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26 papers 100 to 500 followers
https://www.readbyqxmd.com/read/27317306/education-is-a-greater-help-to-women-than-egg-freezing-say-experts
#1
Bryan Christie
No abstract text is available yet for this article.
2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27306650/oestrogens-and-progestagens-synthesis-and-action-in-the-brain
#2
REVIEW
M F Rossetti, M J Cambiasso, M A Holschbach, R Cabrera
When steroids, such as pregnenolone, progesterone and oestrogen, are synthesised de novo in neural tissues, they are more specifically referred to as neurosteroids. These neurosteroids bind specific receptors to promote essential brain functions. Pregnenolone supports cognition and protects mouse hippocampal cells against glutamate and amyloid peptide-induced cell death. Progesterone promotes myelination, spinogenesis, synaptogenesis, neuronal survival and dendritic growth. Allopregnanolone increases hippocampal neurogenesis, neuronal survival and cognitive functions...
July 2016: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/27020131/electroacupuncture-decreases-the-progression-of-ovarian-hyperstimulation-syndrome-in-a-rat-model
#3
Li Chen, Hai-Xiang Sun, You-Bing Xia, Liu-Cai Sui, Ji Zhou, Xuan Huang, Jing-Wei Zhou, Yi-Dan Shao, Tao Shen, Qin Sun, Yuan-Jiao Liang, Bing Yao
This study aimed to elucidate the effect of electroacupuncture treatment on preventing early ovarian hyperstimulation syndrome (OHSS) and the potential mechanisms involved using an induced rat model. The ovarian response was examined by measuring ovary weight, vascular permeability, levels of inflammation (interleukin-6), tumour necrosis factor alpha, chemokine ligand 2 (also known as monocyte chemoactic protein 1), vascular endothelial growth factor and hormone concentrations (oestradiol, progesterone, testosterone and prolactin)...
May 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27083693/n-acetylcysteine-leads-to-greater-ovarian-protection-than-enoxaparin-sodium-in-a-rat-ovarian-torsion-model
#4
Gulcin Sahin Ersoy, Meryem Eken, Reshef Tal, Deniz Oztekin, Belgin Devranoglu, Ecmel Isik Kaygusuz, Ozge Cevik
This study evaluated the effects of N-acetylcysteine (NAC) and enoxaparin on ovarian tissue preservation, ovarian reserve and oxidative damage following ovarian torsion/detorsion injury. Rats were divided into four groups (n = 6/group): control; ischaemia/reperfusion (I/R); I/R + NAC; I/R + enoxaparin. Twenty-four hours after detorsion, ovarian tissues were collected for histopathological analysis and measurement of tissue 8-OHdG, GSH, MDA, MPO and SOD concentrations, as well as pre- and post-operative circulating AMH concentrations...
July 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27031102/synergetic-effects-of-k-ca-cu-and-zn-in-human-semen-in-relation-to-parameters-indicative-of-spontaneous-hyperactivation-of-spermatozoa
#5
Ivan Bolanca, Jasmina Obhodas, Dejan Ljiljak, Lidija Matjacic, Krunoslav Kuna
We have observed that sperm quality parameters indicative of spermatozoa hyperactivation such are lower "linearity" and "straightness", and as showed by this research "elongation", were more pronounced in patients with normal spermiogram compared to the group of men with reduced sperm motility who were undergoing routine in vitro fertilisation. The research encompassed 97 men diagnosed with normozoospermia (n = 20), asthenozoospermia (n = 54) and oligoasthenozoospermia (n = 23). The findings indicate that sperm quality of patients with normal spermiogram diagnosed according to WHO criteria, may be compromised by showing premature spontaneous hyperactivation which can decrease the chances of natural conception...
2016: PloS One
https://www.readbyqxmd.com/read/26917326/role-of-the-medial-preoptic-area-in-electroacupuncture-treatment-of-reproductive-dysfunction-in-ovariectomised-rats
#6
Shulan Ma, Dongju Li, Jianwei Jiang, Bo Shen
OBJECTIVE: To investigate the role of the medial preoptic area (MPOA) of the hypothalamus in electroacupuncture (EA) treatment of reproductive dysfunction in ovariectomised (OVX) rats and to examine the underlying mechanisms of action. METHODS: 62 female Sprague-Dawley rats (200-220 g) underwent bilateral ovariectomy (OVX). Three weeks later, 32 rats assigned to experiment 1 were randomly divided into four groups: two groups underwent MPOA lesioning (n=16) followed by EA at CV4, CV3, SP6 and bilateral Zigong (30 min per day) for 3 days (OVX+MPOA+EA group, n=8) or no treatment (OVX+MPOA group, n=8); and two groups underwent sham (S) surgery (n=16) followed by EA (OVX+SMPOA+EA group, n=8) or no treatment (OVX+SMPOA group, n=8)...
February 25, 2016: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/26945402/controlled-ovarian-stimulation-using-medroxyprogesterone-acetate-and-hmg-in-patients-with-polycystic-ovary-syndrome-treated-for-ivf-a-double-blind-randomized-crossover-clinical-trial
#7
RANDOMIZED CONTROLLED TRIAL
Yun Wang, Qiuju Chen, NingLing Wang, Hong Chen, Qifeng Lyu, Yanping Kuang
Ovarian hyperstimulation syndrome (OHSS) during ovarian stimulation is a current challenge for patients with polycystic ovarian syndrome (PCOS). Our previous studies indicated that progestin can prevent premature luteinizing hormone (LH) surge or moderate/severe OHSS in the general subfertile population, both in the follicular-phase and luteal-phase ovarian stimulation but it is unclear if this is true for patients with PCOS. The aim of the article was to analyze cycle characteristics and endocrinological profiles using human menopausal gonadotropin (hMG) in combination with medroxyprogesterone acetate (MPA) for PCOS patients who are undergoing IVF/intracytoplasmic sperm injection (ICSI) treatments and investigate the subsequently pregnancy outcomes of frozen embryo transfer (FET)...
March 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26279582/ranzcog-crei-consensus-statement-on-treatment-of-ovarian-hyperstimulation-syndrome
#8
REVIEW
Michele Kwik, Sonal Karia, Clare Boothroyd
BACKGROUND: Ovarian hyperstimulation syndrome (OHSS) is an uncommon but important iatrogenic condition associated with considerable morbidity and a small risk of mortality. This document gathers the consensus of a group of fertility subspecialists to aid health professionals in the development of protocols and guidelines for the management of women with OHSS. AIM: To produce evidence-based consensus statements on the treatment of ovarian hyperstimulation syndrome (OHSS)...
October 2015: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/26709195/physiology-and-pharmacology-of-ejaculation
#9
REVIEW
Pierre Clement, François Giuliano
Ejaculation is the final stage of coitus in mammalian male and is mandatory for natural procreation. Two synchronized phases, emission and expulsion, form the ejaculatory response and involve specific organs and anatomical structures. The peripheral events leading to ejaculation are commanded by autonomic (sympathetic and parasympathetic) and somatic divisions of the nervous system. The autonomic and somatic motor efferents originate in spinal nuclei located in thoracolumbar and lumbosacral segments. Co-ordinated activation of autonomic and somatic spinal nuclei is orchestrated by a group of lumbar spinal interneurons defined as the spinal generator of ejaculation...
October 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27003251/vitamin-d-supplement-improved-testicular-function-in-diabetic-rats
#10
Chenzhao Ding, Qinzhu Wang, Yue Hao, Xiaojun Ma, Lina Wu, Mengmeng du, Wen Li, Yang Wu, Feng Guo, Siyuan Ma, Fengjuan Huang, Guijun Qin
This study was designed to investigate the role that 1,25(OH)2D3 plays against testicular lesion in diabetic rats and try to find its possible mechanism of the steroidogenesis and the spermatogenesis. In diabetic rats, prolonged hyperglycemia evaluated inflammatory cytokines, damaged sperm production function and redox balance, diminished serum testosterone. After treated with 1,25(OH)2D3 at two different doses respectively for 12 months, all the alternations were effectively normalized. 1,25(OH)2D3 showed inhibitory effect on excessive inflammatory biomarkers and adjusted the expression reproductive genes and testicular androgen synthesis...
April 22, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/19716665/dl-aspartic-acid-administration-improves-semen-quality-in-rabbit-bucks
#11
G Macchia, E Topo, N Mangano, E D'Aniello, R Boni
Recently, D-aspartic acid (d-Asp) has been suggested as being involved in mechanisms regulating reproduction activity in animals and human. In this study we analyzed the effects of DL-Asp oral administration on sperm production in the rabbit. Bucks from 60, bred in a genetic centre and used for semen production, were divided in 2 subgroups of 6 individuals. The treated group was fed with a concentrate containing DL-Asp which assured a daily administration of 1.3g dl-Asp/head; the control group was fed with the same concentrate without DL-Asp...
April 2010: Animal Reproduction Science
https://www.readbyqxmd.com/read/23958080/protective-effects-of-in-vitro-treatment-with-zinc-d-aspartate-and-coenzyme-q10-on-human-sperm-motility-lipid-peroxidation-and-dna-fragmentation
#12
Riccardo Talevi, Vincenza Barbato, Ilaria Fiorentino, Sabrina Braun, Salvatore Longobardi, Roberto Gualtieri
BACKGROUND: Spermatozoa are extremely vulnerable to oxidative stress caused by the unbalance between concentrations of reactive oxygen species and antioxidant scavenging systems present inside the male reproductive tract. In spite of a large number of clinical studies that claimed the beneficial effects of antioxidant oral administration on sperm physiology and fertility, only a few studies were addressed to evaluate their effects on spermatozoa in vitro. Main aims of the present study were to assess the influence of zinc, D-aspartate and coenzyme Q10, included in the dietary supplement Genadis (Merck Serono), on human sperm motility, DNA fragmentation and lipid peroxidation...
August 16, 2013: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/26776957/pause-menopause-with-rhodiola-rosea-a-natural-selective-estrogen-receptor-modulator
#13
Patricia L Gerbarg, Richard P Brown
BACKGROUND: Menopausal women are challenged by the adverse effects of estrogen loss on energy, mood, cognitive function, and memory. These stresses are compounded by increased risks for cardiovascular disease, osteoporosis, and cancer. Known to have neuroprotective, cardio-protective, anti-oxidative and anti-carcinogenic effects, Rhodiola rosea extracts have also been shown to improve energy, mood, cognitive function and memory. PURPOSE: We propose that R. rosea be investigated for use as a potential selective estrogen receptor modulator (SERM) in the prevention and treatment of menopause-related fatigue, stress, depression, cognitive decline, memory impairment, cardiovascular disease, osteoporosis and cancer...
June 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/20484472/dose-dependent-increase-in-intratesticular-testosterone-by-very-low-dose-human-chorionic-gonadotropin-in-normal-men-with-experimental-gonadotropin-deficiency
#14
RANDOMIZED CONTROLLED TRIAL
M Y Roth, S T Page, K Lin, B D Anawalt, A M Matsumoto, C N Snyder, B T Marck, W J Bremner, J K Amory
CONTEXT AND OBJECTIVE: In men with infertility secondary to gonadotropin deficiency, treatment with relatively high dosages of human chorionic gonadotropin (hCG) stimulates intratesticular testosterone (IT-T) biosynthesis and spermatogenesis. Previously we found that lower dosages of hCG stimulated IT-T to normal. However, the minimal dose of hCG needed to stimulate IT-T and the dose-response relationship between very low doses of hCG and IT-T and serum testosterone in normal men is unknown...
August 2010: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/24014811/approach-to-male-infertility-and-induction-of-spermatogenesis
#15
REVIEW
Bradley D Anawalt
Male subfertility is common, and it causes significant duress to couples. Although the most common cause of male subfertility is idiopathic failure of spermatogenesis, a significant percentage of male subfertility is medically treatable. Compared to reproductive specialists, endocrinologists may see a population of men that have a higher prevalence of treatable causes of subfertility including sexual disorders, endocrinopathies, obesity, drugs, and ejaculatory dysfunction. Seminal fluid analysis is the most important diagnostic study, and at least 2 samples should be analyzed...
September 2013: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26308290/gnrh-agonist-triggering-modulates-pedf-to-vegf-ratio-inversely-to-hcg-in-granulosa-cells
#16
COMPARATIVE STUDY
Irit Miller, Dana Chuderland, Raphael Ron-El, Ruth Shalgi, Ido Ben-Ami
CONTEXT: GnRH agonist (GnRH-a) triggering is associated with a reduced risk of ovarian hyperstimulation syndrome (OHSS) compared with human chorionic gonadotropin (hCG) in assisted reproduction technology cycles. We have shown that ovarian pigment epithelium derived factor (PEDF), a potent antiangiogenic factor, counteracts vascular endothelial growth factor (VEGF) expression and that OHSS is correlated with hCG-induced impaired PEDF to VEGF ratio. OBJECTIVE: The objective of the study was to explore whether GnRH-a triggering could directly modulate PEDF/VEGF balance in granulosa cells...
November 2015: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/16493584/non-steroidal-anti-inflammatory-drugs-nsaids-and-ovulation-lessons-from-morphology
#17
REVIEW
M Gaytán, C Morales, C Bellido, J E Sánchez-Criado, F Gaytán
Ovulation constitutes the central event in ovarian physiology, and ovulatory disfunction is a relevant cause of female infertility. Non-steroidal anti-inflammatory drugs (NSAIDs), widely used due to their analgesic and anti-inflammatory properties, consistently inhibit ovulation in all mammalian species investigated so far, likely due to the inhibition of cyclooxygenase 2 (COX-2), the inducible isoform of COX, that is the rate-limiting enzyme in prostaglandin (PG) synthesis. COX-2 inhibition has major effects on ovulation, fertilization and implantation, and NSAID therapy is likely implicated in human infertility and could be an important, frequently overlooked, cause of ovulatory disfunction in women...
May 2006: Histology and Histopathology
https://www.readbyqxmd.com/read/9002180/zinc-protection-against-cadmium-induced-infertility-in-female-rats-effect-of-zinc-and-cadmium-on-the-progesterone-production-of-cultured-granulosa-cells
#18
K Paksy, B Varga, P Lázár
Adult female rats were treated subcutaneously (s.c.) with zinc chloride (ZnCl2, 10 or 20 mg kg-1 body weight, bw) four times during two ovarian cycles. The third injection was accompanied by cadmium chloride (CdCl2) administration sc (2.5, 5 and 10 mg kg-1 bw). The fourth zinc (Zn) treatment was followed by mating. ZnCl2 (20 mg kg-1) itself impaired fertility by 20%, while CdCl2 dose-dependently blocked the receptivity of female rats. In combination with 2.5 and 5 mg kg-1 CdCl2 the metal salts decreased fertility in an additive fashion, whereas at the highest CdCl2 dose (10 mg kg-1) a marked ameliorating effect of ZnCl2 (10 and 20 mg kg-1) on cadmium (Cd)-caused sterility was observed...
January 1997: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/16868151/the-early-luteal-phase-administration-of-estrogen-and-progesterone-does-not-induce-premature-luteolysis-in-normo-ovulatory-women
#19
RANDOMIZED CONTROLLED TRIAL
Nicole G M Beckers, Peter Platteau, Marinus J Eijkemans, Nicholas S Macklon, Frank H de Jong, Paul Devroey, Bart C J M Fauser
OBJECTIVE: The luteal phase after ovarian hyperstimulation for in vitro fertilization (IVF) is insufficient. Therefore, luteal phase supplementation is routinely applied in IVF. It may be postulated that premature luteolysis after ovarian hyperstimulation is due to supraphysiological steroid levels in the early luteal phase. In the present study, high doses of steroids are administered after the LH surge in normo-ovulatory volunteers in order to investigate whether this intervention gives rise to endocrine changes and a shortening of the luteal phase...
August 2006: European Journal of Endocrinology
https://www.readbyqxmd.com/read/25542992/amelioration-of-nandrolone-decanoate-induced-testicular-and-sperm-toxicity-in-rats-by-taurine-effects-on-steroidogenesis-redox-and-inflammatory-cascades-and-intrinsic-apoptotic-pathway
#20
Maha A E Ahmed
The wide abuse of the anabolic steroid nandrolone decanoate by athletes and adolescents for enhancement of sporting performance and physical appearance may be associated with testicular toxicity and infertility. On the other hand, taurine; a free β-amino acid with remarkable antioxidant activity, is used in taurine-enriched beverages to boost the muscular power of athletes. Therefore, the purpose of this study was to investigate the mechanisms of the possible protective effects of taurine on nandrolone decanoate-induced testicular and sperm toxicity in rats...
February 1, 2015: Toxicology and Applied Pharmacology
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