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Nini H Jonkman, Heleen Westland, Rolf H H Groenwold, Susanna Ågren, Felipe Atienza, Lynda Blue, Pieta W F Bruggink-André de la Porte, Darren A DeWalt, Paul L Hebert, Michele Heisler, Tiny Jaarsma, Gertrudis I J M Kempen, Marcia E Leventhal, Dirk J A Lok, Jan Mårtensson, Javier Muñiz, Haruka Otsu, Frank Peters-Klimm, Michael W Rich, Barbara Riegel, Anna Strömberg, Ross T Tsuyuki, Dirk J van Veldhuisen, Jaap C A Trappenburg, Marieke J Schuurmans, Arno W Hoes
BACKGROUND: Self-management interventions are widely implemented in the care for patients with heart failure (HF). However, trials show inconsistent results, and whether specific patient groups respond differently is unknown. This individual patient data meta-analysis assessed the effectiveness of self-management interventions in patients with HF and whether subgroups of patients respond differently. METHODS AND RESULTS: A systematic literature search identified randomized trials of self-management interventions...
March 22, 2016: Circulation
Toru Suzuki, Liam M Heaney, Sanjay S Bhandari, Donald J L Jones, Leong L Ng
OBJECTIVE: Acute heart failure (AHF) is associated with high mortality and morbidity. Trimethylamine N-oxide (TMAO), a gut-derived metabolite, has reported association with mortality risk in chronic HF but this association in AHF is still unknown. The present study investigated TMAO in patients admitted to hospital with AHF, and association of circulating levels with prognosis. METHODS: In total, 972 plasma samples were analysed for TMAO concentration by liquid chromatography-mass spectrometry...
June 1, 2016: Heart: Official Journal of the British Cardiac Society
Abhishek Singh, Saïd Laribi, John R Teerlink, Alexandre Mebazaa
Millions of patients worldwide are admitted for acute heart failure (AHF) each year and physicians caring for these patients are confronted with the short-term challenges of reducing symptoms while preventing end organ dysfunction without causing additional harm, and the intermediate-term challenges of improving clinical outcomes such as hospital readmission and survival. There are limited data demonstrating the efficacy of any currently available therapies for AHF to meet these goals. After diuretics, vasodilators are the most common intravenous therapy for AHF, but neither nitrates, nitroprusside, nor nesiritide have robust evidence supporting their ability to provide meaningful effects on clinical outcomes, except perhaps early symptom improvement...
February 4, 2016: European Heart Journal
Bernard Iung, Shahbudin H Rahimtoola, Alec Vahanian
No abstract text is available yet for this article.
February 1, 2016: European Heart Journal
Andrew Van Tosh, Kenneth J Nichols
No abstract text is available yet for this article.
January 8, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Stephan Rosenkranz, J Simon R Gibbs, Rolf Wachter, Teresa De Marco, Anton Vonk-Noordegraaf, Jean-Luc Vachiéry
In patients with left ventricular heart failure (HF), the development of pulmonary hypertension (PH) and right ventricular (RV) dysfunction are frequent and have important impact on disease progression, morbidity, and mortality, and therefore warrant clinical attention. Pulmonary hypertension related to left heart disease (LHD) by far represents the most common form of PH, accounting for 65-80% of cases. The proper distinction between pulmonary arterial hypertension and PH-LHD may be challenging, yet it has direct therapeutic consequences...
March 21, 2016: European Heart Journal
William F Peacock, Chad M Cannon, Adam J Singer, Brian C Hiestand
The diagnosis of patients presenting to the emergency department with acute heart failure (AHF) is challenging due to the similarity of AHF symptoms to other conditions such as chronic obstructive pulmonary disease and pneumonia. Additionally, because AHF is most common in an older population, the presentation of coexistent pathologies further increases the challenge of making an accurate diagnosis and selecting the most appropriate treatment. Delays in the diagnosis and treatment of AHF can result in worse outcomes and higher healthcare costs...
2015: Critical Care: the Official Journal of the Critical Care Forum
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