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Amiodarone lung toxicity

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V Mittal, R Kulshrestha, A Arya, P Bajaj
Acute fibrinous and organising pneumonia (AFOP) is an unusual histopathological pattern of acute lung injury. The clinical manifestations, course and treatment of AFOP have yet to be characterised. All reported cases so far have described bilateral diffuse lung involvement radiologically. We report a case of an adolescent girl who presented with acute hypoxaemic respiratory failure with unilateral complete lung consolidation. She was initially diagnosed with severe community-acquired pneumonia. A computed tomography-guided percutaneous transthoracic trucut biopsy of the left lung revealed the classical histopathological pattern typically observed in AFOP...
May 2011: Singapore Medical Journal
Marc B Feinstein, Shilpa A DeSouza, Andre L Moreira, Diane E Stover, Robert T Heelan, Tunç A Iyriboz, Ying Taur, William D Travis
AIMS: Cryptogenic organising pneumonia (COP) and acute fibrinous and organising pneumonia (AFOP) are recognised patterns of organising pneumonia (OP), a condition that resembles pneumonia but is not caused by infection. We have recognised granulomatous organising pneumonia (GOP) to be a similar histopathological entity where non-necrotising granulomata are intimately associated with the organising connective tissue. To what degree COP, AFOP and GOP represent distinct clinical and pathological disorders is unknown...
June 2015: Journal of Clinical Pathology
Tokuhiro Kimura, Shigeru Kuramochi, Takaharu Katayama, Tsutomu Yoshikawa, Taketo Yamada, Yoshihiko Ueda, Yasunori Okada
Amiodarone is an anti-arrhythmic drug for life-threatening tachycardia, but various adverse effects have been reported. Reported herein is an autopsy case of valvular heart disease, in a patient who developed a lung mass (1.5 cm in diameter) and proteinuria (2.76 g/day) after treatment with amiodarone for a long time. The lung mass was highly suspected to be lung cancer on CT and positron emission tomography, but histologically the lesion was composed of lymphoplasmacytic infiltrates in alveolar walls and intra-alveolar accumulation of foamy macrophages containing characteristic myelinoid bodies, indicating that it was an amiodarone-related lesion...
October 2008: Pathology International
Lorenz H Lehmann, Wilko Weichert, Dirk Schnapauff, Rainer Dietz, Martin Stockburger
No abstract text is available yet for this article.
December 2008: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Lioudmila V Karnatovskaia, Emir Festic, Ognjen Gajic, Rickey E Carter, Augustine S Lee
PURPOSE: Amiodarone has been implicated as a risk factor for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) when used in the hospital. This study aims to estimate whether prehospital amiodarone also increases the risk of ALI/ARDS. MATERIALS: Adult patients admitted to 22 centers with at least 1 risk factor for developing ALI were recruited. In a secondary analysis of this cohort, the prehospital use of amiodarone was documented on admission, and the patients followed for the primary outcome of ALI and secondary outcomes of ARDS, the need for invasive ventilation, and mortality...
October 2012: Journal of Critical Care
Bartosz Hudzik, Lech Polonski
No abstract text is available yet for this article.
October 16, 2012: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
B Hochhegger, A Soares Souza, G Zanetti, E Marchiori
No abstract text is available yet for this article.
July 2013: Netherlands Journal of Medicine
Alberto Mella, Maria Messina, Andrea Ranghino, Paolo Solidoro, Giuseppe Tabbia, Giuseppe Paolo Segoloni, Luigi Biancone
Pneumotoxic drugs like amiodarone and m-TOR inhibitors (m-TORi) may be administered contemporaneously in therapy for patients who had renal transplants. We present a case of amiodarone pulmonary toxicity (APT) in a patient treated with amiodarone and everolimus. A 57-year-old Caucasian male, under treatment with both everolimus (for 3 years) and amiodarone (for 2 months), presented with fever, dyspnoea and a negative chest X-ray after his second kidney transplant with suboptimal serum creatinine (3 mg/dl). A non-contrastive high-resolution CT scan showed bilateral interstitial lung disease with an associated reduction in carbon monoxide diffusing capacity...
January 2014: Case Reports in Nephrology and Urology
Hack-Lyoung Kim, Jae-Bin Seo, Woo-Young Chung, Sang-Hyun Kim, Myung-A Kim, Joo-Hee Zo
BACKGROUND/AIMS: Most current knowledge regarding amiodarone toxicity derives from clinical trials. This study was performed to investigate the incidence and risk factors of overall adverse effects of amiodarone in real-world practice using a large sample size. METHODS: Between January 1, 2000 and March 10, 2012, a total of 930 consecutive patients who had been treated with amiodarone for arrhythmia were reviewed retrospectively. An amiodarone-associated adverse event was considered in cases of discontinuation or drug dose reduction due to an unexpected clinical response...
September 2014: Korean Journal of Internal Medicine
Ernest Oh, Nauman Siddiqui, Emma Worringer, Kirsten Schroeder, Stephen Markowiak, Mohammad Alrehaili, Fadi Safi, Bryan T Hinch, Ragheb Assaly
No abstract text is available yet for this article.
January 2015: American Journal of the Medical Sciences
S G Delany, D R Taylor, N Restieaux, T C Doyle
Two cases of pulmonary toxicity associated with chronic ingestion of amiodarone are presented. Special emphasis is given to the radiological features which may aid in the clinical diagnosis of this disorder.
February 1993: Australasian Radiology
Adam Podstawka, Jerzy Mosiewicz, Wojciech Myśliński
Amiodarone is a widely used antiarrhythmic drug, however, not without numerous side-effects. One of them is a potentially adverse reaction upon the respiratory system which can assume the form of acute respiratory failure, interstitial pneumonitis, parenchymal infiltrates, pleural effusion or bronchiolitis obliterans organizing pneumonia. For this reason prior to the onset of the long-term amiodarone therapy initial chest x-ray and spirometry should be made and in the course of the treatment spirometry and radiological monitoring should be carried out...
2004: Annales Universitatis Mariae Curie-Skłodowska. Sectio D: Medicina
S S Kothari, S Balijepally, K Taneja
We report amiodarone-induced pulmonary toxicity in an 18-year-old boy who had undergone corrective surgery for tetralogy of Fallot 4 years earlier, and was treated with amiodarone because of recurrent malignant postoperative ventricular tachyarrhythmias. Toxicity was recognized on the basis of clinical features, chest X-ray, high-resolution contrast enhanced computerized tomography, and resolution of the findings subsequent to withdrawal of amiodarone and treatment with steroids. Pulmonary toxicity due to amiodarone, as far as we know, has not been reported in children and young adults, and its occurence even in young adults requires wider appreciation...
March 1999: Cardiology in the Young
S C Conte, V Pagan, B Murer
The most common lung tissue reaction to amiodarone toxicity is a nonspecific pulmonary chronic interstitial pneumonia. In a minority of patients diffuse alveolar damage, alveolar haemorrhage or bronchiolitis obliterans organizing pneumonia (BOOP) is encountered. We report the case of a patient with clinical, functional, radiological and histological signs of BOOP secondary to amiodarone. The condition was partially reversible after suspending drug treatment, and resolved after corticosteroid treatment without relapse after a 14 month follow-up...
February 1997: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
C W Bedrossian, C J Warren, J Ohar, R Bhan
One hundred ninety cardiac patients were prospectively enrolled in an amiodarone protocol. Over a 10-year period, 16 patients developed new or progressive respiratory symptoms while taking amiodarone. These symptoms included dyspnea associated with abnormal chest radiographs or new or worsening abnormalities on pulmonary function testing. Specimens for microscopic examination were obtained by fiberoptic bronchoscopy with transbronchial lung biopsy (TBB), bronchoalveolar lavage (BAL), open lung biopsy (OLB), or autopsy...
October 1997: Annals of Diagnostic Pathology
M Terra-Filho, J C Meneghetti, A Cukier, L R Teixeira, J Soares Júnior, E E Camargo, F S Vargas
The aim of this study was to compare gallium-67 citrate lung imaging with the pulmonary clearance of 99mTc-DTPA (technetium 99m diethylenetriaminepentaacetic acid) in 9 patients with amiodarone pneumonitis (8 males and 1 female, aged 58 to 76 years). The diagnosis of amiodarone pneumonitis was based on clinical and radiological grounds in all patients, and histological changes in seven. The mean values for the effective half-life of the pulmonary clearance of 99mTc-DTPA aerosol were below the normal range in all 9 patients, and lower than the values obtained previously for patients on a long-term amiodarone regimen without side effects...
November 1996: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
A E Fraire, K K Guntupalli, S D Greenberg, J Cartwright, M H Chasen
Amiodarone, a benzofuran derivative, has proven useful in the control of serious cardiac arrhythmias. We reviewed the English language medical literature to characterize clinical, radiographic, scintigraphic, pathologic, diagnostic, and prognostic data concerning amiodarone pulmonary toxicity. Our review showed that features consistent with amiodarone pulmonary toxicity include exertional dyspnea, fever, and high sedimentation rates, usually in patients taking larger maintenance doses. Positive findings on gallium scan, foamy alveolar macrophages on lung biopsy or bronchoalveolar lavage, and resolution of abnormal chest roentgenogram upon withdrawal of amiodarone and/or institution of corticosteroid therapy support a diagnosis of amiodarone pulmonary toxicity...
January 1993: Southern Medical Journal
Bruce D Uhal, Rongqi Wang, Jeremy Laukka, Jiaju Zhuang, Valerie Soledad-Conrad, Gerasimos Filippatos
Earlier work in this laboratory showed that amiodarone induces apoptosis in alveolar epithelial cells by a mechanism inhibitable by angiotensin system antagonists. A variety of recent studies suggests a critical role for alveolar epithelial cell apoptosis in the pathogenesis of lung fibrosis. On this basis we hypothesized that amiodarone-induced alveolar epithelial cell apoptosis and lung fibrosis in vivo might be inhibitable by the angiotensin converting enzyme inhibitor captopril or the angiotensin receptor antagonist losartan...
February 2003: Pharmacology & Toxicology
V A Varney, M Warren, M Palmer
A 61 year old former paramedic presented to A&E complaining of palpitations. He was found to be in atrial fibrillation, which reverted spontaneously to sinus rhythm. A chest x-ray taken at that time showed multiple pulmonary nodules consistent with metastatic malignancy (Figure 1). In the past he had been treated with amiodarone 200mg daily for 6 years following a previous diagnosis of atrial fibrillation, which had been attributed to alcoholic cardiomyopathy. He had discontinued the drug 8 months earlier, after self diagnosing hypotension and bradycardia...
2005: Acute Medicine
J E Kuhlman, J C Scatarige, E K Fishman, E A Zerhouni, S S Siegelman
We report a case in which CT demonstrated high attenuation pleural-parenchymal lesions (142-175 HU) and increased liver density (96.7 HU) in a patient on long-term amiodarone therapy.
January 1987: Journal of Computer Assisted Tomography
2015-12-02 21:34:10
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