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Intrathecal drug delivery devices literature

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11 papers 0 to 25 followers
https://www.readbyqxmd.com/read/27477589/can-cerebrospinal-fluid-pressure-detect-catheter-complications-in-patients-who-experience-loss-of-effectiveness-with-intrathecal-baclofen-therapy
#1
Michael Saulino, Michael Turner, Keith Miesel, Felicia R Cochran, Katherine Stromberg, Elizabeth Fehrmann, Mary Markert, Robert Spencer
OBJECTIVE: The catheter status of patients who presented with loss of intrathecal baclofen (ITB) therapy effectiveness was investigated using measurements of cerebrospinal fluid (CSF) pressure transmitted through the catheter fluid path to the pump. The aim of the study was to estimate the appropriate threshold separating catheter complications from "normal" catheter function, and to compare catheter status based on CSF pressure with the clinical diagnosis. METHODS: This was a prospective, masked nonsignificant risk, research study...
August 1, 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27228528/near-death-experience-from-placement-of-an-intrathecal-catheter
#2
Devang Padalia, Navdeep Jassal, Sagar Patel
UNLABELLED: The management of pain due to cancer is challenging and often requires invasive therapy in addition to medication management. Intrathecal drug delivery is a form of advanced therapy that delivers medication locally in the intrathecal space while reducing systemic side effects associated with high doses of opioids. Although risks associated with intrathecal drug delivery are low, some common complications include dislodgement, kinking, or fracture of the catheter, bleeding, neurological injury, infection, and cerebrospinal leaks...
May 2016: Pain Physician
https://www.readbyqxmd.com/read/26866298/sudden-intrathecal-drug-delivery-device-motor-stalls-a-case-series
#3
Ryan Galica, Salim M Hayek, Ilir Elias Veizi, Melinda M Lawrence, Al-Amin A Khalil, Matthew T McEwan
BACKGROUND AND OBJECTIVES: Intrathecal (IT) drug delivery systems (IDDSs) have been valuable in managing refractory chronic cancer and noncancer pain for more than 3 decades. These devices, time tested and overall reliable, have lately been noted at this institution to cease infusing unexpectedly. If not immediately recognized and rectified, this abrupt malfunction may lead to significant patient harm. METHODS: A series of 13 patients from 1 academic center whose Medtronic SynchroMed II pumps malfunctioned from 2013 to 2015 is described...
March 2016: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/27008308/thoracic-nerve-root-entrapment-by-intrathecal-catheter-coiling-case-report-and-review-of-the-literature
#4
Jing L Han, Daniel B Loriaux, Caroline Tybout, Merritt D Kinon, Shervin Rahimpour, Scott L Runyon, Thomas J Hopkins, Richard L Boortz-Marx, Shivanand P Lad
BACKGROUND: Intrathecal catheter placement has long-term therapeutic benefits in the management of chronic, intractable pain. Despite the diverse clinical applicability and rising prevalence of implantable drug delivery systems in pain medicine, the spectrum of complications associated with intrathecal catheterization remains largely understudied and underreported in the literature. OBJECTIVE: To report a case of thoracic nerve root entrapment resulting from intrathecal catheter migration...
March 2016: Pain Physician
https://www.readbyqxmd.com/read/27082422/ce-intrathecal-pumps-for-managing-cancer-pain
#5
Laura Hanssen Textor
: It is estimated that more than 1.6 million new cases of cancer were diagnosed in the United States in 2014. Among patients with cancer, moderate to severe pain is prevalent and can be refractory, even with the use of systemic opioids, which may cause adverse effects that are difficult to manage at the doses required to control pain. When delivered intrathecally, however, opioids and adjuvant analgesics may provide greater pain relief at dramatically lower doses and with fewer adverse effects. Although the use of intrathecal drug delivery systems for cancer pain management has increased dramatically over the past several years and is expected to continue growing, patients with intrathecal pumps often report interactions with nurses unfamiliar with the technology...
May 2016: American Journal of Nursing
https://www.readbyqxmd.com/read/26922704/long-term-effects-of-intrathecal-baclofen-in-multiple-sclerosis
#6
Massimo Natale, Salvatore D'Oria, Veronica Venera Nero, Eleonora Squillante, Marisa Gentile, Michele Rotondo
OBJECTIVES: Spasticity is associated with various neurological conditions. In this study the authors analyzed the long term effects of intrathecal baclofen therapy in multiple sclerosis and evalued the benefits of the treatment on spasticity, disability, pain, spasm frequency and rated the incidence of side effects. PATIENTS AND METHODS: A records of 123 patients, with a severe, progressive and refractory to medical therapy spasticity from different causes, underwent baclofen pump placement, after a bolus test, from 2000 to 2012,under Department of Neurosurgery at the Second University of Naples/Italy...
April 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/26814257/intrathecal-hydromorphone-and-bupivacaine-combination-therapy-for-post-laminectomy-syndrome-optimized-with-patient-activated-bolus-device
#7
Salim M Hayek, Elias Veizi, Michael Hanes
BACKGROUND: Intrathecal (IT) pumps have become a valuable tool in managing intractable non-cancer pain. The purpose of this study was to evaluate the efficacy of using a rigorous treatment algorithm for trialing and implanting IT pumps with hydromorphone and bupivacaine in managing a more homogeneous population of post-laminectomy syndrome or failed back surgery syndrome (FBSS) patients. METHODS:  This is a retrospective analysis of FBSS patients with chronic intractable back pain implanted with IT pumps delivering hydromorphone and bupivacaine...
March 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/26592253/unusual-placement-of-intrathecal-baclofen-pumps-report-of-two-cases
#8
Oliver Devine, Andrew Harborne, William B Lo, Daniel Weinberg, Mahesh Ciras, Rupert Price
Intrathecal baclofen delivery via implantable pump represents an important modality for symptomatic relief in patients with chronic spasticity. Pumps are routinely implanted subcutaneously in the anterior abdominal wall. We describe two unusual cases where skin-related complications necessitated revision surgery in order to relocate the pump to alternative sites. The first patient was an international power canoeist, whose strenuous exercise programme interfered with his pump's original siting. The second patient was a cachectic university student with a history of cerebral palsy, who maintained low body mass despite attempted weight gain...
January 2016: Acta Neurochirurgica
https://www.readbyqxmd.com/read/26588457/long-term-follow-up-for-lumbar-intrathecal-baclofen-catheters-placed-using-the-paraspinal-subfascial-technique
#9
Saumitra K Thakur, Benjamin A Rubin, David H Harter
OBJECT Intrathecal baclofen (ITB) is a valuable therapeutic option for patients with spasticity and dystonia. The techniques that place an ITB pump catheter into the subcutaneous fat of a lumbar incision are well described. Because patients who require ITB often have low body fat content, they may be predisposed to catheter-related complications. The senior author used a novel technique to place the catheter in a paraspinal subfascial fashion, and the short-term results were previously published. That study demonstrated no development of hardware erosions, catheter migrations, or CSF leaks within an average follow-up of 5 months...
March 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/26431137/catheter-tip-granulomas-associated-with-intrathecal-drug-delivery-a-two-center-experience-identifying-13-cases
#10
MULTICENTER STUDY
Tobias Kratzsch, Martin N Stienen, Tim Reck, Gerhard Hildebrandt, Petra Hoederath
BACKGROUND: Intrathecal (IT) drug therapy with implanted pumps is an effective treatment modality for chronic pain and/or spasticity, especially after non-invasive treatment has failed. Long-term use of intrathecal opioids may cause formation of inflammatory masses at the tip of intrathecal catheters, possibly leading to neurological deficits and/or catheter revision. OBJECTIVE: We aimed to identify risk factors for catheter-tip granuloma (CG) formation. STUDY DESIGN: Retrospective study...
September 2015: Pain Physician
https://www.readbyqxmd.com/read/26582550/isotopic-scintigraphy-coupled-with-computed-tomography-for-the-investigation-of-intrathecal-baclofen-device-malfunction
#11
Flavie Frémondière, Franck Lacoeuille, Avigaelle Sher, Olivier Couturier, Philippe Menei, Isabelle Richard, Mickaël Dinomais
OBJECTIVE: To assess the potential use of indium-111 diethylenetriamine pentaacetic acid ((111)In-DTPA) scintigraphy coupled with computed tomography (CT) for the investigation of intrathecal baclofen (ITB) device malfunction. DESIGN: Retrospective study of a case series of patients. SETTING: Neurosurgical and physical and rehabilitation medicine departments. PARTICIPANTS: Patients (N=7) with reduced ITB effectiveness in whom prior conventional radiographs were inconclusive...
April 2016: Archives of Physical Medicine and Rehabilitation
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