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Cortisol/DHEA

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2 papers 0 to 25 followers
https://www.readbyqxmd.com/read/16787962/dhea-enhances-effects-of-weight-training-on-muscle-mass-and-strength-in-elderly-women-and-men
#1
RANDOMIZED CONTROLLED TRIAL
Dennis T Villareal, John O Holloszy
The plasma levels of dehydroepiandrosterone (DHEA) and its sulfated form (DHEAS) decline approximately 80% between the ages of 25 and 75 yr. Muscle mass and strength also decrease with aging. Published data on the effects of DHEA replacement on muscle mass and strength are conflicting. The goals of this study were to determine whether DHEA replacement increases muscle mass and strength and/or enhances the effects of heavy resistance exercise in elderly women and men. We conducted a randomized, double-blind, placebo-controlled study of the effects of 10 mo of DHEA replacement therapy with the addition of weightlifting exercise training during the last 4 mo of the study (DHEA + exercise group, n = 29; placebo + exercise group, n = 27)...
November 2006: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/10760294/dehydroepiandrosterone-dhea-dhea-sulfate-and-aging-contribution-of-the-dheage-study-to-a-sociobiomedical-issue
#2
E E Baulieu, G Thomas, S Legrain, N Lahlou, M Roger, B Debuire, V Faucounau, L Girard, M P Hervy, F Latour, M C Leaud, A Mokrane, H Pitti-Ferrandi, C Trivalle, O de Lacharrière, S Nouveau, B Rakoto-Arison, J C Souberbielle, J Raison, Y Le Bouc, A Raynaud, X Girerd, F Forette
The secretion and the blood levels of the adrenal steroid dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) decrease profoundly with age, and the question is posed whether administration of the steroid to compensate for the decline counteracts defects associated with aging. The commercial availability of DHEA outside the regular pharmaceutical-medical network in the United States creates a real public health problem that may be resolved only by appropriate long-term clinical trials in elderly men and women...
April 11, 2000: Proceedings of the National Academy of Sciences of the United States of America
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