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69 papers 0 to 25 followers Remote ischemic preconditioning
https://www.readbyqxmd.com/read/29131250/effects-of-remote-ischemic-preconditioning-on-myocardial-injury-and-endothelial-function-and-prognosis-after-percutaneous-coronary-intervention-in-patients-with-acute-coronary-syndrome
#1
F-Z Zhou, W Song, L-H Yin, Z-F Song, S Yang, F-B Yang, J-F Liu, Y-G Song, H-Y Zhang, Z-M Zhang
OBJECTIVE: To explore the effects of remote ischemic preconditioning on myocardial injury and prognosis after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome. PATIENTS AND METHODS: The study was a single center, prospective, randomized, controlled study. A total of 184 patients with unstable angina undergoing elective PCI were randomly assigned to remote ischemic preconditioning group (induced by four times of 5-min inflations of a blood pressure cuff to 200 mmHg around the upper arm, followed by 5-min intervals of reperfusion at 1 h before PCI therapy) or control group (an uninflated cuff around the arm)...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29076346/a-systematic-review-and-meta-analysis-evaluating-ischemic-conditioning-during-percutaneous-coronary-intervention
#2
David I Blusztein, Matthew J Brooks, David T Andrews
AIM: A systematic review and meta-analysis, evaluating ischemic conditioning during percutaneous coronary intervention (PCI). METHODS & RESULTS: A database search of randomized trials of ischemic conditioning in PCI created three subgroups for meta-analysis: mortality in elective PCI with remote ischemic preconditioning (RIPreC; subgroup 1a, n = 3) - no outcome difference between RIPreC and control (odds ratio: 0.34; 95% CI: 0.08-1.56), myocardial salvage index in ST-elevation myocardial infarction (STEMI) with RIPreC (subgroup 1b, n = 2) - favored RIPreC (mean difference: 0...
November 2017: Future Cardiology
https://www.readbyqxmd.com/read/28951984/remote-ischemic-preconditioning-protects-human-neural-stem-cells-from-oxidative-stress
#3
Ayako Motomura, Mikiko Shimizu, Akira Kato, Kazuya Motomura, Akane Yamamichi, Hiroko Koyama, Fumiharu Ohka, Tomohide Nishikawa, Yusuke Nishimura, Masahito Hara, Tetsuya Fukuda, Yasuhiko Bando, Toshihide Nishimura, Toshihiko Wakabayashi, Atsushi Natsume
In previous clinical trials, we showed that remote ischemic preconditioning (rIPC) reduced myocardial damage in children undergoing treatment for congenital heart defects and postoperative renal failure in patients undergoing abdominal aortic aneurysm surgery. In rabbit experiments, pre-treatment with plasma and plasma dialysate (obtained using 15-kDa cut-off dialysis membrane) from donor rabbits subjected to rIPC similarly protected against cardiac infarction. However, the protective substances containing in rIPC plasma have been unknown...
November 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28980297/remote-ischaemic-preconditioning-of-human-myocardium-ripe-study-protocol-for-a-double-blinded-randomised-controlled-trial
#4
Marek A Deja, Ryszard Wiaderkiewicz, Piotr Czekaj, Ewa Czech, Marcin Malinowski, Leszek Machej, Andrzej Węglarzy, Adam Kowalówka, Magda Piekarska, Bartosz Szurlej, Tomasz Latusek
BACKGROUND: Remote preconditioning has been shown to be a potent protective phenomenon in many animals. Several studies aimed to demonstrate it was feasible in humans by trying to show its protective effect during cardiac surgery. Of these, some small studies and one larger trial were positive while two other bigger studies showed no effectiveness of remote preconditioning as assessed by levels of postoperatively released cardiac markers. Recently, two large clinical trials also failed to prove the benefit of remote preconditioning in cardiac surgery...
2018: Kardiologia Polska
https://www.readbyqxmd.com/read/28988529/effect-of-anesthetics-on-efficiency-of-remote-ischemic-preconditioning
#5
D N Silachev, E A Usatikova, I B Pevzner, L D Zorova, V A Babenko, M V Gulyaev, Yu A Pirogov, E Yu Plotnikov, D B Zorov
Remote ischemic preconditioning of hind limbs (RIPC) is an effective method for preventing brain injury resulting from ischemia. However, in numerous studies RIPC has been used on the background of administered anesthetics, which also could exhibit neuroprotective properties. Therefore, investigation of the signaling pathways triggered by RIPC and the effect of anesthetics is important. In this study, we explored the effect of anesthetics (chloral hydrate and Zoletil) on the ability of RIPC to protect the brain from injury caused by ischemia and reperfusion...
September 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28219918/clinical-outcomes-of-remote-ischemic-preconditioning-prior-to-cardiac-surgery-a-meta-analysis-of-randomized-controlled-trials
#6
REVIEW
Brian Pierce, Indra Bole, Vaiibhav Patel, David L Brown
BACKGROUND: Multiple randomized controlled trials of remote ischemic preconditioning (RIPC) prior to cardiac surgery have failed to demonstrate clinical benefit. The aim of this updated meta-analysis was to evaluate the effect of RIPC on outcomes following cardiac surgery. METHODS AND RESULTS: Searches of PubMed, Cochrane, EMBASE, and Web of Science databases were performed for 1970 to December 13, 2015. Randomized controlled trials comparing RIPC with a sham procedure prior to cardiac surgery performed with cardiopulmonary bypass were assessed...
February 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28174194/safety-and-efficacy-of-remote-ischemic-preconditioning-in-patients-with-severe-carotid-artery-stenosis-before-carotid-artery-stenting-a-proof-of-concept-randomized-controlled-trial
#7
RANDOMIZED CONTROLLED TRIAL
Wenbo Zhao, Ran Meng, Chun Ma, Baojun Hou, Liqun Jiao, Fengshui Zhu, Weijuan Wu, Jingfei Shi, Yunxia Duan, Renling Zhang, Jing Zhang, Yongxin Sun, Hongqi Zhang, Feng Ling, Yuping Wang, Wuwei Feng, Yuchuan Ding, Bruce Ovbiagele, Xunming Ji
BACKGROUND: Remote ischemic preconditioning (RIPC) can inhibit recurrent ischemic events effectively in patients with acute or chronic cerebral ischemia. However, it is still unclear whether RIPC can impede ischemic injury after carotid artery stenting (CAS) in patients with severe carotid artery stenosis. METHODS: Subjects with severe carotid artery stenosis were recruited in this randomized controlled study, and assigned to RIPC, sham, and no intervention (control) groups...
April 4, 2017: Circulation
https://www.readbyqxmd.com/read/28214082/effect-of-remote-ischemia-or-nicorandil-on-myocardial-injury-following-percutaneous-coronary-intervention-in-patients-with-stable-coronary-artery-disease-a-randomized-controlled-trial
#8
RANDOMIZED CONTROLLED TRIAL
Toru Miyoshi, Kentaro Ejiri, Kunihisa Kohno, Makoto Nakahama, Masayuki Doi, Mitsuru Munemasa, Masaaki Murakami, Atsushi Takaishi, Yusuke Kawai, Tetsuya Sato, Katsumasa Sato, Takefumi Oka, Natsuki Takahashi, Satoru Sakuragi, Atsushi Mima, Kenki Enko, Shingo Hosogi, Seiji Nanba, Ryoichi Hirami, Kazufumi Nakamura, Hiroshi Ito
BACKGROUND: The effect of remote ischemic preconditioning (RIPC) and nicorandil on periprocedural myocardial injury (pMI) in patients with planned percutaneous coronary intervention (PCI) remains controversial. The aim of this randomized trial was to evaluate the effect of RIPC or nicorandil on pMI following PCI in patients with stable coronary artery disease (CAD) compared with a control group. METHODS: Patients with stable CAD who planned to undergo PCI were assigned to a 1:1:1 ratio to control, RIPC, or intravenous nicorandil (6mg/h)...
June 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28192894/remote-ischemic-preconditioning-in-cardiac-anesthesia-a-review-focusing-on-translation
#9
Christian Stoppe, Patrick Meybohm, Carina Benstoem, Andreas Goetzenich
Remote ischemic conditioning (RIC) is a powerful cardioprotective strategy. Its clinical application is simple, cheap and so far free from secondary side effects. Given the heterogeneous results of recent large-scale clinical trials, its clinical relevant benefit is still doubted. Following a MEDLINE-based search on all publications concerning RIC in experimental or clinical settings, this review focuses on the translation from bench to bedside. A short resume of mechanistic insights is followed by the presentation of current clinical evidence of beneficial effects of RIC and the critical assessment of the recently published large-scale trials...
June 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28075499/long-term-outcome-following-remote-ischemic-postconditioning-during-percutaneous-coronary-interventions-the-rip-pci-trial-long-term-follow-up
#10
RANDOMIZED CONTROLLED TRIAL
Shahar Lavi, Nour Abu-Romeh, Sabrina Wall, Mistre Alemayehu, Ronit Lavi
The clinical value of ischemic conditioning during percutaneous coronary intervention (PCI) and mode of administration is controversial. Our aim was to assess the long-term effect of remote ischemic postconditioning among patients undergoing PCI. We randomized 360 patients undergoing PCI who presented with a negative troponin T at baseline into 3 groups: 2 groups received remote ischemic postconditioning (with ischemia applied to the arm in 1 group and to the thigh in the other group), and the third group acted as a control group...
May 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28066658/dubious-effects-by-the-choice-of-anesthetics-in-remote-ischemic-preconditioning
#11
COMMENT
Patrick Meybohm, Christian Stoppe, Kai Zacharowski
No abstract text is available yet for this article.
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28065491/meta-analysis-of-randomized-trials-on-remote-ischemic-conditioning-during-primary-percutaneous-coronary-intervention-in-patients-with-st-segment-elevation-myocardial-infarction
#12
Ayman Elbadawi, Le Dung Ha, Ahmed S Abuzaid, Gabriele Crimi, Muhammad S Azzouz
Ischemia/reperfusion injury adversely affects the final infarct size (IS) after primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI). Few studies have evaluated the role of remote ischemic conditioning (RIC) in reducing ischemia/reperfusion injury. However, the results of these studies were not consistent, and an overview of overall effectiveness of this technique in patients with STEMI is lacking. We conducted this meta-analysis to evaluate the available evidence in literature regarding the application of RIC in patients with STEMI who underwent primary PCI...
March 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28060997/effect-of-hypercholesterolaemia-on-myocardial-function-ischaemia-reperfusion-injury-and-cardioprotection-by-preconditioning-postconditioning-and-remote-conditioning
#13
REVIEW
Ioanna Andreadou, Efstathios K Iliodromitis, Antigone Lazou, Anikó Görbe, Zoltán Giricz, Rainer Schulz, Péter Ferdinandy
Hypercholesterolaemia is considered to be a principle risk factor for cardiovascular disease, having direct negative effects on the myocardium itself, in addition to the development of atherosclerosis. Since hypercholesterolaemia affects the global cardiac gene expression profile, among many other factors, it results in increased myocardial oxidative stress, mitochondrial dysfunction and inflammation triggered apoptosis, all of which may account for myocardial dysfunction and increased susceptibility of the myocardium to infarction...
June 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28038863/association-of-remote-ischemic-peri-conditioning-with-reduced-incidence-of-clinical-heart-failure-after-primary-percutaneous-coronary-intervention
#14
Adetola Ladejobi, Max Wayne, Christian Martin-Gill, Francis X Guyette, Andrew D Althouse, Michael S Sharbaugh, Steven E Reis, Clifton W Callaway, John A Kellum, A J Conrad Smith, Catalin Toma, Oladipupo Olafiranye
BACKGROUND: Clinical heart failure (HF) occurs frequently after ST-segment elevation myocardial infarction (STEMI), and is associated with increased mortality. We assessed the impact of remote ischemic peri-conditioning (RIPC) during inter-facility air medical transport of STEMI patients on clinical HF following primary percutaneous coronary intervention (pPCI). METHODS: Data from Acute Coronary Treatment and Intervention Outcomes Network Registry®-Get With the Guidelines™ (ACTION Registry-GWTG) from two PCI-hospitals that are utilizing RIPC during inter-facility helicopter transport of STEMI patients for pPCI between March, 2013 and September, 2015 were used for this study...
March 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/23270554/cardioprotection-techniques-preconditioning-postconditioning-and-remote-conditioning-basic-science
#15
REVIEW
Derek J Hausenloy
Ischemic heart disease (IHD) is the leading cause of death and disability worldwide. The major pathological consequences of IHD arise from the detrimental effects of acute ischemia-reperfusion injury (IRI) on the myocardium. Therefore, in order to improve clinical outcomes in patients with IHD, novel therapeutic strategies are required to protect the myocardium from acute IRI and preserve cardiac function (cardioprotection). In this regard, endogenous cardioprotective strategies such as ischemic preconditioning (IPC), ischemic postconditioning (IPost) and remote ischemic conditioning (RIC) may provide novel approaches for protecting the heart in clinical settings in which the patient experiences acute myocardial IRI...
2013: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28028069/remote-ischaemic-conditioning-reduces-infarct-size-in-animal-in-vivo-models-of-ischaemia-reperfusion-injury-a-systematic-review-and-meta-analysis
#16
REVIEW
Daniel I Bromage, Jack M J Pickard, Xavier Rossello, Oliver J Ziff, Niall Burke, Derek M Yellon, Sean M Davidson
Aims: The potential of remote ischaemic conditioning (RIC) to ameliorate myocardial ischaemia-reperfusion injury (IRI) remains controversial. We aimed to analyse the pre-clinical evidence base to ascertain the overall effect and variability of RIC in animal in vivo models of myocardial IRI. Furthermore, we aimed to investigate the impact of different study protocols on the protective utility of RIC in animal models and identify gaps in our understanding of this promising therapeutic strategy...
March 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/27847563/randomized-controlled-trial-of-remote-ischemic-preconditioning-and-atrial-fibrillation-in-patients-undergoing-cardiac-surgery
#17
Amir S Lotfi, Hossein Eftekhari, Auras R Atreya, Ananth Kashikar, Senthil K Sivalingam, Miguel Giannoni, Paul Visintainer, Daniel Engelman
AIM: To study whether remote ischemic preconditioning (RIPC) has an impact on clinical outcomes, such as post-operative atrial fibrillation (POAF). METHODS: This was a prospective, single-center, single-blinded, randomized controlled study. One hundred and two patients were randomized to receive RIPC (3 cycles of 5 min ischemia and 5 min reperfusion in the upper arm after induction of anesthesia) or no RIPC (control). Primary outcome was POAF lasting for five minutes or longer during the first seven days after surgery...
October 26, 2016: World Journal of Cardiology
https://www.readbyqxmd.com/read/27940009/no-protection-of-heart-kidneys-and-brain-by-remote-ischemic-preconditioning-before-transfemoral-transcatheter-aortic-valve-implantation-interim-analysis-of-a-randomized-single-blinded-placebo-controlled-single-center-trial
#18
Philipp Kahlert, Heike Annelie Hildebrandt, Polykarpos Christos Patsalis, Fadi Al-Rashid, Rolf Alexander Jánosi, Felix Nensa, Thomas Wilfried Schlosser, Marc Schlamann, Daniel Wendt, Matthias Thielmann, Eva Kottenberg, Ulrich Frey, Markus Neuhäuser, Michael Forsting, Heinz Günther Jakob, Tienush Rassaf, Jürgen Peters, Gerd Heusch, Petra Kleinbongard
BACKGROUND: Remote ischemic preconditioning (RIPC) reduces myocardial injury and improves clinical outcome in patients undergoing coronary revascularization, but only in the absence of propofol-anesthesia. We investigated whether RIPC provides protection of heart, kidneys and brain and improves outcome in patients undergoing transfemoral transcatheter aortic valve implantation (TF-TAVI). METHODS: Patients undergoing TF-TAVI were randomized to receive RIPC (3cycles of 5min left upper arm ischemia and 5min reperfusion) or placebo...
March 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/25512268/-myocardial-protection-of-remote-ischemic-postconditioning-during-primary-percutaneous-coronary-intervention-in-patients-with-acute-st-segment-elevation-myocardial-infarction
#19
RANDOMIZED CONTROLLED TRIAL
N Wang, G S Wang, H Y Yu, L Mi, L J Guo, W Gao
OBJECTIVE: To evaluate the cardioprotection of remote ischemic postconditioning (RIPostC) in patients with acute ST-segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI). METHODS: Forty-six STEMI patients undergoing primary PCI at Peking University Third Hospital from January to April 2014 were randomized to RIPostC group (n=23) and control group (n=23).The RIPostC protocol was started within 1 min after reflow by thrombus aspiration or balloon inflation and consisted of 3 cycles of 5 min/5 min ischemia/reperfusion by cuff inflation/deflation of the lower left limb...
December 18, 2014: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/24692535/remote-ischemic-postconditioning-during-percutaneous-coronary-interventions-remote-ischemic-postconditioning-percutaneous-coronary-intervention-randomized-trial
#20
RANDOMIZED CONTROLLED TRIAL
Shahar Lavi, Sabrina D'Alfonso, Pantelis Diamantouros, Anthony Camuglia, Pallav Garg, Patrick Teefy, George Jablonsky, Kumar Sridhar, Ronit Lavi
BACKGROUND: Remote ischemic preconditioning may result in reduction in infarct size during percutaneous coronary intervention (PCI). It is unclear whether remote ischemic postconditioning (RIPost) will reduce the incidence of myocardial injury after PCI, and whether ischemic conditioning of a larger remote organ (thigh versus arm) would provide further myocardial protection. METHODS AND RESULTS: We randomized 360 patients presenting with stable or unstable angina (28% of patients) and negative Troponin T at baseline to 3 groups: 2 groups received RIPost (induced by ischemia to upper or lower limb), and a third was the control group...
April 2014: Circulation. Cardiovascular Interventions
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