collection
https://read.qxmd.com/read/30779645/sex-differences-in-advanced-heart-failure-therapies
#21
REVIEW
Eileen M Hsich
This in-depth review of sex differences in advanced heart failure therapy summarizes the existing literature on implantable cardioverter defibrillators, biventricular pacemakers, mechanical circulatory support, and transplantation with a focus on utilization, efficacy/clinical effectiveness, adverse events, and controversies. One will learn about the controversies regarding efficacy/clinical effectiveness of implantable cardioverter defibrillators and understand why these devices should be implanted in women even if there are sex differences in appropriate shocks...
February 19, 2019: Circulation
https://read.qxmd.com/read/30779651/management-of-cardiovascular-disease-in-women-with-breast-cancer
#22
REVIEW
Rachel Barish, Filipa Lynce, Keith Unger, Ana Barac
Cardio-oncology is a rapidly developing field which seeks to improve patient outcomes through enhanced clinical and research collaboration across the disciplines of oncology and cardiology. Breast cancer (BC) is the most common cancer diagnosis among women in the United States and, as decades of research have resulted in decreased mortality rates, there has been an increasing focus on reducing short- and long-term treatment toxicity and improving morbidity among survivors. Preexisting or emergent cardiovascular disease in a patient with BC requires a multidisciplinary, team-based approach to balance the need for curative cancer treatment while preventing increased cardiovascular disease morbidity and mortality...
February 19, 2019: Circulation
https://read.qxmd.com/read/30779652/sex-differences-in-the-prevalence-of-and-trends-in-cardiovascular-risk-factors-treatment-and-control-in-the-united-states-2001-to-2016
#23
COMPARATIVE STUDY
Sanne A E Peters, Paul Muntner, Mark Woodward
BACKGROUND: Improvements have been made in the treatment and control of some but not all major cardiovascular risk factors in the United States. It remains unclear whether women and men have benefited equally. METHODS: Data from the 2001 to 2002 through the 2015 to 2016 US National Health and Nutrition Examination Survey on adults aged 20 to 79 years were used. We assessed sex differences in temporal trends in the levels of systolic blood pressure, body mass index, smoking status, high-density lipoprotein and total cholesterol, and hemoglobin A1c ...
February 19, 2019: Circulation
https://read.qxmd.com/read/30682562/a-prospective-5-year-study-of-exercise-performance-following-melody-valve-implant
#24
JOURNAL ARTICLE
Bryant Priromprintr, Michael J Silka, Jonathan Rhodes, Anjan S Batra
BACKGROUND: The long-term benefits of Melody valve implant for right ventricular outflow tract conduit obstruction or insufficiency on exercise capacity are undefined. METHODS: As part of the Melody valve clinical trial, 136 patients with congenital heart disease underwent serial cardiopulmonary exercise testing prior to, 6 months after, and annually for up to 5 years postimplant. RESULTS: Mean age at Melody valve implantation was 22.4 ± 0...
March 2019: American Heart Journal
https://read.qxmd.com/read/30731372/heart-failure-and-adverse-heart-failure-outcomes-among-persons-living-with-hiv-in-a-us-tertiary-medical-center
#25
JOURNAL ARTICLE
Raza M Alvi, Maryam Afshar, Anne M Neilan, Noor Tariq, Malek Hassan, Jaime Gerber, Magid Awadalla, Connor P Mulligan, Adam Rokicki, Virginia A Triant, Markella V Zanni, Tomas G Neilan
BACKGROUND: Persons living with HIV (PLHIV) have an increased risk of heart failure (HF). However, little is known about outcomes among PLHIV with HF. The study aim was to compare HF outcomes among PLHIV with HF versus individuals without HIV with HF. METHODS: Our cohort included 2,308 individuals admitted with decompensated HF. We compared baseline characteristics, 30-day HF readmission, and cardiovascular (CV) and all-cause mortality. Within PLHIV, we assessed outcomes stratified between CD4 count and viral load (VL), and tested the association between traditional and HIV-specific parameters with 30-day HF readmission...
April 2019: American Heart Journal
https://read.qxmd.com/read/30738245/early-initiation-of-extracorporeal-life-support-in-refractory-out-of-hospital-cardiac-arrest-design-and-rationale-of-the-inception-trial
#26
JOURNAL ARTICLE
Martine E Bol, Martje M Suverein, Roberto Lorusso, Thijs S R Delnoij, George J Brandon Bravo Bruinsma, Luuk Otterspoor, Marijn Kuijpers, Ka Yan Lam, Alexander P J Vlaar, Carlos V Elzo Kraemer, Joris J van der Heijden, Erik Scholten, Antoine H G Driessen, José M Montero Cabezas, Saskia Z H Rittersma, Bram G Heijnen, Fabio S Taccone, Brigitte Essers, Tammo Delhaas, Patrick W Weerwind, Paul M H J Roekaerts, Jos G Maessen, Marcel C G van de Poll
UNLABELLED: Return of spontaneous circulation occurs in less than 10% of patients with cardiac arrest undergoing cardiopulmonary resuscitation (CPR) for more than 15 minutes. Studies suggest that extracorporeal life support during cardiopulmonary resuscitation (ECPR) improves survival rate in these patients. These studies, however, are hampered by their non-randomized, observational design and are mostly single-center. A multicenter, randomized controlled trial is urgently warranted to evaluate the effectiveness of ECPR...
April 2019: American Heart Journal
https://read.qxmd.com/read/30591319/utility-of-copeptin-for-predicting-long-term-clinical-outcomes-in-patients-with-heart-failure
#27
JOURNAL ARTICLE
Yusuke Yoshikawa, Hiroki Shiomi, Koichiro Kuwahara, Naoya Sowa, Hidenori Yaku, Yugo Yamashita, Junichi Tazaki, Masao Imai, Takao Kato, Naritatsu Saito, Satoshi Shizuta, Koh Ono, Takeshi Kimura
BACKGROUND: Copeptin, a surrogate marker of pro-arginine vasopressin, is expected to be a marker in cardiovascular diseases. Its utility for predicting long-term clinical outcomes in heart failure (HF), however, has not been adequately evaluated in daily clinical practice in Japan. METHODS: To assess the relationship of serum copeptin at admission with long-term clinical outcomes, we evaluated serum copeptin at admission in consecutive 107 patients hospitalized for HF between April 2011 and July 2012...
May 2019: Journal of Cardiology
https://read.qxmd.com/read/30565021/practical-guidance-on-the-use-of-sacubitril-valsartan-for-heart-failure
#28
REVIEW
Andrew J Sauer, Robert Cole, Brian C Jensen, Jay Pal, Nakul Sharma, Amin Yehya, Justin Vader
Sacubitril/valsartan is a first-in-class angiotensin receptor-neprilysin inhibitor (ARNI) that has been recommended in clinical practice guidelines to reduce morbidity and mortality in patients with chronic, symptomatic heart failure (HF) with reduced ejection fraction (HFrEF). This review provides an overview of ARNI therapy, proposes strategies to improve the implementation of sacubitril/valsartan in clinical practice, and provides clinicians with evidence-based, practical guidance on the use of sacubitril/valsartan in patients with HFrEF...
March 2019: Heart Failure Reviews
https://read.qxmd.com/read/30686041/2019-aha-acc-hrs-focused-update-of-the-2014-aha-acc-hrs-guideline-for-the-management-of-patients-with-atrial-fibrillation-a-report-of-the-american-college-of-cardiology-american-heart-association-task-force-on-clinical-practice-guidelines-and-the-heart-rhythm
#29
REVIEW
Craig T January, L Samuel Wann, Hugh Calkins, Lin Y Chen, Joaquin E Cigarroa, Joseph C Cleveland, Patrick T Ellinor, Michael D Ezekowitz, Michael E Field, Karen L Furie, Paul A Heidenreich, Katherine T Murray, Julie B Shea, Cynthia M Tracy, Clyde W Yancy
No abstract text is available yet for this article.
July 9, 2019: Circulation
https://read.qxmd.com/read/30580131/the-prognostic-value-of-various-biomarkers-in-adults-with-pulmonary-hypertension-a-multi-biomarker-approach
#30
JOURNAL ARTICLE
Laurie W Geenen, Vivan J M Baggen, Thomas Koudstaal, Karin A Boomars, Jannet A Eindhoven, Eric Boersma, Jolien W Roos-Hesselink, Annemien E van den Bosch
BACKGROUND: This study aimed to investigate the prognostic value of six different biomarkers in patients with pulmonary hypertension (PH) and to explore whether a multi-biomarker approach can contribute to a better risk stratification. METHODS: In this prospective study, patients with PH were included at the day of the diagnostic right heart catheterization between May 2012 and October 2016. Venous blood sampling included; NT-proBNP, high sensitive troponin-T, high sensitive CRP, galectin-3, red blood cell distribution width and eGFR...
February 2019: American Heart Journal
https://read.qxmd.com/read/30545976/pathophysiology-of-the-right-ventricle-and%C3%A2-of-the-pulmonary-circulation-in-pulmonary-hypertension-an-update
#31
REVIEW
Anton Vonk Noordegraaf, Kelly Marie Chin, François Haddad, Paul M Hassoun, Anna R Hemnes, Susan Roberta Hopkins, Steven Mark Kawut, David Langleben, Joost Lumens, Robert Naeije
The function of the right ventricle determines the fate of patients with pulmonary hypertension. Since right heart failure is the consequence of increased afterload, a full physiological description of the cardiopulmonary unit consisting of both the right ventricle and pulmonary vascular system is required to interpret clinical data correctly. Here, we provide such a description of the unit and its components, including the functional interactions between the right ventricle and its load. This physiological description is used to provide a framework for the interpretation of right heart catheterisation data as well as imaging data of the right ventricle obtained by echocardiography or magnetic resonance imaging...
January 2019: European Respiratory Journal
https://read.qxmd.com/read/30449385/advanced-therapies-for-advanced-heart-failure-in-women
#32
REVIEW
Marlena V Habal, Kelly Axsom, Maryjane Farr
Women with advanced heart failure (HF) are underrepresented in trials of short-term and durable mechanical circulatory support although they derive similar benefit. In acute HF, intensive medical and interventional therapies are effective but underutilized. The smaller, newer generation, left ventricular assist devices (LVADs) have increased the feasibility of durable support in women. Women frequently present late, with more comorbidities, emphasizing the need for timely referral. Compared with men, the stroke risk is higher in women with an LVAD...
January 2019: Heart Failure Clinics
https://read.qxmd.com/read/30447710/advanced-heart-failure-management-and-transplantation
#33
REVIEW
Avi Levine, Chhaya Aggarwal Gupta, Alan Gass
Hypertrophic cardiomyopathy is a genetic heart disease with heterogeneous clinical features, including progression to advanced heart failure. The development of these symptoms can be related to outflow obstruction but in some patients reflects an underlying process of fibrosis and progressive ventricular dysfunction. For patients with end-stage disease, traditional heart failure therapies have not proved beneficial. As such, more advanced therapies, such as left ventricular assist device or cardiac transplantation, should be considered for these patients...
February 2019: Cardiology Clinics
https://read.qxmd.com/read/30505744/surgical-management-of-anomalous-coronary-arteries
#34
REVIEW
Chin Siang Ong, Duke E Cameron, Marshall L Jacobs
Anomalies in the coronary arterial circulation have been described since classical antiquity by Galen and through the Medical Renaissance by Vesalius, but their clinical significance and association with sudden cardiac death (SCD) has only been appreciated over the last 4 decades. Advances in cardiac surgery and cardiovascular intensive care have led to decreasing overall postoperative mortality and morbidity associated with cardiac surgery. The decision whether to surgically treat an anomaly of coronary artery origin and course, and the risk-to-benefit ratio of surgical treatment in preventing a potentially lethal complication of SCD, requires careful, deliberate consideration based on the best available evidence...
September 2018: Annals of Cardiothoracic Surgery
https://read.qxmd.com/read/30394905/a-personalized-approach-to-long-qt-syndrome
#35
REVIEW
Susan Payne Etheridge, Sarah Yukiko Asaki, Mary Chun-I Niu
PURPOSE OF REVIEW: Our purpose is to provide an update on the new clinical and genetic aspects of long QT syndrome (LQTS). LQTS is the most common channelopathy and a cause of syncope and sudden death in the young. Although there are 17 types of LQTS, most patients have types 1 or 2 which are due to mutations in KCNQ1 and KCNH2 (encoding for the cardiac potassium channels), and type 3 which is due to a mutation in SCN5A (encoding for the sodium channel). LQTS is characterized by incomplete penetrance and variable expressivity...
January 2019: Current Opinion in Cardiology
https://read.qxmd.com/read/30394906/advances-in-medical-therapy-for-pulmonary-arterial-hypertension
#36
REVIEW
Carlos Sisniega, Nayeli Zayas, Tomas Pulido
PURPOSE OF REVIEW: The purpose of this review is to demonstrate advances in the medical treatment of pulmonary arterial hypertension (PAH). Reviewed will be the evidence that favors the use of risk assessment in the treatment of PAH. Optimization of combination therapy depending on the risk or worsening will be reviewed. Finally, recent advances in new treatment strategies will be mentioned. RECENT FINDINGS: The use of therapies in sequence or in combination for the treatment of PAH has been shown to decrease morbidity and mortality...
January 2019: Current Opinion in Cardiology
https://read.qxmd.com/read/30444758/imaging-the-itis-endocarditis-myocarditis-and-pericarditis
#37
REVIEW
Matthew J O'Connor
PURPOSE OF REVIEW: Inflammatory and/or infectious conditions affecting the heart and pericardium in children are primarily diagnosed via noninvasive imaging modalities. In addition, the use of multiple imaging modalities (multimodality imaging) is becoming increasingly common to assist in diagnosis, management, and prognosis. This review focuses on the use of noninvasive imaging in endocarditis, myocarditis, and pericarditis, with emphasis placed on the use of echocardiography and cardiac MRI in these conditions...
January 2019: Current Opinion in Cardiology
https://read.qxmd.com/read/30447780/perioperative-management-of-the-cardiac-transplant-recipient
#38
REVIEW
Joseph Rabin, David J Kaczorowski
Management of the cardiac transplant recipient includes careful titration of inotropes and vasopressors. Recipient pulmonary hypertension and ventilatory status must be optimized to prevent allograft right ventricular failure. Vasoplegia, coagulopathy, arrhythmias, and renal dysfunction also require careful management to achieve an optimal outcome. Primary graft dysfunction (PGD) can be an ominous problem after cardiac transplantation. Although mild degrees of PGD may be managed medically, mechanical circulatory support with extracorporeal membrane oxygenation or temporary ventricular assist devices may be required...
January 2019: Critical Care Clinics
https://read.qxmd.com/read/30447781/renal-complications-following-lung-transplantation-and-heart-transplantation
#39
REVIEW
Chethan M Puttarajappa, Jose F Bernardo, John A Kellum
Renal complications are common following heart and/or lung transplantation and lead to increased morbidity and mortality. Renal dysfunction is also associated with increased mortality for patients on the transplant wait list. Dialysis dependence is a relative contraindication for heart or lung transplantation at most centers, and such patients are often listed for a simultaneous kidney transplant. Several factors contribute to the impaired renal function in patients undergoing heart and/or lung transplantation, including the interplay between cardiopulmonary and renal hemodynamics, complex perioperative issues, and exposure to nephrotoxic medications, mainly calcineurin inhibitors...
January 2019: Critical Care Clinics
https://read.qxmd.com/read/30447782/infections-in-heart-and-lung-transplant-recipients
#40
REVIEW
Mohammed Alsaeed, Shahid Husain
Infections in heart and lung transplant recipients are complex and heterogeneous. This article reviews the epidemiology, risk factors, specific clinical syndromes, and most frequent opportunistic infections in heart and/or lung transplant recipients that will be encountered in the intensive care unit and will provide a practical approach of empirical management.
January 2019: Critical Care Clinics
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