Mark J Wehrum, Irina A Buhimschi, Carolyn Salafia, Stephen Thung, Mert O Bahtiyar, Erica F Werner, Katherine H Campbell, Christine Laky, Anna K Sfakianaki, Guomao Zhao, Edmund F Funai, Catalin S Buhimschi
OBJECTIVE: We sought to characterize serum angiogenic factor profile of women with complete placenta previa and determine if invasive trophoblast differentiation characteristic of accreta, increta, or percreta shares features of epithelial-to-mesenchymal transition. STUDY DESIGN: We analyzed gestational age-matched serum samples from 90 pregnant women with either complete placenta previa (n = 45) or uncomplicated pregnancies (n = 45). Vascular endothelial growth factor (VEGF), placental growth factor, and soluble form of fms-like-tyrosine-kinase-1 were immunoassayed...
May 2011: American Journal of Obstetrics and Gynecology