Hanne T Olsen, Helene K Nedergaard, Thomas Strøm, Jakob Oxlund, Karl-Andre Wian, Lars M Ytrebø, Bjørn A Kroken, Michelle Chew, Serkan Korkmaz, Jørgen T Lauridsen, Palle Toft
BACKGROUND: In critically ill, mechanically ventilated patients, daily interruption of sedation has been shown to reduce the time on ventilation and the length of stay in the intensive care unit (ICU). Data on whether a plan of no sedation, as compared with a plan of light sedation, has an effect on mortality are lacking. METHODS: In a multicenter, randomized, controlled trial, we assigned, in a 1:1 ratio, mechanically ventilated ICU patients to a plan of no sedation (nonsedation group) or to a plan of light sedation (i...
March 19, 2020: New England Journal of Medicine