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Acute tubulointerstitial nephritis

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6 papers 0 to 25 followers
By P O Pediatrics, Nephrology
Mathieu Legendre, Hervé Devilliers, Laurent Perard, Matthieu Groh, Habdelamid Nefti, Bertrand Dussol, Salim Trad, Fatouma Touré, Sébastien Abad, Jean-Jacques Boffa, Luc Frimat, Stéphane Torner, Alexandre Seidowsky, Ziad André Massy, David Saadoun, Virginie Rieu, Yoland Schoindre, Emmanuel Heron, Thierry Frouget, Arnaud Lionet, François Glowacki, Laurent Arnaud, Christiane Mousson, Jean-François Besancenot, Jean-Michel Rebibou, Philip Bielefeld
Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disease, defined by the association of idiopathic acute TINU. The aim of our work was to determine the characteristics of adult TINU syndrome in France, and to assess factors (including treatment) influencing medium-term prognosis.We conducted a nationwide study including 20 French hospitals. Clinical, laboratory, and renal histopathologic data of 41 biopsy-proven TINU syndromes were retrospectively collected. The patients were diagnosed between January 1, 1999 and December 1, 2015...
June 2016: Medicine (Baltimore)
Marianella Howell, Neil J Sebire, Stephen D Marks, Kjell Tullus
BACKGROUND: Tubulointerstitial nephritis (TIN) is an uncommon condition in which the aetiology, treatment and outcome is not well defined. We describe a large series of children with biopsy-proven TIN. METHODS: All children with biopsy-proven TIN presenting to our institution during a 23-year period were retrospectively reviewed for aetiology, symptoms, treatment, and long-term outcome. RESULTS: A total of 27 children (16 girls) were described...
October 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Agnieszka A Pozdzik, Celso Matos, Sandrine Rorive, Isabelle Brocheriou, Daniel Van Gansbeke, Myriam Delhaye, Joëlle L Nortier, G H Neild
No abstract text is available yet for this article.
April 2013: Clinical Kidney Journal
Muhammad N Raza, Muhammad Hadid, Charles E Keen, Coralie Bingham, Andrew H J Salmon
BACKGROUND: The use and timing of steroids in the management of acute tubulointerstitial nephritis (ATIN) remains debatable. AIMS: To determine the incidence and aetiology of ATIN in our unit, and to examine trends in the use of steroids and their impact on renal outcomes. METHODS: Patients with a histological diagnosis of ATIN over a 9-year period were identified and divided into steroid-treated (StG) and steroid-naïve groups (SnG). Mean change in estimated glomerular filtration rate (eGFR) was determined...
November 2012: Nephrology
Mahmoud Kamel, Bijin Thajudeen, Erika Bracamonte, Amy Sussman, Yeong-Hau H Lien
BACKGROUND: Tubulointerstitial nephritis and uveitis syndrome (TINU syndrome) is a diagnosis of exclusion based on the presence of uveitis and acute tubulointerstitial nephritis in the absence of other disease entities known to cause both of these disorders. The proximal tubule is frequently affected by this syndrome, resulting in a wide range of presentations that vary from proteinuria to full picture of Fanconi syndrome. However, distal tubular involvement is not common. CASE REPORT: A 32-year-old female patient presented with polyuria, polydipsia and painful red eyes...
November 29, 2014: American Journal of Case Reports
Montserrat Garcia, Ramón Saracho, Nekane Jaio, Kalliopi Vrotsoukanari, Carmelo Aguirre
Drugs are a frequent cause of acute tubulointerstitial nephritis (ATIN). Antibiotics, non-steroidal anti-inflammatory drugs and recently proton pump inhibitors stand among the most commonly responsible ones. However, their respective responsibility is not well known. This study reports 33 cases of drug-induced ATIN (DI-ATIN), the most frequent ones being metamizole and omeprazole. Clinicians often fail to diagnose DI-ATIN because its signs and symptoms are non-specific and differ from the now classic form observed with methicillin...
December 2010: NDT Plus
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