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Amalia Stefanou, Nathan Marshall, Wendy Holdan, Aamir Siddiqui
PURPOSE: We designed a prospective, randomized study to evaluate the effects of iontophoresis delivery of dexamethasone versus corticosteroid injection therapy on patient outcomes. METHODS: We randomized 82 patients to 10 mg dexamethasone via iontophoresis using a self-contained patch with a 24-hour battery; 10 mg dexamethasone injection; or 10 mg triamcinolone injection. All patients received the same hand therapy protocol. Primary outcomes tracked were change in grip strength (flexion vs extension), pain, and function scores on a validated questionnaire...
January 2012: Journal of Hand Surgery
A Burke Gurney, Daniel C Wascher
BACKGROUND: Iontophoresis ostensibly facilitates the delivery of medications through the skin to underlying tissues using a direct electrical current. Dexamethasone is the most commonly used medication with iontophoresis to treat a variety of connective tissue disorders. HYPOTHESIS: Iontophoresis will facilitate the absorption of dexamethasone into connective tissue compared with diffusion. STUDY DESIGN: Controlled laboratory study. METHODS: Twenty-nine adults undergoing anterior cruciate ligament reconstructive surgery using the semitendinosus/gracilis autograft were randomly assigned to either a true iontophoresis (TI) or sham iontophoresis (SI)...
April 2008: American Journal of Sports Medicine
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