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AKI Anemia

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By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Charat Thongprayoon, Wisit Cheungpasitporn, Erin A Gillaspie, Kevin L Greason, Kianoush B Kashani
AIM: To assess red blood cell (RBC) transfusion effects on acute kidney injury (AKI) after transcatheter aortic valve replacement (TAVR). METHODS: A literature search was performed using MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, and from the inception of the databases through December 2015. Studies that reported relative risk, odds ratio or hazard ratio comparing the risks of AKI following TAVR in patients who received periprocedural RBC transfusion were included...
September 6, 2016: World Journal of Nephrology
Wassef Karrowni, Amit Navin Vora, David Dai, Daniel Wojdyla, Habib Dakik, Sunil V Rao
BACKGROUND: Acute kidney injury (AKI) complicating percutaneous coronary intervention (PCI) is associated with adverse clinical outcomes. To date, no studies have evaluated the association of blood transfusion with AKI in patients undergoing PCI. METHODS AND RESULTS: We used a retrospective cohort study of all patients with acute coronary syndrome undergoing PCI from CathPCI Registry (n=1 756 864). The primary outcome was AKI defined as the rise in serum creatinine post procedure ≥0...
September 2016: Circulation. Cardiovascular Interventions
G Gomez, E Curiel, M D Fernandez
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
Vyvyca J Walker, Anupam Agarwal
Iron is an essential metal involved in several major cellular processes required to maintain life. Because of iron's ability to cause oxidative damage, its transport, metabolism, and storage is strictly controlled in the body, especially in the small intestine, liver, and kidney. Iron plays a major role in acute kidney injury and has been a target for therapeutic intervention. However, the therapies that have been effective in animal models of acute kidney injury have not been successful in human beings. Targeting iron trafficking via ferritin, ferroportin, or hepcidin may offer new insights...
January 2016: Seminars in Nephrology
Jonah Powell-Tuck, Siobhan Crichton, Mario Raimundo, Luigi Camporota, Duncan Wyncoll, Marlies Ostermann
BACKGROUND: In hospitalised patients, anaemia increases the risk of developing acute kidney injury (AKI). Our aim was to determine whether anaemia also has an impact on the risk of progression from early AKI to more severe AKI in critically ill patients. METHODS: We retrospectively analysed the data of patients admitted to the adult intensive care unit between 2007 and 2009 who had AKI I as per the AKI Network classification, and who had undergone haemodynamic monitoring within 12 h of AKI I...
2016: Critical Care: the Official Journal of the Critical Care Forum
Barbara A Clark, Liliana Osadchuk, Jones John, Thuyanh Culver, Richard Marcus
BACKGROUND: Little is known about benefit versus risk in treating iron deficiency anemia with intravenous (IV) iron in patients with acute kidney injury (AKI). Concerns about adverse outcomes may dissuade use and could contribute to greater use of red blood cell (RBC) transfusion. STUDY DESIGN AND METHODS: We performed a retrospective case-control study of patients with AKI who received IV iron (cases) compared to those with AKI without IV iron (controls). RESULTS: We identified 67 cases and 67 controls matched for age, stage of chronic kidney disease, and severity of anemia (hemoglobin [Hb], 7...
April 2016: Transfusion
Rinaldo Bellomo, Johan Mårtensson, Kirsi-Maija Kaukonen, Serigne Lo, Martin Gallagher, Alan Cass, John Myburgh, Simon Finfer
OBJECTIVE: To assess the epidemiology and outcomes associated with RBC transfusion in patients with severe acute kidney injury requiring continuous renal replacement therapy. DESIGN: Post hoc analysis of data from a multicenter, randomized, controlled trial. SETTING: Thirty-five ICUs in Australia and New Zealand. PATIENTS: Cohort of 1,465 patients enrolled in the Randomized Evaluation of Normal versus Augmented Level replacement therapy study...
May 2016: Critical Care Medicine
Seung Seok Han, Seon Ha Baek, Shin Young Ahn, Ho Jun Chin, Ki Young Na, Dong-Wan Chae, Sejoong Kim
Acute kidney injury (AKI) is a major health concern, because AKI is related with an increase in morbidity and mortality. Anemia is related to AKI in several clinical settings. However, the relationship between anemia and AKI and the effect of anemia on long-term mortality are unresolved in critically ill patients. A total of 2,145 patients admitted to the intensive care unit were retrospectively analyzed. We calculated a threshold value of hemoglobin associated with an increased risk of AKI and used this value to define anemia...
2015: Tohoku Journal of Experimental Medicine
Hari Padmanabhan, Dincer Aktuerk, Matthew J Brookes, Alan M Nevill, Alex Ng, James Cotton, Heyman Luckraz
OBJECTIVE: To assess the effects of preoperative anemia on outcomes of cardiac surgery and to explore the trend in mortality over an 8-year period. METHODS: During the study period (2005-2012), all 1170 patients undergoing elective or urgent cardiac surgery and classed as anemic were included. A matched group of non-anemic 1170 patients was used as a control group. Postoperative outcomes were compared between the 2 groups. The association between preoperative anemia and postoperative outcomes was analyzed using a logistic regression model...
January 2016: Asian Cardiovascular & Thoracic Annals
A J Fowler, T Ahmad, M K Phull, S Allard, M A Gillies, R M Pearse
BACKGROUND: Numerous published studies have explored associations between anaemia and adverse outcomes after surgery. However, there are no evidence syntheses describing the impact of preoperative anaemia on postoperative outcomes. METHODS: A systematic review and meta-analysis of observational studies exploring associations between preoperative anaemia and postoperative outcomes was performed. Studies investigating trauma, burns, transplant, paediatric and obstetric populations were excluded...
October 2015: British Journal of Surgery
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