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34 papers 0 to 25 followers
https://www.readbyqxmd.com/read/27440524/radiation-protection-for-the-fluoroscopy-operator-and-staff
#1
Quinn C Meisinger, Cosette M Stahl, Michael P Andre, Thomas B Kinney, Isabel G Newton
OBJECTIVE: The purposes of this article are to review available data regarding the range of protection devices and garments with a focus on eye protection and to summarize techniques for reducing scatter radiation exposure. CONCLUSION: Fluoroscopy operators and staff can greatly reduce their radiation exposure by wearing properly fitted protective garments, positioning protective devices to block scatter radiation, and adhering to good radiation practices. By understanding the essentials of radiation physics, protective equipment, and the features of each imaging system, operators and staff can capitalize on opportunities for radiation protection while minimizing ergonomic strain...
July 19, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27706136/evidence-for-a-limit-to-human-lifespan
#2
Xiao Dong, Brandon Milholland, Jan Vijg
Driven by technological progress, human life expectancy has increased greatly since the nineteenth century. Demographic evidence has revealed an ongoing reduction in old-age mortality and a rise of the maximum age at death, which may gradually extend human longevity. Together with observations that lifespan in various animal species is flexible and can be increased by genetic or pharmaceutical intervention, these results have led to suggestions that longevity may not be subject to strict, species-specific genetic constraints...
October 5, 2016: Nature
https://www.readbyqxmd.com/read/27830790/a-brain-spine-interface-alleviating-gait-deficits-after-spinal-cord-injury-in-primates
#3
Marco Capogrosso, Tomislav Milekovic, David Borton, Fabien Wagner, Eduardo Martin Moraud, Jean-Baptiste Mignardot, Nicolas Buse, Jerome Gandar, Quentin Barraud, David Xing, Elodie Rey, Simone Duis, Yang Jianzhong, Wai Kin D Ko, Qin Li, Peter Detemple, Tim Denison, Silvestro Micera, Erwan Bezard, Jocelyne Bloch, Grégoire Courtine
Spinal cord injury disrupts the communication between the brain and the spinal circuits that orchestrate movement. To bypass the lesion, brain-computer interfaces have directly linked cortical activity to electrical stimulation of muscles, and have thus restored grasping abilities after hand paralysis. Theoretically, this strategy could also restore control over leg muscle activity for walking. However, replicating the complex sequence of individual muscle activation patterns underlying natural and adaptive locomotor movements poses formidable conceptual and technological challenges...
November 9, 2016: Nature
https://www.readbyqxmd.com/read/27804259/neuromodulation-by-cerebrovasculature-bdnf-is-it-much-greater-than-we-think
#4
EDITORIAL
C Joakim Ek
The findings published by Monnier et al. (2016) in this journal showing substantial cerebrovascular BDNF synthesis are very interesting and could change our way we perceive BDNF production in the brain under normal and disease states. BDNF is one of the classic neurotrophins first discovered in the 1950s and acts on TrkB and pan75 neurotrophin receptor (p75(NTR) ) receptors. TrkB-signalling leads to increased proliferation and survival, whereas p75(NTR) -signalling is less clear but has mostly been associated with cell damage and apoptosis (Ibanez and Simi, 2012)...
November 2, 2016: Acta Physiologica
https://www.readbyqxmd.com/read/27803649/two-photon-holographic-stimulation-of-reachr
#5
Emmanuelle Chaigneau, Emiliano Ronzitti, Marta A Gajowa, Gilberto J Soler-Llavina, Dimitrii Tanese, Anthony Y B Brureau, Eirini Papagiakoumou, Hongkui Zeng, Valentina Emiliani
Optogenetics provides a unique approach to remotely manipulate brain activity with light. Reaching the degree of spatiotemporal control necessary to dissect the role of individual cells in neuronal networks, some of which reside deep in the brain, requires joint progress in opsin engineering and light sculpting methods. Here we investigate for the first time two-photon stimulation of the red-shifted opsin ReaChR. We use two-photon (2P) holographic illumination to control the activation of individually chosen neurons expressing ReaChR in acute brain slices...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27504261/disrupted-functional-connectivity-in-adolescent-obesity
#6
Laura Moreno-Lopez, Oren Contreras-Rodriguez, Carles Soriano-Mas, Emmanuel A Stamatakis, Antonio Verdejo-Garcia
BACKGROUND/OBJECTIVE: Obesity has been associated with brain alterations characterised by poorer interaction between a hypersensitive reward system and a comparatively weaker prefrontal-cognitive control system. These alterations may occur as early as in adolescence, but this notion remains unclear, as no studies so far have examined global functional connectivity in adolescents with excess weight. SUBJECTS/METHODS: We investigated functional connectivity in a sample of 60 adolescents with excess weight and 55 normal weight controls...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27165936/normal-pressure-hydrocephalus-case-report-self-documented-over-8-years-with-the-author-s-observations
#7
Omer Elsabbagh
Normal-pressure hydrocephalus is an almost curable disease, but the results of management are still not encouraging owing to the deceptive nature of the disease and its sensitivity to treatment. This has made the management of the disease controversial. The following self-documented report clarifies this. I have reported my experience in a scientific manner so that my colleagues can understand thoroughly certain facts related to intracranial hypertension. Achieving the optimal adjustment of the valve is a real challenge...
2016: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/27302679/intraspinal-transplantation-of-subventricular-zone-derived-neural-progenitor-cells-improves-phrenic-motor-output-after-high-cervical-spinal-cord-injury
#8
M S Sandhu, H H Ross, K Z Lee, B K Ormerod, P J Reier, D D Fuller
Following spinal cord injury (SCI), intraspinal transplantation of neural progenitor cells (NPCs) harvested from the forebrain sub-ventricular zone (SVZ) can improve locomotor outcomes. Cervical SCI often results in respiratory-related impairments, and here we used an established model cervical SCI (C2 hemisection, C2Hx) to confirm the feasibility of mid-cervical transplantation of SVZ-derived NPCs and the hypothesis that that this procedure would improve spontaneous respiratory motor recovery. NPCs were isolated from the SVZ of enhanced green fluorescent protein (GFP) expressing neonatal rats, and then intraspinally delivered immediately caudal to an acute C2Hx lesion in adult non-GFP rats...
June 11, 2016: Experimental Neurology
https://www.readbyqxmd.com/read/27333899/the-major-influence-of-the-atmosphere-on-intracranial-pressure-an-observational-study
#9
Leszek Herbowski
The impact of the atmosphere on human physiology has been studied widely within the last years. In practice, intracranial pressure is a pressure difference between intracranial compartments and the surrounding atmosphere. This means that gauge intracranial pressure uses atmospheric pressure as its zero point, and therefore, this method of pressure measurement excludes the effects of barometric pressure's fluctuation. The comparison of these two physical quantities can only take place through their absolute value relationship...
June 22, 2016: International Journal of Biometeorology
https://www.readbyqxmd.com/read/27285540/is-life-worth-living-decompressive-craniectomy-and-the-disability-paradox
#10
Stephen Honeybul, Grant R Gillett, Kwok M Ho, Courtney Janzen, Kate Kruger
No abstract text is available yet for this article.
September 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27083532/google-trends-new-evidence-for-seasonality-of-multiple-sclerosis
#11
LETTER
Marcello Moccia, Raffaele Palladino, Andrea Falco, Francesco Saccà, Roberta Lanzillo, Vincenzo Brescia Morra
No abstract text is available yet for this article.
September 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/27118036/-journal-bias-in-peer-reviewed-literature-an-analysis-of-the-surgical-high-grade-glioma-literature
#12
Brian R Hirshman, Laurie A Jones, Jessica A Tang, James A Proudfoot, Kathleen M Carley, Bob S Carter, Clark C Chen
The core premise of evidence-based medicine is that clinical decisions are informed by the peer-reviewed literature. To extract meaningful conclusions from this literature, one must first understand the various forms of biases inherent within the process of peer review. We performed an exhaustive search that identified articles exploring the question of whether survival benefit was associated with maximal high-grade glioma (HGG) resection and analysed this literature for patterns of publication. We found that the distribution of these 108 articles among the 26 journals to be non-random (p<0...
April 26, 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/27172939/neuronal-network-disintegration-common-pathways-linking-neurodegenerative-diseases
#13
Rebekah M Ahmed, Emma M Devenney, Muireann Irish, Arne Ittner, Sharon Naismith, Lars M Ittner, Jonathan D Rohrer, Glenda M Halliday, Andrew Eisen, John R Hodges, Matthew C Kiernan
Neurodegeneration refers to a heterogeneous group of brain disorders that progressively evolve. It has been increasingly appreciated that many neurodegenerative conditions overlap at multiple levels and therefore traditional clinicopathological correlation approaches to better classify a disease have met with limited success. Neuronal network disintegration is fundamental to neurodegeneration, and concepts based around such a concept may better explain the overlap between their clinical and pathological phenotypes...
November 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/27178897/early-blood-pressure-lowering-in-patients-with-intracerebral-haemorrhage-and-prior-use-of-antithrombotic-agents-pooled-analysis-of-the-interact-studies
#14
Lili Song, Else Charlotte Sandset, Hisatomi Arima, Emma Heeley, Candice Delcourt, Guofeng Chen, Jie Yang, Guojun Wu, Xia Wang, Pablo M Lavados, Yining Huang, Christian Stapf, Jiguang Wang, Thompson G Robinson, John Chalmers, Richard I Lindley, Craig S Anderson
OBJECTIVE: Antithrombotic agents increase risks of intracerebral haemorrhage (ICH) and associated adverse outcomes. We determined differential effects of early blood pressure (BP) lowering in patients with/without antithrombotic-associated ICH in the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trials (INTERACT1 and 2). DESIGN: Post hoc pooled analyses of the INTERACT studies-international, multicentre, prospective, open, blinded end point trials of patients with ICH (<6 h) and elevated systolic BP (SBP 150-180 mm Hg) randomly assigned to intensive (target SBP <140 mm Hg) or guideline-based (SBP <180 mm Hg) BP management...
May 13, 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/26956423/a-subcutaneous-cellular-implant-for-passive-immunization-against-amyloid-%C3%AE-reduces-brain-amyloid-and-tau-pathologies
#15
Aurélien Lathuilière, Vanessa Laversenne, Alberto Astolfo, Erhard Kopetzki, Helmut Jacobsen, Marco Stampanoni, Bernd Bohrmann, Bernard L Schneider, Patrick Aebischer
Passive immunization against misfolded toxic proteins is a promising approach to treat neurodegenerative disorders. For effective immunotherapy against Alzheimer's disease, recent clinical data indicate that monoclonal antibodies directed against the amyloid-β peptide should be administered before the onset of symptoms associated with irreversible brain damage. It is therefore critical to develop technologies for continuous antibody delivery applicable to disease prevention. Here, we addressed this question using a bioactive cellular implant to deliver recombinant anti-amyloid-β antibodies in the subcutaneous tissue...
May 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/27105800/periorbital-rejuvenation-overview-of-nonsurgical-treatment-options
#16
REVIEW
Dee Anna Glaser, Anastasia Kurta
Numerous nonsurgical options for periorbital rejuvenation are available and can be used alone or as adjuncts to other nonsurgical and surgical options. Topicals, chemical peels, laser resurfacing, and dermabrasion therapy, along with neuromodulators and fillers, can be used to enhance the appearance of the periorbital region.
May 2016: Facial Plastic Surgery Clinics of North America
https://www.readbyqxmd.com/read/27128250/a-multimodal-approach-to-rejuvenation-of-the-lower-face
#17
Jean Carruthers, Alastair Carruthers
BACKGROUND: Facial aging is multifactorial, including changes in all the anatomical layers of the face including bone, fat, connective tissues and skin. METHODS: An evaluation of the multifactorial causation of facial aging pointed to the need for a multifactorial approach to restoration and rejuvenation of the aging human face. RESULTS: The varied aetiologies of the expressions of facial aging require more interventions than a unipolar approach...
May 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27128248/rejuvenation-of-the-upper-face-and-periocular-region-combining-neuromodulator-facial-filler-laser-light-and-energy-based-therapies-for-optimal-results
#18
Nicole Langelier, Katie Beleznay, Julie Woodward
BACKGROUND: The upper face and periocular region is a complex and dynamic part of the face. Successful rejuvenation requires a combination of minimally invasive modalities to fill dents and hollows, resurface rhytides, improve pigmentation, and smooth the mimetic muscles of the face without masking facial expression. METHODS: Using review of the literature and clinical experience, the authors discuss our strategy for combining botulinum toxin, facial filler, ablative laser, intense pulsed light, microfocused ultrasound, and microneedle fractional radiofrequency to treat aesthetic problems of the upper face including brow ptosis, temple volume loss, A-frame deformity of the superior sulcus, and superficial and deep rhytides...
May 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27068758/melatonin-administration-reverses-the-alteration-of-amyloid-precursor-protein-cleaving-secretases-expression-in-aged-mouse-hippocampus
#19
Sujira Mukda, Jiraporn Panmanee, Parichart Boontem, Piyarat Govitrapong
Beta-amyloid (Aβ) peptide is the pathological hallmark of Alzheimer's disease (AD). Interestingly, Aβ is normally synthesized in the brain of healthy people; however, during advanced aging, the level of Aβ peptides increases. As a result, the aggregation of Aβ peptides leads to trafficking problems, synaptic loss, inflammation, and cell death. Melatonin, the hormone primarily synthesized and secreted from the pineal gland, is decreased with progressing age, particularly in Alzheimer's disease patients. The loss of melatonin levels and the abnormal accumulation of some proteins, such as Aβ peptides in the brains of AD patients are considered important factors in the initiation of the cognitive symptoms of dementia...
May 16, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/26970480/normal-pressure-hydrocephalus-and-parkinsonism-preliminary-data-on-neurosurgical-and-neurological-treatment
#20
Morgan Broggi, Veronica Redaelli, Giovanni Tringali, Francesco Restelli, Luigi Romito, Silvia Schiavolin, Fabrizio Tagliavini, Giovanni Broggi
OBJECTIVE: Idiopathic normal pressure hydrocephalus (iNPH) may present, besides the classic triad of symptoms, with extrapyramidal parkinsonianlike movement disorders. We present a randomized prospective study comparing adjustable ventriculoperitoneal (VP) shunt insertion plus dopamine oral therapy (group A) versus VP shunt alone (group B) in patients affected by iNPH associated with parkinsonism. METHODS: A detailed screening process included neurologic, neurosurgical, and neuropsychological evaluations, followed by a cerebrospinal fluid tap test and resistance outflow measurement...
June 2016: World Neurosurgery
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