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34 papers 25 to 100 followers
https://www.readbyqxmd.com/read/27492964/medication-induced-diabetes-mellitus
#1
REVIEW
David R Repaske
Epidemiological studies and case reports have demonstrated an increased rate of development of diabetes mellitus consequent to taking diverse types of medication. This review explores this evidence linking these medications and development of diabetes and presents postulated mechanisms by which the medications might cause diabetes. Some medications are associated with a reduction in insulin production, some with reduction in insulin sensitivity, and some appear to be associated with both reduction in insulin production and insulin sensitivity...
September 2016: Pediatric Diabetes
https://www.readbyqxmd.com/read/27068718/acg-clinical-guideline-diagnosis-treatment-and-prevention-of-acute-diarrheal-infections-in-adults
#2
Mark S Riddle, Herbert L DuPont, Bradley A Connor
Acute diarrheal infections are a common health problem globally and among both individuals in the United States and traveling to developing world countries. Multiple modalities including antibiotic and non-antibiotic therapies have been used to address these common infections. Information on treatment, prevention, diagnostics, and the consequences of acute diarrhea infection has emerged and helps to inform clinical management. In this ACG Clinical Guideline, the authors present an evidence-based approach to diagnosis, prevention, and treatment of acute diarrhea infection in both US-based and travel settings...
May 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/26605929/treatment-of-tuberculosis
#3
REVIEW
C Robert Horsburgh, Clifton E Barry, Christoph Lange
Tuberculosis, a scourge since prehistoric times, affects more than 9 million people and causes the death of 1.5 million people each year. Effective treatment has been available for 60 years, but such treatment takes at least 6 months, and resistance to the drugs, which is increasing throughout the..
November 26, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/21366472/diuretic-strategies-in-patients-with-acute-decompensated-heart-failure
#4
RANDOMIZED CONTROLLED TRIAL
G Michael Felker, Kerry L Lee, David A Bull, Margaret M Redfield, Lynne W Stevenson, Steven R Goldsmith, Martin M LeWinter, Anita Deswal, Jean L Rouleau, Elizabeth O Ofili, Kevin J Anstrom, Adrian F Hernandez, Steven E McNulty, Eric J Velazquez, Abdallah G Kfoury, Horng H Chen, Michael M Givertz, Marc J Semigran, Bradley A Bart, Alice M Mascette, Eugene Braunwald, Christopher M O'Connor
BACKGROUND: Loop diuretics are an essential component of therapy for patients with acute decompensated heart failure, but there are few prospective data to guide their use. METHODS: In a prospective, double-blind, randomized trial, we assigned 308 patients with acute decompensated heart failure to receive furosemide administered intravenously by means of either a bolus every 12 hours or continuous infusion and at either a low dose (equivalent to the patient's previous oral dose) or a high dose (2...
March 3, 2011: New England Journal of Medicine
https://www.readbyqxmd.com/read/21632909/how-to-manage-type-2-diabetes-in-medical-and-surgical-patients-in-the-hospital
#5
REVIEW
Guilermo E Umpierez
Many patients admitted to the hospital have diabetes mellitus-diagnosed or undiagnosed-and others develop hyperglycemia from the stress of hospitalization. This paper discusses the prevalence, outcomes, and evidence for best management of hyperglycemia and diabetes in hospitalized patients outside the critical care setting.
June 2011: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/22287700/medical-management-of-hepatorenal-syndrome
#6
REVIEW
Andrew Davenport, Jawad Ahmad, Ali Al-Khafaji, John A Kellum, Yuri S Genyk, Mitra K Nadim
Hepatorenal syndrome (HRS) is defined as the occurrence of renal dysfunction in a patient with end-stage liver cirrhosis in the absence of another identifiable cause of renal failure. The prognosis of HRS remains poor, with a median survival without liver transplantation of <6 months. However, understanding the pathogenesis of HRS has led to the introduction of treatments designed to increase renal perfusion and mean arterial blood pressure using vasopressors and albumin, which has led to improvement in renal function in ∼50% of patients...
January 2012: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/26696689/13-diabetes-care-in-the-hospital
#7
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
January 2016: Diabetes Care
https://www.readbyqxmd.com/read/21482729/hiv-and-tuberculosis-a-deadly-human-syndemic
#8
REVIEW
Candice K Kwan, Joel D Ernst
A syndemic is defined as the convergence of two or more diseases that act synergistically to magnify the burden of disease. The intersection and syndemic interaction between the human immunodeficiency virus (HIV) and tuberculosis (TB) epidemics have had deadly consequences around the world. Without adequate control of the TB-HIV syndemic, the long-term TB elimination target set for 2050 will not be reached. There is an urgent need for additional resources and novel approaches for the diagnosis, treatment, and prevention of both HIV and TB...
April 2011: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/26690796/prevention-and-treatment-of-sepsis-induced-acute-kidney-injury-an-update
#9
Patrick M Honore, Rita Jacobs, Inne Hendrickx, Sean M Bagshaw, Olivier Joannes-Boyau, Willem Boer, Elisabeth De Waele, Viola Van Gorp, Herbert D Spapen
Sepsis-induced acute kidney injury (SAKI) remains an important challenge in critical care medicine. We reviewed current available evidence on prevention and treatment of SAKI with focus on some recent advances and developments. Prevention of SAKI starts with early and ample fluid resuscitation preferentially with crystalloid solutions. Balanced crystalloids have no proven superior benefit. Renal function can be evaluated by measuring lactate clearance rate, renal Doppler, or central venous oxygenation monitoring...
December 2015: Annals of Intensive Care
https://www.readbyqxmd.com/read/26685124/proton-pump-inhibitor-responsive-oesophageal-eosinophilia-an-entity-challenging-current-diagnostic-criteria-for-eosinophilic-oesophagitis
#10
Javier Molina-Infante, Albert J Bredenoord, Edaire Cheng, Evan S Dellon, Glenn T Furuta, Sandeep K Gupta, Ikuo Hirano, David A Katzka, Fouad J Moawad, Marc E Rothenberg, Alain Schoepfer, Stuart J Spechler, Ting Wen, Alex Straumann, Alfredo J Lucendo
Consensus diagnostic recommendations to distinguish GORD from eosinophilic oesophagitis (EoE) by response to a trial of proton pump inhibitors (PPIs) unexpectedly uncovered an entity called 'PPI-responsive oesophageal eosinophilia' (PPI-REE). PPI-REE refers to patients with clinical and histological features of EoE that remit with PPI treatment. Recent and evolving evidence, mostly from adults, shows that patients with PPI-REE and patients with EoE at baseline are clinically, endoscopically and histologically indistinguishable and have a significant overlap in terms of features of Th2 immune-mediated inflammation and gene expression...
March 2016: Gut
https://www.readbyqxmd.com/read/26457719/albumin-and-furosemide-combination-for-management-of-edema-in-nephrotic-syndrome-a-review-of-clinical-studies
#11
REVIEW
Margaret Duffy, Shashank Jain, Nicholas Harrell, Neil Kothari, Alluru S Reddi
The treatment of edema in patients with nephrotic syndrome is generally managed by dietary sodium restriction and loop diuretics. However, edema does not improve in some patients despite adequate sodium restriction and maximal dose of diuretics. In such patients, combination of albumin and a loop diuretic may improve edema by diuresis and natriuresis. The response to this combination of albumin and a diuretic has not been observed in all studies. The purpose of this review is to discuss the physiology of diuresis and natriuresis of this combination therapy, and provide a brief summary of various studies that have used albumin and a loop diuretic to improve diuretic-resistant edema...
October 7, 2015: Cells
https://www.readbyqxmd.com/read/26586276/the-divergent-cardiovascular-effects-of-angiotensin-converting-enzyme-inhibitors-and-angiotensin-receptor-blockers-on-myocardial-infarction-and-death
#12
REVIEW
Martin H Strauss, Alistair S Hall
The renin angiotensin aldosterone system (RAAS) plays a central role in the pathophysiology of hypertension and vascular disease. Angiotensin converting enzyme inhibitors (ACEis) suppress angiotensin II (ANG II) concentrations, whereas angiotensin receptor blockers (ARBs) block the binding of ANG II to AT1 receptors. ACEis and ARBs are both effective anti-hypertensive agents and have similar risk reductions in stroke - a blood pressure dependent phenomenon. ACEis also reduce the risk of myocardial infarction (MI) and mortality in high risk hypertensive patients, as well as in diabetics, the elderly, those with vascular disease, and in congestive heart failure...
March 2016: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/26498416/kdoqi-clinical-practice-guideline-for-hemodialysis-adequacy-2015-update
#13
REVIEW
(no author information available yet)
The National Kidney Foundation's Kidney Disease Outcomes Quality Initiative (KDOQI) has provided evidence-based guidelines for all stages of chronic kidney disease (CKD) and related complications since 1997. The 2015 update of the KDOQI Clinical Practice Guideline for Hemodialysis Adequacy is intended to assist practitioners caring for patients in preparation for and during hemodialysis. The literature reviewed for this update includes clinical trials and observational studies published between 2000 and March 2014...
November 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26558188/hepatorenal-syndrome-update-on-diagnosis-and-treatment
#14
REVIEW
Olga Baraldi, Chiara Valentini, Gabriele Donati, Giorgia Comai, Vania Cuna, Irene Capelli, Maria Laura Angelini, Maria Ilaria Moretti, Andrea Angeletti, Fabio Piscaglia, Gaetano La Manna
Acute kidney injury (AKI) is a common complication in patients with end-stage liver disease and advanced cirrhosis regardless of the underlying cause. Hepatorenal syndrome (HRS), a functional form of kidney failure, is one of the many possible causes of AKI. HRS is potentially reversible but involves highly complex pathogenetic mechanisms and equally complex clinical and therapeutic management. Once HRS has developed, it has a very poor prognosis. This review focuses on the diagnostic approach to HRS and discusses the therapeutic protocols currently adopted in clinical practice...
November 6, 2015: World Journal of Nephrology
https://www.readbyqxmd.com/read/26545825/2015-american-college-of-rheumatology-guideline-for-the-treatment-of-rheumatoid-arthritis
#15
REVIEW
Jasvinder A Singh, Kenneth G Saag, S Louis Bridges, Elie A Akl, Raveendhara R Bannuru, Matthew C Sullivan, Elizaveta Vaysbrot, Christine McNaughton, Mikala Osani, Robert H Shmerling, Jeffrey R Curtis, Daniel E Furst, Deborah Parks, Arthur Kavanaugh, James O'Dell, Charles King, Amye Leong, Eric L Matteson, John T Schousboe, Barbara Drevlow, Seth Ginsberg, James Grober, E William St Clair, Elizabeth Tindall, Amy S Miller, Timothy McAlindon
OBJECTIVE: To develop a new evidence-based, pharmacologic treatment guideline for rheumatoid arthritis (RA). METHODS: We conducted systematic reviews to synthesize the evidence for the benefits and harms of various treatment options. We used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology to rate the quality of evidence. We employed a group consensus process to grade the strength of recommendations (either strong or conditional)...
January 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/26624819/anticoagulant-can-be-reversed
#16
Rebecca Voelker
No abstract text is available yet for this article.
December 1, 2015: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/26624824/effect-of-metformin-added-to-insulin-on-glycemic-control-among-overweight-obese-adolescents-with-type-1-diabetes-a-randomized-clinical-trial
#17
RANDOMIZED CONTROLLED TRIAL
Ingrid M Libman, Kellee M Miller, Linda A DiMeglio, Kathleen E Bethin, Michelle L Katz, Avni Shah, Jill H Simmons, Michael J Haller, Sripriya Raman, William V Tamborlane, Julie K Coffey, Ashleigh M Saenz, Roy W Beck, Kristen J Nadeau
IMPORTANCE: Previous studies assessing the effect of metformin on glycemic control in adolescents with type 1 diabetes have produced inconclusive results. OBJECTIVE: To assess the efficacy and safety of metformin as an adjunct to insulin in treating overweight adolescents with type 1 diabetes. DESIGN, SETTING, AND PARTICIPANTS: Multicenter (26 pediatric endocrinology clinics), double-blind, placebo-controlled randomized clinical trial involving 140 adolescents aged 12...
December 1, 2015: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/26624842/jama-patient-page-pcsk9-inhibitors-for-treating-high-cholesterol
#18
Jill Jin
No abstract text is available yet for this article.
December 1, 2015: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/26608256/liraglutide-safety-and-efficacy-in-patients-with-non-alcoholic-steatohepatitis-lean-a-multicentre-double-blind-randomised-placebo-controlled-phase-2-study
#19
RANDOMIZED CONTROLLED TRIAL
Matthew James Armstrong, Piers Gaunt, Guruprasad P Aithal, Darren Barton, Diana Hull, Richard Parker, Jonathan M Hazlehurst, Kathy Guo, George Abouda, Mark A Aldersley, Deborah Stocken, Stephen C Gough, Jeremy W Tomlinson, Rachel M Brown, Stefan G Hübscher, Philip N Newsome
BACKGROUND: Glucagon-like peptide-1 (GLP-1) analogues reduce hepatic steatosis, concentrations of liver enzymes, and insulin resistance in murine models of fatty liver disease. These analogues are licensed for type 2 diabetes, but their efficacy in patients with non-alcoholic steatohepatitis is unknown. We assessed the safety and efficacy of the long-acting GLP-1 analogue, liraglutide, in patients with non-alcoholic steatohepatitis. METHODS: This multicentre, double-blinded, randomised, placebo-controlled phase 2 trial was conducted in four UK medical centres to assess subcutaneous injections of liraglutide (1·8 mg daily) compared with placebo for patients who are overweight and show clinical evidence of non-alcoholic steatohepatitis...
February 13, 2016: Lancet
https://www.readbyqxmd.com/read/26608257/a-lean-treatment-for-non-alcoholic-steatohepatitis
#20
COMMENT
Vincent Wai-Sun Wong, Grace Lai-Hung Wong
No abstract text is available yet for this article.
February 13, 2016: Lancet
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