collection
MENU ▼
Read by QxMD icon Read
search

Aspergillosis

shared collection
112 papers 0 to 25 followers
https://www.readbyqxmd.com/read/27805757/the-relationship-between-biomarkers-of-fungal-allergy-and-lung-damage-in-asthma
#1
K F Woolnough, M Richardson, C Newby, M Craner, M Bourne, W Monteiro, S Siddiqui, P Bradding, C H Pashley, A J Wardlaw
BACKGROUND: Immunological biomarkers are the key to the diagnosis of allergic bronchopulmonary aspergillosis (ABPA) and fungal sensitisation, but how these relate to clinically relevant outcomes is unclear. OBJECTIVES: To assess how fungal immunological biomarkers are related to fixed airflow obstruction and radiological abnormalities in moderate to severe asthma. METHODS: Cross-sectional study of 431 asthmatics. Inflammatory biomarkers, lung function and an IgE fungal panel to colonising filamentous fungi, yeasts and fungal aeroallergens were measured...
November 2, 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27799353/posaconazole-loaded-leukocytes-as-a-novel-treatment-strategy-targeting-invasive-pulmonary-aspergillosis
#2
Shane R Baistrocchi, Mark J Lee, Melanie Lehoux, Benjamin Ralph, Brendan D Snarr, Robert Robitaille, Donald C Sheppard
BACKGROUND:  Impaired delivery of antifungals to hyphae within necrotic lesions is thought to contribute to therapeutic failure in invasive pulmonary aspergillosis (IPA). We hypothesized that transfusion of leukocytes loaded ex-vivo with the lipophilic antifungal posaconazole could improve delivery of antifungals to the sites of established infection and improve outcome in experimental IPA. METHODS:  The HL-60 leukemia cell line was differentiated to a neutrophil-like phenotype (dHL-60 cells) then exposed to a range of posaconazole concentrations...
October 31, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27744712/developments-in-the-diagnosis-and-treatment-of-allergic-bronchopulmonary-aspergillosis
#3
Ritesh Agarwal, Inderpaul S Sehgal, Sahajal Dhooria, Ashutosh N Aggarwal
Allergic bronchopulmonary aspergillosis (ABPA) is a complex pulmonary disorder characterized by recurrent episodes of wheezing, fleeting pulmonary opacities and bronchiectasis. It is the most prevalent of the Aspergillus disorders with an estimated five million cases worldwide. Despite six decades of research, the pathogenesis, diagnosis and treatment of this condition remains controversial. The International Society for Human and Animal Mycology has formed a working group to resolve the controversies around this entity...
November 7, 2016: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/27682064/home-environment-as-a-source-of-life-threatening-azole-resistant-aspergillus-fumigatus-in-immunocompromised-patients
#4
Rose-Anne Lavergne, Taieb Chouaki, Ferry Hagen, Bénédicte Toublanc, Hervé Dupont, Vincent Jounieaux, Jacques F Meis, Florent Morio, Patrice Le Pape
A case of fatal aspergillosis due to a TR46/Y121F/T289A azole-resistant Aspergillus fumigatus is reported. Environmental investigations at the patient's residence led to the recovery of TR46/Y121F/T289A isolates, genotypically indistinguishable from the clinical isolate, supporting for the first time the direct role of household as potential source of azole-resistant invasive aspergillosis.
September 28, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27623423/intrabronchial-voriconazole-is-a-safe-and-effective-measure-for-hemoptysis-control-in-pulmonary-aspergilloma
#5
Anant Mohan, Pawan Tiwari, Karan Madan, Vijay Hadda, Rosemary Poulose, Ashu S Bhalla, Rohit Khandelwal, Gopi C Khilnani, Randeep Guleria
BACKGROUND: Hemoptysis is common in pulmonary aspergilloma. Current treatment modalities such as surgical resection or bronchial artery embolization (BAE) are limited by lack of technical expertise and risk of recurrence, respectively. We describe our experience of treating aspergilloma and hemoptysis with bronchoscopic instillation of voriconazole. METHODS: We retrospectively reviewed records of patients with symptomatic aspergilloma undergoing bronchoscopic voriconazole instillation...
September 10, 2016: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/27614086/values-of-radiological-examinations-for-the-diagnosis-and-prognosis-of-invasive-bronchial-pulmonary-aspergillosis-in-critically-ill-patients-with-chronic-obstructive-pulmonary-diseases
#6
Linna Huang, Hangyong He, Yi Ding, Jingjing Jin, Qingyuan Zhan
INTRODUCTION: The important role of radiological examinations of invasive pulmonary aspergillosis (IPA) in patients with neutropenia has been well studied; however, little is known about IPA in critically ill chronic obstructive pulmonary disease (COPD) patients. OBJECTIVES: To evaluate the value of radiological examinations in the diagnosis and prognosis of invasive bronchial-pulmonary aspergillosis (IBPA) in critically ill COPD patients. METHODS: We included 61 critically ill COPD patients in the intensive care unit (ICU) in a retrospective, single-center cohort study...
September 10, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27538521/aspergillus-nodules-another-presentation-of-chronic-pulmonary-aspergillosis
#7
Eavan G Muldoon, Anna Sharman, Iain Page, Paul Bishop, David W Denning
BACKGROUND: There are a number of different manifestations of pulmonary aspergillosis. This study aims to review the radiology, presentation, and histological features of lung nodules caused by Aspergillus spp. METHODS: Patients were identified from a cohort attending our specialist Chronic Pulmonary Aspergillosis clinic. Patients with cavitating lung lesions, with or without fibrosis and those with aspergillomas or a diagnosis of invasive aspergillosis were excluded...
2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27481947/executive-summary-practice-guidelines-for-the-diagnosis-and-management-of-aspergillosis-2016-update-by-the-infectious-diseases-society-of-america
#8
Thomas F Patterson, George R Thompson, David W Denning, Jay A Fishman, Susan Hadley, Raoul Herbrecht, Dimitrios P Kontoyiannis, Kieren A Marr, Vicki A Morrison, M Hong Nguyen, Brahm H Segal, William J Steinbach, David A Stevens, Thomas J Walsh, John R Wingard, Jo-Anne H Young, John E Bennett
It is important to realize that guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment with respect to particular patients or special clinical situations. IDSA considers adherence to these guidelines to be voluntary, with the ultimate determination regarding their application to be made by the physician in the light of each patient's individual circumstances.
August 15, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27126721/allergic-bronchopulmonary-aspergillosis-a-perplexing-clinical-entity
#9
REVIEW
Ashok Shah, Chandramani Panjabi
In susceptible individuals, inhalation of Aspergillus spores can affect the respiratory tract in many ways. These spores get trapped in the viscid sputum of asthmatic subjects which triggers a cascade of inflammatory reactions that can result in Aspergillus-induced asthma, allergic bronchopulmonary aspergillosis (ABPA), and allergic Aspergillus sinusitis (AAS). An immunologically mediated disease, ABPA, occurs predominantly in patients with asthma and cystic fibrosis (CF). A set of criteria, which is still evolving, is required for diagnosis...
July 2016: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/27076567/transmission-of-hepatitis-b-core-antibody-and-galactomannan-enzyme-immunoassay-positivity-via-immunoglobulin-products-a-comprehensive-analysis
#10
Isobel Ramsay, Rebecca L Gorton, Mauli Patel, Sarita Workman, Andrew Symes, Tanzina Haque, Dianne Irish, Suranjith L Seneviratne, Siobhan O Burns, Emmanuel Wey, David M Lowe
BACKGROUND: Therapeutic immunoglobulins are used as replacement or immunomodulatory therapy, but can transmit clinically important molecules. We investigated hepatitis B virus (HBV) antibodies and galactomannan enzyme immunoassay (GM-EIA) positivity. Detection of HBV core antibody may prompt antiviral prophylaxis when commencing therapy such as rituximab; a positive GM-EIA result prompts investigation or treatment for invasive fungal disease. METHODS: We performed a cross-sectional analysis of HBV serology in 80 patients established (>6 months) on immunoglobulin therapy; prospective analysis of HBV serology in 16 patients commencing intravenous immunoglobulin (IVIG); and pre- and post-infusion analysis of GM-EIA in 37 patients receiving IVIG...
July 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/26905365/ct-imaging-assessment-of-response-to%C3%A2-treatment-in-chronic-pulmonary-aspergillosis
#11
Cendrine Godet, François Laurent, Anne Bergeron, Pierre Ingrand, Catherine Beigelman-Aubry, Boubou Camara, Vincent Cottin, Patrick Germaud, Bruno Philippe, Christophe Pison, Cécile Toper, Marie France Carette, Jean-Pierre Frat, Guillaume Béraud, France Roblot, Jacques Cadranel
BACKGROUND: Long-term antifungal therapy is usually the only treatment option for chronic pulmonary aspergillosis. However, response rates are difficult to compare because the reported clinical, mycologic, or radiologic criteria are not standardized. Objective parameters are therefore needed. To define the most relevant CT imaging variables in assessment of response to treatment, we investigated changes over time in CT imaging variables. METHODS: Changes in CT imaging variables were assessed by systematic analysis of the CT scan findings of 36 patients at diagnosis and 6 months after initiation of treatment...
July 2016: Chest
https://www.readbyqxmd.com/read/26879477/recent-advances-in-chronic-pulmonary-aspergillosis
#12
REVIEW
Koichi Izumikawa
Chronic pulmonary aspergillosis (CPA) is a slowly progressing pulmonary syndrome caused by Aspergillus spp. Specific knowledge regarding the disease entity, diagnosis method, and management is needed. This review focuses on the recent advances in our understanding of CPA. A new clinical disease entity of chronic progressive pulmonary aspergillosis consisting of chronic necrotizing pulmonary aspergillosis and chronic cavitary pulmonary aspergillosis is proposed. Although newer antifungals are not available, evidence describing the treatment of CPA is accumulating...
March 2016: Respiratory Investigation
https://www.readbyqxmd.com/read/26755100/clinical-evaluation-and-management-of-patients-with-suspected-fungus-sensitivity
#13
Desiree Larenas-Linnemann, Sachin Baxi, Wanda Phipatanakul, Jay M Portnoy
Fungus-sensitized patients usually present with symptoms that are similar to symptoms presented by those who are sensitized to other aeroallergens. Therefore, diagnosis and management should follow the same pathways used for patients with allergic conditions in general. The physician should consider that a relationship between fungal exposure and symptoms is not necessarily caused by an IgE-mediated mechanism, even when specific fungal IgE is detected. Until recently, IgE-mediated allergy has been documented only for a limited number of fungi...
May 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/26740298/serological-diagnosis-of-allergic-bronchopulmonary-mycosis-progress-and-challenges
#14
REVIEW
Yuma Fukutomi, Hidenori Tanimoto, Hiroshi Yasueda, Masami Taniguchi
Prompt diagnosis of allergic bronchopulmonary mycosis (ABPM) is an important clinical issue in preventing irreversible lung damage. Therefore, a good serological marker for the diagnosis of ABPM is desired in clinical practice. The measurement of IgE antibody to crude Aspergillus fumigatus allergen is considered the first step in screening asthmatic patients for allergic bronchopulmonary aspergillosis (ABPA). However, presence of IgE to A. fumigatus does not always indicate genuine sensitization to A. fumigatus because of cross-reactivity between crude extracts from different fungal sources...
January 2016: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/26631029/putative-invasive-pulmonary-aspergillosis-in-critically-ill-patients-with-chronic-obstructive-pulmonary-disease-a-matched-cohort-study
#15
Claire Delsuc, Aurélie Cottereau, Emilie Frealle, Anne-Lise Bienvenu, Rodrigue Dessein, Sophie Jarraud, Oana Dumitrescu, Marion Le Maréchal, Florent Wallet, Arnaud Friggeri, Laurent Argaud, Thomas Rimmelé, Saad Nseir, Florence Ader
INTRODUCTION: Patients with advanced chronic obstructive pulmonary disease (COPD) are at risk for developing invasive pulmonary aspergillosis. A clinical algorithm has been validated to discriminate colonization from putative invasive pulmonary aspergillosis (PIPA) in Aspergillus-positive respiratory tract cultures of critically ill patients. We focused on critically ill patients with COPD who met the criteria for PIPA. METHODS: This matched cohort study included critically ill patients with COPD from two university hospital intensive care units (ICUs)...
2015: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/25664007/misdiagnosis-of-invasive-pulmonary-aspergillosis-a-clinical-analysis-of-26-immunocompetent-patients
#16
Rongrong Zhang, Sufang Wang, Huaiwei Lu, Zhihua Wang, Xiaoling Xu
The clinical feature of invasive pulmonary aspergillosis (IPA) in immunocompromised patients is well studied in the past decades. While the manifestations of IPA in immunocompetent patients remain unclear. The purpose of this study was to determine the clinical and radiological manifestations of invasive pulmonary aspergillosis (IPA) in patients without immunosuppression, as well as the reasons for the misdiagnosis of IPA. We retrieved and retrospectively reviewed the records of 102 patients from whom surgical lung specimens of chronic inflammatory granulomas were harvested...
2014: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/25550924/clinical-in-vestigation-of-misdiagnosis-of-invasive-pulmonary-aspergillosis-in-26-immunocompetent-patients
#17
Rong-Rong Zhang, Su-Fang Wang, Huai-Wei Lu, Zhi-Hua Wang, Xiao-Ling Xu
The clinical features of invasive pulmonary aspergillosis (IPA) in immunocompromised patients is well studied in the past decades. While the manifestations of IPA in immunocompetent patients remain unclear.The purpose of this study was to determine the clinical and radiological manifestations of invasive pulmonary aspergillosis (IPA) in patients without immunosuppression, as well as the reasons for the misdiagnosis of IPA. We retrieved and retrospectively reviewed the records of 102 patients from whom surgical lung specimens of chronic inflammatory granulomas were harvested...
2014: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/9726758/acute-community-acquired-pneumonia-due-to-aspergillus-in-presumably-immunocompetent-hosts-clues-for-recognition-of-a-rare-but-fatal-disease
#18
REVIEW
C J Clancy, M H Nguyen
This article reports a case of acute community-acquired pneumonia due to Aspergillus fumigatus in a healthy patient and reviews 11 previously reported cases occurring in presumably immunocompetent hosts. The diagnosis was delayed for all patients; mortality was 100%. Clues that might suggest Aspergillus as a pathogen in community-acquired pneumonia include a chest radiograph revealing diffuse infiltrates or new cavitation; lack of bacterial or viral cause; a preceding influenza A infection; and respiratory secretion cultures positive for Aspergillus...
August 1998: Chest
https://www.readbyqxmd.com/read/21985304/aspergillosis-in-the-nonimmunocompromised-host
#19
REVIEW
David A Stevens, George L Melikian
Invasive aspergillosis has been classically associated with certain risk factors: cytotoxic chemotherapy, prolonged neutropenia, corticosteroids, transplantation, AIDS. However, the literature is growing that this mycosis, particularly pulmonary aspergillosis, can be seen in patients lacking these factors. Many of the latter patients are in the intensive care unit. Other associated conditions include influenza, nonfungal pneumonia, chronic obstructive lung disease, immaturity, sepsis, liver failure, alcoholism, chronic granulomatous disease and surgery...
2011: Immunological Investigations
https://www.readbyqxmd.com/read/14748800/new-clinical-presentations-of-invasive-aspergillosis-in-non-conventional-hosts
#20
REVIEW
D L Paterson
Infections by Aspergillus spp. are most typically associated with invasive pulmonary aspergillosis. However, an increasing number of reports deal with unusual manifestations of invasive aspergillosis. In the lung this may take the form of chronic invasive pulmonary aspergillosis, bronchocentric granulomatosis or tracehobronchitis. A number of extrapulmonary infections have been noted, sometimes in immunocompetent individuals. Examples include vertebral osteomyelitis, primary cutaneous aspergillosis (such as in premature neonates), prosthetic vascular graft infection and infective endocarditis...
March 2004: Clinical Microbiology and Infection
label_collection
label_collection
5876
1
2
2015-12-03 08:37:15
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"