Takako Saeki, Mitsuhiro Kawano, Ichiro Mizushima, Motohisa Yamamoto, Yoko Wada, Yoshifumi Ubara, Hitoshi Nakashima, Tomoyuki Ito, Hajime Yamazaki, Ichiei Narita, Takao Saito
BACKGROUND: Although renal dysfunction in IgG4-related kidney disease (IgG4-RKD) shows rapid resolution with glucocorticoid therapy, little is known about the appropriate initial glucocorticoid dose for induction therapy or long-term renal outcome. METHODS: We retrospectively examined the differences in recovery of renal function according to the dose of glucocorticoid used for induction therapy and the long-term renal outcome in 43 patients with definite IgG4-RKD (mostly IgG4-tubulointerstitial nephritis), in whom the estimated glomerular filtration rate (eGFR) before glucocorticoid therapy was <60 ml/min...
February 2016: Clinical and Experimental Nephrology