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IgG4-related kidney disease

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4 papers 0 to 25 followers
By P O Pediatrics, Nephrology
Takako Saeki, Mitsuhiro Kawano, Ichiro Mizushima, Motohisa Yamamoto, Yoko Wada, Yoshifumi Ubara, Hitoshi Nakashima, Tomoyuki Ito, Hajime Yamazaki, Ichiei Narita, Takao Saito
BACKGROUND: Although renal dysfunction in IgG4-related kidney disease (IgG4-RKD) shows rapid resolution with glucocorticoid therapy, little is known about the appropriate initial glucocorticoid dose for induction therapy or long-term renal outcome. METHODS: We retrospectively examined the differences in recovery of renal function according to the dose of glucocorticoid used for induction therapy and the long-term renal outcome in 43 patients with definite IgG4-RKD (mostly IgG4-tubulointerstitial nephritis), in whom the estimated glomerular filtration rate (eGFR) before glucocorticoid therapy was <60 ml/min...
February 2016: Clinical and Experimental Nephrology
Loreto Fernández Lorente, Dolores López Álvarez, Virginia García López, Vesna Abujder Kollros, Aurelio Ariza, Alejandro Gálvez, Josep Bonet
This is a case report of a 73-year-old man with new-onset acute renal failure while being investigated for pulmonary infiltrates and mediastinal lymphadenopathies. Urine tests showed tubular range proteinuria with no microhaematuria. Immunology tests showed elevated serum IgG and hypocomplementaemia (classical pathway activation). Renal biopsy and clinical-pathological correlation were crucial in this case, reinforcing their important role in the final diagnosis of acute kidney injury.
2015: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
Nieun Seo, Jin Hee Kim, Jae Ho Byun, Seung Soo Lee, Hyoung Jung Kim, Moon-Gyu Lee
Immunoglobulin G4 (IgG4)-related kidney disease (IgG4-KD) has recently been demonstrated to be an important part of IgG4-related sclerosing disease (IgG4-SD). However, since IgG4-KD is still relatively unfamiliar to radiologists and physicians as compared to IgG4-SD involving other organs, it could, therefore, be easily missed. In this article, we present a comprehensive pictorial review of IgG4-KD with regards to the imaging spectrum, mimickers, and clinicopathologic characteristics, based on our clinical experience with 48 patients during the past 13 years, as well as a literature review...
September 2015: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
Vijaya B P Ramasamy, Rhiannon Trefor, Kaushik Rajamani, Divya Santosh, David Griffiths, Kieron Donovan
Immunoglobulin G4-related disease (IgG4-RD) is a systemic inflammatory condition that may involve any organ in the body, including the kidneys. However, renal parenchymal lesions are not seen frequently and the treatment strategy remains unclear. We describe a case of IgG4-related renal mass, which resolved spontaneously. The patient presented with right loin pain, constitutional symptoms and raised inflammatory markers. Magnetic resonance imaging (MRI) showed a large infiltrative mass centered on the right renal hilum and biopsy demonstrated histological changes in keeping with IgG4-RD...
August 2015: Clinical Medicine: Journal of the Royal College of Physicians of London
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