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Marie-Anne Couturier, Françoise Huguet, Patrice Chevallier, Felipe Suarez, Xavier Thomas, Martine Escoffre-Barbe, Victoria Cacheux, Jean-Michel Pignon, Caroline Bonmati, Laurence Sanhes, Pierre Bories, Etienne Daguindau, Véronique Dorvaux, Oumedaly Reman, Jamile Frayfer, Corentin Orvain, Véronique Lhéritier, Norbert Ifrah, Hervé Dombret, Mathilde Hunault-Berger, Aline Tanguy-Schmidt
Central nervous system (CNS) thrombotic events are a well-known complication of acute lymphoblastic leukemia (ALL) induction therapy, especially with treatments including l-asparaginase (l-ASP). Data on risk factors and clinical evolution is still lacking in adult patients. We report on the clinical evolution of 22 CNS venous thrombosis cases occurring in 708 adults treated for ALL or lymphoblastic lymphoma (LL) with the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL)-induction protocol, which included eight L-ASP (6,000 IU/m(2) ) infusions...
November 2015: American Journal of Hematology
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