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Sickle cell

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3 papers 0 to 25 followers
https://www.readbyqxmd.com/read/24084325/hydroxyurea-is-associated-with-lower-prevalence-of-albuminuria-in-adults-with-sickle-cell-disease
#1
Louis-Philippe Laurin, Patrick H Nachman, Payal C Desai, Kenneth I Ataga, Vimal K Derebail
BACKGROUND: Albuminuria is an early manifestation of sickle cell nephropathy. Prior small case series suggests benefit of hydroxyurea in reducing albuminuria, with a similar trend noted in pediatric studies. We aimed to comprehensively evaluate hydroxyurea use and prevalence of albuminuria in adult sickle cell patients. METHODS: We performed a cross-sectional study of 149 adult patients followed between 2000 and 2011 in a comprehensive sickle cell clinic. All patients were assessed for albuminuria either by direct measurement or by urinary chemical strip (dipstick) testing...
June 2014: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/15940917/-pathophysiology-and-treatment-of-sickle-cell-disease
#2
REVIEW
E J van Beers, M Peters, B J Biemond
Sickle-cell disease is a hereditary haemoglobinopathy caused by a mutation in the beta-globin gene. The disease is characterised by recurrent vaso-occlusive crises resulting in severe organ damage and a sharply reduced life expectancy. The formation of haemoglobin-S polymers in hypoxic conditions plays a pivotal role in sickle-cell disease and produces the characteristic phenotype of sickle-shaped erythrocytes that promote vasoocclusion. Endothelial cell activation, enhanced erythrocyte and leukocyte adhesion, vasoconstriction and coagulation activation play an important role in vaso-occlusive crises...
May 21, 2005: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/7993409/mortality-in-sickle-cell-disease-life-expectancy-and-risk-factors-for-early-death
#3
O S Platt, D J Brambilla, W F Rosse, P F Milner, O Castro, M H Steinberg, P P Klug
BACKGROUND: Information on life expectancy and risk factors for early death among patients with sickle cell disease (sickle cell anemia, sickle cell-hemoglobin C disease, and the sickle cell-beta-thalassemias) is needed to counsel patients, target therapy, and design clinical trials. METHODS: We followed 3764 patients who ranged from birth to 66 years of age at enrollment to determine the life expectancy and calculate the median age at death. In addition, we investigated the circumstances of death for all 209 adult patients who died during the study, and used proportional-hazards regression analysis to identify risk factors for early death among 964 adults with sickle cell anemia who were followed for at least two years...
June 9, 1994: New England Journal of Medicine
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