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Cirrhotic cardiomyopathy

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https://www.readbyqxmd.com/read/25848474/cirrhotic-cardiomyopathy-implications-for-the-perioperative-management-of-liver-transplant-patients
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Suehana Rahman, Susan V Mallett
Cirrhotic cardiomyopathy is a disease that has only recently been recognised as a definitive clinical entity. In the setting of liver cirrhosis, it is characterized by a blunted inotropic and chronotropic response to stress, impaired diastolic relaxation of the myocardium and prolongation of the QT interval in the absence of other known cardiac disease. A key pathological feature is the persistent over-activation of the sympathetic nervous system in cirrhosis, which leads to down-regulation and dysfunction of the β-adrenergic receptor...
March 27, 2015: World Journal of Hepatology
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