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By Venkatesh Ariyamuthu Transplant Nephrologist at UT Southwestern Medical Center
Jeffrey A Klein, Stevan A Gonzalez, Bernard V Fischbach, Angelito F Yango, Arthi Rajagopal, Kim M Rice, Muhammad Saim, Yousri M Barri, Larry B Melton, Goran B Klintmalm, Arun Chandrakantan
Renal cell carcinoma (RCC) has a high incidence in the kidney transplant population and annual surveillance detects these tumors early in their natural history. Minimal guidelines exist regarding RCC surveillance in ESRD patients awaiting transplant. A retrospective review of our kidney transplant database examined the outcomes of annual ultrasonographic surveillance during initial kidney transplant evaluation and upon annual reassessment. Of 2642 patients listed for transplant, 145 patients were found to have masses during initial kidney transplant evaluation or annual imaging consistent with new complex cystic disease or RCC...
August 2016: Clinical Transplantation
Susie L Hu, Anthony Chang, Mark A Perazella, Mark D Okusa, Edgar A Jaimes, Robert H Weiss
Kidney cancer, or renal cell carcinoma (RCC), is a disease of increasing incidence that is commonly seen in the general practice of nephrology. However, RCC is under-recognized by the nephrology community, such that its presence in curricula and research by this group is lacking. In the most common form of RCC, clear cell renal cell carcinoma (ccRCC), inactivation of the von Hippel-Lindau tumor suppressor is nearly universal; thus, the biology of ccRCC is characterized by activation of hypoxia-relevant pathways that lead to the associated paraneoplastic syndromes...
August 2016: Journal of the American Society of Nephrology: JASN
Tetsuya Shindo, Naoya Masumori, Ko Kobayashi, Fumimasa Fukuta, Megumi Hirobe, Akiko Tonooka, Tadashi Hasegawa, Hiroshi Kitamura, Taiji Tsukamoto
UNLABELLED: WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Small, organ-confined renal cell carcinoma (RCC) generally has favourable pathological characteristics and a good prognosis. However, late recurrence is a known characteristic of the biological behaviour of RCC and no consensus has been established for surveillance protocols from 5 years after radical or partial nephrectomy. In the present study with long-term follow-up of patients with small RCCs, 18 of 172 patients (10...
May 2013: BJU International
Kaisa L Sunela, Eero T Lehtinen, Matti J Kataja, Paula M Kujala, Seppo Soimakallio, Pirkko-Liisa I Kellokumpu-Lehtinen
OBJECTIVE: To evaluate imaging methods and prognoses between small renal cell carcinomas (RCCs) and larger tumours according to the era of diagnostics. PATIENTS AND METHODS: In all, 784 consecutive patients diagnosed with RCC between 1964 and 1997 at the Pirkanmaa Hospital District in Finland were included. Patients were divided into two groups: tumours of ≤3.0 and >3.0 cm in diameter. Prognosis was analysed according to the era of diagnostics: (i) pre-computed tomography (CT) and pre-ultrasound (US), (ii) US era and (iii) CT era...
February 2014: BJU International
Brian Rini, Audrey Goddard, Dejan Knezevic, Tara Maddala, Ming Zhou, Hakan Aydin, Steven Campbell, Paul Elson, Serge Koscielny, Margarita Lopatin, Christer Svedman, Jean-Francois Martini, J Andrew Williams, Virginie Verkarre, Camelia Radulescu, Yann Neuzillet, Isabelle Hemmerlé, Marc Olivier Timsit, Athanasios C Tsiatis, Michael Bonham, Thierry Lebret, Arnaud Mejean, Bernard Escudier
BACKGROUND: The likelihood of tumour recurrence after nephrectomy in localised clear cell renal cell carcinoma is well characterised by clinical and pathological parameters. However, these assessments can be improved and personalised by the addition of molecular characteristics of each patient's tumour. We aimed to develop and validate a prognostic multigene signature to improve prediction of recurrence risk in clear cell renal cell carcinoma. METHODS: In the development stage, we investigated the association between expression of 732 genes, measured by reverse-transcription PCR, and clinical outcome in 942 patients with stage I-III clear cell renal cell carcinoma who had undergone a nephrectomy at the Cleveland Clinic (OH, USA)...
June 2015: Lancet Oncology
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