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Safety of budesonide

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Li-Xing Man, Zachary Farhood, Amber Luong, Samer Fakhri, Robert M Feldman, Philip R Orlander, Martin J Citardi
BACKGROUND: Intranasal corticosteroid irrigations, especially budesonide, are used increasingly in the management of chronic rhinosinusitis. In post-endoscopic sinus surgery patients, irrigations may offer improved delivery at higher doses to the paranasal sinuses than intranasal spray preparations. Fluticasone propionate may have higher potency and lower systemic bioavailability than budesonide, but there is little data on its effects as an intranasal irrigation on the hypothalamic-pituitary-adrenal axis or on ocular findings...
December 2013: International Forum of Allergy & Rhinology
Kevin C Welch, Erica R Thaler, Laurie L Doghramji, James N Palmer, Alexander G Chiu
BACKGROUND: The delivery of topical intranasal corticosteroid sprays has traditionally been the primary method of treating recurrent nasal polyposis. An emerging treatment for polyposis is budesonide nasal irrigations. Delivered at concentrations nearly 100 times greater than found in prescription nasal sprays, there have been little studies on the effects of budesonide irrigation on the adrenal axis. Therefore, we investigated whether irrigation with budesonide solution was associated with any increase in serum cortisol and 24-hour urinary cortisol levels...
January 2010: American Journal of Rhinology & Allergy
Kristin A Seiberling, Dennis F Chang, Janice Nyirady, Francine Park, Christopher A Church
BACKGROUND: Intranasal and oral corticosteroids are widely used in the management of chronic rhinosinusitis with nasal polyps (CRSwNP). Higher-dose topical nasal steroids (HDTNS) such as budesonide irrigations are increasingly used for long-term maintenance in these patients. Oral steroids have the potential to cause increased intraocular pressure (IOP) and glaucoma. It is unclear whether HDTNS have the same potential. The objective of this study was to determine the effect of intranasal budesonide irrigations on IOP...
September 2013: International Forum of Allergy & Rhinology
Neil S Sachanandani, Jay F Piccirillo, Maggie A Kramper, Stanley E Thawley, Anna Vlahiotis
OBJECTIVES: To evaluate whether nasal administration of budesonide in adults with chronic rhinosinusitis for 30 days suppresses adrenal function and to assess its clinical efficacy. DESIGN: An open-label prospective study. SETTING: Academic medical center. PATIENTS: We assessed adrenal function in 9 patients using the cosyntropin test before and after budesonide therapy. INTERVENTION: Budesonide respule therapy...
March 2009: Archives of Otolaryngology—Head & Neck Surgery
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