, the clinical effects of RIPC have been controversial. Heterogeneity of inclusion and exclusion criteria and confounding factors such as comedication, anesthesia, comorbidities, and other risk factors may have influenced the efficacy of RIPC...
September 20, 2016: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/26385956/cardioprotection-by-combined-intrahospital-remote-ischaemic-perconditioning-and-postconditioning-in-st-elevation-myocardial-infarction-the-randomized-lipsia-conditioning-trial
#10
RANDOMIZED CONTROLLED TRIAL
Ingo Eitel, Thomas Stiermaier, Karl P Rommel, Georg Fuernau, Marcus Sandri, Norman Mangner, Axel Linke, Sandra Erbs, Phillip Lurz, Enno Boudriot, Meinhard Mende, Steffen Desch, Gerhard Schuler, Holger Thiele
AIMS: Remote ischaemic conditioning (RIC) and postconditioning (PostC) are both potent activators of innate protection against ischaemia-reperfusion injury and have demonstrated cardioprotection in experimental and clinical ST-elevation myocardial infarction (STEMI) trials. However, their combined effects have not been studied in detail. The aim of this study was to evaluate if the co-application of intrahospital RIC and PostC has a more powerful effect on myocardial salvage compared with either PostC alone or control...
November 21, 2015: European Heart Journal
https://www.readbyqxmd.com/read/27400294/remote-ischemic-preconditioning-in-patients-undergoing-cardiovascular-surgery-evidence-from-a-meta-analysis-of-randomized-controlled-trials
#11
Partha Sardar, Saurav Chatterjee, Amartya Kundu, Habib Samady, Theophilus Owan, Jay Giri, Ramez Nairooz, Craig H Selzman, Gerd Heusch, Bernard J Gersh, J Dawn Abbott, Debabrata Mukherjee, James C Fang
BACKGROUND: Remote ischemic preconditioning (RIPC) has been associated with reduced risk of myocardial injury in patients undergoing cardiovascular surgery, but uncertainty about clinical outcomes remains, particularly in the light of 2 recent large randomized clinical trials (RCTs) which were neutral. We performed a meta-analysis to evaluate the efficacy of RIPC on clinically relevant outcomes in patients undergoing cardiovascular surgery. METHODS: We searched PubMed, Cochrane CENTRAL, EMBASE, EBSCO, Web of Science and CINAHL databases from inception through November 30, 2015...
October 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27174955/the-coronary-circulation-as-a-target-of-cardioprotection
#12
REVIEW
Gerd Heusch
The atherosclerotic coronary vasculature is not only the culprit but also a victim of myocardial ischemia/reperfusion injury. Manifestations of such injury are increased vascular permeability and edema, endothelial dysfunction and impaired vasomotion, microembolization of atherothrombotic debris, stasis with intravascular cell aggregates, and finally, in its most severe form, capillary destruction with hemorrhage. In animal experiments, local and remote ischemic pre- and postconditioning not only reduce infarct size but also these manifestations of coronary vascular injury, as do drugs which recruit signal transduction steps of conditioning...
May 13, 2016: Circulation Research
https://www.readbyqxmd.com/read/27177446/remote-ischaemic-conditioning-and-remodelling-following-myocardial-infarction-current-evidence-and-future-perspectives
#13
A P Vanezis, G C Rodrigo, I B Squire, N J Samani
Remote ischaemic conditioning (rIC) has demonstrated its effectiveness as a powerful cardioprotective tool in number of preclinical and limited clinical settings. More recently, ischaemic postconditioning given after an ischaemic event such as a myocardial infarction (MI) has shown not only to reduce infarct size but also to have beneficial effects on acute remodelling post-MI and to reduce the burden of heart failure and other detrimental outcomes. Building on this platform, repeated rIC over a number of days has the potential to augment the protective process even further...
September 2016: Heart Failure Reviews
https://www.readbyqxmd.com/read/27157518/unraveling-the-role-of-adenosine-in-remote-ischemic-preconditioning-induced-cardioprotection
#14
REVIEW
Puneet Kaur Randhawa, Amteshwar Singh Jaggi
Remote ischemic preconditioning (RIPC) induced by alternate cycles of preconditioning ischemia and reperfusion protects the heart against sustained ischemia-reperfusion-induced injury. This technique has been translated to clinical levels in patients undergoing various surgical interventions including coronary artery bypass graft surgery, abdominal aortic aneurysm repair, percutaneous coronary intervention and heart valve surgery. Adenosine is a master regulator of energy metabolism and reduces myocardial ischemia-reperfusion-induced injury...
June 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/27161750/po-62-remote-ischemic-preconditioning-in-head-and-neck-cancer-reconstruction-a-randomized-controlled-trial
#15
A E Krag, B J Kiil, C L Hvas, G T Eschen, A M Hvas
INTRODUCTION: In reconstructive head and neck cancer surgery, tissue flaps are transferred to the surgical defect and revascularized by anastomosis of small vessels. Cancer patients are in a hypercoagulable state with high risk of peri- and postoperative thrombotic events. Thrombosis to the tissue flap anastomoses or microcirculation is the main reason for total flap necrosis with potential fatal consequences for the patient. Remote ischemic preconditioning (RIPC), where brief cycles of upper extremity ischemia are induced with an inflatable tourniquet, triggers a global protection of tissues subjected to ischemia-reperfusion injury...
April 2016: Thrombosis Research
https://www.readbyqxmd.com/read/27135869/-remote-ischemic-conditioning-endogenous-tissue-protection-and-its-possible-applications-in-surgery
#16
A Sogorski, K Harati, N Kapalschinski, A Daigeler, T Hirsch, M Lehnhardt, O Goertz, J Kolbenschlag
Tissue perfusion is pivotal to wound healing and tissue regeneration after surgery. Ischemia and reperfusion lead to inflammatory reactions with consecutive tissue damage and necrosis. Multiple conditioning techniques have been described to protect tissue from those damaging mechanisms in the perioperative period. However, most of these fail to meet the requirements of a good therapeutic effect, time and cost efficiency, non-invasiveness and applicability without the need for additional devices or drugs. Remote ischemic conditioning (RIC) is a technique to provide endogenous tissue protection, which fully meets those requirements...
May 2, 2016: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/27083943/combined-morphine-and-limb-remote-ischemic-perconditioning-provides-an-enhanced-protection-against-myocardial-ischemia-reperfusion-injury-by-antiapoptosis
#17
Shi-Yu Wang, Xin-Long Cui, Fu-Shan Xue, Ran Duan, Rui-Ping Li, Gao-Pu Liu, Gui-Zhen Yang, Chao Sun
BACKGROUND: Both morphine and limb remote ischemic perconditioning (RIPer) can protect against myocardial ischemia/reperfusion injury (IRI). This experiment was designed to assess whether combined morphine and limb RIPer could provide and enhanced protection against myocardial IRI in an in vivo rat model. METHODS: One hundred male Sprague-Dawley rats were randomly allocated to six groups: sham, ischemia/reperfusion (IR), ischemic preconditioning, RIPer, morphine (M), and combined morphine and remote ischemic perconditioning (M + RIPer)...
May 1, 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27034273/remote-ischemic-preconditioning-for-cardiac-surgery-reflections-on-evidence-of-efficacy
#18
Anweshan Samanta, Buddhadeb Dawn
No abstract text is available yet for this article.
April 1, 2016: Circulation Research
https://www.readbyqxmd.com/read/26979771/preconditioning-at-a-distance-involvement-of-endothelial-vasoactive-substances-in-cardioprotection-against-ischemia-reperfusion-injury
#19
REVIEW
Sapna Aggarwal, Puneet Kaur Randhawa, Nirmal Singh, Amteshwar Singh Jaggi
There is growing preclinical as well as clinical evidence supporting remote ischemic preconditioning (RIPC), in which short cycles of non-fatal ischemia followed by reperfusion to an organ or tissue distant from the heart elicits cardioprotection. It is the most practical, non-invasive, cost-free, and clinically compatible, secure procedure for reducing ischemia-reperfusion induced injury. The use of a conventional blood pressure cuff on the upper or lower limb in eliciting cardioprotection has expedited its clinical applicability...
April 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/26963434/effects-of-ischemic-reperfusion-injury-and-remote-conditioning-on-passive-leg-raising-induced-brachial-artery-dilation
#20
Manasi Bapat, Bhawna Sharma, Andrew Persits, Hue Van Le, Jack Janani, Haroon Kamran, Keshwar Ramkissoon, Louis Salciccioli, Jason M Lazar
OBJECTIVES: Passive leg raising (PLR) has been proposed to assess arterial vasodilator reserve and possibly endothelial function. Since endothelial function is sensitive to ischemic-reperfusion (I-R) injury, we determined the effects of I-R injury and ischemic conditioning on PLR-induced brachial-artery dilation (BAD), i.e. PLR-BAD. METHODS: We induced PLR-BAD before and after ipsilateral arm I-R injury (7.5 min of occlusion) in 20 healthy males aged 29 ± 6 years...
2016: Cardiology
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