collection
https://read.qxmd.com/read/38335136/preoperative-anemia-and-postoperative-outcomes-in-cardiac-surgery-a-mediation-analysis-evaluating-intraoperative-transfusion-exposures
#1
JOURNAL ARTICLE
Matthew A Warner, Andrew C Hanson, Phillip J Schulte, Juan Ripoll Sanz, Mark M Smith, Marissa L Kauss, Juan A Crestanello, Daryl J Kor
BACKGROUND: Preoperative anemia is associated with adverse outcomes in cardiac surgery, yet it remains unclear what proportion of this association is mediated through red blood cell (RBC) transfusions. METHODS: This is a historical observational cohort study of adults undergoing coronary artery bypass grafting or valve surgery on cardiopulmonary bypass at an academic medical center between May 1, 2008, and May 1, 2018. A mediation analysis framework was used to evaluate the associations between preoperative anemia and postoperative outcomes, including a primary outcome of acute kidney injury (AKI)...
February 9, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38017198/postoperative-anemia-in-cardiac-surgery-patients-a-narrative-review
#2
REVIEW
Michelle M Li, Sarah Miles, Jeannie Callum, Yulia Lin, Keyvan Karkouti, Justyna Bartoszko
PURPOSE: Anemia reduces the blood's ability to carry and deliver oxygen. Following cardiac surgery, anemia is very common and affects up to 90% of patients. Nevertheless, there is a paucity of data examining the prognostic value of postoperative anemia. In this narrative review, we present findings from the relevant literature on postoperative anemia in cardiac surgery patients, focusing on the incidence, risk factors, and prognostic value of postoperative anemia. We also explore the potential utility of postoperative anemia as a therapeutic target to improve clinical outcomes...
November 28, 2023: Canadian Journal of Anaesthesia
https://read.qxmd.com/read/37824112/red-blood-cell-transfusion-in-the-intensive-care-unit
#3
JOURNAL ARTICLE
Senta Jorinde Raasveld, Sanne de Bruin, Merijn C Reuland, Claudia van den Oord, Jimmy Schenk, Cécile Aubron, Jan Bakker, Maurizio Cecconi, Aarne Feldheiser, Jens Meier, Marcella C A Müller, Thomas W L Scheeren, Zoe McQuilten, Andrew Flint, Tarikul Hamid, Michaël Piagnerelli, Tina Tomic Mahecic, Jan Benes, Lene Russell, Hernan Aguirre-Bermeo, Konstantina Triantafyllopoulou, Vasiliki Chantziara, Mohan Gurjar, Sheila Nainan Myatra, Vincenzo Pota, Muhammed Elhadi, Ryszard Gawda, Mafalda Mourisco, Marcus Lance, Vojislava Neskovic, Matej Podbregar, Juan V Llau, Manual Quintana-Diaz, Maria Cronhjort, Carmen A Pfortmueller, Nihan Yapici, Nathan D Nielsen, Akshay Shah, Harm-Jan de Grooth, Alexander P J Vlaar
IMPORTANCE: Red blood cell (RBC) transfusion is common among patients admitted to the intensive care unit (ICU). Despite multiple randomized clinical trials of hemoglobin (Hb) thresholds for transfusion, little is known about how these thresholds are incorporated into current practice. OBJECTIVE: To evaluate and describe ICU RBC transfusion practices worldwide. DESIGN, SETTING, AND PARTICIPANTS: International, prospective, cohort study that involved 3643 adult patients from 233 ICUs in 30 countries on 6 continents from March 2019 to October 2022 with data collection in prespecified weeks...
November 21, 2023: JAMA
https://read.qxmd.com/read/37824153/red-blood-cell-transfusion-2023-aabb-international-guidelines
#4
JOURNAL ARTICLE
Jeffrey L Carson, Simon J Stanworth, Gordon Guyatt, Stacey Valentine, Jane Dennis, Sara Bakhtary, Claudia S Cohn, Allan Dubon, Brenda J Grossman, Gaurav K Gupta, Aaron S Hess, Jessica L Jacobson, Lewis J Kaplan, Yulia Lin, Ryan A Metcalf, Colin H Murphy, Katerina Pavenski, Micah T Prochaska, Jay S Raval, Eric Salazar, Nabiha H Saifee, Aaron A R Tobian, Cynthia So-Osman, Jonathan Waters, Erica M Wood, Nicole D Zantek, Monica B Pagano
IMPORTANCE: Red blood cell transfusion is a common medical intervention with benefits and harms. OBJECTIVE: To provide recommendations for use of red blood cell transfusion in adults and children. EVIDENCE REVIEW: Standards for trustworthy guidelines were followed, including using Grading of Recommendations Assessment, Development and Evaluation methods, managing conflicts of interest, and making values and preferences explicit. Evidence from systematic reviews of randomized controlled trials was reviewed...
November 21, 2023: JAMA
https://read.qxmd.com/read/37676636/low-hemoglobin-levels-are-associated-with-bowman-s-capsule-rupture-and-peritubular-capillaritis-in-anca-associated-renal-vasculitis-a-link-of-vascular-injury-to-anemia
#5
JOURNAL ARTICLE
Eva Baier, Ingmar Alexander Kluge, Samy Hakroush, Björn Tampe
BACKGROUND: Anemia in anti-neutrophil cytoplasmic antibody (ANCA)-associated renal vasculitis is a severe complication that predicts renal survival. We here conducted correlative analyses to evaluate correlations of low hemoglobin levels and histopathological characteristics in ANCA-associated renal vasculitis. METHODS: Fifty-two patients with biopsy-proven ANCA-associated renal vasculitis observed between 2015 and 2020 were retrospectively evaluated. Spearman's correlation was performed to assess correlations, and statistical evaluation was performed by simple and stepwise multivariable regression...
November 2023: Journal of Nephrology
https://read.qxmd.com/read/37191280/anemia-and-periprocedural-complications-determine-contrast-associated-acute-kidney-injury-after-recanalization-of-chronic-coronary-occlusions-in-chronic-kidney-disease
#6
JOURNAL ARTICLE
Gerald S Werner, Simon Lorenz, Zisis Dimitriadis, Bernd Krueger
BACKGROUND: Contrast-associated acute kidney injury (CA-AKI) is a potential risk associated with the percutaneous coronary interventions (PCI) for chronic total coronary occlusions (CTO) particularly with pre-existing chronic kidney disease (CKD). The determinants of CA-AKI in patients with pre-existing CKD in an era of advanced strategies of CTO recanalization techniques need to be considered for a risk evaluation of the procedure. METHODS: A consecutive cohort of 2504 recanalization procedures for a CTO between 2013 and 2022 was analyzed...
May 16, 2023: Catheterization and Cardiovascular Interventions
https://read.qxmd.com/read/37029431/intraoperative-use-of-tranexamic-acid-to-reduce-blood-loss-during-cytoreductive-surgery-for-advanced-ovarian-cancer-a-randomized-controlled-clinical-trial
#7
JOURNAL ARTICLE
Xijun Yang, Mao Chai, Lingfang Xia, Zhiyong He, Xiaohua Wu, Jun Zhang
INTRODUCTION: Tranexamic acid reduces blood loss and allogeneic transfusion requirements in various surgical procedures. The role of tranexamic acid during cytoreductive procedures in advanced ovarian cancer is not clear. MATERIAL AND METHODS: This was a single center randomized, controlled, three-armed clinical trial. A total of 150 ovarian cancer patients undergoing cytoreductive surgery were recruited and assigned to three groups (n = 50/group): the control group (normal saline), low-dose group (10 mg/kg bolus + 1 mg/kg continuous infusion of tranexamic acid), and high-dose group (20 mg/kg bolus + 5 mg/kg continuous infusion of tranexamic acid)...
April 7, 2023: Acta Obstetricia et Gynecologica Scandinavica
https://read.qxmd.com/read/36891761/relative-contributions-of-anaemia-and-hypotension-to-myocardial-infarction-and-renal-injury-post-hoc-analysis-of-the-poise-2-trial
#8
RANDOMIZED CONTROLLED TRIAL
Alparslan Turan, Eva Rivas, P J Devereaux, Xuan Pu, Fabio A Rodriguez-Patarroyo, Esra Kutlu Yalcin, Rod Nault, Kamal Maheshwari, Kurt Ruetzler, Daniel I Sessler
BACKGROUND: Hypotension and postoperative anaemia are associated with myocardial and renal injury after noncardiac surgery, but the interaction between them remains unknown. OBJECTIVES: To test the hypothesis that a double-hit of postoperative anaemia and hypotension synergistically worsens a 30-day composite of myocardial infarction (MI) and mortality and acute kidney injury (AKI). Characterising the interaction when hypotension and anaemia occur at same time on myocardial infarction and acute kidney injury...
May 1, 2023: European Journal of Anaesthesiology
https://read.qxmd.com/read/36651696/characteristics-and-risk-factors-for-renal-recovery-after-acute-kidney-injury-in-critically-ill-patients-in-cohorts-of-elderly-and-non-elderly-a-multicenter-retrospective-cohort-study
#9
MULTICENTER STUDY
Xiujuan Zhao, Chengjian Li, Yunwei Lu, Shu Li, Fuzheng Guo, Haiyan Xue, Zhenzhou Wang, Yulan Jiang, Shaoguang Liu, Mingming Chai, Tonghai Du, Fengxue Zhu
BACKGROUND: The purpose of this study was to explore the risk factors for renal nonrecovery among elderly and nonelderly patients with acute kidney injury (AKI) in critically ill patients. METHODS: A multicenter retrospective cohort of 583 critically ill patients with AKI was examined. We found the best cutoff value for predicting renal recovery by age was 63 years old through logistic regression. All patients were divided into two cohorts, age <63 and age ≥63-years old; on the basis of renal recovery at 30 days after AKI, the two patient cohorts were further divided into a renal recovery group and a renal nonrecovery group...
December 2023: Renal Failure
https://read.qxmd.com/read/36377057/importance-of-assessing-biomarkers-and-physiological-parameters-of-anemia-induced-tissue-hypoxia-in-the-perioperative-period
#10
REVIEW
Kyle Chin, Hannah Joo, Helen Jiang, Chloe Lin, Iryna Savinova, Sarah Joo, Ahmad Alli, Michael C Sklar, Fabio Papa, Jeremy Simpson, Andrew J Baker, C David Mazer, William Darrah, Gregory M T Hare
Anemia is associated with increased risk of Acute Kidney Injury (AKI), stroke and mortality in perioperative patients. We sought to understand the mechanism(s) by assessing the integrative physiological responses to anemia (kidney, brain), the degrees of anemia-induced tissue hypoxia, and associated biomarkers and physiological parameters. Experimental measurements demonstrate a linear relationship between blood Oxygen Content (Ca O2 ) and renal microvascular PO2 (y = 0.30x + 6.9, r2  = 0...
October 28, 2022: Brazilian Journal of Anesthesiology
https://read.qxmd.com/read/36364144/the-role-of-hypoxia-inducible-factor-1-alpha-in-renal-disease
#11
REVIEW
Huixia Liu, Yujuan Li, Jing Xiong
Partial pressure of oxygen (pO2 ) in the kidney is maintained at a relatively stable level by a unique and complex functional interplay between renal blood flow, glomerular filtration rate (GFR), oxygen consumption, and arteriovenous oxygen shunting. The vulnerability of this interaction renders the kidney vulnerable to hypoxic injury, leading to different renal diseases. Hypoxia has long been recognized as an important factor in the pathogenesis of acute kidney injury (AKI), especially renal ischemia/reperfusion injury...
October 28, 2022: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/36314312/preoperative-anemia-and-complications-after-total-joint-arthroplasty-a-systematic-review-and-meta-analysis
#12
JOURNAL ARTICLE
H-C Zhang, Y Zhang, H-B Dai, D Wu, B Xu
OBJECTIVE: The purpose of this review was to collect data from the literature to assess the impact of preoperative anemia on complications after total joint arthroplasty (TJA). MATERIALS AND METHODS: We conducted a literature search on the websites of PubMed, Scopus, CENTRAL, Embase, and Google Scholar for comparative TJA studies reporting complication rates based on the presence of anemia. The last search was conducted on the 15th of May 2022. Studies only on hip and knee replacements were eligible for inclusion...
October 2022: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/36241669/aminoglycosides-use-has-a-risk-of-acute-kidney-injury-in-patients-without-prior-chronic-kidney-disease
#13
JOURNAL ARTICLE
Chu-Lin Chou, Nai-Chen Chuang, Hui-Wen Chiu, Chia-Te Liao, Yung-Ho Hsu, Tzu-Hao Chang
The outcome of acute kidney injury (AKI) as a result of aminoglycosides (AGs) use remains uncertain in patients without prior chronic kidney disease (CKD). Therefore, we explored the outcomes of AGs use on AKI episodes associated with renal recovery and progress in patients without prior CKD in Taiwan. This was a retrospective cohort study by using the Taipei Medical University Research Database from January 2008 to December 2019. 43,259 individuals without CKD who had received parenteral AGs were enrolled...
October 14, 2022: Scientific Reports
https://read.qxmd.com/read/36026931/risk-factors-for-hospitalization-for-a-major-acute-cardiovascular-event-after-acute-kidney-injury-with-full-recovery-a-single-center-experience
#14
JOURNAL ARTICLE
Nouha Ben Mahmoud, Mouna Hamouda, Jihene Maatoug, Meriem Ben Salem, Manel Ben Salah, Ahmed Letaief, Sabra Aloui, Habib Skhiri
OBJECTIVE: Acute kidney injury (AKI) was found to be associated with an increased risk of major adverse cardiovascular events (MACE) in the general population. We aim to evaluate the risk factors of patients having had an episode of AKI with full recovery exposing them to the risk of MACE. DESIGN AND METHOD: We conducted a retrospective single center study including all patients hospitalized in the nephrology ward since 2002 to 2015, which experienced an AKI episode with full recovery...
June 1, 2022: Journal of Hypertension
https://read.qxmd.com/read/36067996/perioperative-anemia-predicts-kidney-injury-after-partial-nephrectomy
#15
JOURNAL ARTICLE
Quan Li, Yunteng Huang, Lin Zhang, Liujian Duan, Subo Qian
PURPOSE: Partial nephrectomy (PN) induced kidney injury is still a challenging clinical matter that has not been completely conquered. This study aimed to explore the influences of perioperative anemia on renal function after PN. MATERIALS AND METHODS: A total of 114 patients undergoing PN were retrospectively studied. Serum creatinine was tested preoperatively and 24 hours and 3 days after PN to evaluate the occurrence of acute kidney injury (AKI). Perioperative anemia was evaluated on the basis of the hemoglobin (Hb) value at 24 hours and 3 days postoperation...
September 2022: Investigative and Clinical Urology
https://read.qxmd.com/read/35946481/interaction-of-hemoglobin-transfusion-and-acute-kidney-injury-in-patients-undergoing-cardiopulmonary-bypass-a-group-based-trajectory-analysis
#16
JOURNAL ARTICLE
Lingyong Cao, Weizhe Ru, Caibao Hu, Yanfei Shen
Anemia is a risk factor for acute kidney injury (AKI) following cardiopulmonary bypass (CPB). Whether red blood cell (RBC) transfusion-enhanced hemoglobin levels contribute to low AKI rates remains unclear. We investigated the interaction between hemoglobin, RBC transfusion, and AKI after CPB. Hemoglobin trajectories within 72 h were analyzed using group-based trajectory analysis. Multivariable logistic analysis and inverse probability-weighted regression were adopted to evaluate the associations between hemoglobin and AKI in RBC and non-RBC transfusion subgroups...
December 2022: Renal Failure
https://read.qxmd.com/read/35690725/threshold-heterogeneity-of-perioperative-hemoglobin-drop-for-acute-kidney-injury-after-noncardiac-surgery-a-propensity-score-weighting-analysis
#17
JOURNAL ARTICLE
Yan Zhou, Si Liu
BACKGROUND: Perioperative hemoglobin drop after noncardiac surgery is associated with acute kidney injury (AKI). However, opinion on the tolerable difference in postoperative hemoglobin drop in patients with different preoperative hemoglobin levels does not reach a consensus. This study aimed to identify hemoglobin drop thresholds for AKI after noncardiac surgery stratified by preoperative hemoglobin levels. METHOD: This was a single-center retrospective cohort study for elective noncardiac surgery from January 1, 2012, to December 31, 2018...
June 11, 2022: BMC Nephrology
https://read.qxmd.com/read/35261757/anaemia-and-acute-kidney-injury-the-tip-of-the-iceberg
#18
EDITORIAL
Yannis Lombardi, Christophe Ridel, Maxime Touzot
Acute kidney injury (AKI) is a common disorder that complicates the hospital course of many patients. AKI is linked with an independent risk of death, hospital length of stay and chronic kidney disease (CKD). Several preoperative predictors are found to be associated with AKI after surgery independent of its origin (cardiac versus non-cardiac). Among these, anaemia has been widely recognized and studied. Anaemia is more common within the surgical population for various reasons (iron deficiency, blood loss, anaemia of chronic disease such as inflammatory state, malignancy or CKD)...
February 2021: Clinical Kidney Journal
https://read.qxmd.com/read/35261759/anemia-following-acute-kidney-injury-after-noncardiac-surgery-and-long-term-outcomes-the-nara-aki-cohort-study
#19
JOURNAL ARTICLE
Masatoshi Nishimoto, Miho Murashima, Maiko Kokubu, Masaru Matsui, Masahiro Eriguchi, Ken-Ichi Samejima, Yasuhiro Akai, Kazuhiko Tsuruya
Background: This study was conducted to investigate whether acute kidney injury (AKI) is an independent predictor of anemia and whether anemia following AKI is a mediator of mortality after AKI. Methods: This is a retrospective cohort study. Adults with noncardiac surgery from 2007 to 2011 were included. Obstetric or urological surgery, missing data or preoperative dialysis were excluded. Subjects were followed until the end of 2015 or lost to follow-up. Exposures of interest were postoperative AKI...
February 2021: Clinical Kidney Journal
https://read.qxmd.com/read/35279078/erythropoietin-in-acute-kidney-injury-eaki-a-pragmatic-randomized-clinical-trial
#20
MULTICENTER STUDY
Mabel Aoun, Ghassan Sleilaty, Celine Boueri, Eliane Younes, Kim Gabriel, Reine-Marie Kahwaji, Najla Hilal, Jenny Hawi, Rita Araman, Dania Chelala, Chadia Beaini
BACKGROUND: Treatment with erythropoietin is well established for anemia in chronic kidney disease patients but not well studied in acute kidney injury. METHODS: This is a multicenter, randomized, pragmatic controlled clinical trial. It included 134 hospitalized patients with anemia defined as hemoglobin < 11 g/dL and acute kidney injury defined as an increase of serum creatinine of ≥ 0.3 mg/dL within 48 h or 1.5 times baseline...
March 13, 2022: BMC Nephrology
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