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26 papers 25 to 100 followers
Barbara Jones, Nathan Dean, Richard Wunderink, Marianna Sockrider
No abstract text is available yet for this article.
January 1, 2016: American Journal of Respiratory and Critical Care Medicine
Bryan R Haugen, Erik K Alexander, Keith C Bible, Gerard M Doherty, Susan J Mandel, Yuri E Nikiforov, Furio Pacini, Gregory W Randolph, Anna M Sawka, Martin Schlumberger, Kathryn G Schuff, Steven I Sherman, Julie Ann Sosa, David L Steward, R Michael Tuttle, Leonard Wartofsky
BACKGROUND: Thyroid nodules are a common clinical problem, and differentiated thyroid cancer is becoming increasingly prevalent. Since the American Thyroid Association's (ATA's) guidelines for the management of these disorders were revised in 2009, significant scientific advances have occurred in the field. The aim of these guidelines is to inform clinicians, patients, researchers, and health policy makers on published evidence relating to the diagnosis and management of thyroid nodules and differentiated thyroid cancer...
January 2016: Thyroid: Official Journal of the American Thyroid Association
(no author information available yet)
No abstract text is available yet for this article.
January 2016: Diabetes Care
Martin H Strauss, Alistair S Hall
The renin angiotensin aldosterone system (RAAS) plays a central role in the pathophysiology of hypertension and vascular disease. Angiotensin converting enzyme inhibitors (ACEis) suppress angiotensin II (ANG II) concentrations, whereas angiotensin receptor blockers (ARBs) block the binding of ANG II to AT1 receptors. ACEis and ARBs are both effective anti-hypertensive agents and have similar risk reductions in stroke - a blood pressure dependent phenomenon. ACEis also reduce the risk of myocardial infarction (MI) and mortality in high risk hypertensive patients, as well as in diabetics, the elderly, those with vascular disease, and in congestive heart failure...
March 2016: Progress in Cardiovascular Diseases
Ferenc Czeyda-Pommersheim, Misun Hwang, Sue Si Chen, Diane Strollo, Carl Fuhrman, Sanjeev Bhalla
Amyloidosis is a rare diverse condition caused by the pathologic extracellular deposition of abnormal insoluble proteins throughout the body. It may exist as a primary disease or, more commonly, may be secondary to a wide variety of pathologic processes ranging from chronic infection or inflammation to malignancy. Hereditary forms also exist. On the basis of the structure of the protein deposits, more than two dozen subtypes of amyloidosis have been described. A single organ or multiple organ systems may be affected...
September 2015: Radiographics: a Review Publication of the Radiological Society of North America, Inc
L Lee Hamm, Nazih Nakhoul, Kathleen S Hering-Smith
Acid-base homeostasis and pH regulation are critical for both normal physiology and cell metabolism and function. The importance of this regulation is evidenced by a variety of physiologic derangements that occur when plasma pH is either high or low. The kidneys have the predominant role in regulating the systemic bicarbonate concentration and hence, the metabolic component of acid-base balance. This function of the kidneys has two components: reabsorption of virtually all of the filtered HCO3(-) and production of new bicarbonate to replace that consumed by normal or pathologic acids...
December 7, 2015: Clinical Journal of the American Society of Nephrology: CJASN
Tricia M McKeever, Glenn Hearson, Gemma Housley, Catherine Reynolds, William Kinnear, Tim W Harrison, Anne-Maree Kelly, Dominick E Shaw
INTRODUCTION: Identifying acute hypercapnic respiratory failure is crucial in the initial management of acute exacerbations of COPD. Guidelines recommend obtaining arterial blood samples but these are more difficult to obtain than venous. We assessed whether blood gas values derived from venous blood could replace arterial at initial assessment. METHODS: Patients requiring hospital treatment for an exacerbation of COPD had paired arterial and venous samples taken...
March 2016: Thorax
Eric C Eichenwald
Apnea of prematurity is one of the most common diagnoses in the NICU. Despite the frequency of apnea of prematurity, it is unknown whether recurrent apnea, bradycardia, and hypoxemia in preterm infants are harmful. Research into the development of respiratory control in immature animals and preterm infants has facilitated our understanding of the pathogenesis and treatment of apnea of prematurity. However, the lack of consistent definitions, monitoring practices, and consensus about clinical significance leads to significant variation in practice...
January 2016: Pediatrics
Paul Elbers, Tim Rodrigus, Esther Nossent, Manu L N G Malbrain, Anton Vonk-Noordegraaf
As right heart function can affect outcome in the critically ill patient, a thorough understanding of factors determining right heart performance in health and disease is pivotal for the critical care physician. This review focuses on fluid therapy, which remains controversial in the setting of impending or overt right heart failure. In this context, we will attempt to elucidate which patients are likely to benefit from fluid administration and for which patients fluid therapy would likely be harmful. Following a general discussion of right heart function and failure, we specifically focus on important causes of right heart failure in the critically ill, i...
2015: Anaesthesiology Intensive Therapy
Julian L Wichmann, Richard W Katzberg, Sheldon E Litwin, Peter L Zwerner, Carlo N De Cecco, Thomas J Vogl, Philip Costello, U Joseph Schoepf
No abstract text is available yet for this article.
November 17, 2015: Circulation
(no author information available yet)
No abstract text is available yet for this article.
May 5, 2015: Annals of Internal Medicine
Anne R Cappola, David S Cooper
No abstract text is available yet for this article.
May 5, 2015: Annals of Internal Medicine
A Lianne Messchendorp, Ron T Gansevoort
No abstract text is available yet for this article.
March 5, 2015: New England Journal of Medicine
Libby Schaefer, Julie M Paik, Helmut Rennke, Bruce D Levy, Joseph Loscalzo
A 58-year-old woman presented with a 2-week history of generalized pruritus. She also reported having fatigue, dizziness, and decreased appetite. A week before the onset of symptoms, a mild upper respiratory tract infection had developed.
March 5, 2015: New England Journal of Medicine
Dong-Lai Ma, Jin Hu
A 4-year-old girl presented for evaluation of cutaneous nodules that had been present on the left side of her trunk since birth. Physical examination revealed numerous soft, nontender papules and nodules across the left upper abdomen and wrapping around to the back.
March 5, 2015: New England Journal of Medicine
Amesh A Adalja, Eric Toner, Thomas V Inglesby
The agents most likely to be used in bioterrorism attacks are reviewed, along with the clinical syndromes they produce and their treatment.
March 5, 2015: New England Journal of Medicine
Shlomi Laufer, Elaine R Cohen, Calvin Kwan, Anne-Lise D D'Angelo, Rachel Yudkowsky, John R Boulet, William C McGaghie, Carla M Pugh
To the Editor: Clinical-skills assessments provide motivation and direction for learning. Adoption of simulation-based education methods has introduced a wide variety of options for clinical-performance assessment. To explore the potential value added by integrating sensor technology with a skills..
February 19, 2015: New England Journal of Medicine
Eduardo A Rodriguez, Marvin A Lopez, Kartik Valluri, Danlu Wang, Andrew Fischer, Tatiana Perdomo
BACKGROUND: The gastrointestinal tract is a rare site for extramedullary involvement in acute promyelocytic leukemia (APL). CASE REPORT: A 43-year-old female with no past medical history presented complaining of mild abdominal pain, fever, and chills for the past day. On examination, she was tachycardic and febrile, with mild tenderness of her right lower quadrant and without signs of peritoneal irritation. Laboratory examination revealed pancytopenia and DIC, with a fibrinogen level of 290 mg/dL...
2015: American Journal of Case Reports
Dmitri Belov, Radmila Lyubarova, Steven Fein, Mikhail Torosoff
BACKGROUND: Coagulation abnormalities can accompany acute congestive heart failure (CHF). However, disseminated intravascular coagulation (DIC) is rarely documented in such patients. DIC is characterized by generalized excessive activation of coagulation pathways followed by their depletion with secondary activation of anticoagulation and fibrinolysis. Treatment of the cause is an integral part of management of DIC; thus, recognition of the cause is critical. CASE REPORT: A 55-year-old previously healthy man presented with breathlessness, swelling of both legs, and left leg pain...
January 31, 2015: American Journal of Case Reports
John Wain, Rene S Hendriksen, Matthew L Mikoleit, Karen H Keddy, R Leon Ochiai
Control of typhoid fever relies on clinical information, diagnosis, and an understanding for the epidemiology of the disease. Despite the breadth of work done so far, much is not known about the biology of this human-adapted bacterial pathogen and the complexity of the disease in endemic areas, especially those in Africa. The main barriers to control are vaccines that are not immunogenic in very young children and the development of multidrug resistance, which threatens efficacy of antimicrobial chemotherapy...
March 21, 2015: Lancet
2015-12-02 13:19:41
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