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AKI Diagnosis

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7 papers 0 to 25 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/28616210/acute-kidney-injury-an-overview-of-diagnostic-methods-and-clinical-management
#1
Daniel Hertzberg, Linda Rydén, John W Pickering, Ulrik Sartipy, Martin J Holzmann
Acute kidney injury (AKI) is a common condition in multiple clinical settings. Patients with AKI are at an increased risk of death, over both the short and long term, and of accelerated renal impairment. As the condition has become more recognized and definitions more unified, there has been a rapid increase in studies examining AKI across many different clinical settings. This review focuses on the classification, diagnostic methods and clinical management that are available, or promising, for patients with AKI...
June 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28545421/diagnostic-performance-of-serum-blood-urea-nitrogen-to-creatinine-ratio-for-distinguishing-prerenal-from-intrinsic-acute-kidney-injury-in-the-emergency-department
#2
Guillaume Manoeuvrier, Kalyane Bach-Ngohou, Eric Batard, Damien Masson, David Trewick
BACKGROUND: The blood urea nitrogen to creatinine ratio (BCR) has been used since the early 1940s to help clinicians differentiate between prerenal acute kidney injury (PR AKI) and intrinsic AKI (I AKI). This ratio is simple to use and often put forward as a reliable diagnostic tool even though little scientific evidence supports this. The aim of this study was to determine whether BCR is a reliable tool for distinguishing PR AKI from I AKI. METHODS: We conducted a retrospective observational study over a 13 months period, in the Emergency Department (ED) of Nantes University Hospital...
May 25, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28454562/diagnosis-and-outcomes-of-acute-kidney-injury-using-surrogate-and-imputation-methods-for-missing-preadmission-creatinine-values
#3
Amélie Bernier-Jean, William Beaubien-Souligny, Rémi Goupil, François Madore, François Paquette, Stéphan Troyanov, Josée Bouchard
BACKGROUND: Missing preadmission serum creatinine (SCr) values are a common obstacle to assess acute kidney injury (AKI) diagnosis and outcomes. The Kidney Disease Improving Global Outcomes (KDIGO) guidelines suggest using a SCr computed from the Modification of Diet in Renal Disease (MDRD) with an estimated glomerular filtration rate of 75 ml/min/1.73 m(2). We aimed to identify the best surrogate method for baseline SCr to assess AKI diagnosis and outcomes. METHODS: We compared the use of 1) first SCr at hospital admission 2) minimal SCr over 2 weeks after intensive care unit admission 3) MDRD computed SCr and 4) Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) computed SCr to assess AKI diagnosis and outcomes...
April 28, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28444409/diagnostic-work-up-and-specific-causes-of-acute-kidney-injury
#4
REVIEW
Michael Darmon, Marlies Ostermann, Jorge Cerda, Meletios A Dimopoulos, Lui Forni, Eric Hoste, Matthieu Legrand, Nicolas Lerolle, Eric Rondeau, Antoine Schneider, Bertrand Souweine, Miet Schetz
Acute kidney injury (AKI) is common in critically ill patients and associated with grim short- and long-term outcome. Although in the vast majority of cases AKI is multifactorial, with sepsis, shock and nephrotoxicity accounting for most episodes, specific causes of AKI are not uncommon. Despite remaining uncertainties regarding their prevalence in the ICU, prompt recognition of specific aetiologies of AKI is likely to ensure timely management, limit worsening of renal dysfunction, and ultimately limit renal and systemic consequences of AKI...
April 25, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28167845/acute-kidney-injury-diagnostic-approaches-and-controversies
#5
REVIEW
Konstantinos Makris, Loukia Spanou
Acute kidney injury (AKI) is a significant independent risk factor for morbidity and mortality. In the last ten years a large number of publications have highlighted the limitations of traditional approaches and the inadequacies of conventional biomarkers to diagnose and monitor renal insufficiency in the acute setting. A great effort was directed not only to the discovery and validation of new biomarkers aimed to detect AKI more accurately but also to standardise the definition of AKI. Despite the advances in both areas, biomarkers have not yet entered into routine clinical practice and the definition of this syndrome has many areas of uncertainty...
December 2016: Clinical Biochemist. Reviews
https://www.readbyqxmd.com/read/26410133/diagnostic-criteria-for-acute-kidney-injury-present-and-future
#6
REVIEW
John A Kellum
Acute kidney injury (AKI) is a clinical diagnosis guided by standard criteria based on changes in serum creatinine, urine output, or both. Severity of AKI is determined by the magnitude of increase in serum creatinine or decrease in urine output. Patients manifesting both oliguria and azotemia and those in which these impairments are persistent are more likely to have worse disease and worse outcomes. Short- and long-term outcomes are worse when patients have some stage of AKI by both criteria. New biomarkers for AKI may substantially aid in the risk assessment and evaluation of patients at risk for AKI...
October 2015: Critical Care Clinics
https://www.readbyqxmd.com/read/26398357/assessment-of-fractional-excretion-of-urea-for-early-diagnosis-of-cardiac-surgery-associated-acute-kidney-injury
#7
Carlos Federico Varela, Gustavo Greloni, Carlos Schreck, Griselda Bratti, Angel Medina, Ricardo Marenchino, Rodolfo Pizarro, Cesar Belziti, Guillermo Rosa-Diez
BACKGROUND: Acute kidney injury (AKI) is a common complication after cardiac surgery (CS). Recently, neutrophil gelatinase-associated lipocalin (NGAL) was shown to predict AKI development earlier than serum creatinine, but it is not widely used in clinical practice. Fractional excretion of urea (FeU) has been referred to as a useful tool to discriminate between prerenal and established AKI. The aim of our study is to evaluate the sensitivity and specificity of FeU, in the early diagnosis of AKI in patients undergoing CS...
November 2015: Renal Failure
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