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ETD Study

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4 papers 0 to 25 followers
Richard J Harvey, Nick Debnath, Aviva Srubiski, Ben Bleier, Rodney J Schlosser
OBJECTIVE: Topical treatment options in chronic rhinosinusitis (CRS) are growing with our increased understanding of the inflammatory process. Additives to irrigation devices have become popular. Additives such as menthol provide little more than sensory feedback. However, glucocorticosteroids and antibiotics represent powerful pharmaceutical agents for which we have little knowledge regarding patient exposure and absorption. There is little data on fluid retained after nasal irrigation...
December 2009: Otolaryngology—Head and Neck Surgery
Kai Zhao, John R Craig, Noam A Cohen, Nithin D Adappa, Sammy Khalili, James N Palmer
OBJECTIVES/HYPOTHESIS: Topical sinus irrigations play a critical role in the management of sinonasal disease, and the improvement in irrigant penetration into the sinuses postoperatively greatly contributes to the success of endoscopic sinus surgery. Prior investigations on postoperative sinus irrigations have been mostly limited to cadaver studies, which are labor intensive and do not capture the full dynamics of the flows. A pilot study was conducted to investigate the impact of surgery on sinus irrigation through computational fluid dynamics (CFD) simulations...
March 2016: Laryngoscope
Li-Xing Man, Zachary Farhood, Amber Luong, Samer Fakhri, Robert M Feldman, Philip R Orlander, Martin J Citardi
BACKGROUND: Intranasal corticosteroid irrigations, especially budesonide, are used increasingly in the management of chronic rhinosinusitis. In post-endoscopic sinus surgery patients, irrigations may offer improved delivery at higher doses to the paranasal sinuses than intranasal spray preparations. Fluticasone propionate may have higher potency and lower systemic bioavailability than budesonide, but there is little data on its effects as an intranasal irrigation on the hypothalamic-pituitary-adrenal axis or on ocular findings...
December 2013: International Forum of Allergy & Rhinology
Richard J Harvey, John C Goddard, Sarah K Wise, Rodney J Schlosser
OBJECTIVE: Assess paranasal sinus distribution of topical solutions following endoscopic sinus surgery (ESS) using various delivery devices. STUDY DESIGN: Experimental prospective study. SUBJECTS AND METHODS: Ten cadaver sinus systems were irrigated with Gastroview before surgery, after ESS, and after medial maxillectomy. Delivery was via pressurized spray (NasaMist), neti pot (NasaFlo), and squeeze bottle (Sinus Rinse). Scans were performed before and after each delivery with a portable CT machine (Xoran xCAT), and blinded assessments were made for distribution to individual sinuses...
July 2008: Otolaryngology—Head and Neck Surgery
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