Read by QxMD icon Read


shared collection
23 papers 0 to 25 followers
David H Birnie, Riina Kandolin, Pablo B Nery, Markku Kupari
Approximately 5% of patients with sarcoidosis will have clinically manifest cardiac involvement presenting with one or more of ventricular arrhythmias, conduction abnormalities, and heart failure. Cardiac presentations can be the first (and/or an unrecognized) manifestation of sarcoidosis in a variety of circumstances. Cardiac symptoms are usually dominant over extra-cardiac as most patients with clinically manifest disease have minimal extra-cardiac disease and up to two-thirds have isolated cardiac sarcoidosis (CS)...
July 28, 2016: European Heart Journal
Alfonso Carleo, David Bennett, Paola Rottoli
PURPOSE OF REVIEW: System biology is an interdisciplinary approach with the purpose to evaluate the experimental results of '-omics' sciences as a whole. The '-omics' sciences do not start generally from a-priori assumptions and are aimed to study the constituents of a specific biological domain (genome, transcriptome, proteome and metabolome) in a given state, using different high-throughput technologies (as polymerase chain reaction, arrays, liquid chromatography, mass spectrometry, etc...
September 2016: Current Opinion in Pulmonary Medicine
Stefano Palmucci, Sebastiano Emanuele Torrisi, Daniele Carmelo Caltabiano, Silvia Puglisi, Viviana Lentini, Emanuele Grassedonio, Virginia Vindigni, Ester Reggio, Riccardo Giuliano, Giuseppe Micali, Rosario Caltabiano, Cosma Andreula, Pietro Valerio Foti, Giovanni Carlo Ettorre, Simon Lf Walsh, Carlo Vancheri
UNLABELLED: The aim of this manuscript is to describe radiological findings of extra-pulmonary sarcoidosis. Sarcoidosis is an immune-mediated systemic disease of unknown origin, characterized by non-caseating epitheliod granulomas. Ninety percent of patients show granulomas located in the lungs or in the related lymph nodes. However, lesions can affect any organ. Typical imaging features of liver and spleen sarcoidosis include visceromegaly, with multiple nodules hypodense on CT images and hypointense on T2-weighted MRI acquisitions...
August 2016: Insights Into Imaging
Eva M Carmona, Sanjay Kalra, Jay H Ryu
Sarcoidosis is a chronic granulomatous disease of unknown cause that is seen worldwide and occurs mainly in patients between the ages of 20 and 60 years. It can be difficult to diagnose because it can mimic many other diseases including lymphoproliferative disorders and granulomatous infections and because there is no specific test for diagnosis, which depends on correlation of clinicoradiologic and histopathologic features. This review will focus on recent discoveries regarding the pathogenesis of sarcoidosis, common clinical presentations, diagnostic evaluation, and indications for treatment...
July 2016: Mayo Clinic Proceedings
Catherine A Bonham, Mary E Strek, Karen C Patterson
PURPOSE OF REVIEW: Up to twenty percent of patients with sarcoidosis develop pulmonary fibrosis, transforming an often benign disease into a highly morbid and potentially fatal one. We highlight the fibrotic pulmonary sarcoidosis phenotype as an area of intense clinical and translational investigation, review recent developments in treatment, and provide a roadmap for future research in sarcoidosis associated pulmonary fibrosis. RECENT FINDINGS: Granulomatous inflammation in a lymphatic distribution is the hallmark finding of pulmonary sarcoidosis and the nidus for fibrosis...
September 2016: Current Opinion in Pulmonary Medicine
Florence Jeny, Diane Bouvry, Olivia Freynet, Michael Soussan, Michel Brauner, Carole Planes, Hilario Nunes, Dominique Valeyre
Sarcoidosis is a systemic disease of unknown cause with very diverse presentation, outcome, severity and need for treatments. While some presentations may be very typical, for many patients, the presentation is nonspecific, with shared associations with other diseases at times being by far more frequent or misleading, which can be a cause of significant delay and often several consultations before a diagnosis of sarcoidosis can be confirmed. This is particularly the case when pulmonary manifestations are in the forefront...
June 2016: European Respiratory Review: An Official Journal of the European Respiratory Society
Heleen A Crommelin, Leone M van der Burg, Adriane D M Vorselaars, Marjolein Drent, Coline H M van Moorsel, Ger T Rijkers, Vera H M Deneer, Jan C Grutters
BACKGROUND: Tumor necrosis factor-alpha (TNF-α) inhibitors are regarded as the third-line therapy in sarcoidosis, the first choice generally being infliximab. To date, data regarding response to adalimumab in sarcoidosis patients intolerant to infliximab are lacking. The objective of this retrospective observational study was to establish if adalimumab could achieve stabilization or improvement of the disease in refractory sarcoidosis patients who developed intolerance to infliximab...
June 2016: Respiratory Medicine
Mafalda Trindade Soares, Carolina Sousa, Luísa Garanito, Filipe Freire
Sarcoidosis is a chronic granulomatous disease of unknown aetiology. It can affect any part of the organism, although the lung is the most frequently affected organ. Upper airway involvement is rare, particularly if isolated. Sarcoidosis is a diagnosis of exclusion, established by histological evidence of non-caseating granulomas and the absence of other granulomatous diseases. The authors report a case of a man with sarcoidosis manifesting as a chronic inflammatory stenotic condition of the upper respiratory tract and trachea...
2016: BMJ Case Reports
Ying Zhou, Elyse E Lower, Huiping Li, Robert P Baughman
Sarcoidosis is a multisystem disease for which diagnosis relies on the integration of clinical, radiologic, laboratory, and pathologic information. Assessment of clinical features is an important part of the disease evaluation. Computer Tomography provides information not available on routine chest roentgenogram which can assist diagnosing and establishing extent of disease. Monitoring for pulmonary and extra-pulmonary disease facilitates disease management. Patients with quality of life affecting symptoms or threatened end organ damage require systemic treatment which can be recommended in a stepwise fashion...
2016: Expert Review of Respiratory Medicine
Francesca Conti, Saul Oswaldo Lugo-Reyes, Lizbeth Blancas Galicia, Jianxin He, Güzide Aksu, Edgar Borges de Oliveira, Caroline Deswarte, Marjorie Hubeau, Neslihan Karaca, Maylis de Suremain, Antoine Guérin, Laila Ait Baba, Carolina Prando, Gloria G Guerrero, Melike Emiroglu, Fatma Nur Öz, Marco Antonio Yamazaki Nakashimada, Edith Gonzalez Serrano, Sara Espinosa, Isil Barlan, Nestor Pérez, Lorena Regairaz, Héctor Eduardo Guidos Morales, Liliana Bezrodnik, Daniela Di Giovanni, Ghassan Dbaibo, Fatima Ailal, Miguel Galicchio, Matias Oleastro, Jalel Chemli, Silvia Danielian, Laura Perez, Maria Claudia Ortega, Susana Soto Lavin, Joseph Hertecant, Ozden Anal, Nadia Kechout, Eman Al-Idrissi, Gehad ElGhazali, Anastasia Bondarenko, Liudmyla Chernyshova, Peter Ciznar, Rose-Marie Herbigneaux, Aminata Diabate, Stéphanie Ndaga, Barik Konte, Ambre Czarna, Mélanie Migaud, Sigifredo Pedraza-Sánchez, Mussaret Bano Zaidi, Guillaume Vogt, Stéphane Blanche, Imen Benmustapha, Davood Mansouri, Laurent Abel, Stéphanie Boisson-Dupuis, Nizar Mahlaoui, Ahmed Aziz Bousfiha, Capucine Picard, Ridha Barbouche, Saleh Al-Muhsen, Francisco J Espinosa-Rosales, Necil Kütükçüler, Antonio Condino-Neto, Jean-Laurent Casanova, Jacinta Bustamante
BACKGROUND: Chronic granulomatous disease (CGD) is a rare primary immunodeficiency caused by inborn errors of the phagocyte nicotinamide adenine dinucleotide phosphate oxidase complex. From the first year of life onward, most affected patients display multiple, severe, and recurrent infections caused by bacteria and fungi. Mycobacterial infections have also been reported in some patients. OBJECTIVE: Our objective was to assess the effect of mycobacterial disease in patients with CGD...
July 2016: Journal of Allergy and Clinical Immunology
Y Uzunhan, F Jeny, F Crockett, D Piver, M Kambouchner, D Valeyre, H Nunes
Sarcoidosis is a granulomatous disease of unknown cause. This proteiform disease is characterized by an almost constant and often predominant lung involvement. The natural history of disease is difficult to predict at presentation. Diagnosis is based on a compatible clinical and radiological presentation and evidence of non-caseating granulomas. Exclusion of alternative diseases is also required according to clinical presentation. Biopsy samples of superficial lesions should be considered before other sites like per-endoscopic bronchial biopsies or endobronchial ultrasound-guided transbronchial needle aspiration...
September 2016: La Revue de Médecine Interne
Vanessa Yap, Edward Salerno, Debapriya Datta
Sarcoidosis is a systemic granulomatous disease of unknown etiology. Pulmonary involvement is common, but lung nodules in sarcoidosis are uncommon, and solitary nodules that cavitate are extremely rare. Nodular sarcoidosis is usually found in young, healthy, predominantly female individuals. These lesions need to be differentiated from multiple other conditions, including neoplasms and granulomatous infections. A thorough workup for other etiologies of cavitary lung lesions is required for diagnosis. Despite an ominous presentation, nodular cavitary sarcoidosis portends a favorable outcome...
January 2016: Connecticut Medicine
Keishi Fujiwara, Yasushi Furuta, Satoshi Fukuda
Heerfordt's syndrome is a rare manifestation of sarcoidosis characterized by the presence of facial nerve palsy, parotid gland enlargement, anterior uveitis, and low grade fever. Two cases of Heerfordt's syndrome and a literature review are presented. Case  1. A 53-year-old man presented with swelling of his right eyelid, right facial nerve palsy, and swelling of his right parotid gland. A biopsy specimen from the swollen eyelid indicated sarcoidosis and he was diagnosed with incomplete Heerfordt's syndrome based on the absence of uveitis...
2016: Case Reports in Otolaryngology
Edward Hulten, Saira Aslam, Michael Osborne, Siddique Abbasi, Marcio Sommer Bittencourt, Ron Blankstein
Sarcoidosis is a multi-system inflammatory disorder of unknown etiology resulting in formation of non-caseating granulomas. Cardiac involvement-which is associated with worse prognosis-has been detected in approximately 25% of individuals based on autopsy or cardiac imaging studies. Nevertheless, the diagnosis of cardiac sarcoidosis is challenging due to the low yield of endomyocardial biopsy, and the limited accuracy of various clinical criteria. Thus, no gold standard diagnostic criterion exists. This review will summarize the pathophysiology, diagnosis, and treatment of cardiac sarcoidosis with a focus on advanced cardiovascular imaging, We review the evidence to support a role for cardiac magnetic resonance (CMR) imaging in the initial evaluation of selected patients with suspected cardiac sarcoidosis, with cardiac positron emission tomography (PET) as an alternative or complementary initial diagnostic test in a subgroup of patients in whom CMR may be contra-indicated or when CMR is negative with continued clinical concern for myocardial inflammation...
February 2016: Cardiovascular Diagnosis and Therapy
Anna Goljan-Geremek, Marcin Geremek, Elzbieta Puscinska, Pawel Sliwinski
The association between venous thromboembolism (VTE) and sarcoidosis has been reported recently, nevertheless the true incidence of co-incident sarcoidosis and VTE is unknown. Sarcoidosis as a chronic disease of immune dysregulation might be associated with an increased risk of VTE. The mechanisms responsible for VTE development are not clear and may be influenced by several factors: activity of inflammation, clinical characteristics of sarcoidosis and comorbidities. Pulmonary embolism (PE) as a potentially fatal condition should be considered in all of the patients with sarcoidosis in whom worsening of the respiratory status is diagnosed...
2015: Central-European Journal of Immunology
Brian A Houston, Carolyn Park, Monica Mukherjee
Cardiac sarcoidosis is a protean disease, capable of causing nearly any cardiac abnormality. Electrical abnormalities including heart block and ventricular tachyarrhythmias are some of the most feared manifestations of cardiac sarcoidosis. Despite increasing awareness, cardiac sarcoidosis remains underdiagnosed in clinical practice, and as a result, many patients do not receive potentially disease-altering immunosuppressant therapy. In this review, we discuss cardiac sarcoidosis and its management, focusing diagnostic and therapeutic approaches to arrhythmias in cardiac sarcoidosis...
March 2016: Current Treatment Options in Cardiovascular Medicine
Simon Dubrey, Rakesh Sharma, Richard Underwood, Tarun Mittal, Athol Wells
Sarcoidosis is a multi-system disease with a wide range of phenotypes. Pulmonary involvement is the most frequently identified target for sarcoidosis and is responsible for the majority of deaths. Cardiac sarcoid is less commonly identified, may be occult, is significantly influenced by race, and can portend an unpredictable and sometimes fatal outcome. Sarcoidosis remains an enigmatic disease spectrum of unknown aetiology, frequently difficult to diagnose and with a variable disease course. This article summarises current views on the diagnosis and management of cardiopulmonary involvement...
February 2016: Clinical Medicine: Journal of the Royal College of Physicians of London
Gillian Murtagh, Luke J Laffin, John F Beshai, Francesco Maffessanti, Catherine A Bonham, Amit V Patel, Zoe Yu, Karima Addetia, Victor Mor-Avi, Joshua D Moss, D Kyle Hogarth, Nadera J Sweiss, Roberto M Lang, Amit R Patel
BACKGROUND: Cardiac sarcoidosis is associated with an increased risk of heart failure and sudden death, but its risk in patients with preserved left ventricular ejection fraction is unknown. Using cardiovascular magnetic resonance in patients with extracardiac sarcoidosis and preserved left ventricular ejection fraction, we sought to (1) determine the prevalence of cardiac sarcoidosis or associated myocardial damage, defined by the presence of late gadolinium enhancement (LGE), (2) quantify their risk of death/ventricular tachycardia (VT), and (3) identify imaging-based covariates that predict who is at greatest risk of death/VT...
January 2016: Circulation. Cardiovascular Imaging
Patompong Ungprasert, Eva M Carmona, James P Utz, Jay H Ryu, Cynthia S Crowson, Eric L Matteson
OBJECTIVE: To characterize the epidemiology of sarcoidosis from 1946 through 2013. PATIENTS AND METHODS: An inception cohort of patients with incident sarcoidosis from January 1, 1976, through December 31, 2013, in Olmsted County, Minnesota, was identified based on comprehensive individual medical record review. Inclusion required physician diagnosis supported by histopathologic confirmation, radiologic features of intrathoracic sarcoidosis, and a compatible clinical presentation...
February 2016: Mayo Clinic Proceedings
Kengo F Kusano, Kazuhiro Satomi
Sarcoidosis is a systemic granulomatous disease of unknown aetiology. The frequency of cardiac involvement (cardiac sarcoidosis (CS)) varies in the different geographical regions, but it has been reported that it is an absolutely important prognostic factor in this disease. Complete atrioventricular block is the most common, and ventricular tachycardia/ventricular fibrillation the second most common arrhythmia in this disease, both of which are associated with cardiac sudden death. Diagnosing CS is sometimes difficult because of the non-specific ECG and echocardiographic findings, and CS is sometimes misdiagnosed as dilated cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy or an idiopathic ventricular aneurysm, and therefore, endomyocardial biopsy is important, but has a low sensitivity...
February 2016: Heart: Official Journal of the British Cardiac Society
2015-12-10 22:25:45
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"